Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes

Journal of Molecular Biology - Tập 304 - Trang 323-334 - 2000
Kristina Schoonjans1, Laurent Gelman1, Céline Haby1, Michael Briggs2, Johan Auwerx1
1Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 67404 Illkirch, France
2Ligand Pharmaceuticals, San Diego, CA 92121, USA

Tài liệu tham khảo

Athanikar, 1998, Specificity in cholesterol regulation of gene expression by co-evolution of sterol regulatory DNA element and its binding protein, Proc. Natl Acad. Sci. USA, 95, 4935, 10.1073/pnas.95.9.4935 Auwerx, 1989, Lipoprotein lipase gene expression in THP-1 cells, Biochemistry, 28, 4563, 10.1021/bi00437a009 Auwerx, 1992, Lipoprotein lipase, Crit. Rev. Clin. Lab. Sci., 29, 243, 10.3109/10408369209114602 Bennet, 1995, Sterol regulation of fatty acid synthase promoter; coordinate feedback regulation of two major lipid pathways, J. Biol. Chem, 270, 25578, 10.1074/jbc.270.43.25578 Boizard, 1998, Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors, J. Biol. Chem, 273, 29164, 10.1074/jbc.273.44.29164 Briggs, 1993, Nuclear protein that binds sterol regulatory element of LDL receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence, J. Biol. Chem, 268, 14490, 10.1016/S0021-9258(19)85265-1 Brown, 1997, The SREBP pathway, Cell, 89, 331, 10.1016/S0092-8674(00)80213-5 Currie, 1992, Characterization of a high affinity octamer transcription factor binding site in the human lipoprotein lipase promoter, Arch. Biochem. Biophys., 298, 630, 10.1016/0003-9861(92)90459-A Dignam, 1983, Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei, Nucl. Acids Res, 11, 1475, 10.1093/nar/11.5.1475 Enerback, 1992, Characterization of the human lipoprotein lipase (LPL) promotor, Mol. Cell. Biol, 12, 4622 Ericsson, 1996, Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene, Proc. Natl Acad. Sci. USA, 93, 945, 10.1073/pnas.93.2.945 Ericsson, 1997, Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene, J. Biol. Chem, 272, 7298, 10.1074/jbc.272.11.7298 Foretz, 1999, Sterol regulatory element binding protein 1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes, Proc. Natl Acad. Sci. USA, 96, 12737, 10.1073/pnas.96.22.12737 Foretz, 1999, ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose, Mol. Cell. Biol, 19, 3760, 10.1128/MCB.19.5.3760 Guan, 1997, Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene, J. Biol. Chem, 272, 10295, 10.1074/jbc.272.15.10295 Horton, 1998, Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice, Proc. Natl Acad. Sci. USA, 95, 5987, 10.1073/pnas.95.11.5987 Janowski, 1996, An oxysterol signalling pathway mediated by the nuclear receptor LXRα, Nature, 383, 728, 10.1038/383728a0 Jones, 1985, Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro, Cell, 42, 559, 10.1016/0092-8674(85)90113-8 Kim, 1996, ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism, Genes Dev., 10, 1096, 10.1101/gad.10.9.1096 Kim, 1995, Dual DNA binding specificity of ADD-1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain, Mol. Cell. Biol, 15, 2582, 10.1128/MCB.15.5.2582 Kim, 1998, Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1, J. Clin. Invest, 101, 1, 10.1172/JCI1411 Kim, 1998, ADD1/SREBP1 activates PPARγ through the production of endogeneous ligand, Proc. Natl Acad. Sci. USA, 95, 4333, 10.1073/pnas.95.8.4333 Lopez, 1996, Sterol regulation of acetyl coenzyme A carboxylase, Proc. Natl Acad. Sci. USA, 93, 1049, 10.1073/pnas.93.3.1049 MacGregor, 1989, Construction of plasmids that express E. coli β-galactosidase in mammalian cells, Nucl. Acids Res, 17, 2365, 10.1093/nar/17.6.2365 Magana, 1996, Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty acid synthase promoter, J. Biol. Chem, 271, 32689, 10.1074/jbc.271.51.32689 Magana, 1997, Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins, J. Lipid Res, 38, 1630, 10.1016/S0022-2275(20)37181-9 Magana, 2000, Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase, J. Biol. Chem., 275, 4726, 10.1074/jbc.275.7.4726 Masiakowski, 1982, Cloning of cDNA sequences of hormone-regulated genes from MCF-7 human breast cancer cell line, Nucl. Acids Res., 10, 7895, 10.1093/nar/10.24.7895 Nakshatri, 1995, Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter, J. Biol. Chem, 270, 19613, 10.1074/jbc.270.33.19613 O’Reilly, 1992 Peet, 1998, Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha, Cell, 93, 693, 10.1016/S0092-8674(00)81432-4 Pissios, 1999, SREBP-1 binds to multiple sites and transactivates the human ApoA-II promoter in vitro, Arterioscler. Thromb. Vasc. Biol., 19, 1456, 10.1161/01.ATV.19.6.1456 Previato, 1991, Transcriptional regulation of the human lipoprotein lipase gene in 3T3-L1 adipocytes, J. Biol. Chem, 266, 18958, 10.1016/S0021-9258(18)55156-5 Sanchez, 1995, Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene, J. Biol. Chem, 270, 1161, 10.1074/jbc.270.3.1161 Schoonjans, 1993, Developmental extinction of liver lipoprotein lipase mRNA expression might be regulated by an NF-1 like site, FEBS Letters, 329, 89, 10.1016/0014-5793(93)80200-E Schoonjans, 1996, PPARα and PPARγ activators direct a tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene, EMBO J., 15, 5336, 10.1002/j.1460-2075.1996.tb00918.x Schoonjans, 1999, HMG-CoA reductase inhibitors reduce serum triglyceride levels through effects on apolipoprotein C-III and lipoprotein lipase levels, FEBS Letters, 452, 160, 10.1016/S0014-5793(99)00632-8 Shimano, 1996, Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a, J. Clin. Invest., 98, 1575, 10.1172/JCI118951 Shimano, 1997, Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells, J. Clin. Invest, 99, 846, 10.1172/JCI119248 Shimomura, 1997, Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver, Proc. Natl Acad. Sci. USA, 94, 12345, 10.1073/pnas.94.23.12354 Shimomura, 2000, Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice, Mol Cell, 6, 77, 10.1016/S1097-2765(05)00010-9 Smith, 1990, Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene, J. Biol. Chem, 265, 2306, 10.1016/S0021-9258(19)39976-4 Swinnen, 1998, Identification of diazepam-binding inhibitor/acyl-coA-binding protein as a sterol regulatory element-binding protein-responsive gene, J. Biol. Chem, 273, 19938, 10.1074/jbc.273.32.19938 Tabor, 1998, Transcriptional activation of the stearoyl-coA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differenciation factor 1, J. Cell. Biochem, 273, 22052 Thewke, 1998, Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins, J. Cell. Biochem, 273, 21402 Tontonoz, 1993, ADD1, Mol. Cell. Biol, 13, 4753, 10.1128/MCB.13.8.4753 Vallett, 1996, A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene, J. Biol. Chem, 271, 12247, 10.1074/jbc.271.21.12247 Wang, 1993, Nuclear protein that binds sterol regulatory element of LDL receptor promoter, J. Biol. Chem, 268, 14497, 10.1016/S0021-9258(19)85266-3 Wang, 1994, SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis, Cell, 77, 53, 10.1016/0092-8674(94)90234-8 Worgall, 1998, Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein, J. Biol. Chem, 273, 25537, 10.1074/jbc.273.40.25537