One‐Pot Aqueous Synthesis of Highly Biocompatible Near Infrared CuInS2 Quantum Dots for Target Cell Imaging

Chinese Journal of Chemistry - Tập 34 Số 6 - Trang 576-582 - 2016
Anila Arshad1, Hongli Chen1, Xilin Bai1, Suying Xu1, Leyu Wang1
1State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing 100029, China

Tóm tắt

Abstract

In this study, we report a novel and facile autoclave strategy for synthesis of near‐infrared (NIR) CuInS2 QDs by employing glutathione (GSH) as capping ligand and stabilizer in aqueous media under 100°C. Various experimental parameters including the ratio of precursors, reaction time, reaction temperature, pH effect and stability have been systematically studied. The QDs were characterized by X‐ray diffraction (XRD), transmission electron microscope (TEM), and Fourier transform infrared spectroscopy (FT‐IR). The as‐synthesized NIR QDs exhibited low cytotoxicity and maintained excellent cell viability even up to 100 µg/mL. After bioconjugation with Arg‐Gly‐Asp (RGD) peptide, the obtained CuInS2‐RGD QDs have demonstrated high targeting ability with good fluorescence cell imaging performance.

Từ khóa


Tài liệu tham khảo

10.1021/ja908250r

Kairdolf B. A., 2013, Annual Review of Analytical Chemistry, 143

10.1038/nmat1390

10.1126/science.1104274

10.1021/ac5026489

10.1021/ac504322s

10.1016/S0958-1669(02)00282-3

10.1016/j.cclet.2013.10.032

10.1016/S1872-1508(08)60086-8

10.6023/A14080618

10.6023/A15040283

10.1002/cjoc.201200601

Hong Y., 2014, Chem. J. Chin. Univ. Chin., 35, 724

10.1039/C4TB01957A

10.1038/nbt929

10.1038/nmat961

10.1038/nbt764

10.1016/j.copbio.2004.11.003

10.1002/cjoc.201100113

10.1016/j.biomaterials.2008.07.025

10.1002/smll.200700595

10.1016/j.jcis.2011.09.043

10.1016/j.addr.2008.03.015

10.1039/c2jm30679d

Chen B. K., 2011, Prog. Chem., 23, 2276

10.1021/ja9005767

10.6023/cjoc201406026

10.1002/smll.201101558

10.1021/nn901421v

10.1021/ja903558r

10.1039/C1JM13170B

10.1021/cm8000688

10.1063/1.1928321

10.1016/j.orgel.2009.09.017

10.1021/cm301285g

10.1002/cjoc.201100672

10.1016/S0003-2697(03)00287-2

10.1063/1.3085964

10.1021/am402328t

10.1039/c3tb20638f

10.1039/C1RA00802A

10.1021/ic400083w

10.1039/b904381k

Thông tin
Thông tin xuất bản

Chinese Journal of Chemistry

Tập 34 Số 6

576-582

Thông tin tác giả