Sertraline and Psychotic Symptoms: A Case Series
Tóm tắt
Sertraline and other SSRIs have a relatively favorable side-effect profile and are widely prescribed. We report the emergence of psychotic symptoms during treatment with sertraline in four patients. Three of these patients had a history of psychotic illness and were on antipsychotic medication, when sertraline was added. The psychotic symptoms emerged within 3 days–7 weeks of starting sertraline and resolved on its discontinuation. We wish to alert clinicians to the possibility that sertraline may provoke or exacerbate positive psychotic symptoms, particularly in patients on neuroleptics, with a previous history of psychosis.
Tài liệu tham khảo
Naranjo CA, Busto U, Sellers EM, Sandor EM, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ: A method for estimating the probability of adverse reactions. Clin Pharmacol Ther 1991; 30:239–245
Wehr TA, Goodwin FK: Can antidepressants cause mania and worsen the course of affective illness? Am J Psychiatry 1987; 144(1);403–411
Bunney WE Jr: Psychopharmacology of the switch process in affective illness. In: Lipton MA, DiMascio A, Kellem KF, eds. Psychopharmacology: A Generation of Progress. New York: Raven Press; 1978
Keshavan MS, Keshavan A: Drug-induced psychotic disorders. In: Keshavan MS, Kennedy JS, eds. Drug-Induced Dysfunction in Psychiatry. New York: Hemisphere; 1992
Nelson JC, Bowers MB, Sweeney DR: Exacerbation of psychosis by tricyclic antidepressants in delusional depression. Am J Psychiatry 1979; 136:574–576
Stoll AL, Mayer PV, Kolbrener M, Goldstein E, Suplit B, Lucier J, Cohen BM, Tohen M: Antidepressant-associated mania: A controlled comparison with spontaneous mania. Am J Psychiatry 1994; 151:1642–1645
Pach J: Pharmacotoxic psychosis and extrapyramidal motor syndrome. A case of acute adverse effect of fluoxetine and flupenthixol. Nervenarzt 1992; 63:575–576 (in German)
Hersch CB, Sokol MS, Pfeffer CR: Transient psychosis with fluoxetine. J Am Acad Child Adol Psychiatry 1991; 30:851–852 (letter)
Lauterbach EC: Serotonin reuptake inhibitors, paranoia, and the ventral basal ganglia. Clin Neuropharmacol 1991; 14:547–555
Mandalos GE, Szarek BL: dose related paranoid reaction associated with fluoxetine. J Nerv Ment Dis 1990; 178:57–58
Markel H, Lee A, Holmes RD, Domino EF: LSD flashback syndrome exacerbated by selective serotonin reuptake inhibitor antidepressants in adolescents. J Pediatr 1994; 125:817–819
Koe BK, Weisman A, Welch WM, Brown RG: Sertraline, 1S, 4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naph thyline, a new uptake inhibitor with selectivity for serotonin. J Pharmacol Exp Ther 1983; 230:94–102
Matthysse S: Dopamine and the pharmacology of schizophrenia: The state of the evidence. J Psychiatr Res 1974; 11:107–113
Hornykiewicz O: Psychopharmacological implications of dopamine and dopamine antagonists: A critical evaluation of current evidence. Neuroscience 1978; 3:773–783
Goff DC, Brotman AW, Waites M, McCormick S: Trial of fluoxetine added to neuroleptics for treatment-resistant schizophrenic patients. Am J Psychiatry 1990; 147:492–494