Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

Cancer Cell - Tập 5 - Trang 317-328 - 2004
Matthew C Franklin1, Kendall D Carey2, Felix F Vajdos1, Daniel J Leahy3,4, Abraham M de Vos1, Mark X Sliwkowski2
1Department of Protein Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94114 USA
2Department of Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94114 USA
3Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
4Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 USA

Tài liệu tham khảo

Agus, 2000, A potential role for activated HER-2 in prostate cancer, Semin. Oncol., 27, 76 Agus, 2002, Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth, Cancer Cell, 2, 127, 10.1016/S1535-6108(02)00097-1 Aroian, 1990, The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily, Nature, 348, 693, 10.1038/348693a0 Arteaga, 2003, ErbB-targeted therapeutic approaches in human cancer, Exp. Cell Res., 284, 122, 10.1016/S0014-4827(02)00104-0 Burgess, 2003, An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors, Mol. Cell, 12, 541, 10.1016/S1097-2765(03)00350-2 Carter, 1992, Humanization of an anti-p185HER2 antibody for human cancer therapy, Proc. Natl. Acad. Sci. USA, 89, 4285, 10.1073/pnas.89.10.4285 Carter, 2000, Development of Herceptin, Breast Disease, 11, 103, 10.3233/BD-1999-11109 Cho, 2002, Structure of the extracellular region of HER3 reveals an interdomain tether, Science, 297, 1330, 10.1126/science.1074611 Cho, 2003, Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab, Nature, 421, 756, 10.1038/nature01392 Clynes, 2000, Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets, Nat. Med., 6, 443, 10.1038/74704 Cobleigh, 1999, Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease, J. Clin. Oncol., 17, 2639, 10.1200/JCO.1999.17.9.2639 Eigenbrot, 1993, X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling, J. Mol. Biol., 229, 969, 10.1006/jmbi.1993.1099 Falls, 2003, Neuregulins, Exp. Cell Res., 284, 14, 10.1016/S0014-4827(02)00102-7 Fendly, 1990, Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product, Cancer Res., 50, 1550 Ferguson, 2000, Extracellular domains drive homo- but not hetero-dimerization of erbB receptors, EMBO J., 19, 4632, 10.1093/emboj/19.17.4632 Ferguson, 2003, EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization, Mol. Cell, 11, 507, 10.1016/S1097-2765(03)00047-9 Fry, 2003, Mechanism of action of erbB tyrosine kinase inhibitors, Exp. Cell Res., 284, 131, 10.1016/S0014-4827(02)00095-2 Garrett, 2002, Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha, Cell, 110, 763, 10.1016/S0092-8674(02)00940-6 Garrett, 2003, The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors, Mol. Cell, 11, 495, 10.1016/S1097-2765(03)00048-0 Graus-Porta, 1997, ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling, EMBO J., 16, 1647, 10.1093/emboj/16.7.1647 Groenen, 1997, A model for the activation of the epidermal growth factor receptor kinase involvement of an asymmetric dimer?, Biochemistry, 36, 3826, 10.1021/bi9614141 Hanks, 1995, Protein kinases 6. The eukaryotic protein kinase superfamily, FASEB J., 9, 576, 10.1096/fasebj.9.8.7768349 Holbro, 2003, The ErbB receptors and their role in cancer progression, Exp. Cell Res., 284, 99, 10.1016/S0014-4827(02)00099-X Hudziak, 1991, Cell transformation potential of a HER2 transmembrane domain deletion mutant retained in the endoplasmic reticulum, J. Biol. Chem., 266, 24109, 10.1016/S0021-9258(18)54400-8 Jorissen, 2003, Epidermal growth factor receptor, Exp. Cell Res., 284, 31, 10.1016/S0014-4827(02)00098-8 Kelley, 1992, Antigen binding thermodynamics and antiproliferative effects of chimeric and humanized anti-p185HER2 antibody Fab fragments, Biochemistry, 31, 5434, 10.1021/bi00139a003 Livneh, 1985, The Drosophila EGF receptor gene homolog, Cell, 40, 599, 10.1016/0092-8674(85)90208-9 Mann, 2001, Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth, Gastroenterology, 120, 1713, 10.1053/gast.2001.24844 Mendoza, 2002, Inhibition of ligand-mediated HER2 activation in androgen-independent prostate cancer, Cancer Res., 62, 5485 Molina, 2001, Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells, Cancer Res., 61, 4744 Murali, 1996, Structural analysis of p185c-neu and epidermal growth factor receptor tyrosine kinases, Proc. Natl. Acad. Sci. USA, 93, 6252, 10.1073/pnas.93.13.6252 Murshudov, 1997, Refinement of Macromolecular Structures by the Maximum-Likelihood Method, Acta Crystallogr. D, 53, 240, 10.1107/S0907444996012255 Navaza, 1994, AMoRe, Acta Crystallogr. A, 50, 157, 10.1107/S0108767393007597 Ogiso, 2002, Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains, Cell, 110, 775, 10.1016/S0092-8674(02)00963-7 Olayioye, 2000, The ErbB signaling network, EMBO J., 19, 3159, 10.1093/emboj/19.13.3159 Paborsky, 1990, Mammalian cell transient expression of tissue factor for the production of antigen, Protein Eng., 3, 547, 10.1093/protein/3.6.547 Paik, 2000, HER2 as a predictor of therapeutic response in breast cancer, Breast Disease, 11, 91, 10.3233/BD-1999-11108 Ross, 1998, The HER-2/neu oncogene in breast cancer, Stem Cells, 16, 413, 10.1002/stem.160413 Schaefer, 1999, A discrete three-amino acid segment (LVI) at the C-terminal end of kinase-impaired ErbB3 is required for transactivation of ErbB2, J. Biol. Chem., 274, 859, 10.1074/jbc.274.2.859 Schlessinger, 2000, Cell signaling by receptor tyrosine kinases, Cell, 103, 211, 10.1016/S0092-8674(00)00114-8 Slamon, 1987, Human breast cancer, Science, 235, 177, 10.1126/science.3798106 Slamon, 2001, Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2, N. Engl. J. Med., 344, 783, 10.1056/NEJM200103153441101 Stamos, 2002, Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor, J. Biol. Chem., 277, 46265, 10.1074/jbc.M207135200 Stein, 2000, Evolutionary analysis of the ErbB receptor and ligand families, J. Mol. Evol., 50, 397, 10.1007/s002390010043 Vajdos, 2002, Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis, J. Mol. Biol., 320, 415, 10.1016/S0022-2836(02)00264-4 Vogel, 2002, Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer, J. Clin. Oncol., 20, 719, 10.1200/JCO.20.3.719 Wadsworth, 1985, A Drosophila genomic sequence with homology to human epidermal growth factor receptor, Nature, 314, 178, 10.1038/314178a0 Ward, 2001, The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules, BMC Bioinformatics, 2, 4, 10.1186/1471-2105-2-4 Werther, 1996, Humanization of an anti-lymphocyte function-associated antigen (LFA)-1 monoclonal antibody and reengineering of the humanized antibody for binding to rhesus LFA-1, J. Immunol., 157, 4986, 10.4049/jimmunol.157.11.4986 Yarden, 2001, Untangling the ErbB signalling network, Nat. Rev. Mol. Cell Biol., 2, 127, 10.1038/35052073