PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

Cell Stem Cell - Tập 4 - Trang 226-235 - 2009
Anne-Marie Bleau1,2, Dolores Hambardzumyan1,2, Tatsuya Ozawa1,2, Elena I. Fomchenko1,2, Jason T. Huse1,3, Cameron W. Brennan2,4, Eric C. Holland1,2,4
1Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
2Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
3Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021 USA
4Department of Neurosurgery and Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA

Tài liệu tham khảo

Bao, 2006, Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, Nature, 444, 756, 10.1038/nature05236 Casorelli, 2007, Methylation damage response in hematopoietic progenitor cells, DNA Repair (Amst.), 6, 1170, 10.1016/j.dnarep.2007.03.024 Chua, 2008, Characterization of a side population of astrocytoma cells in response to temozolomide, J. Neurosurg., 109, 856, 10.3171/JNS/2008/109/11/0856 Dai, 2001, PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo, Genes Dev., 15, 1913, 10.1101/gad.903001 Dean, 2005, Tumour stem cells and drug resistance, Nat. Rev. Cancer, 5, 275, 10.1038/nrc1590 Diop, 2005, N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane, Biochemistry, 44, 5420, 10.1021/bi0479858 Donnenberg, 2005, Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis, J. Clin. Pharmacol., 45, 872, 10.1177/0091270005276905 Franklin, 2007 Goodell, 1996, Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo, J. Exp. Med., 183, 1797, 10.1084/jem.183.4.1797 Hambardzumyan, 2008, Cancer stem cells and survival pathways, Cell Cycle, 7, 1371, 10.4161/cc.7.10.5954 Hambardzumyan, 2008, PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo, Genes Dev., 22, 436, 10.1101/gad.1627008 Hirschmann-Jax, 2004, A distinct “side population” of cells with high drug efflux capacity in human tumor cells, Proc. Natl. Acad. Sci. USA, 101, 14228, 10.1073/pnas.0400067101 Ho, 2007, Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells, Cancer Res., 67, 4827, 10.1158/0008-5472.CAN-06-3557 Hu, 2005, mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma, Neoplasia, 7, 356, 10.1593/neo.04595 Islam, 2005, Functional expression of ABCG2 transporter in human neural stem/progenitor cells, Neurosci. Res., 52, 75, 10.1016/j.neures.2005.01.013 Kitange, 2008, Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts, Neuro Oncol. McConville, 2007, Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of glioma, Clin. Cancer Res., 13, 2897, 10.1158/1078-0432.CCR-06-3058 Mouthon, 2006, Neural stem cells from mouse forebrain are contained in a population distinct from the ‘side population’, J. Neurochem., 99, 807, 10.1111/j.1471-4159.2006.04118.x Ostermann, 2004, Plasma and cerebrospinal fluid population pharmacokinetics of temozolomide in malignant glioma patients, Clin. Cancer Res., 10, 3728, 10.1158/1078-0432.CCR-03-0807 Patrawala, 2005, Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic, Cancer Res., 65, 6207, 10.1158/0008-5472.CAN-05-0592 Provenzale, 2005, The role of blood-brain barrier permeability in brain tumor imaging and therapeutics, AJR Am. J. Roentgenol., 185, 763, 10.2214/ajr.185.3.01850763 Rabindran, 2000, Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein, Cancer Res., 60, 47 Regenbrecht, 2008, Stemming Cancer: Functional Genomics of Cancer Stem Cells in Solid Tumors, Stem Cell Rev., 4, 319, 10.1007/s12015-008-9034-0 Robey, 2007, ABCG2: determining its relevance in clinical drug resistance, Cancer Metastasis Rev., 26, 39, 10.1007/s10555-007-9042-6 Shih, 2004, Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis, Cancer Res., 64, 4783, 10.1158/0008-5472.CAN-03-3831 Szakacs, 2006, Targeting multidrug resistance in cancer, Nat. Rev. Drug Discov., 5, 219, 10.1038/nrd1984 Wu, 2008, Side population cells in human cancers, Cancer Lett., 268, 1, 10.1016/j.canlet.2008.03.048 Yuan, 2004, Isolation of cancer stem cells from adult glioblastoma multiforme, Oncogene, 23, 9392, 10.1038/sj.onc.1208311 Zhou, 2007, Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance, Proc. Natl. Acad. Sci. USA, 104, 16158, 10.1073/pnas.0702596104