Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects

Neuroscience Letters - Tập 532 - Trang 44-48 - 2013
Brit Mollenhauer1,2, Ellen Trautmann1,3, Peggy Taylor4, Paul Manninger5, Friederike Sixel-Döring1, Jens Ebentheuer1, Claudia Trenkwalder1,2, Michael G. Schlossmacher5
1Paracelsus-Elena-Klinik, Kassel, Germany
2Georg August University, Goettingen, Germany
3University of Kassel, Kassel, Germany
4Covance Inc., Dedham, MA,USA
5Division of Neuroscience, Ottawa Hospital Research Institute, University of Ottawa, Ontario, Canada

Tài liệu tham khảo

Frasier, 2010, The Parkinson's progression markers initiative: a prospective biomarker study, Movement Disorders, 25, P340 Hall, 2012, Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or Parkinsonian disorders, Archives of Neurology, 1, 10.1001/archneurol.2012.1654 Hong, 2010, DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease, Brain, 133, 713, 10.1093/brain/awq008 Kasuga, 2010, Differential levels of alpha-synuclein, beta-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease, Journal of Neurology, Neurosurgery and Psychiatry, 81, 608, 10.1136/jnnp.2009.197483 Mignini, 2000, Dopamine receptor immunohistochemistry in the rat choroid plexus, Journal of Autonomic Pharmacology, 20, 325, 10.1046/j.1365-2680.2000.00198.x Mollenhauer, 2008, Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration, Experimental Neurology, 213, 315, 10.1016/j.expneurol.2008.06.004 Mollenhauer, 2010, Quantification of alpha-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies, Biomarkers Medicine, 4, 683, 10.2217/bmm.10.90 Mollenhauer, 2011, alpha-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with Parkinsonism: a cohort study, Lancet Neurology, 10, 230, 10.1016/S1474-4422(11)70014-X Mollenhauer, 2008, Purification and quantification of neural alpha-synuclein: relevance for pathogenesis and biomarker development, 559 Mollenhauer, 2012, alpha-Synuclein in human cerebrospinal fluid is principally derived from neurons of the central nervous system, Journal of Neural Transmission, 119, 739, 10.1007/s00702-012-0784-0 Noguchi-Shinohara, 2009, CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease, Brain Research, 1251, 1, 10.1016/j.brainres.2008.11.055 Ohrfelt, 2009, Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?, Neuroscience Letters, 450, 332, 10.1016/j.neulet.2008.11.015 Mollenhauer, 2011, CSF α-synuclein, tau, and amyloid-β in Parkinson's disease, Lancet Neurology, 10, 681, 10.1016/S1474-4422(11)70161-2 Spies, 2009, Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders, Journal of Alzheimer's Disease, 16, 363, 10.3233/JAD-2009-0955 Tateno, 2012, Alpha-synuclein in the cerebrospinal fluid differentiates synucleinopathies (Parkinson disease, dementia with Lewy bodies, multiple system atrophy) from Alzheimer disease, Alzheimer Disease and Associated Disorders, 26, 213, 10.1097/WAD.0b013e31823899cc Tokuda, 2010, Detection of elevated levels of {alpha}-synuclein oligomers in CSF from patients with Parkinson disease, Neurology, 75, 1766, 10.1212/WNL.0b013e3181fd613b Tokuda, 2006, Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease, Biochemical and Biophysical Research Communications, 349, 162, 10.1016/j.bbrc.2006.08.024 Wang, 2012, Phosphorylated alpha-synuclein in Parkinson's disease, Science Translational Medicine, 4, 121ra20, 10.1126/scitranslmed.3002566 Wennstrom, 2012, Altered CSF orexin and alpha-synuclein levels in dementia patients, Journal of Alzheimer's Disease, 29, 125, 10.3233/JAD-2012-111655