Association of IL-10 and IL-10Rβ gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor

BMC Immunology - Tập 10 Số 1 - 2009
Jyrki Sivula1, Hannu Turpeinen1, Liisa Volin2, Jukka Partanen1
1Research and Development, Finnish Red Cross Blood Service, Helsinki, Finland
2Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland

Tóm tắt

Abstract Background Extensive allelic matching in the human leukocyte antigen (HLA) genes is regarded as a prerequisite for good clinical success of allogeneic haematopoietic stem cell transplantation (HSCT). Also other genetic factors can be assumed to play a role in preventing and controlling the complications associated with allogeneic HSCT, in particular graft-versus-host disease (GvHD). Interleukin-10 (IL-10) and its receptor (IL-10R), key regulators of the immune response, are among these candidates. We studied the association of IL-10 and IL-10Rβ gene polymorphisms with the occurrence of GvHD in 309 HLA-identical sibling donor and recipient pairs. Results The difference in genotypic IL-10 production between patient and donor in combination with patient IL-10Rβ A/A genotype predisposed strongly to acute GvHD (OR = 7.15, p = 0.000023). On the other hand, a combination of same genotypic IL-10 production with patient IL-10Rβ A/A genotype protected from chronic GvHD (OR = 0.407, p = 0.0097). Conclusion Our results suggest that IL-10 and IL-10Rβ genes have a synergistic effect on the risk of GvHD.

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Tài liệu tham khảo

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BMC Immunology

Tập 10 Số 1

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