The large-scale organization of metabolic networks

Hartwell, L. H., Hopfield, J. J., Leibler, S. & Murray, A. W. From molecular to modular cell biology. Nature 402, C47–52 (1999).

Barabási, A.-L. & Albert, R. Emergence of scaling in random networks. Science 286, 509– 512 (1999).

West, G. B., Brown, J. H. & Enquist, B. J. The fourth dimension of life: fractal geometry and allometric scaling of organisms. Science 284, 1677–1679 (1999).

Banavar, J. R., Maritan, A. & Rinaldo, A. Size and form in efficient transportation networks. Nature 399, 130–132 (1999).

Albert, R., Jeong, H. & Barabási, A.-L. Error and attack tolerance of complex networks. Nature 406, 378–382 ( 2000).

Ingber, D. E. Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton. J. Cell Sci. 104, 613 –627 (1993).

Bray, D. Protein molecules as computational elements in living cells. Nature 376, 307–312 (1995).

McAdams, H. H. & Arkin, A. It's a noisy business! Genetic regulation at the nanomolar scale. Trends Genet. 15, 65–69 (1999).

Gardner, T. S., Cantor, C. R. & Collins, J. J. Construction of a genetic toggle switch in Escherichia coli. Nature 403, 339– 342 (2000).

Elowitz, M. B. & Leibler, S. A synthetic oscillatory network of transcriptional regulators. Nature 403, 335–338 (2000).

Hasty, J., Pradines, J., Dolnik, M. & Collins, J. J. Noise-based switches and amplifiers for gene expression. Proc. Natl Acad. Sci. USA 97, 2075–2080 ( 2000).

Becskei, A. & Serrano, L. Engineering stability in gene networks by autoregulation. Nature 405, 590– 593 (2000).

Kirschner, M., Gerhart, J. & Mitchison, T. Molecular ‘vitalism’. Cell 100, 79–88 (2000).

Barkai, N. & Leibler, S. Robustness in simple biochemical networks. Nature 387, 913– 917 (1997).

Yi, T. M., Huang, Y., Simon, M. I. & Doyle, J. Robust perfect adaptation in bacterial chemotaxis through integral feedback control. Proc. Natl Acad. Sci. USA 97, 4649–4653 (2000).

Bhalla, U. S. & Iyengar, R. Emergent properties of networks of biological signaling pathways. Science 283, 381–387 (1999).

Karp, P. D., Krummenacker, M., Paley, S. & Wagg, J. Integrated pathway–genome databases and their role in drug discovery. Trends Biotechnol. 17, 275– 281 (1999).

Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27– 30 (2000).

Overbeek, R. et al. WIT: integrated system for high-throughput genome sequence analysis and metabolic reconstruction. Nucleic Acids Res. 28, 123–125 (2000).

Erdös, P. & Rényi, A. On the evolution of random graphs. Publ. Math. Inst. Hung. Acad. Sci. 5, 17–61 (1960).

Bollobás, B. Random Graphs (Academic, London, 1985).

Albert, R., Jeong, H. & Barabási, A.-L. Diameter of the World-Wide Web. Nature 400, 130–131 ( 1999).

Faloutsos, M., Faloutsos, P. & Faloutsos, C. On power-law relationships of the internet topology. Comp. Comm. Rev. 29, 251 ( 1999).

Amaral, L. A. N., Scala, A., Barthelemy, M. & Stanley, H. E. Classes of behavior of small-world networks. (cited 31 January 2000) 〈http://xxx.lanl.gov/abs/cond-mat/0001458〉 (2000).

Dorogovtsev, S. N. & Mendes, J. F. F. Evolution of reference networks with aging (cited 28 January 2000) 〈http://xxx.lanl.gov/abs/cond-mat/0001419〉 (2000).

Watts, D. J. & Strogatz, S. H. Collective dynamics of ‘small-world’ networks. Nature 393, 440– 442 (1998).

Barthelemy, M. & Amaral, L. A. N. Small-world networks: Evidence for a crossover picture. Phys. Rev. Lett. 82, 3180–3183 (1999).

Edwards, J. S. & Palsson, B. O. The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities. Proc. Natl Acad. Sci. USA 97, 5528–5533 (2000).