The comprehensive therapy of diabetic foot ulcers
Tóm tắt
Foot wounds are a common complication of diabetes mellitus, and a significant number of them lead to amputation. Fortunately, the majority of diabetic foot wounds are preventable. In this article, we review the different factors leading to ulceration and outline the essentials of a thorough evaluation. Finally, we present the various management strategies available to the treating physician.
Tài liệu tham khảo
Palumbo JP, Melton LT. Peripheral vascular disease and diabetes. In: Diabetes in America. (Harris M, Hamman R, eds.) US Government Printing Office, Washington, DC, 1985;XV 1–21.
Mayfield JA, Reiber FE, Sanders LJ, et al. Technical review: preventive foot care in people with diabetes. Diabetes Care 1998;21:2161–2177.
Consensus development of diabetic foot wound care. Diabetes Care 1999;22:1354–1360.
Ramsey SD, Newton K, Blough D, et al. Incidence, outcomes and cost of foot ulcers in patients with diabetes. Diabetes Care 1999;22:382–387.
Carrington AL, Mawdsley SK, Morley M, et al. Psychological status of diabetic people with or without lower limb disability. Diabetes Res Clin Pract 1996;32:19–25.
Reiber GE, Vileikyte L, Boyko EJ, et al. Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. Diabetes Care 1999;22:157–162.
Macfarlane RM, Jeffcoate WJ. Factors contributing to the presentation of diabetic foot ulcers. Diabet Med 1997;14:867–870.
Sommer TC, Lee TH. Charcot foot: the diagnostic dilemma. Am Fam Physician 2001;64:1591–1598.
Lavery L, Gazewood JD. Assessing the feet of patients with diabetes. J Fam Pract 2000;49(Suppl.):S9-S16.
Birke JA, Franks BD, Foto JG. First ray joint limitation, pressure, and ulceration of the first metatarsal head in diabetes mellitus. Foot Ankle Int 1995;16:277–284.
Mueller MJ, Diamond JE, Delitto A, et al. Insensitivity, limited joint mobility, and plantar ulcers in patients with diabetes mellitus. Phys Ther 1989;69:453–459.
Rosenbloom AL, Silverstien JH. Connective tissue and joint disease in diabetes mellitus. Endocrinol Metab Clin North Am 1996; 25:473–483.
Armstrong DG, Lavery LA. Diabetic foot ulcers: prevention, diagnosis and classification. Am Fam Physician 1998;57:1325–1333.
Wagner FW. The dysvascular foot: a system for diagnosis and treatment. Foot Ankle 1981;2:64–122.
Lavery LA, Armstrong DG, Harkless LB. Classification of diabetic foot wounds. J Foot Ankle Surg 1996;35:528–531.
Oyibo SO, Jude EB, Tarawneh I, et al. A comparison of two diabetic foot ulcer classification systems. Diabetes Care 2001;24:84–88.
Stotts NA, Wipke-Tevis D. Co-factors in impaired healing. In: Chronic Wound Care: A Clinical Source Book for Healthcare Professionals. (Krseener D, Kane D, eds.), 2nd edn. Wayne, PA, Health Management Publications, Inc. 1997:64–72.
Katoulis EC, Boulton AJM, Raptis SA. The role of diabetic neuropathy and high plantar pressures in the pathogenesis of foot ulceration. Horm Metab Res 1996;28:159–164.
Armstrong DG, Lavery LA. Evidence-based options for offloading diabetic wounds. Clin Podiatr Med Surg 1998;15:95–104.
Edmonds J, Apelqvist J, Agardh CD, et al. Decreasing incidence of major amputation in diabetic patients: a consequence of a multidisciplinary foot care team approach? Diabetic Med 1995; 12:770–776.
Millington JT, Norris TW. Effective treatment strategies for diabetic foot wounds. J Fam Pract 2000;49(Suppl.)S40-S48.
Steed DL, Donohoe D, Webster MW, et al. Effect of extensive debridement and treatment on the healing diabetic foot ulcer. J Am Coll Surg 1996;183:61–64.
Hellgren L, Vincent J., Debridement: an essential step in wound healing. In: Leg Ulcers: Diagnosis and Treatment. (Westerhof W, ed.). Elsevier Science Publishers, Amsterdam, The Netherlands, 1993.
Erlichman RJ, Seckel BR, Buran DJ, et al. Common complications of wound healing: prevention and management. Surg Clin North Am 1991;71(6)1323–1351.
Steed DL. Foundations of good ulcer care. Am J Surg 1998; 176(Suppl): 20S-25S.
Robson MC, Stenberg BD, Heggars JP. Wound healing alterations caused by infection. Clin Plast Surg 1990;17:485–492.
Kertesz D, Chow AW. Infected pressure and diabetic ulcers. Infect Dis 1992;8:835–853.
Boulton AJM, Kirsner RS, Vileikyte K. Neuropathic diabetic foot ulcers. N Engl J Med 2004;351:38–55.
Bergstrom NJ, Bennett MA, Carlson CE, eds. Treatment of pressure ulcers. Agency for Health Care Policy and Research, Public Health Service, UK Dept of Health and Human Service, Rockville, MD, 1994 Clinical Practice Guidelines. Number 15, AHCPR pub 95-0652.
Newman LG, Waller J, Palestro CJ, et al. Unsuspected osteomyelitis in diabetic foot ulcers: diagnosis and monitoring by leukocyte scanning with indium in 111 oxyquinoline. JAMA 1991;266: 1246–1251.
Craig JG, Amin MB, Wu K, et al. osteomyelitis of the diabetic foot: MR imaging-pathological correlation. Radiology 1997;203: 849–855.
Lipsky BA. A report from the international consensus on diagnosing and treating the infected diabetic foot. Diabetes Metab Res Rev 2004;20(Suppl 1):S68-S77.
Grayson ML, Gibbons GW, Balogh K, et al. Probing to bone in infected pedal ulcers: a clinical sign of underlying osteomyelitis in diabetic patients. JAMA 1995;273:721–723.
Greenhalgh D. The role of growth factors in wound healing. J Trauma 1996;41:159–167.
Ross R. Platelet-derived growth factor. Lancet 1989;1:1179–1182.
Steed D, Donohoe D, Webster M, et al. Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. J Am Coll Surg 1996;183:61–64.
Pham HT. Treatment with a human skin equivalent, Graftskin (Apligraf), improves healing rate in diabetic foot ulcers. Abstract 104. 35th Annual Meeting of the European Association for the Study of Diabetes, Brussels, Belgium, September, 1999
Brown A, Sibbald R. The diabetic neuropathic ulcer: an overview. Ostomy Wound Manage 1999;45(Suppl):6S-20S.
Cianci P, Hunt TK. Adjunctive hyperbaric oxygen therapy in treatment of diabetic foot wounds. In: The Diabetic Foot. (Levin MD, O'Neal LW, Bowker JH, eds.) 5th edn. Mosby Year Book. St Louis, MO, 1993.
Bonomo S, Davidson J, Yu Y, et al. Hyperbaric oxygen as a signal transducer: upregulation of platelet-derived growth factor-β receptor in the presence of HBO2 and PDGF. Undersea Hyperb Med 1998;4:211–216.
Zhao LL, Davidson JD, Wee SC, et al. Effect of hyperbaric oxygen and growth factors on rabbit ear ischemic ulcers. Arch Surg 1994:129:211–216.
Faglia E, Favales F, Aldeghi A, et al. Change in major amputation rate in a center dedicated to diabetic foot care during the 1980s: prognostic determinants for major amputation. J Diabet Complications 1998;12:96–102.
Kumar D, Marshall HJ. Diabetic peripheral neuropathy: amelioration of pain with transcutaneous electrostimulation. Diabetes Care 1997;20:1702–1705.
Forst T, Kunt T, Goitem K, et al. Acta Diabetol 2002;39(1):1–6.
Yuen KC, Baker NR, Rayman G. Treatment of chronic painful diabetic neuropathy with isosorbide dinitrate spray. Diabetes Care 2002;25:1699–1703.
Barinov A, Dyck PJ, Hermann R, et al. The sensory symptoms of diabetic polyneuropathy are improved with α-lipoic acid. Diabetes Care 2003;26:770–776.
Hotta N, Toyota T, Matsuoka K, et al. Clinical efficacy, of fidarestat, a novel aldose reductase inhibor, for diabetic peripheral neuropathy. Diabetes Care 2001;24:1776–1782.
Leonard DR, Farooqi MH, Restoration of sensation, reduced pain, and improved balance in subjects with diabetic peripheral neuropathy. Diabetes Care. 2004;27:168–172.
American Diabetes Association. Position Statement. Preventive foot care in Diabetes. Diabetes Care 2004;27(Suppl 1):S63-S64.
Bloomgarden ZT. The diabetic foot. Diabetes Care 2001;24:946–951.