Update on the adverse effects of microcystins on the liver
Tài liệu tham khảo
Alkhateeb, 2015, The small molecule ferristatin II induces hepatic hepcidin expression in vivo and in vitro, Am. J. Physiol. Gastrointest. Liver Physiol., 308, G1019, 10.1152/ajpgi.00324.2014
Bahl, 1997, In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase, Biochem. Pharmacol., 53, 67, 10.1016/S0006-2952(96)00660-0
Bao, 2016, Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis, J. Hepatol., 65, 137, 10.1016/j.jhep.2016.03.007
Batista, 2020, Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver, Proc. Natl. Acad. Sci. U. S. A., 117, 6733, 10.1073/pnas.1922370117
Bellém, 2013, Cyanobacteria toxicity: potential public health impact in South Portugal populations, J. Toxicol. Environ. Health, 76, 263, 10.1080/15287394.2013.757204
Benard, 2018, vol. 10, 275
Bittencourt-Oliveira Mdo, 2014, Cyanobacteria, microcystins and cylindrospermopsin in public drinking supply reservoirs of Brazil, An. Acad. Bras. Cienc., 86, 297, 10.1590/0001-3765201302512
Brzuzan, 2016, Illumina sequencing reveals aberrant expression of MicroRNAs and their variants in whitefish (Coregonus lavaretus) liver after exposure to microcystin-LR, PloS One, 11, 10.1371/journal.pone.0158899
Bui, 2018
Cai, 2014, Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis, Nat. Cell Biol., 16, 55, 10.1038/ncb2883
Chang-Feng, 2012
Chen, 2018, Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells, Toxicol. Lett., 289, 42, 10.1016/j.toxlet.2018.03.003
Chen, 2019, Epigenetic inactivation of LHX6 mediated microcystin-LR induced hepatocarcinogenesis via the Wnt/β-catenin and P53 signaling pathways, Environ. Pollut., 252, 216, 10.1016/j.envpol.2019.05.049
Chen, 2009, First identification of the hepatotoxic microcystins in the serum of a chronically exposed human population together with indication of hepatocellular damage, Toxicol. Sci., 108, 81, 10.1093/toxsci/kfp009
Chen, 2017, Responses of the proteome and metabolome in livers of zebrafish exposed chronically to environmentally relevant concentrations of microcystin-LR, Environ. Sci. Technol., 51, 596, 10.1021/acs.est.6b03990
Chen, 2016, Mechanisms of microcystin-induced cytotoxicity and apoptosis, Mini Rev. Med. Chem., 16, 1018, 10.2174/1389557516666160219130407
Chen, 2013, The interactive effects of cytoskeleton disruption and mitochondria dysfunction lead to reproductive toxicity induced by microcystin-LR, PloS One, 8
Chen, 2005, Induction of apoptosis in mouse liver by microcystin-LR: a combined transcriptomic, proteomic, and simulation strategy, Mol. Cell. Proteomics, 4, 958, 10.1074/mcp.M400185-MCP200
Chen, 2017, Epigenetic modification of nucleic acids: from basic studies to medical applications, Chem. Soc. Rev., 46, 2844, 10.1039/C6CS00599C
Costa, 2018, Hepatotoxicity induced by paclitaxel interaction with turmeric in association with a microcystin from a contaminated dietary supplement, Toxicon, 150, 207, 10.1016/j.toxicon.2018.05.022
Cunhabellém, 2014
Cuvin-Aralar, 2002, Microcystins in natural blooms and laboratory cultured Microcystis aeruginosa from Laguna de Bay, Philippines, 25, 179
Czabotar, 2014, Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy, Nat. Rev. Mol. Cell Biol., 15, 49, 10.1038/nrm3722
Dao, 2016, Dynamics of cyanobacteria and cyanobacterial toxins and their correlation with environmental parameters in Tri an Reservoir, Vietnam, 14, 699
Delaby, 2005, Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin, Blood, 106, 3979, 10.1182/blood-2005-06-2398
Díez-Quijada, 2020, Cylindrospermopsin-microcystin-LR combinations may induce genotoxic and histopathological damage in rats, Toxins, 12, 10.3390/toxins12060348
Díez-Quijada, 2019, Microcystin-RR: occurrence, content in water and food and toxicological studies. A review, Environ. Res., 168, 467, 10.1016/j.envres.2018.07.019
Ding, 2000, Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes, Hepatology, 32, 547, 10.1053/jhep.2000.16183
Drobac, 2013, Human exposure to cyanotoxins and their effects on health, 64, 305
Falconer, 1983, Evidence of liver damage by toxin from a bloom of the blue-green alga, Microcystis aeruginosa, Med. J. Aust., 1, 511, 10.5694/j.1326-5377.1983.tb136192.x
Falconer, 1983, Evidence of liver damage by toxin from a bloom of the blue-green alga, Microcystis aeruginosa, 1, 511
Falconer, 1988, Oral toxicity of a bloom of the Cyanobacterium microcystis Aeruginosa administered to mice over periods up to 1 year, J. Toxicol. Environ. Health, 24, 291, 10.1080/15287398809531163
Fang, 2007, Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity, J. Biol. Chem., 282, 11221, 10.1074/jbc.M611871200
Farkas, 2014, Variability of microcystins and its synthetase gene cluster in Microcystis and Planktothrix waterblooms in shallow lakes of Hungary, 65, 227
Feurstein, 2010, Investigation of microcystin congener-dependent uptake into primary murine neurons, Environ. Health Perspect., 118, 1370, 10.1289/ehp.0901289
Fischer, 2000, Pathological and biochemical characterization of microcystin-induced hepatopancreas and kidney damage in carp (Cyprinus carpio), Toxicol. Appl. Pharmacol., 164, 73, 10.1006/taap.1999.8861
Fladmark, 2002, Ca2+/calmodulin-dependent protein kinase II is required for microcystin-induced apoptosis, J. Biol. Chem., 277, 2804, 10.1074/jbc.M109049200
Fu, 2005, Altered expression of p53, Bcl-2 and Bax induced by microcystin-LR in vivo and in vitro, Toxicon, 46, 171, 10.1016/j.toxicon.2005.03.021
Giannuzzi, 2011, An acute case of intoxication with cyanobacteria and cyanotoxins in recreational water in Salto Grande Dam, Argentina, Mar. Drugs, 9, 2164, 10.3390/md9112164
Gregor, 2007, Thematic review series: adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease, J. Lipid Res., 48, 1905, 10.1194/jlr.R700007-JLR200
Gutiérrez-Praena, 2019, Cytotoxic and morphological effects of microcystin‐LR, cylindrospermopsin, and their combinations on the human hepatic cell line HepG2, Environ. Toxicol., 34, 240, 10.1002/tox.22679
Hao, 2008, The effect of cyanobacterial crude extract on the transcription of GST mu, GST kappa and GST rho in different organs of goldfish (Carassius auratus), 90, 1
He, 2017, Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study, Arch. Toxicol., 91, 465, 10.1007/s00204-016-1681-3
He, 2018, Chronic microcystin-LR exposure induces hepatocarcinogenesis via increased Gankyrin in vitro and in vivo, Cell. Physiol. Biochem., 49, 1420, 10.1159/000493446
Herry, 2008, Seasonal occurrence and toxicity of microcystis spp. and oscillatoria tenuis in the lebna dam, Tunisia, 42, 1263
Hu, 2017
Huang, 2013, The mitochondria-mediate apoptosis of Lepidopteran cells induced by azadirachtin, PloS One, 8
Ibrahim, 2019, vol. 226
Jančula, 2014, Survey of cyanobacterial toxins in Czech water reservoirs--the first observation of neurotoxic saxitoxins, Environ. Sci. Pollut. Res. Int., 21, 8006, 10.1007/s11356-014-2699-9
Jia, 2019, Down-regulation of GCLC is involved in microcystin-LR-induced malignant transformation of human liver cells, Toxicology, 421, 49, 10.1016/j.tox.2019.03.010
Jones, 1995
Khanna, 2013, Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target, Canc. Res., 73, 6548, 10.1158/0008-5472.CAN-13-1994
Kist, 2012, Microcystin-LR acute exposure increases AChE activity via transcriptional ache activation in zebrafish (Danio rerio) brain, Comp. Biochem. Physiol. C Toxicol. Pharmacol., 155, 247, 10.1016/j.cbpc.2011.09.002
Kleppe, 2015, Cell death inducing microbial protein phosphatase inhibitors--mechanisms of action, Mar. Drugs, 13, 6505, 10.3390/md13106505
Koduru, 2018, Non-coding RNAs in various stages of liver disease leading to hepatocellular carcinoma: differential expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs, Sci. Rep., 8, 7967, 10.1038/s41598-018-26360-1
Krakstad, 2006, CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation, Cell Death Differ., 13, 1191, 10.1038/sj.cdd.4401798
Labine, 2015, The geographic distribution of liver cancer in Canada does not associate with cyanobacterial toxin exposure, Int. J. Environ. Res. Publ. Health, 12, 15143, 10.3390/ijerph121214969
Labine, 2020, A lack of association between increases in gastrointestinal, liver, and urologic cancers and cyanobacterial contamination of fresh water lakes in Manitoba, Environ. Sci. Pollut. Res. Int., 10.1007/s11356-020-09731-y
Le Manach, 2018, Physiological effects caused by microcystin-producing and non-microcystin producing Microcystis aeruginosa on medaka fish: a proteomic and metabolomic study on liver, Environ. Pollut., 234, 523, 10.1016/j.envpol.2017.11.011
Lei, 2020, PP2A and tumor radiotherapy, Hereditas, 157, 36, 10.1186/s41065-020-00149-7
Li, 2009, In vivo study on the effects of microcystin extracts on the expression profiles of proto-oncogenes (c-fos, c-jun and c-myc) in liver, kidney and testis of male Wistar rats injected i.v. with toxins, Toxicon, 53, 169, 10.1016/j.toxicon.2008.10.027
Li, 2013, Renal accumulation and effects of intraperitoneal injection of extracted microcystins in omnivorous crucian carp (Carassius auratus), Toxicon, 70, 62, 10.1016/j.toxicon.2013.03.022
Li, 2017, Alterations in transcription and protein expressions of HCC-related genes in HepG2 cells caused by microcystin-LR, Toxicol. Vitro, 40, 115, 10.1016/j.tiv.2016.12.016
Li, 2011, A cross-sectional investigation of chronic exposure to microcystin in relationship to childhood liver damage in the Three Gorges Reservoir Region, China, Environ. Health Perspect., 119, 1483, 10.1289/ehp.1002412
Li, 2014, c-fos and c-jun expression in the liver of silver carp and the effect of microcystins, J. Biochem. Mol. Toxicol., 28, 157, 10.1002/jbt.21548
Lian, 2006, Hepatitis B virus x gene and cyanobacterial toxins promote aflatoxin B1-induced hepatotumorigenesis in mice, World J. Gastroenterol., 12, 3065, 10.3748/wjg.v12.i19.3065
Liang, 2017, Combined effects of microcystin and nitrite on the growth, lipid peroxidation, and antioxidant responses of the freshwater rotifer Brachionus calyciflorus, Aquat. Toxicol., 192, 78, 10.1016/j.aquatox.2017.09.013
Lin, 2018, The synergistic effects of waterborne microcystin-LR and nitrite on hepatic pathological damage, lipid peroxidation and antioxidant responses of male zebrafish, Environ. Pollut., 235, 197, 10.1016/j.envpol.2017.12.059
Liu, 2016, Microcystin-LR promotes cell proliferation in the mice liver by activating Akt and p38/ERK/JNK cascades, Chemosphere, 163, 14, 10.1016/j.chemosphere.2016.08.002
Liu, 2018, Microcystin-LR disrupts insulin signaling by hyperphosphorylating insulin receptor substrate 1 and glycogen synthase, Environ. Toxicol., 33, 16, 10.1002/tox.22456
Liu, 2017, Environmental microcystin exposure increases liver injury risk induced by hepatitis B virus combined with aflatoxin: a cross-sectional study in Southwest China, Environ. Sci. Technol., 51, 6367, 10.1021/acs.est.6b05404
Liu, 2018, Microcystin-LR increases genotoxicity induced by aflatoxin B1 through oxidative stress and DNA base excision repair genes in human hepatic cell lines, Environ. Pollut., 233, 455, 10.1016/j.envpol.2017.10.067
Lone, 2016, Microcystin-LR induced immunotoxicity in mammals, J. Toxicol., 2016, 8048125, 10.1155/2016/8048125
Luo, 2005
M, 1981, Deformation of isolated rat hepatocytes by a peptide hepatotoxin from the blue-green alga Microcystis aeruginosa, 317, 268
Ma, 2020, IRE1 and CaMKKβ pathways to reveal the mechanism involved in microcystin-LR-induced autophagy in mouse ovarian cells - ScienceDirect, Food Chem. Toxicol., 147, 111911, 10.1016/j.fct.2020.111911
Malhotra, 2007, Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?, Antioxidants Redox Signal., 9, 2277, 10.1089/ars.2007.1782
Massey, 2020, A mini review on microcystins and bacterial degradation, Toxins, 12
Massey, 2018, Exposure routes and health effects of microcystins on animals and humans: a mini-review, Toxicon, 151, 156, 10.1016/j.toxicon.2018.07.010
McCain, 2020, Myonecrosis and death due to presumed microcystin toxicosis IN AMERICAN white pelicans (PELECANUS ERYTHRORHYNCOS), J. Zoo Wildl. Med., 51, 407, 10.1638/2019-0117
McLellan, 2017, Toxic mechanisms of microcystins in mammals, Toxicol Res (Camb), 6, 391, 10.1039/C7TX00043J
Menezes, 2013, Involvement of endoplasmic reticulum and autophagy in microcystin-LR toxicity in Vero-E6 and HepG2 cell lines, 27, 138
Moreno, 2005, Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally, Toxicon, 45, 395, 10.1016/j.toxicon.2004.11.001
Nagata, 1997, vol. 80, 408
Nasri, 2008, First reported case of turtle deaths during a toxic Microcystis spp, bloom in Lake Oubeira, Algeria, 71, 535
Ndebele, 2006, Management. The occurrence of microcystin‐LR in lake chivero, Zimbabwe, 11, 57
Niedermeyer, 2014, Selectivity and potency of microcystin congeners against OATP1B1 and OATP1B3 expressing cancer cells, PloS One, 9, 10.1371/journal.pone.0091476
Okello, 2011, vol. 16
Paerl, 2013, Harmful cyanobacterial blooms: causes, consequences, and controls, Microb. Ecol., 65, 995, 10.1007/s00248-012-0159-y
Pandey, 2013, Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway, Br. J. Canc., 108, 2590, 10.1038/bjc.2013.160
Pisoschi, 2015, The role of antioxidants in the chemistry of oxidative stress, A Rev., 46, 55
Pouria, 1998, Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil, Lancet, 352, 21, 10.1016/S0140-6736(97)12285-1
Puddick, 2014, High levels of structural diversity observed in microcystins from Microcystis CAWBG11 and characterization of six new microcystin congeners, Mar. Drugs, 12, 5372, 10.3390/md12115372
Qin, 2010, Endoplasmic reticulum stress in murine liver and kidney exposed to microcystin-LR, Toxicon, 56, 1334, 10.1016/j.toxicon.2010.07.017
Qin, 2015, Microcystin-LR altered mRNA and protein expression of endoplasmic reticulum stress signaling molecules related to hepatic lipid metabolism abnormalities in mice, Environ. Toxicol. Pharmacol., 40, 114, 10.1016/j.etap.2015.05.002
Raska, 2018, Tumor-promoting cyanotoxin microcystin-LR does not induce procarcinogenic events in adult human liver stem cells, Toxicol. Appl. Pharmacol., 345, 103, 10.1016/j.taap.2018.03.011
Reed, 2000, Mech. Apoptos., 157, 1415
Rider, 2016, Role of AMP-activated protein kinase in metabolic depression in animals, J. Comp. Physiol. B, 186, 1, 10.1007/s00360-015-0920-x
Sauvé, 2014, A review of what is an emerging contaminant, Chem. Cent. J., 8, 15, 10.1186/1752-153X-8-15
Sebbag, 2013, Liver failure in a dog following suspected ingestion of blue-green algae (Microcystis spp.): a case report and review of the toxin, J. Am. Anim. Hosp. Assoc., 49, 342, 10.5326/JAAHA-MS-5913
Sekijima, 1999, Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats, Carcinogenesis, 20, 161, 10.1093/carcin/20.1.161
Sheik Abdul, 2020, (1) -induced mitochondrial toxicity and hepatoprotective potential of rooibos: an update, J. Appl. Toxicol., 10.1002/jat.4036
Singh, 2014, vol. 92, 687
Smith, 2008, A review of cyanobacterial odorous and bioactive metabolites: impacts and management alternatives in aquaculture, 280, 5
Spoof, 2017
Sun, 2012, Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase, Cell, 148, 213, 10.1016/j.cell.2011.11.031
Sun, 2011, Regulation of heat shock protein 27 phosphorylation during microcystin-LR-induced cytoskeletal reorganization in a human liver cell line, Toxicol. Lett., 207, 270, 10.1016/j.toxlet.2011.09.025
Sun, 2014, Microcystin-LR induces protein phosphatase 2A alteration in a human liver cell line, Environ. Toxicol., 29, 1236
Svirčev, 2014, Epidemiology of cancers in Serbia and possible connection with cyanobacterial blooms, J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev., 32, 319, 10.1080/10590501.2014.967053
Svirčev, 2017, Toxicology of microcystins with reference to cases of human intoxications and epidemiological investigations of exposures to cyanobacteria and cyanotoxins, Arch. Toxicol., 91, 621, 10.1007/s00204-016-1921-6
Svirčev, 2013, Epidemiology of primary liver cancer in Serbia and possible connection with cyanobacterial blooms, J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev., 31, 181, 10.1080/10590501.2013.824187
Svircev, 2009, Freshwater cyanobacterial blooms and primary liver cancer epidemiological studies in Serbia, J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev., 27, 36, 10.1080/10590500802668016
Szegezdi, 2006, Mediators of endoplasmic reticulum stress-induced apoptosis, EMBO Rep., 7, 880, 10.1038/sj.embor.7400779
Testai, 2016, Risk to human health associated with the environmental occurrence of cyanobacterial neurotoxic alkaloids anatoxins and saxitoxins, Crit. Rev. Toxicol., 46, 385, 10.3109/10408444.2015.1137865
Vanden Berghe, 2007, NADPH oxidases: new players in TNF-induced necrotic cell death, Mol. Cell, 26, 769, 10.1016/j.molcel.2007.06.002
Vasconcelos~*O, 1996, Hepatotoxic microcystin diversity in cyanobacterial blooms collected in Portuguese freshwaters, 30, 2377
Vidal, 2017, Recreational exposure during algal bloom in carrasco beach, Uruguay: a liver failure case report, Toxins, 9, 10.3390/toxins9090267
W P, 2009, Climate change: a catalyst for global expansion of harmful cyanobacterial blooms, J. Environ. Microbiol. Rep., 1
Wang, 2014, MCLR-induced PP2A inhibition and subsequent Rac 1 inactivation and hyperphosphorylation of cytoskeleton-associated proteins are involved in cytoskeleton rearrangement in SMMC-7721 human liver cancer cell line, Chemosphere, 112, 141, 10.1016/j.chemosphere.2014.03.130
Wang, 2020, Persistent exposure to environmental levels of microcystin-LR disturbs cortisol production via hypothalamic-pituitary-interrenal (HPI) Axis and subsequently liver glucose metabolism in adult male zebrafish (Danio rerio), Toxins, 12, 10.3390/toxins12050282
Wang, 2010, Proteomic analysis of hepatic tissue of zebrafish (Danio rerio) experimentally exposed to chronic microcystin-LR, Toxicol. Sci., 113, 60, 10.1093/toxsci/kfp248
Wang, 2014, The impact of the endoplasmic reticulum protein-folding environment on cancer development, Nat. Rev. Canc., 14, 581, 10.1038/nrc3800
Wang, 2013, Microcystin (-LR) induced testicular cell apoptosis via up-regulating apoptosis-related genes in vivo, Food Chem. Toxicol., 60, 309, 10.1016/j.fct.2013.07.039
Weidberg, 2011, Biogenesis and cargo selectivity of autophagosomes, 80, 125
Wen, 2018, Analysis of long non-coding RNA profiled following MC-LR-induced hepatotoxicity using high-throughput sequencing, J. Toxicol. Environ. Health, 81, 1165, 10.1080/15287394.2018.1532717
Wood, S. A., Holland, P. T., Stirling, D. J., Briggs, L. R., Wear, R. G. J. N. Z. J. o. M., et al. Survey of Cyanotoxins in New Zealand Water Bodies between 2001 and 2004. 2006;vol. 40:585-597. doi:10.1080/00288330.2006.9517447.
Woolbright, 2017, Microcystin-LR induced liver injury in mice and in primary human hepatocytes is caused by oncotic necrosis, Toxicon, 125, 99, 10.1016/j.toxicon.2016.11.254
Wu, 2019, p53-Dependent pathway and the opening of mPTP mediate the apoptosis of co-cultured Sertoli-germ cells induced by microcystin-LR, Environ. Toxicol., 34, 1074, 10.1002/tox.22808
Wu, 2014, Reproductive toxicity on female mice induced by microcystin-LR, Environ. Toxicol. Pharmacol., 37, 1, 10.1016/j.etap.2013.10.012
Wu, 2018, MC-LR induces dysregulation of iron homeostasis by inhibiting hepcidin expression: a preliminary study, Chemosphere, 212, 572, 10.1016/j.chemosphere.2018.08.077
Wu, 2019, Microcystin-LR promotes necroptosis in primary mouse hepatocytes by overproducing reactive oxygen species, Toxicol. Appl. Pharmacol., 377, 114626, 10.1016/j.taap.2019.114626
Xiong, 2006
Xiong, 2010, Acute effects of microcystins exposure on the transcription of antioxidant enzyme genes in three organs (liver, kidney, and testis) of male Wistar rats, J. Biochem. Mol. Toxicol., 24, 361, 10.1002/jbt.20347
Xu, 2006, Structure of the protein phosphatase 2A holoenzyme, Cell, 127, 1239, 10.1016/j.cell.2006.11.033
Yang, 2020, A complete route for biodegradation of potentially carcinogenic cyanotoxin microcystin-LR in a novel indigenous bacterium, Water Res., 174, 115638, 10.1016/j.watres.2020.115638
Yang, 2018, RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis, Nat. Cell Biol., 20, 186, 10.1038/s41556-017-0022-y
Yao, 2017, A global analysis of the receptor tyrosine kinase-protein phosphatase interactome, Mol. Cell, 65, 347, 10.1016/j.molcel.2016.12.004
Yoshida, 1997, Acute oral toxicity of microcystin-LR, a cyanobacterial hepatotoxin, in mice, Nat. Toxins, 5, 91, 10.1002/nt.1
Yu, 1994, Blue-green algae toxins and liver cancer, 6, 9
Yuan, 2012, Vivo studies on the immunotoxic effects of microcystins on rabbit, Environ. Toxicol., 27, 83, 10.1002/tox.20615
Yuan, 2020, Epigenetic modification of H3K4 and oxidative stress are involved in MC-LR-induced apoptosis in testicular cells of SD rats, Environ. Toxicol., 35, 277, 10.1002/tox.22865
Zamora-Barrios, 2019, Bioaccumulation of microcystins in seston, zooplankton and fish: a case study in Lake Zumpango, Mexico, 249, 267
Zhan, 2020, Microcystin-LR triggers different endoplasmic reticulum stress pathways in the liver, ovary, and offspring of zebrafish (Danio rerio), J. Hazard Mater., 386, 121939, 10.1016/j.jhazmat.2019.121939
Zhang, 2010, Chemistry. CYCLIC PEPTIDE HEPATOTOXINS FROM FRESH-WATER CYANOBACTERIAL (BLUE-GREEN-ALGAE) WATERBLOOMS COLLECTED IN CENTRAL China, 10, 313
Zhang, 2020, The latest advances in the reproductive toxicity of microcystin-LR, Environ. Res., 192, 110254, 10.1016/j.envres.2020.110254
Zhang, 2017, Magnetic porous β-cyclodextrin polymer for magnetic solid-phase extraction of microcystins from environmental water samples, J. Chromatogr. A, 1503, 1, 10.1016/j.chroma.2017.04.063
Zhang, 2016, Comprehensive insights into microcystin-LR effects on hepatic lipid metabolism using cross-omics technologies, J. Hazard Mater., 315, 126, 10.1016/j.jhazmat.2016.05.011
Zhao, 2019, Epigenetic silencing of ALX4 regulates microcystin-LR induced hepatocellular carcinoma through the P53 pathway, Sci. Total Environ., 683, 317, 10.1016/j.scitotenv.2019.05.144
Zhao, 2016, A proteomic study on liver impairment in rat pups induced by maternal microcystin-LR exposure, Environ. Pollut., 212, 197, 10.1016/j.envpol.2015.12.055
Zhao, 2008, Vivo studies on the toxic effects of microcystins on mitochondrial electron transport chain and ion regulation in liver and heart of rabbit, Comp. Biochem. Physiol. C Toxicol. Pharmacol., 148, 204, 10.1016/j.cbpc.2008.05.008
Zheng, 2017, Serum microcystin levels positively linked with risk of hepatocellular carcinoma: a case-control study in southwest China, Hepatology, 66, 1519, 10.1002/hep.29310
Zheng, 2019, Circular RNA expression profiles following MC-LR treatment in human normal liver cell line (HL7702) cells using high-throughput sequencing analysis, J. Toxicol. Environ. Health, 82, 1103, 10.1080/15287394.2019.1698120
Zhong, 2017, Water metabolism dysfunction via renin-angiotensin system activation caused by liver damage in mice treated with microcystin-RR, Toxicol. Lett., 273, 86, 10.1016/j.toxlet.2017.03.019
Zhou, 2015, Mechanisms of microcystin-LR-induced cytoskeletal disruption in animal cells, Toxicon, 101, 92, 10.1016/j.toxicon.2015.05.005
Zhu, 2019, 1