Polydeoxyribonucleotide: A promising skin anti-aging agent

Aawrish Khan1, Guobao Wang1, Feng Zhou1, Lunli Gong1, Jun Zhang1, Lili Qi1, Haiyan Cui1
1Department of Plastic and Cosmetic Surgery, Tongji Hospital of Tongji University, Shanghai, 200065, China

Tài liệu tham khảo

Tobin, 2017, Introduction to skin aging, J Tissue Viability, 26, 37, 10.1016/j.jtv.2016.03.002 Durai, 2012, Aging in elderly: chronological versus photoaging, Indian J Dermatol, 57, 343, 10.4103/0019-5154.100473 Buck, 2009, Injectable fillers for facial rejuvenation: a review, J Plast Reconstr Aesthetic Surg, 62, 11, 10.1016/j.bjps.2008.06.036 Ganceviciene, 2012, Skin anti-aging strategies, Dermatoendocrinol, 4, 308, 10.4161/derm.22804 Squadrito, 2017, Pharmacological activity and clinical use of PDRN, Front Pharmacol, 8, 224, 10.3389/fphar.2017.00224 Belmontesi, 2020, Polydeoxyribonucleotide for the improvement of a hypertrophic retracting scar-An interesting case report, J Cosmet Dermatol, 19, 2982, 10.1111/jocd.13710 Yoon, 2019, Efficacy and safety of intra-articular injections of hyaluronic acid combined with polydeoxyribonucleotide in the treatment of knee osteoarthritis, Ann Rehabil Med, 43, 204, 10.5535/arm.2019.43.2.204 Squadrito, 2017, Polydeoxyribonucleotide, an adenosine-A2A receptor agonist, preserves blood testis barrier from cadmium-induced injury, Front Pharmacol, 7, 537, 10.3389/fphar.2016.00537 Ryu, 2018, Ultrasound-guided prolotherapy with polydeoxyribonucleotide for painful rotator cuff tendinopathy, Pain Res Manag, 2018, 10.1155/2018/8286190 Lee, 2019, The effect of polydeoxyribonucleotide extracted from salmon sperm on the restoration of bisphosphonate-related osteonecrosis of the jaw, Mar Drugs, 17, 51, 10.3390/md17010051 Kim, 2017, Polydeoxyribonucleotide improves peripheral tissue oxygenation and accelerates angiogenesis in diabetic foot ulcers, Arch Plast Surg, 44, 482, 10.5999/aps.2017.00801 Lee, 2018, The effect of polydeoxyribonucleotide on the treatment of radiating leg pain due to cystic mass lesion in inner aspect of right sciatic foramen: a CARE compliant case report, Medicine (Baltim), 97, 10.1097/MD.0000000000012794 Kim, 2020, Comparative evaluation of the effectiveness of novel hyaluronic acid-polynucleotide complex dermal filler, Sci Rep, 10, 5127, 10.1038/s41598-020-61952-w Dallari, 2020, Efficacy of intra-articular polynucleotides associated with hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis: a randomized, double-blind, controlled clinical trial, Clin J Sport Med, 30, 1, 10.1097/JSM.0000000000000569 Hwang, 2021, Attenuation effect of polydeoxyribonucleotide on inflammatory cytokines and apoptotic factors induced by particulate matter (PM10) damage in human bronchial cells, J Biochem Mol Toxicol, 35 Gu, 2020, Biomarkers, oxidative stress and autophagy in skin aging, Ageing Res Rev, 59, 10.1016/j.arr.2020.101036 Koohgoli, 2017, Bad air gets under your skin, Exp Dermatol, 26, 384, 10.1111/exd.13257 Rittié, 2015, Natural and sun-induced aging of human skin, Cold Spring Harb Perspect Med, 5, a015370, 10.1101/cshperspect.a015370 Baumann, 2018, How to use oral and topical cosmeceuticals to prevent and treat skin aging, Facial Plast Surg Clin North Am, 26, 407, 10.1016/j.fsc.2018.06.002 Varani, 2004, Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin, J Invest Dermatol, 122, 1471, 10.1111/j.0022-202X.2004.22614.x Watson, 2014, Damage to skin extracellular matrix induced by UV exposure, Antioxidants Redox Signal, 21, 1063, 10.1089/ars.2013.5653 Poljšak, 2012, Intrinsic skin aging: the role of oxidative stress, Acta Dermatovenerol Alpina Pannonica Adriatica, 21, 33 Birch-Machin, 2016, Oxidative stress and ageing, Br J Dermatol, 175, 26, 10.1111/bjd.14906 Irrera, 2018, Activation of A2A receptor by PDRN reduces neuronal damage and stimulates WNT/β-CATENIN driven neurogenesis in spinal cord injury, Front Pharmacol, 9, 506, 10.3389/fphar.2018.00506 Ko, 2020, Polydeoxyribonucleotide exerts protective effect against CCl4-induced acute liver injury through inactivation of NF-κB/MAPK signaling pathway in mice, Int J Mol Sci, 21, 7894, 10.3390/ijms21217894 Picciolo, 2021, PDRN, a natural bioactive compound, blunts inflammation and positively reprograms healing genes in an “in vitro” model of oral mucositis, Biomed Pharmacother, 138, 10.1016/j.biopha.2021.111538 Kim, 2020, Polydeoxyribonucleotide activates mitochondrial biogenesis but reduces MMP-1 activity and melanin biosynthesis in cultured skin cells, Appl Biochem Biotechnol, 191, 540, 10.1007/s12010-019-03171-2 Chan, 2006, Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma, Arthritis Rheum, 54, 2632, 10.1002/art.21974 Chan, 2013, Adenosine A(₂A) receptors promote collagen production by a Fli1- and CTGF-mediated mechanism, Arthritis Res Ther, 15, R58, 10.1186/ar4229 Han, 2018, Anti-inflammatory effect of polydeoxyribonucleotide on zoledronic acid-pretreated and lipopolysaccharide-stimulated RAW 264.7 cells, Exp Ther Med, 16, 400 Baek, 2018, Anti-inflammatory effect of DNA polymeric molecules in a cell model of osteoarthritis, Inflammation, 41, 677, 10.1007/s10753-017-0722-2 Castellini, 2017, Anti inflammatory property of PDRN-an in vitro study on cultured macrophages, Adv Biosci Biotechnol, 13, 10.4236/abb.2017.81002 Bitto, 2011, Polydeoxyribonucleotide reduces cytokine production and the severity of collagen-induced arthritis by stimulation of adenosine A(₂A) receptor, Arthritis Rheum, 63, 3364, 10.1002/art.30538 Kim, 2020, Polydeoxyribonucleotide exerts therapeutic effect by increasing VEGF and inhibiting inflammatory cytokines in ischemic colitis rats, BioMed Res Int, 2020, 10.1155/2020/2169083 An, 2017, Polydeoxyribonucleotide ameliorates lipopolysaccharide-induced lung injury by inhibiting apoptotic cell death in rats, Int J Mol Sci, 18, 1847, 10.3390/ijms18091847 Wellbrock, 2015, Microphthalmia-associated transcription factor in melanoma development and MAP-kinase pathway targeted therapy, Pigment Cell Melanoma Res, 28, 390, 10.1111/pcmr.12370 Bitto, 2008, Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease, J Vasc Surg, 48, 1292, 10.1016/j.jvs.2008.06.041 Lee, 2015, The effect of polydeoxyribonucleotide on ischemic rat skin flap survival, Ann Plast Surg, 75, 84, 10.1097/SAP.0000000000000053 Lee, 2016, The effect of MCP-1/CCR2 on the proliferation and senescence of epidermal constituent cells in solar lentigo, Int J Mol Sci, 17, 948, 10.3390/ijms17060948 Noh, 2016, Novel anti-melanogenesis properties of polydeoxyribonucleotide, a popular wound healing booster, Int J Mol Sci, 17, 1448, 10.3390/ijms17091448 Cole, 2018, Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging, J Cell Commun Signal, 12, 35, 10.1007/s12079-018-0459-1 Arseni, 2018, From structure to phenotype: impact of collagen alterations on human health, Int J Mol Sci, 19, 1407, 10.3390/ijms19051407 Edgar, 2018, Effects of collagen-derived bioactive peptides and natural antioxidant compounds on proliferation and matrix protein synthesis by cultured normal human dermal fibroblasts, Sci Rep, 8, 10.1038/s41598-018-28492-w Ishii, 2000, Collagen and elastin degradation by matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in aortic dissection, Hum Pathol, 31, 640, 10.1053/hupa.2000.7642 Mora Huertas, 2016, Molecular-level insights into aging processes of skin elastin, Biochimie, 128–129, 163, 10.1016/j.biochi.2016.08.010 Kim, 2014, UV-induced DNA damage and histone modification may involve MMP-1 gene transcription in human skin in vivo, J Dermatol Sci, 73, 169, 10.1016/j.jdermsci.2013.10.004 Bhat, 2020, Female pattern hair loss-An update, Indian Dermatol Online J, 11, 493, 10.4103/idoj.IDOJ_334_19 Gupta, 2016, Classifications of patterned hair loss: a review, J Cutan Aesthetic Surg, 9, 3, 10.4103/0974-2077.178536 Cho, 2016, Therapeutic efficacy of 1,927-nm fractionated thulium laser energy and polydeoxyribonucleotide on pattern hair loss, Med Lasers, 5, 22, 10.25289/ML.2016.5.1.22 C hoi, 2017, Improvement of hair graying during a treatment of male pattern hair loss using 1,927-nm fractionated thulium laser energy and polydeoxyribonucleotide injections, Med Lasers, 6, 37, 10.25289/ML.2017.6.1.37 Lee, 2015, Therapeutic efficacy of autologous platelet-rich plasma and polydeoxyribonucleotide on female pattern hair loss, Wound Repair Regen, 23, 30, 10.1111/wrr.12250 Sorrell, 2004, Fibroblast heterogeneity: more than skin deep, J Cell Sci, 117, 667, 10.1242/jcs.01005 Cavallini, 2022, PN-HPT® (Polynucleotides Highly Purified Technology) in facial middle third rejuvenation. Exploring the potential, J Cosmet Dermatol, 21, 615, 10.1111/jocd.14578 Guizzardi, 2013, Hyaluronate increases polynucleotides effect on human cultured fibroblasts, J Cosmet Dermatol Sci Appl, 124 Arora, 2021, Biorevitalization of the skin with skin boosters: concepts, variables, and limitations, J Cosmet Dermatol, 20, 2458, 10.1111/jocd.13871 Pullar, 2017, The roles of vitamin C in skin health, Nutrients, 9, 866, 10.3390/nu9080866 Zucchi, 2016, Genital lichen sclerosus in male patients: a new treatment with polydeoxyribonucleotide, Urol Int, 97, 98, 10.1159/000443184 Galeano, 2008, Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse, Wound Repair Regen, 16, 208, 10.1111/j.1524-475X.2008.00361.x Squadrito, 2014, The effect of PDRN, an adenosine receptor A2A agonist, on the healing of chronic diabetic foot ulcers: results of a clinical trial, J Clin Endocrinol Metab, 99, E746 Park, 2016, Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients, Dermatol Ther, 29, 37, 10.1111/dth.12299 Kim, 2015, Effectiveness of polydeoxyribonucleotide injection versus normal saline injection for treatment of chronic plantar fasciitis: a prospective randomised clinical trial, Int Orthop, 39, 1329, 10.1007/s00264-015-2772-0 Valdatta, 2004, Evaluation of the efficacy of polydeoxyribonucleotides in the healing process of autologous skin graft donor sites: a pilot study, Curr Med Res Opin, 20, 403, 10.1185/030079904125003116 Strnadova, 2019, Skin aging: the dermal perspective, Clin Dermatol, 37, 326, 10.1016/j.clindermatol.2019.04.005 Bos, 2000, The 500 Dalton rule for the skin penetration of chemical compounds and drugs, Exp Dermatol, 9, 165, 10.1034/j.1600-0625.2000.009003165.x