FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis
Tài liệu tham khảo
Chong, 2020, The cytokine IL-17A limits Th17 pathogenicity via a negative feedback loop driven by autocrine induction of IL-24, Immunity, 53, 384, 10.1016/j.immuni.2020.06.022
Wang, 2012, Decreased IL-27 expression in association with an increased Th17 response in Vogt-Koyanagi-Harada disease, Invest Ophthalmol Vis Sci, 53, 4668, 10.1167/iovs.12-9863
Stadhouders, 2018, A cellular and molecular view of T helper 17 cell plasticity in autoimmunity, J Autoimmun, 87, 1, 10.1016/j.jaut.2017.12.007
Lee, 2014, Autoimmune and autoinflammatory mechanisms in uveitis, Semin Immunopathol, 36, 581, 10.1007/s00281-014-0433-9
Wang, 2021, Activated γδ T cells promote dendritic cell maturation and exacerbate the development of experimental autoimmune uveitis (EAU) in mice, Immunol Invest, 50, 164, 10.1080/08820139.2020.1716786
Stratoulias, 2019, Microglial subtypes: diversity within the microglial community, EMBO J, 38, 10.15252/embj.2019101997
Fan, 2022, Retinal microglia: functions and diseases, Immunology, 166, 268, 10.1111/imm.13479
Lan, 2017, Modulators of microglial activation and polarization after intracerebral haemorrhage, Nat Rev Neurol, 13, 420, 10.1038/nrneurol.2017.69
Heng, 2019, Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing, Proc Natl Acad Sci U S A, 116, 26734, 10.1073/pnas.1915571116
O'Koren, 2019, Microglial function is distinct in different anatomical locations during retinal homeostasis and degeneration, Immunity, 50, 723, 10.1016/j.immuni.2019.02.007
Okunuki, 2019, Retinal microglia initiate neuroinflammation in ocular autoimmunity, Proc Natl Acad Sci U S A, 116, 9989, 10.1073/pnas.1820387116
Wang, 2021, The emerging role of m6A modification in regulating the immune system and autoimmune diseases, Front Cell Dev Biol, 9
Qin, 2021, m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity, Cell Rep, 37, 10.1016/j.celrep.2021.109968
Shi, 2019, Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers, Mol Cell, 74, 640, 10.1016/j.molcel.2019.04.025
Meng, 2022, METTL3 inhibits inflammation of retinal pigment epithelium cells by regulating NR2F1 in an m6A-dependent manner, Front Immunol, 13, 10.3389/fimmu.2022.905211
Tang, 2022, N6-methyladenosine demethylase FTO regulates inflammatory cytokine secretion and tight junctions in retinal pigment epithelium cells, Clin Immunol, 241, 10.1016/j.clim.2022.109080
Zhou, 2021, m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity, Sci Adv, 7, 10.1126/sciadv.abg0470
Lu, 2020, A new model of spontaneous colitis in mice induced by deletion of an RNA m 6 A methyltransferase component METTL14 in T cells, Cell Mol Gastroenterol Hepatol, 10, 747, 10.1016/j.jcmgh.2020.07.001
Bechara, 2021, The m6A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis, Sci Immunol, 6, 10.1126/sciimmunol.abd1287
Yang, 2020, N 6-methyladenosine METTL3 modulates the proliferation and apoptosis of lens epithelial cells in diabetic cataract, Mol Ther Nucleic Acids, 20, 111, 10.1016/j.omtn.2020.02.002
Paramasivam, 2020, Implications of m6A modification in autoimmune disorders, Cell Mol Immunol, 17, 550, 10.1038/s41423-019-0307-0
Luo, 2020, Decreased ALKBH5, FTO, and YTHDF2 in peripheral blood are as risk factors for rheumatoid arthritis, Biomed Res Int, 2020, 10.1155/2020/5735279
Hjort, 2020, Physical activity, genetic susceptibility, and the risk of latent autoimmune diabetes in adults and type 2 diabetes, J Clin Endocrinol Metab, 105, e4112, 10.1210/clinem/dgaa549
Huang, 2018, Aryl hydrocarbon receptor regulates apoptosis and inflammation in a murine model of experimental autoimmune uveitis, Front Immunol, 9, 1713, 10.3389/fimmu.2018.01713
Huang, 2019, Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia, Cancer Cell, 35, 677, 10.1016/j.ccell.2019.03.006
Zheng, 2022, Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma, Nat Biomed Eng, 6, 32, 10.1038/s41551-021-00807-9
Ono, 2020, TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice, Sci Rep, 10, 694, 10.1038/s41598-020-57714-3
Xu, 2022, P2X7/P2X4 receptors mediate proliferation and migration of retinal microglia in experimental Glaucoma in mice, Neurosci Bull, 38, 901, 10.1007/s12264-022-00833-w
Liu, 2018, EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model, Acta Neuropathol Commun, 6, 111, 10.1186/s40478-018-0618-x
Chen, 2022, METTL3-mediated m 6 A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression, Ann Rheum Dis, 81, 87, 10.1136/annrheumdis-2021-221091
Lin, 2019, RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail, Nat Commun, 10, 2065, 10.1038/s41467-019-09865-9
Li, 2017, FTO plays an oncogenic role in acute myeloid leukemia as a N 6-methyladenosine RNA demethylase, Cancer Cell, 31, 127, 10.1016/j.ccell.2016.11.017
Tan, 2020, Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation, Cell Death Dis, 11, 697, 10.1038/s41419-020-02891-2
Qin, 2018, Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway, Theranostics, 8, 5434, 10.7150/thno.27882
Liu, 2022, Galectin-3 regulates microglial activation and promotes inflammation through TLR4/MyD88/NF-kB in experimental autoimmune uveitis, Clin Immunol, 236, 10.1016/j.clim.2022.108939
Anderson, 2015, Targeting the AAA ATPase p97 as an approach to treat cancer through disruption of protein homeostasis, Cancer Cell, 28, 653, 10.1016/j.ccell.2015.10.002
Wang, 2018, Novel insights on m 6 A RNA methylation in tumorigenesis: a double-edged sword, Mol Cancer, 17, 101, 10.1186/s12943-018-0847-4
Mikolajczyk, 2021, Role of inflammatory chemokines in hypertension, Pharmacol Ther, 223, 10.1016/j.pharmthera.2020.107799
Kitamei, 2006, Amelioration of experimental autoimmune uveoretinitis (EAU) with an inhibitor of nuclear factor-kappaB (NF-kappaB), pyrrolidine dithiocarbamate, J Leukoc Biol, 79, 1193, 10.1189/jlb.0805453
Hsu, 2015, Proteasome inhibitor bortezomib suppresses nuclear factor-kappa B activation and ameliorates eye inflammation in experimental autoimmune uveitis, Mediat Inflamm, 2015, 10.1155/2015/847373
Napier, 2020, T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis, Nat Commun, 11, 5406, 10.1038/s41467-020-18961-0
Hughes, 2014, Epigenome-wide scan identifies a treatment-responsive pattern of altered DNA methylation among cytoskeletal remodeling genes in monocytes and CD4+ T cells from patients with Behçet's disease, Arthritis Rheumatol, 66, 1648, 10.1002/art.38409
Qiu, 2017, Hypermethylation of interferon regulatory factor 8 (IRF8) confers risk to vogt-koyanagi-harada disease, Sci Rep, 7, 1007, 10.1038/s41598-017-01249-7
Qiu, 2018, Dynamic DNA methylation changes of Tbx21 and Rorc during experimental autoimmune uveitis in mice, Mediat Inflamm, 2018, 10.1155/2018/9129163
Zhu, 2017, Promoter hypermethylation of GATA3, IL-4, and TGF-β confers susceptibility to vogt-koyanagi-harada disease in Han Chinese, Invest Ophthalmol Vis Sci, 58, 1529, 10.1167/iovs.16-21188
Zhou, 2021, Low expression of YTH domain-containing 1 promotes microglial M1 polarization by reducing the stability of sirtuin 1 mRNA, Front Cell Neurosci, 15, 10.3389/fncel.2021.774305
Fico, 2011, Fine-tuning of cell signaling by glypicans, Cell Mol Life Sci, 68, 923, 10.1007/s00018-007-7471-6
Fang, 2019, CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis, Nat Commun, 10, 3981, 10.1038/s41467-019-11662-3
Müller, 2018, The release of glycosylphosphatidylinositol-anchored proteins from the cell surface, Arch Biochem Biophys, 656, 1, 10.1016/j.abb.2018.08.009
Chen, 2020, METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer, Mol Cancer, 19, 106, 10.1186/s12943-020-01220-7
Tong, 2018, RNA m6A modification and its function in diseases, Front Med, 12, 481, 10.1007/s11684-018-0654-8
Shi, 2017, YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA, Cell Res, 27, 315, 10.1038/cr.2017.15
Huang, 2017, Ranibizumab injection as primary treatment in patients with retinopathy of prematurity: anatomic outcomes and influencing factors, Ophthalmology, 124, 1156, 10.1016/j.ophtha.2017.03.018
Zaccara, 2020, A unified model for the function of YTHDF proteins in regulating m 6 A-modified mRNA, Cell, 181, 1582, 10.1016/j.cell.2020.05.012
Caspi, 1988, A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens, J Immunol, 140, 1490, 10.4049/jimmunol.140.5.1490
Chan, 1990, Pathology of experimental autoimmune uveoretinitis in mice, J Autoimmun, 3, 247, 10.1016/0896-8411(90)90144-H
Chandler, 2021, Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina, Mol Ther Methods Clin Dev, 22, 52, 10.1016/j.omtm.2021.05.011
Lipski, 2017, MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis, J Neuroinflammation, 14, 136, 10.1186/s12974-017-0915-5
Lückoff, 2017, Comprehensive analysis of mouse retinal mononuclear phagocytes, Nat Protoc, 12, 1136, 10.1038/nprot.2017.032
Ma, 2019, Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization, Elife, 8, 10.7554/eLife.42049
Wang, 2022, Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization, Redox Biol, 52, 10.1016/j.redox.2022.102297
Zhang, 1999, Differential expression of nitric oxide synthase in experimental uveoretinitis, Invest Ophthalmol Vis Sci, 40, 1899
Bansal, 2015, Experimental autoimmune uveitis and other animal models of uveitis: an update, Indian J Ophthalmol, 63, 211, 10.4103/0301-4738.156914
Maes, 2019, Targeting microglia with lentivirus and AAV: recent advances and remaining challenges, Neurosci Lett, 707, 10.1016/j.neulet.2019.134310
Zhang, 2008, Macrophage activation by endogenous danger signals, J Pathol, 214, 161, 10.1002/path.2284