FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis

Genes and Diseases - Tập 10 - Trang 2179-2193 - 2023
Siyuan He1,2,3,4, Wanqian Li1,2,3,4, Guoqing Wang1,2,3,4, Xiaotang Wang1,2,3,4, Wei Fan1,2,3,4, Zhi Zhang1,2,3,4, Na Li5, Shengping Hou1,2,3,4
1The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
2Chongqing Key Laboratory of Ophthalmology, Chongqing 400016, China
3Chongqing Eye Institute, Chongqing 400016, China
4Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing 400016, China
5College of Basic Medicine, Chongqing Medical University, Chongqing 400016, China

Tài liệu tham khảo

Chong, 2020, The cytokine IL-17A limits Th17 pathogenicity via a negative feedback loop driven by autocrine induction of IL-24, Immunity, 53, 384, 10.1016/j.immuni.2020.06.022 Wang, 2012, Decreased IL-27 expression in association with an increased Th17 response in Vogt-Koyanagi-Harada disease, Invest Ophthalmol Vis Sci, 53, 4668, 10.1167/iovs.12-9863 Stadhouders, 2018, A cellular and molecular view of T helper 17 cell plasticity in autoimmunity, J Autoimmun, 87, 1, 10.1016/j.jaut.2017.12.007 Lee, 2014, Autoimmune and autoinflammatory mechanisms in uveitis, Semin Immunopathol, 36, 581, 10.1007/s00281-014-0433-9 Wang, 2021, Activated γδ T cells promote dendritic cell maturation and exacerbate the development of experimental autoimmune uveitis (EAU) in mice, Immunol Invest, 50, 164, 10.1080/08820139.2020.1716786 Stratoulias, 2019, Microglial subtypes: diversity within the microglial community, EMBO J, 38, 10.15252/embj.2019101997 Fan, 2022, Retinal microglia: functions and diseases, Immunology, 166, 268, 10.1111/imm.13479 Lan, 2017, Modulators of microglial activation and polarization after intracerebral haemorrhage, Nat Rev Neurol, 13, 420, 10.1038/nrneurol.2017.69 Heng, 2019, Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing, Proc Natl Acad Sci U S A, 116, 26734, 10.1073/pnas.1915571116 O'Koren, 2019, Microglial function is distinct in different anatomical locations during retinal homeostasis and degeneration, Immunity, 50, 723, 10.1016/j.immuni.2019.02.007 Okunuki, 2019, Retinal microglia initiate neuroinflammation in ocular autoimmunity, Proc Natl Acad Sci U S A, 116, 9989, 10.1073/pnas.1820387116 Wang, 2021, The emerging role of m6A modification in regulating the immune system and autoimmune diseases, Front Cell Dev Biol, 9 Qin, 2021, m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity, Cell Rep, 37, 10.1016/j.celrep.2021.109968 Shi, 2019, Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers, Mol Cell, 74, 640, 10.1016/j.molcel.2019.04.025 Meng, 2022, METTL3 inhibits inflammation of retinal pigment epithelium cells by regulating NR2F1 in an m6A-dependent manner, Front Immunol, 13, 10.3389/fimmu.2022.905211 Tang, 2022, N6-methyladenosine demethylase FTO regulates inflammatory cytokine secretion and tight junctions in retinal pigment epithelium cells, Clin Immunol, 241, 10.1016/j.clim.2022.109080 Zhou, 2021, m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity, Sci Adv, 7, 10.1126/sciadv.abg0470 Lu, 2020, A new model of spontaneous colitis in mice induced by deletion of an RNA m 6 A methyltransferase component METTL14 in T cells, Cell Mol Gastroenterol Hepatol, 10, 747, 10.1016/j.jcmgh.2020.07.001 Bechara, 2021, The m6A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis, Sci Immunol, 6, 10.1126/sciimmunol.abd1287 Yang, 2020, N 6-methyladenosine METTL3 modulates the proliferation and apoptosis of lens epithelial cells in diabetic cataract, Mol Ther Nucleic Acids, 20, 111, 10.1016/j.omtn.2020.02.002 Paramasivam, 2020, Implications of m6A modification in autoimmune disorders, Cell Mol Immunol, 17, 550, 10.1038/s41423-019-0307-0 Luo, 2020, Decreased ALKBH5, FTO, and YTHDF2 in peripheral blood are as risk factors for rheumatoid arthritis, Biomed Res Int, 2020, 10.1155/2020/5735279 Hjort, 2020, Physical activity, genetic susceptibility, and the risk of latent autoimmune diabetes in adults and type 2 diabetes, J Clin Endocrinol Metab, 105, e4112, 10.1210/clinem/dgaa549 Huang, 2018, Aryl hydrocarbon receptor regulates apoptosis and inflammation in a murine model of experimental autoimmune uveitis, Front Immunol, 9, 1713, 10.3389/fimmu.2018.01713 Huang, 2019, Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia, Cancer Cell, 35, 677, 10.1016/j.ccell.2019.03.006 Zheng, 2022, Biomaterial-mediated modulation of oral microbiota synergizes with PD-1 blockade in mice with oral squamous cell carcinoma, Nat Biomed Eng, 6, 32, 10.1038/s41551-021-00807-9 Ono, 2020, TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice, Sci Rep, 10, 694, 10.1038/s41598-020-57714-3 Xu, 2022, P2X7/P2X4 receptors mediate proliferation and migration of retinal microglia in experimental Glaucoma in mice, Neurosci Bull, 38, 901, 10.1007/s12264-022-00833-w Liu, 2018, EphrinB/EphB forward signaling in Müller cells causes apoptosis of retinal ganglion cells by increasing tumor necrosis factor alpha production in rat experimental glaucomatous model, Acta Neuropathol Commun, 6, 111, 10.1186/s40478-018-0618-x Chen, 2022, METTL3-mediated m 6 A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression, Ann Rheum Dis, 81, 87, 10.1136/annrheumdis-2021-221091 Lin, 2019, RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail, Nat Commun, 10, 2065, 10.1038/s41467-019-09865-9 Li, 2017, FTO plays an oncogenic role in acute myeloid leukemia as a N 6-methyladenosine RNA demethylase, Cancer Cell, 31, 127, 10.1016/j.ccell.2016.11.017 Tan, 2020, Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation, Cell Death Dis, 11, 697, 10.1038/s41419-020-02891-2 Qin, 2018, Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway, Theranostics, 8, 5434, 10.7150/thno.27882 Liu, 2022, Galectin-3 regulates microglial activation and promotes inflammation through TLR4/MyD88/NF-kB in experimental autoimmune uveitis, Clin Immunol, 236, 10.1016/j.clim.2022.108939 Anderson, 2015, Targeting the AAA ATPase p97 as an approach to treat cancer through disruption of protein homeostasis, Cancer Cell, 28, 653, 10.1016/j.ccell.2015.10.002 Wang, 2018, Novel insights on m 6 A RNA methylation in tumorigenesis: a double-edged sword, Mol Cancer, 17, 101, 10.1186/s12943-018-0847-4 Mikolajczyk, 2021, Role of inflammatory chemokines in hypertension, Pharmacol Ther, 223, 10.1016/j.pharmthera.2020.107799 Kitamei, 2006, Amelioration of experimental autoimmune uveoretinitis (EAU) with an inhibitor of nuclear factor-kappaB (NF-kappaB), pyrrolidine dithiocarbamate, J Leukoc Biol, 79, 1193, 10.1189/jlb.0805453 Hsu, 2015, Proteasome inhibitor bortezomib suppresses nuclear factor-kappa B activation and ameliorates eye inflammation in experimental autoimmune uveitis, Mediat Inflamm, 2015, 10.1155/2015/847373 Napier, 2020, T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis, Nat Commun, 11, 5406, 10.1038/s41467-020-18961-0 Hughes, 2014, Epigenome-wide scan identifies a treatment-responsive pattern of altered DNA methylation among cytoskeletal remodeling genes in monocytes and CD4+ T cells from patients with Behçet's disease, Arthritis Rheumatol, 66, 1648, 10.1002/art.38409 Qiu, 2017, Hypermethylation of interferon regulatory factor 8 (IRF8) confers risk to vogt-koyanagi-harada disease, Sci Rep, 7, 1007, 10.1038/s41598-017-01249-7 Qiu, 2018, Dynamic DNA methylation changes of Tbx21 and Rorc during experimental autoimmune uveitis in mice, Mediat Inflamm, 2018, 10.1155/2018/9129163 Zhu, 2017, Promoter hypermethylation of GATA3, IL-4, and TGF-β confers susceptibility to vogt-koyanagi-harada disease in Han Chinese, Invest Ophthalmol Vis Sci, 58, 1529, 10.1167/iovs.16-21188 Zhou, 2021, Low expression of YTH domain-containing 1 promotes microglial M1 polarization by reducing the stability of sirtuin 1 mRNA, Front Cell Neurosci, 15, 10.3389/fncel.2021.774305 Fico, 2011, Fine-tuning of cell signaling by glypicans, Cell Mol Life Sci, 68, 923, 10.1007/s00018-007-7471-6 Fang, 2019, CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis, Nat Commun, 10, 3981, 10.1038/s41467-019-11662-3 Müller, 2018, The release of glycosylphosphatidylinositol-anchored proteins from the cell surface, Arch Biochem Biophys, 656, 1, 10.1016/j.abb.2018.08.009 Chen, 2020, METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer, Mol Cancer, 19, 106, 10.1186/s12943-020-01220-7 Tong, 2018, RNA m6A modification and its function in diseases, Front Med, 12, 481, 10.1007/s11684-018-0654-8 Shi, 2017, YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA, Cell Res, 27, 315, 10.1038/cr.2017.15 Huang, 2017, Ranibizumab injection as primary treatment in patients with retinopathy of prematurity: anatomic outcomes and influencing factors, Ophthalmology, 124, 1156, 10.1016/j.ophtha.2017.03.018 Zaccara, 2020, A unified model for the function of YTHDF proteins in regulating m 6 A-modified mRNA, Cell, 181, 1582, 10.1016/j.cell.2020.05.012 Caspi, 1988, A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens, J Immunol, 140, 1490, 10.4049/jimmunol.140.5.1490 Chan, 1990, Pathology of experimental autoimmune uveoretinitis in mice, J Autoimmun, 3, 247, 10.1016/0896-8411(90)90144-H Chandler, 2021, Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina, Mol Ther Methods Clin Dev, 22, 52, 10.1016/j.omtm.2021.05.011 Lipski, 2017, MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis, J Neuroinflammation, 14, 136, 10.1186/s12974-017-0915-5 Lückoff, 2017, Comprehensive analysis of mouse retinal mononuclear phagocytes, Nat Protoc, 12, 1136, 10.1038/nprot.2017.032 Ma, 2019, Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization, Elife, 8, 10.7554/eLife.42049 Wang, 2022, Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization, Redox Biol, 52, 10.1016/j.redox.2022.102297 Zhang, 1999, Differential expression of nitric oxide synthase in experimental uveoretinitis, Invest Ophthalmol Vis Sci, 40, 1899 Bansal, 2015, Experimental autoimmune uveitis and other animal models of uveitis: an update, Indian J Ophthalmol, 63, 211, 10.4103/0301-4738.156914 Maes, 2019, Targeting microglia with lentivirus and AAV: recent advances and remaining challenges, Neurosci Lett, 707, 10.1016/j.neulet.2019.134310 Zhang, 2008, Macrophage activation by endogenous danger signals, J Pathol, 214, 161, 10.1002/path.2284