The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development

Alward, 2000, Axenfeld–Rieger syndrome in the age of molecular genetics, Am. J. Ophthalmol., 130, 107, 10.1016/S0002-9394(00)00525-0

Alward, 1998, Autosomal dominant iris hypoplasia is caused by a mutation in the Rieger syndrome (RIEG/PITX2) gene, Am. J. Ophthalmol., 125, 98, 10.1016/S0002-9394(99)80242-6

Amendt, 1998, The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities, J. Biol. Chem., 273, 20066, 10.1074/jbc.273.32.20066

Asai-Coakwell, 2006, Reduced human and murine corneal thickness in an Axenfeld–Rieger syndrome subtype, Invest. Ophthalmol. Visual Sci., 47, 4905, 10.1167/iovs.06-0457

Berger, 1992, Isolation of a candidate gene for Norrie disease by positional cloning, Nat. Genet., 1, 199, 10.1038/ng0692-199

Berry, 2006, Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld–Rieger syndrome and anterior segment dysgenesis, Hum. Mol. Genet., 15, 905, 10.1093/hmg/ddl008

Black, 1999, Coats' disease of the retina (unilateral retinal telangiectasis) caused by somatic mutation in the NDP gene: a role for norrin in retinal angiogenesis, Hum. Mol. Genet., 8, 2031, 10.1093/hmg/8.11.2031

Briata, 2003, The Wnt/beta-catenin–>Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs, Mol. Cell, 12, 1201, 10.1016/S1097-2765(03)00407-6

Chen, 1993, A mutation in the Norrie disease gene (NDP) associated with X-linked familial exudative vitreoretinopathy, Nat. Genet., 5, 180, 10.1038/ng1093-180

Chen, 2004, Expression of Frizzleds and secreted frizzled-related proteins (Sfrps) during mammalian lens development, Int. J. Dev. Biol., 48, 867, 10.1387/ijdb.041882yc

Chow, 2001, Early eye development in vertebrates, Annu. Rev. Cell Dev. Biol., 17, 255, 10.1146/annurev.cellbio.17.1.255

Crofford, 1994, Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids, J. Clin. Invest., 93, 1095, 10.1172/JCI117060

Cvekl, 1996, Lens development and crystallin gene expression: many roles for Pax-6, BioEssays, 18, 621, 10.1002/bies.950180805

Cvekl, 2004, Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases, BioEssays, 26, 374, 10.1002/bies.20009

Danielian, 1998, Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase, Curr. Biol., 8, 1323, 10.1016/S0960-9822(07)00562-3

Dean, 2005, Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland, Dev. Biol., 286, 270, 10.1016/j.ydbio.2005.07.034

Diehl, 2006, Extraocular muscle morphogenesis and gene expression are regulated by Pitx2 gene dose, Invest. Ophthalmol. Visual Sci., 47, 1785, 10.1167/iovs.05-1424

Diep, 2004, Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain, Brain Res. Dev. Brain Res., 153, 261, 10.1016/j.devbrainres.2004.09.008

Doward, 1999, A mutation in the RIEG1 gene associated with Peters' anomaly, J. Med. Genet., 36, 152, 10.1136/jmg.36.2.152

Duplaa, 1999, Identification and cloning of a secreted protein related to the cysteine-rich domain of frizzled. Evidence for a role in endothelial cell growth control, Circ. Res., 84, 1433, 10.1161/01.RES.84.12.1433

Easwaran, 1999, Cross-regulation of beta-catenin-LEF/TCF and retinoid signaling pathways, Curr. Biol., 9, 1415, 10.1016/S0960-9822(00)80088-3

Evans, 2005, Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development, Hum. Mol. Genet., 14, 3347, 10.1093/hmg/ddi365

Fang, 2000, Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome, Am. J. Hum. Genet., 67, 1382, 10.1086/316915

Ferraris, 1994, Transdifferentiation of embryonic and postnatal rabbit corneal epithelial cells, Differentiation, 57, 89, 10.1046/j.1432-0436.1994.5720089.x

Ferraris, 2000, Adult corneal epithelium basal cells possess the capacity to activate epidermal, pilosebaceous and sweat gland genetic programs in response to embryonic dermal stimuli, Development, 127, 5487, 10.1242/dev.127.24.5487

Fjeld, 2005, Dynamic expression of Wnt signaling-related Dickkopf1, -2, and -3 mRNAs in the developing mouse tooth, Dev. Dyn., 233, 161, 10.1002/dvdy.20285

Gage, 1997, Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation, Hum. Mol. Genet., 6, 457, 10.1093/hmg/6.3.457

Gage, 1999, Dosage requirement of Pitx2 for development of multiple organs, Development, 126, 4643, 10.1242/dev.126.20.4643

Gage, 2005, Fate maps of neural crest and mesoderm in the mammalian eye, Invest. Ophthalmol. Visual Sci., 46, 4200, 10.1167/iovs.05-0691

Goodwin, 2006, Cultured endothelial cells display endogenous activation of the canonical Wnt signaling pathway and express multiple ligands, receptors, and secreted modulators of Wnt signaling, Dev. Dyn., 235, 3110, 10.1002/dvdy.20939

Gummow, 2006, Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex, Mol. Endocrinol., 20, 2711, 10.1210/me.2005-0461

Hecht, 2000, The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates, EMBO J., 19, 1839, 10.1093/emboj/19.8.1839

Hjalt, 2000, The Pitx2 protein in mouse development, Dev. Dyn., 218, 195, 10.1002/(SICI)1097-0177(200005)218:1<195::AID-DVDY17>3.0.CO;2-C

Holmberg, 2004, PITX2 gain-of-function in Rieger Syndrome eye model, Am. J. Pathol., 165, 1633, 10.1016/S0002-9440(10)63420-7

Jho, 2002, Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway, Mol. Cell. Biol., 22, 1172, 10.1128/MCB.22.4.1172-1183.2002

Kidson, 1999, The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye, Dev. Biol., 211, 306, 10.1006/dbio.1999.9314

Kioussi, 2002, Identification of a Wnt/Dvl/beta-Catenin→Pitx2 pathway mediating cell-type-specific proliferation during development, Cell., 111, 673, 10.1016/S0092-8674(02)01084-X

Kitamura, 1999, Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism, Development, 126, 5749, 10.1242/dev.126.24.5749

Kozlowski, 2000, Variation in residual PITX2 activity underlies the phenotypic spectrum of anterior segment developmental disorders, Hum. Mol. Genet., 9, 2131, 10.1093/hmg/9.14.2131

Kriederman, 2003, FOXC2 haploinsufficient mice are a model for human autosomal dominant lymphedema-distichiasis syndrome, Hum. Mol. Genet., 12, 1179, 10.1093/hmg/ddg123

Kulak, 1998, Mutation in the RIEG1 gene in patients with iridogoniodysgenesis syndrome, Hum. Mol. Genet., 7, 1113, 10.1093/hmg/7.7.1113

Kume, 2000, Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract, Development, 127, 1387, 10.1242/dev.127.7.1387

Kurpakus, 1994, Expression of keratins K12, K4 and K14 during development of ocular surface epithelium, Curr. Eye Res., 13, 805, 10.3109/02713689409025135

Li, 2001, Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin formation and patterning, Dev. Dyn., 222, 471, 10.1002/dvdy.1205

Li, 2005, Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation, Nat. Genet., 37, 945, 10.1038/ng1614

Lines, 2002, Molecular genetics of Axenfeld–Rieger malformations, Hum. Mol. Genet., 11, 1177, 10.1093/hmg/11.10.1177

Liu, 2003, Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina, Dev. Dyn., 227, 323, 10.1002/dvdy.10315

Logan, 2004, The Wnt signaling pathway in development and disease, Annu. Rev. Cell Dev. Biol., 20, 781, 10.1146/annurev.cellbio.20.010403.113126

Longo, 2002, Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors, J. Biol. Chem., 277, 38239, 10.1074/jbc.M206402200

Lu, 1999, Function of Rieger syndrome gene in left–right asymmetry and craniofacial development, Nature, 401, 276, 10.1038/45797

Luetteke, 1993, TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice, Cell, 73, 263, 10.1016/0092-8674(93)90228-I

Lustig, 2002, Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors, Mol. Cell. Biol., 22, 1184, 10.1128/MCB.22.4.1184-1193.2002

Mao, 2003, Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling, Gene, 302, 179, 10.1016/S0378-1119(02)01106-X

Masckauchan, 2005, Wnt/beta-catenin signaling induces proliferation, survival and interleukin-8 in human endothelial cells, Angiogenesis, 8, 43, 10.1007/s10456-005-5612-9

Matt, 2005, Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells, Development, 132, 4789, 10.1242/dev.02031

Miller, 2006, Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice, BMC Dev. Biol., 6, 14, 10.1186/1471-213X-6-14

Mine, 2005, HB-EGF promotes epithelial cell migration in eyelid development, Development, 132, 4317, 10.1242/dev.02030

Moll, 1982, The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells, Cell, 31, 11, 10.1016/0092-8674(82)90400-7

Molotkov, 2006, Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning, Development, 133, 1901, 10.1242/dev.02328

Mukhopadhyay, 2006, Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium, Development, 133, 2149, 10.1242/dev.02381

Nybakken, 2005, A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway, Nat. Genet., 37, 1323, 10.1038/ng1682

Ohlmann, 2004, Norrie gene product is necessary for regression of hyaloid vessels, Invest. Ophthalmol. Visual Sci., 45, 2384, 10.1167/iovs.03-1214

Pearton, 2005, Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals, Proc. Natl. Acad. Sci. U. S. A., 102, 3714, 10.1073/pnas.0500344102

Prinos, 2001, Multiple pathways governing Cdx1 expression during murine development, Dev. Biol., 239, 257, 10.1006/dbio.2001.0446

Priston, 2001, Functional analyses of two newly identified PITX2 mutants reveal a novel molecular mechanism for Axenfeld-Rieger syndrome, Hum. Mol. Genet., 10, 1631, 10.1093/hmg/10.16.1631

Robitaille, 2002, Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy, Nat. Genet., 32, 326, 10.1038/ng957

Roop, 1984, Synthetic peptides corresponding to keratin subunits elicit highly specific antibodies, J. Biol. Chem., 259, 8037, 10.1016/S0021-9258(17)39682-5

Semina, 1996, Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome, Nat. Genet., 14, 392, 10.1038/ng1296-392

Skurk, 2005, Glycogen-synthase kinase3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells, Circ. Res., 96, 308, 10.1161/01.RES.0000156273.30274.f7

Smith, 2000, Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development, Hum. Mol. Genet., 9, 1021, 10.1093/hmg/9.7.1021

Smith, 2005, The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm, Dev. Biol., 285, 477, 10.1016/j.ydbio.2005.07.019

Suh, 2002, Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification, Development, 129, 329, 10.1242/dev.129.2.329

Szeto, 2001, Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid, Cancer Res., 61, 4197

Tao, 2005, A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development, Development, 132, 3217, 10.1242/dev.01892

Tice, 2002, Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes, J. Biol. Chem., 277, 6118, 10.1074/jbc.M111255200

Tice, 2002, Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling, J. Biol. Chem., 277, 14329, 10.1074/jbc.M200334200

Toomes, 2004, Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q, Am. J. Hum. Genet., 74, 721, 10.1086/383202

Tseng, 1982, Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies, Cell, 30, 361, 10.1016/0092-8674(82)90234-3

Vassalli, 1994, Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction, Genes Dev., 8, 414, 10.1101/gad.8.4.414

Verani, 2007, Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid, J. Neurochem., 100, 242, 10.1111/j.1471-4159.2006.04207.x

Wolosin, 2002, Changes in connexin43 in early ocular surface development, Curr. Eye Res., 24, 430, 10.1076/ceyr.24.6.430.8599

Wolosin, 2004, Ocular surface epithelial and stem cell development, Int. J. Dev. Biol., 48, 981, 10.1387/ijdb.041876jw

Wright, 1999, Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells, Biochem. Biophys. Res. Commun., 263, 384, 10.1006/bbrc.1999.1344

Xu, 2004, Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand–receptor pair, Cell, 116, 883, 10.1016/S0092-8674(04)00216-8

Yan, 2001, Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta-catenin signaling is activated in human colon tumors, Proc. Natl. Acad. Sci. U. S. A., 98, 14973, 10.1073/pnas.261574498

Zenz, 2003, c-Jun regulates eyelid closure and skin tumor development through EGFR signaling, Dev. Cell, 4, 879, 10.1016/S1534-5807(03)00161-8

Zhang, 2003, A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure, EMBO J., 22, 4443, 10.1093/emboj/cdg440