Dimerization of cell surface receptors in signal transduction

Cell - Tập 80 Số 2 - Trang 213-223 - 1995
Carl‐Henrik Heldin1
1Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden

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Tài liệu tham khảo

Aguet, 1988, Molecular cloning and expression of the human interferon-y receptor, Cell, 55, 273, 10.1016/0092-8674(88)90050-5

Banner, 1993, Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: implications for TNF receptor activation, Cell, 73, 431, 10.1016/0092-8674(93)90132-A

Bazan, 1990, Structural design and molecular evolution of a cytokine receptor superfamily, 87, 6934

Bazan, 1993, Emerging families of cytokines and receptors, Curr. Biol., 3, 603, 10.1016/0960-9822(93)90009-D

Blechman, 1995, The fourth immunoglobin domain of the stem cell factor receptor couples ligand binding to signal transduction, Cell, 80, 105, 10.1016/0092-8674(95)90455-7

Boulton, 1994, Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common setof proteins overlapping those induced by other cytokines and growth factors, J. Biol. Chem., 269, 11648, 10.1016/S0021-9258(19)78174-5

Cambier, 1994, The hetero-oligomeric antigen receptor complex and its coupling to cytoplasmic effectors, Curr. Opin. Genet. Dev., 4, 55, 10.1016/0959-437X(94)90091-4

Carraway, 1994, A Neu acquaintance for ErbB3 and ErbB4: a role for receptor heterodimerization in growth signaling, Cell, 78, 5, 10.1016/0092-8674(94)90564-9

Chen, 1994, Homomeric interactions between type II transforming growth factor-p receptors, J. Biol. Chem., 269, 22868, 10.1016/S0021-9258(17)31725-8

Claesson-Welsh, 1994, Platelet-derived growth factor receptor signals, J. Biol. Chem., 269, 32023, 10.1016/S0021-9258(18)31591-6

Clark, 1994, Analysis of ig-α-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-σtimulation of Fyn activity, EMBO J., 13, 1911, 10.1002/j.1460-2075.1994.tb06460.x

Cohen, 1995, Modular binding domains in signal transduction proteins, Cell, 80, 10.1016/0092-8674(95)90406-9

Corey, 1994, Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases, 91, 4683

Cunningham, 1991, Dimerization of the extracellulardomain ofthe human growth hormone receptor by a single hormone molecule, Science, 254, 821, 10.1126/science.1948064

Darnell, 1994, Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, Science, 264, 1415, 10.1126/science.8197455

Davis, 1993, Released form of CNTF receptor a component as a soluble mediator of CNTF responses, Science, 259, 1736, 10.1126/science.7681218

Davis, 1994, Ligands for EPH-related receptor kinases that require membrane attachment or clustering for activity, Science, 266, 816, 10.1126/science.7973638

de Vos, 1992, Human growth hormone and extracellular domain of its receptor: crystal structure of the complex, Science, 255, 306, 10.1126/science.1549776

Duquesnoy, 1994, A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization, EMBO J., 13, 1386, 10.1002/j.1460-2075.1994.tb06392.x

Eck, 1993, Recognition of a high affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck, Nature, 362, 87, 10.1038/362087a0

Engelmann, 1990, Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNFlike activity, J. Biol. Chem., 265, 14497, 10.1016/S0021-9258(18)77330-4

Ernst, 1994, Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells, EMBO J., 13, 1574, 10.1002/j.1460-2075.1994.tb06420.x

Fantl, 1993, Signalling by receptor tyrosine kinases, Annu. Rev. Biochem., 62, 453, 10.1146/annurev.bi.62.070193.002321

Fedi, 1994, Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase Cy or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members, Mol. Cell. Biol., 14, 492, 10.1128/MCB.14.1.492

Fu, 1993, Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter, Cell, 74, 1135, 10.1016/0092-8674(93)90734-8

Fuh, 1992, Rational design of potent antagonists to the human growth hormone receptor, Science, 256, 1677, 10.1126/science.256.5064.1677

Fukunaga, 1993, Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor, Cell, 74, 1079, 10.1016/0092-8674(93)90729-A

Gearing, 1992, The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor, Science, 255, 1434, 10.1126/science.1542794

Gouilleux, 1994, Prolactin induces phosphorylation of Tyr694 and Stat5 (MGF), a prerequisite for DNA binding and induction of transcription, EMBO J., 13, 4361, 10.1002/j.1460-2075.1994.tb06756.x

Greco, 1992, Trk-t1 is a novel oncogene formed by the fusion of tpr and irk genes in a human papillary thyroid carcinoma, Oncogene, 7, 237

Greenlund, 1994, Ligand-induced IFNγ receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91), EMBO J., 13, 1591, 10.1002/j.1460-2075.1994.tb06422.x

Hatakeyama, 1991, Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association, Science, 252, 1523, 10.1126/science.2047859

Heldin, 1989, Dimerization of B-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation, J. Biol. Chem., 264, 8905, 10.1016/S0021-9258(18)81879-8

Hemmi, 1994, A novel member of the interferon receptor family complements functionality of the murine interferon γ receptor in human cells, Cell, 76, 803, 10.1016/0092-8674(94)90355-7

Henis, 1994, The types II and III transforming growth factor-p receptors form homooligomers, J. Cell Biol., 126, 139, 10.1083/jcb.126.1.139

Hercus, 1994, Specific human granulocyte-macrophage colony-stimulating factor antagonists, 91, 5838

Hilton, 1994, Cloning of a murine IL-11 receptor α-chain; requirement for gp130 for high affinity binding and signal transduction, EMBO J., 13, 4765, 10.1002/j.1460-2075.1994.tb06802.x

Hou, 1994, An interleukin-4-induced transcription factor: IL-4 Stat, Science, 265, 1701, 10.1126/science.8085155

Hunter, 1995, Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling, Cell, 80, 10.1016/0092-8674(95)90405-0

Ihle, 1994, Signaling by the cytokine receptor superfamily: JAKs and TATs, Trends Biol. Sci., 19, 222, 10.1016/0968-0004(94)90026-4

Irving, 1991, The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways, Cell, 64, 891, 10.1016/0092-8674(91)90314-O

Iwashima, 1994, Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases, Science, 263, 1136, 10.1126/science.7509083

Kanakaraj, 1991, Ligand-induced interaction between a- and p-type platelet derived growth factor (PDGF) receptors: role of receptor heterodimers in kinase activation, Biochemistry, 30, 1761, 10.1021/bi00221a005

Kawahara, 1994, Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor γ chain in IL-2, IL-4, and IL-7 signalling, Mol. Cell. Biol., 14, 5433, 10.1128/MCB.14.8.5433

Kishimoto, 1994, Cytokine signal transduction, Cell, 76, 253, 10.1016/0092-8674(94)90333-6

Kruse, 1992, Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement, EMBO J., 11, 3237, 10.1002/j.1460-2075.1992.tb05401.x

Law, 1993, B cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn, Curr. Biol., 3, 645, 10.1016/0960-9822(93)90062-S

Lemmon, 1994, Regulation of signal transduction and signal diversity by receptor oligomerization, Trends Biol. Sci., 19, 459, 10.1016/0968-0004(94)90130-9

Letourneur, 1992, Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3ε, Science, 255, 79, 10.1126/science.1532456

Martin-Zanca, 1986, A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences, Nature, 319, 743, 10.1038/319743a0

Massagué, 1994, The TGF-β family and its composite receptors, Trends Cell Biol., 4, 172, 10.1016/0962-8924(94)90202-X

Miyazaki, 1994, Functional activation of Jakl and Jak3 by selective assocation with IL-2 receptor subunits, Science, 266, 1045, 10.1126/science.7973659

Miyazono, 1994, Receptors for transforming growth factor-β, Adv. Immunol., 55, 181, 10.1016/S0065-2776(08)60510-6

Mui, 1994, Cytokine receptors and signal transduction, Prog. Growth Factor Res., 5, 15, 10.1016/0955-2235(94)90015-9

Murakami, 1991, Critical cytoplasmic region of the interleukin-6 signal transducer gp130 is conserved in the cytokine receptor family, 88, 11349

Murakami, 1993, IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase, Science, 260, 1808, 10.1126/science.8511589

Müller, 1993, The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction, Nature, 366, 129, 10.1038/366129a0

Nakamura, 1994, Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling, Nature, 369, 330, 10.1038/369330a0

Naldini, 1991, The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation, Mol. Cell. Biol., 11, 1793, 10.1128/MCB.11.4.1793

Nelson, 1994, Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation, Nature, 369, 333, 10.1038/369333a0

Novick, 1994, The human interferon α/β receptor: characterization and molecular cloning, Cell, 77, 391, 10.1016/0092-8674(94)90154-6

Okadome, 1994, Distinct roles of the intracellular domains of transforming growth factor β type I and type II receptors in signal transduction, J. Biol. Chem., 269, 30753, 10.1016/S0021-9258(18)47342-5

Park, 1986, Mechanism of met oncogene activation, Cell, 45, 895, 10.1016/0092-8674(86)90564-7

Pascal, 1994, Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-γ1 complexed with a3 high affinity binding peptide, Cell, 77, 461, 10.1016/0092-8674(94)90160-0

Pawson, 1993, SH2 and SH3 domains, Curr. Biol., 3, 434, 10.1016/0960-9822(93)90350-W

Peles, 1993, Cell-type specific interaction of Neu differentiation factor (NDF/ heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships, EMBO J., 12, 961, 10.1002/j.1460-2075.1993.tb05737.x

Plowman, 1993, Heregulin induces tyrosine phosphorylation of HER4/p180erbB4, Nature, 366, 473, 10.1038/366473a0

Prigent, 1994, Identification of c-erbB-3 binding sites for phosphatidylinositol 3′-kinase and SHC using an EGF receptor/c-erbB-3 chimera, EMBO J., 13, 2831, 10.1002/j.1460-2075.1994.tb06577.x

Qian, 1994, Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: a mechanism of interreceptor kinase activation and transphosphorylation, 91, 1500

Ravetch, 1994, Fc receptors: rubor redux, Cell, 78, 553, 10.1016/0092-8674(94)90521-5

Reth, 1989, Antigen receptor tail clue, Nature, 338, 383, 10.1038/338383b0

Rodrigues, 1994, Oncogenic activation of tyrosine kinases, Curr. Opin. Genet. Dev., 4, 15, 10.1016/0959-437X(94)90086-8

Romeo, 1991, Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides, Cell, 64, 1037, 10.1016/0092-8674(91)90327-U

Rothe, 1994, A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor, Cell, 78, 681, 10.1016/0092-8674(94)90532-0

Ruff-Jamison, 1993, Induction by EGF and interferon-γ of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei, Science, 261, 1733, 10.1126/science.8378774

Rupp, 1994, A unique autophosphorylation site in the PDGF a-receptor from a heterodimeric receptor complex, Eur. J. Biochem., 225, 29, 10.1111/j.1432-1033.1994.00029.x

Russell, 1994, Interaction of IL-219β and γc. chains with Jakl and Jak3: implications for XSCID and XCID, Science, 266, 1042, 10.1126/science.7973658

Sadowski, 1993, A common nuclear signal transduction pathway activated by growth factor and cytokine receptors, Science, 261, 1739, 10.1126/science.8397445

Sato, 1993, Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common β subunit responsible for different signaling, EMBO J., 12, 4181, 10.1002/j.1460-2075.1993.tb06102.x

Savino, 1994, Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation, EMBO J., 13, 1357, 10.1002/j.1460-2075.1994.tb06389.x

Schindler, 1992, Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor, Science, 257, 809, 10.1126/science.1496401

Seifert, 1989, Two different subunits associate to create isoform-specific platelet-derived growth factor receptors, J. Biol. Chem., 264, 8771, 10.1016/S0021-9258(18)81860-9

Shuai, 1992, Activation of transcription by IFN-γ: tyrosine phosphorylation of a 91-kD DNA binding protein, Science, 259, 1808, 10.1126/science.1281555

Shuai, 1993, A single phosphotyrosine residue of Stat91 required for gene activation by interferon-γ., Science, 261, 1744, 10.1126/science.7690989

Shuai, 1994, Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions, Cell, 76, 821, 10.1016/0092-8674(94)90357-3

Silvennoinen, 1993, Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation, Science, 261, 1736, 10.1126/science.8378775

Sliwkowski, 1994, Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin, J. Biol. Chem., 269, 14661, 10.1016/S0021-9258(17)36676-0

Smith, 1994, The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death, Cell, 76, 959, 10.1016/0092-8674(94)90372-7

Soh, 1994, Identification and sequence of an accessory factor required for activation of the human interferon γ receptor, Cell, 76, 793, 10.1016/0092-8674(94)90354-9

Soltoff, 1994, ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor, Mol. Cell. Biol., 14, 3550, 10.1128/MCB.14.6.3550

Soos, 1989, Immunological relationships between receptors for insulin and insulin-like growth factor I, Biochem. J., 263, 553, 10.1042/bj2630553

Sorokin, 1994, Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond, J. Biol. Chem., 269, 9752, 10.1016/S0021-9258(17)36947-8

Taga, 1989, Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130, Cell, 58, 573, 10.1016/0092-8674(89)90438-8

Takahashi, 1985, Activation of a novel human transforming gene, ret, by DNA rearrangement, Cell, 42, 581, 10.1016/0092-8674(85)90115-1

Takahashi, 1994, Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases, FEBS Lett., 342, 124, 10.1016/0014-5793(94)80485-0

Ullrich, 1990, Signal transduction by receptors with tyrosine kinase activity, Cell, 61, 203, 10.1016/0092-8674(90)90801-K

Ultsch, 1991, Crystals of the complex between human growth hormone and the extracellular domain of its receptor, J. Mol. Biol., 22, 865, 10.1016/0022-2836(91)90578-T

Velazques, 1992, A protein tyrosine kinase in the interferon α/β signaling pathway, Cell, 70, 313, 10.1016/0092-8674(92)90105-L

Wada, 1990, Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function, Cell, 61, 1339, 10.1016/0092-8674(90)90697-D

Waksman, 1993, Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms, Cell, 72, 779, 10.1016/0092-8674(93)90405-F

Watling, 1993, Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-γ signal transduction pathway, Nature, 366, 166, 10.1038/366166a0

Watowich, 1992, Homodimerization and constitutive activation of the erythropoietin receptor, 89, 2140

Weiner, 1989, A point mutation in the neu oncogene mimics ligand induction of receptor aggregation, Nature, 339, 230, 10.1038/339230a0

Weiss, 1994, Signal transduction by lymphocyte antigen receptors, Cell, 76, 263, 10.1016/0092-8674(94)90334-4

White, 1994, The IRS-1 signaling system, Curr. Opin. Genet. Dev., 4, 47, 10.1016/0959-437X(94)90090-6

White, 1988, A cascade of tyrosine autophosphorylation in the β-subunit activates the phosphotransferase of the insulin receptor, J. Biol. Chem., 263, 2969, 10.1016/S0021-9258(18)69163-X

Wrana, 1992, TGFP signals through a heteromeric protein kinase receptor complex, Cell, 71, 1003, 10.1016/0092-8674(92)90395-S

Wrana, 1994, Mechanism of activation of the TGF-β receptor, Nature, 370, 341, 10.1038/370341a0

Yamashita, 1994, Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-β, J. Biol. Chem., 269, 20172, 10.1016/S0021-9258(17)32142-7

Yarden, 1987, Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor, Biochemistry, 26, 1443, 10.1021/bi00379a035

Zhong, 1994, Stat3 and Stat4: members of the family of signal transducers and activators of transcription, 91, 4806

Ziemiecki, 1994, JAK protein tyrosine kinases: their role in cytokine signalling, Trends Cell Biol., 4, 207, 10.1016/0962-8924(94)90143-0