Dermatophyte Virulence Factors: Identifying and Analyzing Genes That May Contribute to Chronic or Acute Skin Infections

International Journal of Microbiology - Tập 2012 - Trang 1-8 - 2012
Rebecca Rashid Achterman1, Theodore C. White2,1
1Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109-5219, USA
2School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, BSB 404, Kansas City, MO 64110, USA

Tóm tắt

Dermatophytes are prevalent causes of cutaneous mycoses and, unlike many other fungal pathogens, are able to cause disease in immunocompetent individuals. They infect keratinized tissue such as skin, hair, and nails, resulting in tinea infections, including ringworm. Little is known about the molecular mechanisms that underlie the ability of these organisms to establish and maintain infection. The recent availability of genome sequence information and improved genetic manipulation have enabled researchers to begin to identify and study the role of virulence factors of dermatophytes. This paper will summarize our current understanding of dermatophyte virulence factors and discuss future directions for identifying and testing virulence factors.

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International Journal of Microbiology

Tập 2012

1-8

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