Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy

Bioorganic & Medicinal Chemistry Letters - Tập 20 - Trang 1293-1297 - 2010
Juraj Velcicky1, Roland Feifel1, Stuart Hawtin1, Richard Heng1, Christine Huppertz1, Guido Koch1, Markus Kroemer1, Henrik Moebitz1, Laszlo Revesz1, Clemens Scheufler1, Achim Schlapbach1
1Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland

Tài liệu tham khảo

Feldmann, 2003, Nat. Med., 9, 1245, 10.1038/nm939 Nikolaus, 2008, Der Internist, 49, 947, 10.1007/s00108-008-2058-3 Valesini, 2007, Autoimmunity Rev., 7, 35, 10.1016/j.autrev.2007.03.003 Mousa, 2007, Expert Opin. Biol. Ther., 7, 617, 10.1517/14712598.7.5.617 Takeuchi, 2005, Allergol. Int., 54, 191, 10.2332/allergolint.54.191 Schindler, 2007, J. Dent. Res., 86, 800, 10.1177/154405910708600902 Peifer, 2006, Curr. Top. Med. Chem., 6, 113, 10.2174/156802606775270323 Dominguez, 2005, Curr. Opin. Drug Disc. Dev., 8, 421 Kotlyarov, 1999, Nat. Cell Biol., 1, 94, 10.1038/10061 Kotlyarov, 2002, Mol. Cell. Biol., 22, 4827, 10.1128/MCB.22.13.4827-4835.2002 Neininger, 2002, J. Biol. Chem., 277, 3065, 10.1074/jbc.C100685200 Duraisamy, 2008, Expert Opin. Ther. Targets, 12, 921, 10.1517/14728222.12.8.921 Hegen, 2006, J. Immunol., 177, 1913, 10.4049/jimmunol.177.3.1913 Schlapbach, 2008, Bioorg. Med. Chem. Lett., 18, 6142, 10.1016/j.bmcl.2008.10.039 Anderson, 2005, Bioorg. Med. Chem. Lett., 15, 1587, 10.1016/j.bmcl.2005.01.067 Wu, 2007, Bioorg. Med. Chem. Lett., 17, 4664, 10.1016/j.bmcl.2007.05.101 Trujillo, 2007, Bioorg. Med. Chem. Lett., 17, 4657, 10.1016/j.bmcl.2007.05.070 Goldberg, 2008, Bioorg. Med. Chem. Lett., 18, 938, 10.1016/j.bmcl.2007.12.037 Xiong, 2008, Bioorg. Med. Chem. Lett., 18, 1994, 10.1016/j.bmcl.2008.01.119 Anderson, 2007, J. Med. Chem., 50, 2647, 10.1021/jm0611004 Lin, 2009, Bioorg. Med. Chem. Lett., 19, 3238, 10.1016/j.bmcl.2009.04.088 Anderson, 2009, Bioorg. Med. Chem. Lett., 19, 4878, 10.1016/j.bmcl.2009.02.015 Anderson, 2009, Bioorg. Med. Chem. Lett., 19, 4882, 10.1016/j.bmcl.2009.02.017 Schneider, 1999, Angew. Chem., Int. Ed., 38, 2894, 10.1002/(SICI)1521-3773(19991004)38:19<2894::AID-ANIE2894>3.0.CO;2-F Schneider, 2006, QSAR Comb. Sci., 25, 1162, 10.1002/qsar.200610091 Böhm, 2004, Drug Discovery Today, 1, 217, 10.1016/j.ddtec.2004.10.009 Mauser, 2008, Curr. Opin. Drug Disc. Dev., 11, 365 Zhao, 2007, Drug Discovery Today, 12, 149, 10.1016/j.drudis.2006.12.003 Silvestri, 2008, J. Med. Chem., 51, 1560, 10.1021/jm070566z Harvey, 1997, J. Chem. Res., Synop., 11, 420, 10.1039/a703502k Iida, 2005, J. Org. Chem., 70, 9222, 10.1021/jo0512709 γ-lactame-bromide: Clayton, J.; Ma, F.; Van Wagenen, B.; Ukkiramapandian, R.; Egle, I.; Empfield, J.; Isaac, M.; Slassi, A.; Steelman, G.; Urbanek, R.; Walsh, S. WO 2006/020879. δ-lactame-bromide: Coppola, G. M.; Damon, R. E.; Kukkola, P. J.; Stanton, J. L. WO 2004/065351. Shtacher, 1973, J. Med. Chem., 16, 516, 10.1021/jm00263a024 Wermuth, 2003, Vol. 2 Lima, 2005, Curr. Med. Chem., 12, 23, 10.2174/0929867053363540 Chen, 2003, Ann. Rep. Med. Chem., 38, 333, 10.1016/S0065-7743(03)38033-9