Prediction of survival and recurrence in bladder carcinoma
Tóm tắt
We have followed a large population of patients receiving radiation treatment for bladder carcinoma with respect to survival and recurrence-free survival. Bivariate and multivariate life table analyses have been performed using a set of independent variables. The most important were T class, grade (G), urinary carcinoembryonic antigen (U-CEA) taken before treatment and cytological analysis 4 months after treatment. We compared the usual way of classifying a patient (T+G) with the combination of U-CEA and cytology since the latter two variables seemed to have great prognostic importance. The analyses show that T+G gives the best significance for survival (P=0.0003) while U-CEA and cytology is better for recurrence-free survival (ρ=0.0002). 0.0002).
Tài liệu tham khảo
Bergkvist A, Ljungqvist A, Moberger G (1965) Classification of bladder tumors based on the cellular pattern. Preliminary report of a clinical-pathological study of 300 cases with a minimum follow-up of eight years. Acta Chir Scand 130:371
Cox DR (1972) Regression models and life tables. Journal of the Royal Statistical Society B 34:187
De Voogt HJ, Rathert T, Beyer-Boon ME (1977) Urinary cytology. Springer, Berlin Heidelberg New York
Edsmyr F, Esposti PL, Giertz G, Littbrand B (1978) Radiation treatment of urinary bladder carcinoma. Urol Res 6:229
Edsmyr E, Johansson B (1978) Bladder carcinoma treated by preoperative radiotherapy followed by cystectomy. Urol Res 6:253
Esposti PL, Edsmyr F, Tribukait B (1978) The role of exfoliative cytology in the management of bladder carcinoma. Urol Res 6:197
Esposti PL, Zajicek J (1972) Grading of transitional cell neoplasms of the urinary bladder from smears of bladder washings. Acta Cytol 16:529
International Union Against Cancer (1974) TNM Classification of malignant tumors, Geneva
Mostofi FK, Sobin LH, Torloni H (1973) Histological typing of urinary bladder tumors. WHO
Oliver RTD, Hendry WF, Bloom HSG (1981) Bladder cancer. Principles of combination therapy. Butterworths. London Boston
Palmer MK, Hann IM, Jones PM, Evans DIK (1980) A score at diagnosis for predicting length of remission in childhood acute lymphoblastic leukemia. Br J Cancer 42:841
Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPhersson K, Peto J, Smith PG (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35:1
Sarma KP (1969) Tumours of the urinary bladder. Butterworth & Co, London
Tirbukait B, Esposti PL (1978) Quantitative Flow-microfluorometric analysis of the DNA in cells from neoplasms of the urinary bladder: Correlation of aneuploidy with histological grading and the cytological findings. Urol Res 6:201
Wahren B, Edsmyr F, Zimmerman R (1975) Measurement of urinary CEA-like substance. An aid in management of patients with bladder carcinoma. Cancer 36:1490
Wahren B, Esposti P, Zimmerman R (1977) Characterization of urothelial carcinoma with respect to the content of carcinoembryonic antigen in exfoliated cells. Cancer 40:1511
Wahren B, Nilsson B, Zimmerman R (in press 1982) Urinary CEA for prediction of survival time and recurrence in bladder cancer. Cancer
Wahren B, Perlmann P (1982) Tumor markers in bladder and renal carcinomas. In: Sell S, Wahren B (eds) Cancer Markers. Humana Press
Zimmerman R (1979) Improved performance of a double antibody radioimmunoassay for carcinoembryonic antigen. Journal of Immunol Methods 25:311
Zimmerman R, Wahren B, Edsmyr F (1980) Assessment of serial CEA determinations in urine of patients with bladder carcinoma. Cancer 46:1802