A patient with Huntington’s disease and long-surviving fetal neural transplants that developed mass lesions

Springer Science and Business Media LLC - Tập 117 Số 3 - Trang 329-338 - 2009
C. Dirk Keene1, Rubens Chang1, James B. Leverenz2, Oleg Kopyov3, Susan Perlman4, Robert F. Hevner5,1, Donald E. Born1, Thomas D. Bird2, Thomas J. Montine1
1Division of Neuropathology, Department of Pathology, Harborview Medical Center, University of Washington Medical Center, Seattle, USA
2Department of Neurology, VA-Puget Sound Health Care System, University of Washington Medical Center, Seattle, USA
3Neurosciences Institute, St. John’s Regional Medical Center, Oxnard, USA
4Department of Neurology, UCLA, Los Angeles, USA
5Department of Neurosurgery, University of Washington Medical Center, Seattle Children’s Hospital and Regional Medical Center, Seattle, USA

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Tài liệu tham khảo

Bachoud-Lévi A, Bourdet C, Brugières P, Nguyen JP, Grandmougin T, Haddad B, Jény R, Bartolomeo P, Boissé MF, Barba GD, Degos JD, Ergis AM, Lefaucheur JP, Lisovoski F, Pailhous E, Rémy P, Palfi S, Defer GL, Cesaro P, Hantraye P, Peschanski M (2000) Safety and tolerability assessment of intrastriatal neural allografts in five patients with Huntington’s disease. Exp Neurol 161:194–202. doi: 10.1006/exnr.1999.7239

Bachoud-Lévi AC, Gaura V, Brugières P, Lefaucheur JP, Boissé MF, Maison P, Baudic S, Ribeiro MJ, Bourdet C, Remy P, Cesaro P, Hantraye P, Peschanski M (2006) Effect of fetal neural transplants in patients with Huntington’s disease 6 years after surgery: a long-term follow-up study. Lancet Neurol 5:303–309. doi: 10.1016/S1474-4422(06)70381-7

Bachoud-Lévi AC, Rémy P, Nguyen JP, Brugières P, Lefaucheur JP, Bourdet C, Baudic S, Gaura V, Maison P, Haddad B, Boissé MF, Grandmougin T, Jény R, Bartolomeo P, Dalla Barba G, Degos JD, Lisovoski F, Ergis AM, Pailhous E, Cesaro P, Hantraye P, Peschanski M (2000) Motor and cognitive improvements in patients with Huntington’s disease after neural transplantation. Lancet 356:1975–1979. doi: 10.1016/S0140-6736(00)03310-9

Collier TJ, Elsworth JD, Taylor JR, Sladek JR Jr, Roth RH, Redmond DE Jr (1994) Peripheral nerve-dopamine neuron co-grafts in MPTP-treated monkeys: augmentation of tyrosine hydroxylase-positive fiber staining and dopamine content in host systems. Neuroscience 61:875–879. doi: 10.1016/0306-4522(94)90410-3

Dunnett SB, Rosser AE (2007) Cell transplantation for Huntington’s disease: should we continue? Brain Res Bull 72:132–147. doi: 10.1016/j.brainresbull.2006.10.019

Folkerth RD, Durso R (1996) Survival and proliferation of non-neural tissues, with obstruction of cerebral ventricles, in a parkinsonian patient treated with fetal allografts. Neurology 46:1219–1225

Freeman TB, Cicchetti F, Hauser RA, Deacon TW, Li XJ, Hersch SM, Nauert GM, Sanberg PR, Kordower JH, Saporta S, Isacson O (2000) Transplanted fetal striatum in Huntington’s disease: phenotypic development and lack of pathology. Proc Natl Acad Sci USA 97:13877–13882. doi: 10.1073/pnas.97.25.13877

Hauser RA, Furtado S, Cimino CR, Delgado H, Eichler S, Schwartz S, Scott D, Nauert GM, Soety E, Sossi V, Holt DA, Sanberg PR, Stoessl AJ, Freeman TB (2002) Bilateral human fetal striatal transplantation in Huntington’s disease. Neurology 58:687–695

Keene CD, Sonnen JA, Swanson PD, Kopyov O, Leverenz JB, Bird TD, Montine TJ (2007) Neural transplantation in Huntington’s disease: long-term grafts in two patients. Neurology 68:2093–2098. doi: 10.1212/01.wnl.0000264504.14301.f5

Kopyov OV, Jacques S, Lieberman A, Duma CM, Eagle KS (1998) Safety of intrastriatal neurotransplantation for Huntington’s disease patients. Exp Neurol 149:97–108. doi: 10.1006/exnr.1997.6685

Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW (2008) Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson’s disease. Nat Med 14:504–506. doi: 10.1038/nm1747

Kordower JH, Freeman TB, Bakay RA, Goetz CG, Olanow CW (1997) Treatment with fetal allografts. Neurology 48:1737–1738

Li JY, Englund E, Holton JL, Soulet D, Hagell P, Lees AJ, Lashley T, Quinn NP, Rehncrona S, Bjorklund A, Widner H, Revesz T, Lindvall O, Brundin P (2008) Lewy bodies in grafted neurons in subjects with Parkinson’s disease suggest host-to-graft disease progression. Nat Med 14:501–503. doi: 10.1038/nm1746

Madrazo I, Franco-Bourland RE, Castrejon H, Cuevas C, Ostrosky-Solis F (1995) Fetal striatal homotransplantation for Huntington’s disease: first two case reports. Neurol Res 17:312–315

Mamelak AN, Eggerding FA, Oh DS, Wilson E, Davis RL, Spitzer R, Hay JA, Caton WL 3rd (1998) Fatal cyst formation after fetal mesencephalic allograft transplant for Parkinson’s disease. J Neurosurg 89:592–598

Mendez I, Sanchez-Pernaute R, Cooper O, Viñuela A, Ferrari D, Björklund L, Dagher A, Isacson O (2005) Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson’s disease. Brain 128:1498–1510. doi: 10.1093/brain/awh510

Mendez I, Vinuela A, Astradsson A, Mukhida K, Hallett P, Robertson H, Tierney T, Holness R, Dagher A, Trojanowski JQ, Isacson O (2008) Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years. Nat Med 14:507–509. doi: 10.1038/nm1752

Peschanski M, Cesaro P, Hantraye P (1995) Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington’s disease. Neuroscience 68:73–285. doi: 10.1016/0306-4522(95)00162-C

Peschanski M, Cesaro P, Hantraye P (1996) What is needed versus what would be interesting to know before undertaking neural transplantation in patients with Huntington’s disease. Neuroscience 71:899–900. doi: 10.1016/0306-4522(95)00575-7

Quinn N, Brown R, Craufurd D, Goldman S, Hodges J, Kieburtz K, Lindvall O, MacMillan J, Roos R (1996) Core assessment program for intracerebral transplantation in Huntington’s disease (CAPIT-HD). Mov Disord 11:143–150. doi: 10.1002/mds.870110202

Ross BD, Hoang TO, Blüml S, Dubowitz D, Kopyov OV, Jacques DB, Lin A, Seymour K, Tan J (1999) In vivo magnetic resonance spectroscopy of human fetal neural transplants. NMR Biomed 12:221–236. doi:10.1002/(SICI)1099-1492(199906)12:4<221::AID-NBM582>3.0.CO;2-Q

Rosser AE, Barker RA, Harrower T, Watts C, Farrington M, Ho AK, Burnstein RM, Menon DK, Gillard JH, Pickard J, Dunnett SB, NEST-UK (2002) Unilateral transplantation of human primary fetal tissue in four patients with Huntington’s disease: NEST-UK safety report ISRCTN no 36485475. J Neurol Neurosurg Psychiatry 73:678–685. doi: 10.1136/jnnp.73.6.678

Sramka M, Rattaj M, Molina H, Vojtassák J, Belan V, Ruzický E (1992) Stereotactic technique and pathophysiological mechanisms of neurotransplantation in Huntington’s chorea. Stereotact Funct Neurosurg 58:79–83. doi: 10.1159/000098976

Ulrisch R, Jacques S, Kopyov O (2000) Neural transplantation. J Neurosurg 93:163–164

Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP Jr (1985) Neuropathological classification of Huntington’s disease. J Neuropathol Exp Neurol 44:559–577. doi: 10.1097/00005072-198511000-00003

Watts RL, Mandir AS, Bakay RA (1995) Intrastriatal cografts of autologous adrenal medulla and sural nerve in MPTP-induced parkinsonian macaques: behavioral and anatomical assessment. Cell Transplant 4:27–38. doi: 10.1016/0963-6897(95)92155-R

Watts RL, Subramanian T, Freeman A, Goetz CG, Penn RD, Stebbins GT, Kordower JH, Bakay RA (1997) Effect of stereotaxic intrastriatal cografts of autologous adrenal medulla and peripheral nerve in Parkinson’s disease: two-year follow-up study. Exp Neurol 147:510–517. doi: 10.1006/exnr.1997.6626