Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial

1994, Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S), Lancet, 344, 1383 Shepherd, 1995, Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia, N EnglJ Med, 333, 1301, 10.1056/NEJM199511163332001 Sacks, 1996, The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels, N Engl J Med, 335, 1001, 10.1056/NEJM199610033351401 Downs, 1998, Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS Airforce/Texas Coronary Atherosclerosis Prevention Study, JAMA, 279, 1615, 10.1001/jama.279.20.1615 1998, Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels, N Engl J Med, 339, 1349, 10.1056/NEJM199811053391902 2002, MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo-controlled trial, Lancet, 360, 7, 10.1016/S0140-6736(02)09327-3 Shipley, 1991, Does plasma cholesterol concentration predict mortality from coronary heart disease in elderly people? 18-year follow-up of the Whitehall Study, BMJ, 303, 89, 10.1136/bmj.303.6794.89 Weverling-Rijnsburger, 1997, Total cholesterol and risk of mortality in the oldest old, Lancet, 350, 1119, 10.1016/S0140-6736(97)04430-9 Schatz, 2001, Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study, Lancet, 358, 351, 10.1016/S0140-6736(01)05553-2 1995, Cholesterol, diastolic blood pressure and stroke: 13 000 strokes in 450 000 people in 45 prospective cohorts, Lancet, 346, 1647, 10.1016/S0140-6736(95)92836-7 Jick, 2000, Statins and the risk of dementia, Lancet, 356, 1627, 10.1016/S0140-6736(00)03155-X Wolozin, 2000, Decreased prevalence of Alzheimers disease associated with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, Arch Neural, 57, 1439, 10.1001/archneur.57.10.1439 Shepherd, 1999, The design of a prospective study of pravastatin in the elderly at risk (PROSPER), Am J Cardiol, 84, 1192, 10.1016/S0002-9149(99)00533-0 Ford, 2002, A prospective study of pravastatin in the elderly at risk (PROSPER): screening experience and baseline characteristics, Curr Controlled Trials Cardiovasc Med, 3, 8, 10.1186/1468-6708-3-8 Houx, 2002, Testing cognitive function in elderly populations: The PROSPER study, J Neural Neurosurg Psychiatry, 73, 385, 10.1136/jnnp.73.4.385 Macfarlane, 1996, Automated serial EGG comparison based on the Minnesota Code, J Electrocardiol, 29, 29, 10.1016/S0022-0736(96)80016-1 Yusuf, 1985, Beta blockade during and after myocardial infarction: an overview of the randomized trials, Prog Card Dis, 27, 335, 10.1016/S0033-0620(85)80003-7 Serruys, 2002, Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: a randomized controlled trial, JAMA, 287, 3215, 10.1001/jama.287.24.3215 1995, Design, rationale and baseline characteristics of the prospective pravastatin pooling PPP project: a combined analysis of three large scale randomised trials, Am J Cardiol, 76, 899, 10.1016/S0002-9149(99)80259-8 Byington, 2001, Reduction of stroke events with Pravastatin, Circulation, 103, 387, 10.1161/01.CIR.103.3.387 Pedersen, 1998, Effect of simvastatin on ischemic signs and symptoms in the Scandinavian Simvastatin Survival Study, Am J Cardiol, 83, 333, 10.1016/S0002-9149(97)00904-1 Hofman, 1997, Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study, Lancet, 349, 151, 10.1016/S0140-6736(96)09328-2 2001, Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales, Lancet, 357, 169, 10.1016/S0140-6736(00)03589-3 Breteler, 1994, Cerebral white matter lesions, vascular risk factors, and cognitive decline in a population-based study: The Rotterdam Study, Neurology, 44, 1246, 10.1212/WNL.44.7.1246 Pyorala, 1997, Cholesterol lowering with simvastatin improves prognosis of diabetic patients with coronary heart disease: a subgroup analysis of the Scandinavian Simvastatin Survival Study, Diabetes Care, 20, 614, 10.2337/diacare.20.4.614 Sacks, 2000, The effect of pravastatin on coronary disease events in subgroups defined by coronary risk factors: the Prospective Pravastatin Pooling Project, Circulation, 102, 1893, 10.1161/01.CIR.102.16.1893 Keech, 1992, Does cholesterol lowering reduce total mortality?, Postgrad Med J, 68, 870 Davey Smith, 1992, Should there be a moratorium on the use of cholesterol lowering drugs?, BMJ, 304, 431, 10.1136/bmj.304.6824.431 Bjerre, 2001, Do statins cause cancer? A Meta-analysis of large randomised clinical trials, Am J Med, 110, 716, 10.1016/S0002-9343(01)00705-7