67-kDa laminin receptor and cGMP induced cancer-selective apoptosis

Shanafelt TD, Call TG, Zent CS, Leis LF, Plant BL, Bowen DA, Roos M, Laumann K, Ghosh AK, Lesnick C, Lee MJ, Yang CS, Jelinek DF, Erlichman C, Kay NE: Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia. Cancer. 2013, 119: 363-370. 10.1002/cncr.27719. Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A: Chemo- prevention of human prostate cancer by oral administrationof green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year Proof-of-Principle study. Cancer Res. 2006, 66: 1234-1244. 10.1158/0008-5472.CAN-05-1145. Tachibana H, Koga K, Fujimura Y, Yamada K: A receptor for green tea polyphenol EGCG. Nat Struct Mol Biol. 2004, 11: 380-381. 10.1038/nsmb743. Shammas MA, Neri P, Koley H, Batchu PB, Bertheau RC, Munshi V, Prabhala R, Fulciniti M, Tai Y, Steven P, Treon SP, Goyal RK, Anderson CK, Munshi NC: Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications. Blood. 2006, 108: 2804-2810. 10.1182/blood-2006-05-022814. Tsukamoto S, Hirotsu K, Kumazoe M, Goto Y, Sugihara K, Suda T, Tsurudome Y, Suzuki T, Yamashita S, Kim Y, Huang Y, Yamada K, Tachibana H: Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase Cdelta and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells. Biochem J. 2012, 443: 525-534. 10.1042/BJ20111837. Kumazoe M, Sugihara K, Tsukamoto S, Huang Y, Tsurudome Y, Suzuki T, Suemasu Y, Ueda N, Yamashita S, Kim Y, Yamada K, Tachibana H: 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. J Clin Invest. 2013, 123: 787-799.