The Management of Uterine Leiomyomas

Day Baird, 2003, High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence, Am J Obstet Gynecol, 188, 100, 10.1067/mob.2003.99 Marshall, 1997, Variation in the incidence of uterine leiomyoma among premenopausal women by age and race, Obstet Gynecol, 90, 967, 10.1016/S0029-7844(97)00534-6 Cramer, 1990, The frequency of uterine leiomyomas, Am J Clin Pathol, 94, 435, 10.1093/ajcp/94.4.435 Zimmermann, 2012, Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 women, BMC Womens Health, 12, 6, 10.1186/1472-6874-12-6 Downes, 2010, The burden of uterine fibroids in five European countries, Eur J Obstet Gynecol Reprod Biol, 152, 96, 10.1016/j.ejogrb.2010.05.012 Pritts, 2009, Fibroids and infertility: an updated systematic review of the evidence, Fertil Steril, 91, 1215, 10.1016/j.fertnstert.2008.01.051 Vilos, 2014, Symptomatic uterine fibroids (UFs) are common in premenopausal Canadian women and lead to reduced quality of life (QoL) across multiple domains, J Obstet Gynecol Can, 36, S26 Canadian Institute for Health Information, 2010 Boyd, 2010, Effect of surgical volume on route of hysterectomy and short-term morbidity, Obstet Gynecol, 116, 909, 10.1097/AOG.0b013e3181f395d9 Clark-Pearson, 2013, Complications of hysterectomy, Obstet Gynecol, 121, 654, 10.1097/AOG.0b013e3182841594 Bulun, 2013, Uterine fibroids, N Engl J Med, 369, 1344, 10.1056/NEJMra1209993 Munro, 2011, The FIGO Classification System (“PALM-COEIN”) for causes of abnormal uterine bleeding in non-gravid women in the reproductive years, including guidelines for clinical investigation, Int J Gynaecol Obstet, 113, 3, 10.1016/j.ijgo.2010.11.011 Flake, 2003, Etiology and pathophysiology of uterine leiomyomas; a review, Environ Health Perspect, 111, 1037, 10.1289/ehp.5787 Buttram, 1981, Uterine leiomyomata: etiology, symptomatology and management, Fertil Steril, 36, 433, 10.1016/S0015-0282(16)45789-4 Lumsden, 1998, Clinical presentation of uterine fibroids, Baillieres Clin Obstet Gynaecol, 12, 177, 10.1016/S0950-3552(98)80060-6 Miura, 2006, Differential infiltration of macrophages and prostaglandin by different uterine leiomyomas, Hum Reprod, 21, 2545, 10.1093/humrep/del205 Singh, 2013, Society of Obstetrics and Gynaecology Canada Clinical Practice – Gynaecology Committee. Abnormal uterine bleeding in pre-menopausal women, J Obstet Gynaecol Can, 35, 473, 10.1016/S1701-2163(15)30939-7 Schwartz, 1993, Leiomyosarcomas: clinical presentation, Am J Obstet Gynecol, 168, 180, 10.1016/S0002-9378(12)90910-2 Carranza-Mamane, 2015, Society of Obstetrics and Gynaecology Canada Reproductive Endocrinology and Infertility Committee. The management of uterine fibroids in women with otherwise unexplained infertility. SOGC Clinical Practice Guidelines, J Obstet Gynaecol Can, 10.1016/S1701-2163(15)30318-2 Laughlin, 2009, Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study, Obstet Gynecol, 113, 630, 10.1097/AOG.0b013e318197bbaf Muram, 1980, Myomas of the uterus in pregnancy: ultrasonographic follow-up, Am J Obstet Gynecol, 138, 16, 10.1016/0002-9378(80)90005-8 Neiger, 2006, Pregnancy-related changes in the size of uterine leiomyomas, J Reprod Med, 51, 671 Hammoud, 2006, Volume change of uterine myomas during pregnancy: do myomas really grow?, J Minim Invasive Gynecol, 13, 386, 10.1016/j.jmig.2006.04.003 Laughlin, 2010, Pregnancy-related fibroid reduction, Fertil Steril, 94, 2421, 10.1016/j.fertnstert.2010.03.035 De Vivo, 2011, Uterine myomas during pregnancy: a longitudinal sonographic study, Ultrasound Obstet Gynecol, 37, 361, 10.1002/uog.8826 Exacoustos, 1993, Ultrasound diagnosis of uterine myomas and complications in pregnancy, Obstet Gynecol, 82, 97 Sheiner, 2004, Obstetric characteristics and perinatal outcome of pregnancies with uterine leiomyomas, J Reprod Med, 49, 182 Qidwai, 2006, Obstetric outcomes in women with sonographically identified uterine leiomyomata, Obstet Gynecol, 107, 376, 10.1097/01.AOG.0000196806.25897.7c Vergani, 2007, Large uterine leiomyomata and risk of cesarean delivery, Obstet Gynecol, 109, 410, 10.1097/01.AOG.0000250470.78700.f0 Chen, 2009, Increased risk of preterm births among women with uterine leiomyoma: a nationwide population-based study, Hum Reprod, 24, 3049, 10.1093/humrep/dep320 Klatsky, 2008, Fibroids and reproductive outcomes: a systematic literature review from conception to delivery, Am J Obstet Gynecol, 198, 357, 10.1016/j.ajog.2007.12.039 Stout, 2010, Leiomyomas at routine second-trimester ultrasound examination and adverse obstetric outcomes, Obstet Gynecol, 116, 1056, 10.1097/AOG.0b013e3181f7496d Lolis, 2003, Successful myomectomy during pregnancy, Hum Reprod, 18, 1699, 10.1093/humrep/deg318 Mu, 2011, Successful pregnancies with uterine leiomyomas and myomectomy at the time of caesarean section, Postgrad Med J, 87, 601, 10.1136/pgmj.2009.089748 Gbadebo, 2009, Myomectomy at caesarean section: descriptive study of clinical outcome in a tropical setting, J Ayub Med Coll Abbottabad, 21, 7 Park, 2009, Safety of cesarean myomectomy, J Obstet Gynaecol Res, 35, 906, 10.1111/j.1447-0756.2009.01121.x Parker, 1994, Uterine sarcoma in patients operated on for presumed leiomyoma and rapidly growing leiomyoma, Obstet Gynecol, 83, 414 Leibsohn, 1990, Leiomyosarcoma in a series of hysterectomies performed for presumed uterine leiomyomas, Am J Obstet Gynecol, 162, 968, 10.1016/0002-9378(90)91298-Q Knight, 2014, Tissue extraction by morcellation: a clinical dilemma, J Min Invas Gynecol, 21, 319, 10.1016/j.jmig.2014.03.005 Vilos, 2001, Hysteroscopic endomyometrial resection of three uterine sarcomas, J Am Assoc Gynecol Laparosc, 8, 545, 10.1016/S1074-3804(05)60619-6 Vilos, 2009, Miscellaneous uterine malignant neoplasms detected during hysteroscopic surgery, J Min Invas Gynecol, 16, 318, 10.1016/j.jmig.2009.02.004 Ip, 2010, Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy, Adv Anat Pathol, 17, 91, 10.1097/PAP.0b013e3181cfb901 Vilos, 2012, Uterine smooth muscle tumors of uncertain malignant potential; diagnostic challenges and therapeutic dilemmas. Report of 2 cases and review of literature, J Min Invas Gynecol, 19, 288, 10.1016/j.jmig.2011.12.025 Cantuaria, 1998, Comparison of bimanual examination with ultrasound before hysterectomy for uterine leiomyoma, Obstet Gynecol, 92, 109, 10.1016/S0029-7844(98)00131-8 Farquhar, 2003, A systematic review of transvaginal ultrasonography, sonohysterography and hysteroscopy for the investigation of abnormal uterine bleeding in premenopausal women, Acta Obstet Gynecol Scand, 82, 493, 10.1034/j.1600-0412.2003.00191.x Makris, 2007, Three dimensional hysterosonography versus hysteroscopy for the detection of intracavitary uterine abnormalities, Int J Gynecol Obstet, 95, 6, 10.1016/j.ijgo.2006.10.012 Vercellini, 1998, Treatment with a gonadotrophin releasing hormone agonist before hysterectomy for leiomyomas: results of a multicentre, randomized controlled trial, Br J Obstet Gynaecol, 105, 1148, 10.1111/j.1471-0528.1998.tb09967.x Bradley, 2000, Radiographic imaging techniques for the diagnosis of abnormal uterine bleeding, Obstet Gynecol Clin North Am, 27, 245, 10.1016/S0889-8545(00)80019-4 Adusumilli, 2006, MRI of sonographically indeterminate adnexal masses, AJR Am J Roentgenol, 187, 732, 10.2214/AJR.05.0905 Dueholm, 2002, Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas, Am J Obstet Gynecol, 186, 409, 10.1067/mob.2002.121725 Omary, 2002, The effect of pelvic MR imaging on the diagnosis and treatment of women with presumed symptomatic uterine fibroids, J Vasc Interv Radiol, 13, 1149, 10.1016/S1051-0443(07)61957-5 Stamatopoulos, 2012, Value of magnetic resonance imaging in diagnosis of adenomyosis and myomas of the uterus, J Min Invas Gynecol, 19, 620, 10.1016/j.jmig.2012.06.003 Myers, 2002, Management of uterine leiomyomata: what do we really know?, Obstet Gynecol, 100, 8 Peddada, 2008, Growth of uterine leiomyomata among premenopausal black and white women, Proc Natl Acad Sci USA, 105, 19887, 10.1073/pnas.0808188105 DeWaay, 2002, Natural history of uterine polyps and leiomyomata, Obstet Gynecol, 100, 3 Ang, 2001, Effect of hormone replacement therapies and selective estrogen receptor modulators in postmenopausal women with uterine leiomyomas: a systematic review, Climacteric, 4, 284, 10.1080/cmt.4.4.284.292 Yang, 2002, Effect of hormone replacement therapy on uterine fibroids in postmenopausal women—a 3-year study, Maturitas, 43, 35, 10.1016/S0378-5122(02)00159-7 Al-Hendy, 2006, Gene therapy and uterine leiomyoma: a review, Hum Reprod Update, 12, 385, 10.1093/humupd/dml015 Sayed, 2011, A randomized clinical trial of a levonorgestrel-releasing intrauterine system and a low-dose combined oral contraceptive for fibroid-related menorrhagia, Int J Gynaecol Obstet, 112, 126, 10.1016/j.ijgo.2010.08.009 Maruo, 2010, Translational research with progesterone receptor modulator motivated by the use of levonorgestrel-releasing intrauterine system, Contraception, 82, 435, 10.1016/j.contraception.2010.05.006 Englund, 1998, Sex steroid receptors in human myometrium and fibroids: changes during the menstrual cycle and gonadotropin-releasing hormone treatment, J Clin Endocrinol Metab, 83, 4092 Magalhães, 2007, Uterine volume and menstrual patterns in users of the levonorgestrel-releasing intrauterine system with idiopathic menorrhagia or menorrhagia due to leiomyomas, Contraception, 75, 193, 10.1016/j.contraception.2006.11.004 Verspyck, 2000, Leuprorelin depot 3.75mg versus lynestrenol in the preoperative treatment of symptomatic uterine myomas: a multicentre randomised trial, Eur J Obstet Gynecol Reprod Biol, 89, 7, 10.1016/S0301-2115(99)00168-2 Sangkomkamhang, 2013, Progestogens or progestogen-releasing intrauterine systems for uterine fibroids, Cochrane Database Syst Rev, 2, 10.1002/14651858.CD008994.pub2 Carr, 1993, An evaluation of the effect of gonadotropin-releasing hormone analogs and medroxyprogesterone acetate on uterine leiomyomata volume by magnetic resonance imaging: a prospective, randomized, double blind, placebo-controlled, crossover trial, J Clin Endocrinol Metab, 76, 1217 Friedman, 1993, A prospective, randomized trial of gonadotropin-releasing hormone agonist plus estrogen-progestin or progestin “add-back” regimens for women with leiomyomata uteri, J Clin Endocrinol Metab, 76, 1439 Friedman, 1991, Treatment of leiomyomata uteri with leuprolide acetate depot: a double-blind, placebo-controlled, multicenter study, The Leuprolide Study Group. Obstet Gynecol, 77, 720 Reissmann, 1994, Introduction of LHRH-antagonists into the treatment of gynaecological disorders, Human Reprod, 9, 767, 10.1093/oxfordjournals.humrep.a138593 Britten, 2012, Gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate and GnRH antagonist cetrorelix acetate directly inhibit leiomyoma extracellular matrix production, Fertil Steril, 98, 1299, 10.1016/j.fertnstert.2012.07.1123 Panidis, 1994, Danazol influences gonadotropin secretion acting at the hypothalamic level, Int J Gynaecol Obstet, 45, 241, 10.1016/0020-7292(94)90249-6 A.C.O.G. Committee on Practice Bulletins-Gynecology, 2001, ACOG practice bulletin: surgical alternatives to hysterectomy in the management of leiomyomas, Int J Gynaecol Obstet, 73, 285, 10.1016/S0020-7292(01)00414-3 Ke, 2009, Danazol for uterine fibroids, Cochrane Database Syst Rev, 3, 10.1002/14651858.CD007692 Sumitani, 2000, In situ estrogen synthesized by aromatase P450 in uterine leiomyoma cells promotes cell growth probably via an autocrine/intracrine mechanism, Endocrinology, 141, 3852, 10.1210/endo.141.10.7719 Song, 2013, Aromatase inhibitors for uterine fibroids, Cochrane Database Syst Rev, 10, 10.1002/14651858.CD009505.pub2 Wakeling, 1991, A potent specific pure antiestrogen with clinical potential, Cancer Res, 51, 3867 Donnez, 2003, A randomized, placebo-controlled, dose-ranging trial comparing fulvestrant with goserelin in premenopausal patients with uterine fibroids awaiting hysterectomy, Fertil Steril, 79, 1380, 10.1016/S0015-0282(03)00261-9 Dutertre, 2000, Molecular mechanisms of selective estrogen receptor modulator (SERM) action, J Pharmacol Exp Ther, 295, 431 Deng, 2012, Selective estrogen receptor modulators (SERMs) for uterine leiomyomas, Cochrane Database Syst Rev, 10, 10.1002/14651858.CD005287.pub4 Chegini, 2002, Effects of GnRH analogues, ‘add-back’ steroid therapy, antiestrogen and antiprogestins on leiomyoma and myometrial smooth muscle cell growth and transforming growth factor-beta expression, Mol Hum Reprod, 8, 1071, 10.1093/molehr/8.12.1071 Maruo, 2004, Sex steroidal regulation of uterine leiomyoma growth and apoptosis, Hum Reprod Update, 10, 207, 10.1093/humupd/dmh019 Kawaguschi, 1989, Mitotic activity in uterine leiomyomas during the menstrual cycle, Am J Obstet Gynecol, 160, 637, 10.1016/S0002-9378(89)80046-8 Kawaguschi, 1991, Immunohistochemical analysis of oestrogen receptors, progesterone receptors and Ki-67 in leiomyoma and myometrium during the menstrual cycle and pregnancy, Virchows Arch A Pathol Anat Histopathol, 419, 309, 10.1007/BF01606522 Seagaloff, 1949, The progesterone therapy of human uterine leiomyomas, J Clin Endocrinol Metrab, 9, 1273, 10.1210/jcem-9-12-1273 Friedman, 1994, Long-term medical therapy for leiomyomata uteri: a prospective, randomized study of leuprolide acetate depot plus either oestrogen-progestin or progestin ‘add-back’ for 2 years, Hum Reprod, 9, 1618, 10.1093/oxfordjournals.humrep.a138762 Chwalisz, 2005, Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis, Endocr Rev, 26, 423, 10.1210/er.2005-0001 Shen, 2013, Effects of mifepristone on uterine leiomyoma in premenopausal women: a meta-analysis, Fertil Steril, 100, 1722, 10.1016/j.fertnstert.2013.08.039 Chabbert-Buffet, 2007, VA2914 Study Group. Effects of the progesterone receptor modulator VA2914 in a continuous low dose on the hypothalamic-pituitary-ovarian axis and endometrium in normal women: a prospective, randomized, placebo-controlled trial, J Clin Endocrinol Metab, 92, 3582, 10.1210/jc.2006-2816 Donnez, 2012, Ulipristal acetate versus placebo for fibroid treatment before surgery, N Engl J Med, 366, 409, 10.1056/NEJMoa1103182 Donnez, 2012, Ulipristal acetate versus leuprolide acetate for uterine fibroids, N Engl J Med, 366, 421, 10.1056/NEJMoa1103180 Donnez, 2014, PEARL III and PEARL III Extension Study Group. Long-term treatment of uterine fibroids with ulipristal acetate*, Fertil Steril, 101, 1565, 10.1016/j.fertnstert.2014.02.008 Weber, 1997, Uterine myomas and factors associated with hysterectomy in premenopausal women, Am J Obstet Gynecol, 176, 1213, 10.1016/S0002-9378(97)70337-5 Friedman, 1993, Should uterine size be an indication for surgical intervention in women with myomas?, Am J Obstet Gynecol, 168, 751, 10.1016/S0002-9378(12)90813-3 Lefebvre, 2002, Hysterectomy; Socoiety of Obstetricians Clinical Practice Committee, J Obstet Gynaecol Can, 24, 37 Thakar, 2002, Outcomes after total versus subtotal abdominal hysterectomy, N Engl J Med, 347, 1318, 10.1056/NEJMoa013336 Learman, 2003, Total or Supracervical Hysterectomy (TOSH) Research Group. A randomized comparison of total or supracervical hysterectomy: surgical complications and clinical outcomes, Obstet Gynecol, 102, 453 American Association of Gynecologic Laparoscopists (AAGL), 2014, Practice report: practice guidelines for laparoscopic/subtotal supracervical hysterectomy, J Min Invas Gynecol, 21, 9, 10.1016/j.jmig.2013.08.001 Garcia, 1993, Management of the symptomatic fibroid in women older than 40 years of age: hysterectomy or myomectomy?, Obstet Gynecol Clin North Am, 20, 337, 10.1016/S0889-8545(21)00523-4 Yoo, 2007, Predictors of leiomyoma recurrence after laparoscopic myomectomy, J Minim Invasive Gynecol, 14, 690, 10.1016/j.jmig.2007.06.003 Al-Mahrizi, 2007, Treatment of uterine fibroids for abnormal uterine bleeding: myomectomy and uterine artery embolization, Best Pract Res Clin Obstet Gynaecol, 21, 995, 10.1016/j.bpobgyn.2007.03.017 Cagnacci, 2003, Early outcome of myomectomy by laparotomy, minilaparotomy and laparoscopically assisted minilaparotomy. A randomized prospective study, Hum Reprod, 18, 2590, 10.1093/humrep/deg478 American Association of Gynecologic Laparoscopists (AAGL), 2012, AAGL practice report: practice guidelines for the diagnosis and management of submucous leiomyomas, J Minim Invasive Gynecol, 19, 152, 10.1016/j.jmig.2011.09.005 Munro, 2001, Abnormal uterine bleeding: surgical management – part 3, J Am Assoc Gynecol Laparosc, 8, 18, 10.1016/S1074-3804(05)60544-0 College National des Gynécologues et Obstétriciens Français (CNGOF), 2011, Actualisation de la prise en charge des myomes [Myoma management recommandations], J Gynecol Obstet Biol Reprod, 40, 693 Wamsteker, 1993, Transcervical hysteroscopic resection of submucous fibroids for abnormal uterine bleeding: results regarding the degree of intramural extension, Obstet Gynecol, 82, 736 Loffer, 2005, Improving results of hysteroscopic submucusal myomectomy for menorrhagia by concomitant endometrial ablation, J Min Invas Gynecol, 12, 254, 10.1016/j.jmig.2005.04.001 Emanuel, 1999, Long-term results of hysteroscopic myomectomy for abnormal uterine bleeding, Obstet Gynecol, 93, 743 Hart, 1999, Long-term follow-up of hysteroscopic myomectmoy assessed by survical analysis, Br J Obstet Gynaecol, 106, 700, 10.1111/j.1471-0528.1999.tb08370.x Margiani, 2005, Transcervical myomectomy: long-term effects on abnormal uterine bleeding, Clin Exp Obstet Gynecol, 32, 23 Bradley, 2002, Complications in hysteroscopy: prevention, treatment and legal risk, Curr Opin Obstet Gynecol, 14, 409, 10.1097/00001703-200208000-00008 Vilos, 2004, Chapter on hysteroscopic surgery: indications, contraindications and complications, 237 AAGL Advancing Minimally Invasive Gynecology Worldwide, 2013, AAGL practice report. practice guidelines for the management of hysteroscopic distendng media, J Minim Invasive Gynecol, 20, 137, 10.1016/j.jmig.2012.12.002 Vilos, 2000, Genital tract electrical burns during hysteroscopic endometrial ablation: report of 13 cases in the United States and Canada, J Am Assoc Gynecol Laparosc, 7, 141, 10.1016/S1074-3804(00)80026-2 Vilos, 2000, Intended and stray radiofrequency electrical currents during resectoscopic surgery, J Am Assoc Gynecol Laparsc, 7, 55, 10.1016/S1074-3804(00)80010-9 Vilos, 2006, Characterization and mitigation of stray radiofrequency currents during monopolar resectoscopic electrosurgery, J Minim Invasive Gynecol, 13, 134, 10.1016/j.jmig.2005.12.001 Jin, 2009, Laparoscopic versus open myomectomy – a meta-analysis of randomized controlled trials, Eur J Obstet Gynecol Reprod Biol, 145, 14, 10.1016/j.ejogrb.2009.03.009 Holzer, 2006, Laparoscopic versus open myomectomy: a double-blind study to evaluate postoperative pain, Anesth Analg, 102, 1480, 10.1213/01.ane.0000204321.85599.0d Alessandri, 2006, Randomized study of laparoscopic versus minilaparotomic myomectomy for uterine myomas, J Minim Invasive Gynecol, 13, 92, 10.1016/j.jmig.2005.11.008 Malzoni, 2010, Laparoscopy versus minilaparotomy in women with symptomatic uterine myomas: short-term and fertility results, Fertil Steril, 93, 2368, 10.1016/j.fertnstert.2008.12.127 Sinha, 2003, Laparoscopic excision of very large myomas, J Am Assoc Gynecol Laparosc, 10, 461, 10.1016/S1074-3804(05)60145-4 Vilos, 2007, Society of Obstetricians and Gynaecologists of Canada Clinical Practice Gynaecology Committee. Laparoscopic entry: a review of techniques, technologies, and complications, J Obstet Gynaecol Can, 29, 433, 10.1016/S1701-2163(16)35496-2 Lemyre, 2012, Comparison of morbidity associated with laparoscopic myomectomy and hysterectomy for the treatment of uterine leiomyomas, J Obstet Gynaecol Can, 34, 57, 10.1016/S1701-2163(16)35134-9 Gyamfi-Bannerman, 2012, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Risk of uterine rupture and placenta accreta with prior uterine surgery outside of the lower segment, Obstet Gynecol, 120, 1332, 10.1097/AOG.0b013e318273695b Kumakiri, 2008, Prospective evaluation for the feasibility and safety of vaginal birth after laparoscopic myomectomy, J Minim Invasive Gynecol, 15, 420, 10.1016/j.jmig.2008.04.008 Seracchioli, 2006, Obstetric and delivery outcome of pregnancies achieved after laparoscopic myomectomy, Fertil Steril, 86, 159, 10.1016/j.fertnstert.2005.11.075 Seinera, 1997, Laparoscopic myomectomy: indications, surgical technique and complications, Hum Reprod, 12, 1927, 10.1093/humrep/12.9.1927 Parker, 2010, Risk factors for uterine rupture after laparoscopic myomectomy, J Minim Invasive Gynecol, 17, 551, 10.1016/j.jmig.2010.04.015 Dicle, 1997, Magnetic resonance imaging evaluation of incision healing after cesarean sections, Eur Radiol, 7, 31, 10.1007/s003300050103 Seracchioli, 2000, Fertility and obstetric outcome after laparoscopic myomectomy of large myomata: a randomized comparison with abdominal myomectomy, Hum Reprod, 15, 2663, 10.1093/humrep/15.12.2663 Hurst, 2005, Laparoscopic myomectomy for symptomatic uterine myomas, Fertil Steril, 83, 1, 10.1016/j.fertnstert.2004.09.011 Prapas, 2009, Laparoscopy vs laparoscopically assisted myomectomy in the management of uterine myomas: a prospective study, Am J Obstet Gynecol, 200, 144, 10.1016/j.ajog.2008.08.063 Wright, 2013, Robotically assisted vs laparoscopic hysterectomy among women with benign gynecologic disease, JAMA, 309, 689, 10.1001/jama.2013.186 Gargiulo, 2012, Robot-assisted laparoscopic myomectomy compared with standard laparoscopic myomectomy, Obstet Gynecol, 120, 284, 10.1097/AOG.0b013e3182602c7d Liu, 2012, Robotic surgery for benign gynaecological disease, Cochrane Database Syst Rev, 2 AAGL Advancing Minimally Invasive Gynecology Worldwide, 2013, AAGL position statement: robotic-assisted laparoscopic surgery in benign gynecology, J Min Invasiv Gynecol, 20, 2, 10.1016/j.jmig.2012.12.007 Milad, 2014, Laparoscopic morcellator-related complications, J Min Invas Gynecol, 21, 486, 10.1016/j.jmig.2013.12.003 Sizzi, 2007, Italian multicenter study on complications of laparoscopic myomectomy, J Minim Invasive Gynecol, 14, 453, 10.1016/j.jmig.2007.01.013 Cucinella, 2011, Parasitic myomas after laparoscopic surgery: an emerging complication in the use of morcellator? Description of four cases, Fertil Steril, 96, e90, 10.1016/j.fertnstert.2011.05.095 Hilger, 2006, Removal of pelvic leiomyomata and endometriosis five years after supracervical hysterectomy, Obstet Gynecol, 108, 772, 10.1097/01.AOG.0000209187.90019.d3 Hutchins, 1998, Retained myoma after laparoscopic supracervical hysterectomy with morcellation, J Am Assoc Gynecol Laparosc, 5, 293, 10.1016/S1074-3804(98)80035-2 Ordulu, 2010, Disseminated peritoneal leiomyomatosis after laparoscopic supracervical hysterectomy with characteristic molecular cytogenetic findings of uterine leiomyoma, Genes Chromosomes Cancer, 49, 1152, 10.1002/gcc.20824 Sinha, 2007, Multiple leiomyomas after laparoscopic hysterectomy: report of two cases, J Minim Invasive Gynecol, 14, 123, 10.1016/j.jmig.2006.08.002 Worthington-Kirsch, 2001, Retained myoma fragment after LASH procedure, Clin Radiol, 56, 777, 10.1053/crad.1999.0288 Sihna, 2009, Recurrent leiomyomatosis, J Min Invas Gynecol, 16, 668 Ribič-Pucelj, 2013, Leiomyomatosis peritonealis disseminata as a possible result of laparoscopic myomectomy—report of four cases, Gynecol Surg, 10, 253, 10.1007/s10397-013-0806-4 Amercian Cancer Society, 2014 Health Canada, 2014 Society of Gynecologic Oncology, 2013 AAGL Advancing Minimally Invasive Gynecology Worldwide, 2014, Morcellation during uterine tissue extraction, J Minim Invasive Gynecol, 21, 517, 10.1016/j.jmig.2014.05.010 American College of Obstetricians and Gynecologists, 2014 Food and Drug Administration, 2014 Mussalam, 2011, Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study, Lancet, 378, 1396, 10.1016/S0140-6736(11)61381-0 Lethaby, 2001, Pre-operative GnRH analogue therapy before hysterectomy or myomectomy for uterine fibroids, Cochrane Database Syst Rev, 2, 10.1002/14651858.CD000547 Chen, 2011, Gonadotropin-releasing hormone agonist in laparoscopic myomectomy: systematic review and meta-analysis of randomized controlled trials, J Minim Invasive Gynecol, 18, 303, 10.1016/j.jmig.2011.02.010 De Falco, 2009, Leiomyoma pseudocapsule after pre-surgical tratment with gonadotropin-releasing hormone agonists: relationship between clinical features and immunohistochemical changes, Eur J Obstet Gynecol Reprod Biol, 144, 44, 10.1016/j.ejogrb.2009.02.006 Mavrelos, 2010, The value of pre-operative treatment with GnRH analogues in women with submucous fibroids: a double-blind, placebo-controlled randomized trial, Hum Reprod, 25, 2264, 10.1093/humrep/deq188 Chang, 2006, Effect of uterotonics on intra-operative blood loss during laparoscopy-assisted vaginal hysterectomy: a randomised controlled trial, BJOG, 113, 47, 10.1111/j.1471-0528.2005.00804.x Celik, 2003, Use of a single preoperative dose of misoprostol is efficacious for patients who undergo abdominal myomectomy, Fertil Steril, 79, 1207, 10.1016/S0015-0282(03)00076-1 Frederick, 2013, A trial comparing the use of rectal misoprostol plus perivascular vasopressin with perivascular vasopressin alone to decrease myometrial bleeding at the time of abdominal myomectomy, Fertil Steril, 100, 1044, 10.1016/j.fertnstert.2013.06.022 Preutthipan, 2000, Vaginal misoprostol for cervical priming before operative hysteroscopy: a randomized controlled trial, Obstet Gynecol, 96, 890 Cesen-Cummings, 2003, Uterine leiomyomas express myometrial contractile-associated proteins involved in pregnancy-related hormone signaling, J Soc Gynecol Investig, 10, 11, 10.1177/107155760301000104 Wang, 2004, A simplified method to decrease operative blood loss in laparoscopic-assisted vaginal hysterectomy for the large uterus, J Am Assoc Gynecol Laparosc, 11, 370, 10.1016/S1074-3804(05)60053-9 Kongnyuy, 2011, Interventions to reduce haemorrhage during myomectomy for fibroids, Cochrane Database Syst Rev, 11, 10.1002/14651858.CD005355.pub4 Riess, 2011, Case report: severe vasospasm mimics hypotension after high-dose intrauterine vasopressin, Anesth Analg, 113, 1103, 10.1213/ANE.0b013e31822cef10 Okin, 2001, Vasopressin during abdominal hysterectomy: a randomized controlled trial, Obstet Gynecol, 97, 867 Ginsburg, 1993, The effect of operative technique and uterine size on blood loss during myomectomy: a prospective randomized study, Fertil Steril, 60, 956, 10.1016/S0015-0282(16)56392-4 Fletcher, 1996, A randomized comparison of vasopressin and tourniquet as hemostatic agents during myomectomy, Obstet Gynecol, 87, 1014, 10.1016/0029-7844(96)00071-3 Zhao, 2011, Evaluation of loop ligation of larger myoma pseudocapsule combined with vasopressin on laparoscopic myomectomy, Fertil Steril, 95, 762, 10.1016/j.fertnstert.2010.08.059 Zullo, 2004, Bupivacaine plus epinephrine for laparoscopic myomectomy: a randomized placebo-controlled trial, Obstet Gynecol, 104, 243, 10.1097/01.AOG.0000132801.41880.e8 Wellington, 2003, Tranexamic acid: a review of its use in the management of menorrhagia, Drugs, 63, 1417, 10.2165/00003495-200363130-00008 Caglar, 2008, Intravenous tranexamic acid use in myomectomy: a prospective randomized double-blind placebo controlled study, Eur J Obstet Gynecol Reprod Biol, 137, 227, 10.1016/j.ejogrb.2007.04.003 Bae, 2011, Benefit of uterine artery ligation in laparoscopic myomectomy, Fertil Steril, 95, 775, 10.1016/j.fertnstert.2010.07.1079 Chang, 2012, Comparison of laparoscopic myomectomy using in situ morcellation with and without uterine artery ligation for treatment of symptomatic myomas, J Minim Invasive Gynecol, 19, 715, 10.1016/j.jmig.2012.07.008 Ikechebelu, 2010, The use of tourniquet to reduce blood loss at myomectomy, Niger J Clin Pract, 13, 154 Taylor, 2005, Reducing blood loss at open myomectomy using triple tourniquets: a randomised controlled trial, BJOG, 112, 340, 10.1111/j.1471-0528.2004.00430.x Tinelli, 2011, Adhesion formation after intracapsular myomectomy with or without adhesion barrier, Fertil Steril, 95, 1780, 10.1016/j.fertnstert.2010.12.049 Mettler, 2008, A safety and efficacy study of a resorbable hydrogel for reduction of post-operative adhesions following myomectomy, Hum Reprod, 23, 1093, 10.1093/humrep/den080 Takeuchi, 2005, Adhesion-prevention effects of fibrin sealants after laparoscopic myomectomy as determined by second-look laparoscopy: a prospective, randomized, controlled study, J Reprod Med, 50, 571 Lefebvre, 2004, Society of Obstetricians and Gynaecologists of Canada; Canadian Association of Radiologists; Canadian Interventional Radiology Association. Uterine fibroid embolization (UFE), J Obstet Gynaecol Can, 26, 913 Pron, 2005, Pregnancy after uterine artery embolization for leiomyomata: the Ontario multicenter trial, Obstet Gynecol, 105, 67, 10.1097/01.AOG.0000149156.07061.1f Mara, 2014, Embolization of uterine fibroids from the point of view of the gynecologist: pros and cons, Int J Womens Health, 6, 623, 10.2147/IJWH.S43591 Martin, 2013, Complications and reinterventions in uterine artery embolization for symptomatic uterine fibroids: a literature review and meta-analysis, Cardiovasc Intervent Radiol, 36, 395, 10.1007/s00270-012-0505-y Zupi, 2006, Myolysis of uterine fibroids: is there a role?, Clin Obstet Gynecol, 49, 821, 10.1097/01.grf.0000211961.91616.78 National Institute for Health and Clinical Excellence (NICE), 2014 Ghezzi, 2007, Midterm outcome of radiofrequency thermal ablation for symptomatic uterine myomas, Surg Endosc, 21, 2081, 10.1007/s00464-007-9307-8 Pansky, 2009, Laparoscopically assisted uterine fibroid cryoablation, Am J Obstet Gynecol, 201, 571, 10.1016/j.ajog.2009.06.028 Bourlev, 2003, Different proliferative and apoptotic activity in peripheral versus central parts of human uterine leiomyomas, Gynecol Obstet Invest, 55, 199, 10.1159/000072074 Bouwsma, 2011, Comparing focused ultrasound and uterine artery embolization for uterine fibroids-rationale and design of the Fibroid Interventions: Reducing Symptoms Today and Tomorrow (FIRSTT) trial, Fertil Steril, 96, 704, 10.1016/j.fertnstert.2011.06.062 Bouwsma, 2011, Magnetic resonance-guided focused ultrasound surgery for leiomyoma-associated infertility, Fertil Steril, 96, e9, 10.1016/j.fertnstert.2011.04.056 Chudnoff, 2013, Outpatient procedure for the treatment and relief of symptomatic uterine myomas, Obstet Gynecol, 121, 1075, 10.1097/AOG.0b013e31828b7962 Munro, 2013, Southern California Permanente Medical Group’s Abnormal Uterine Bleeding Working Group. Acute uterine bleeding unrelated to pregnancy: a Southern California Permanente Medical Group practice guideline, Perm J, 17, 43, 10.7812/TPP/13-018 Friedman, 1993, Combined oestrogen-progestin treatment of vaginal hemorrhage following gonadotropin-releasing hormone agonist therapy of uterine myomas, Hum Reprod, 8, 540, 10.1093/oxfordjournals.humrep.a138091 Thomas, 1991, Multiple therapies for vaginal bleeding secondary to large uterine myomas, Int J Gynaecol Obstet, 36, 239, 10.1016/0020-7292(91)90720-P Lakhani, 1998, Uterine artery blood flow parameters in women with dysfunctional uterine bleeding and uterine fibroids: the effects of tranexamic acid, Ultrasound Obstet Gynecol, 11, 23, 10.1046/j.1469-0705.1998.11040283.x Lukes, 2010, Tranexamic acid treatment for heavy menstrual bleeding: a randomized controlled trial, Obstet Gynecol, 116, 865, 10.1097/AOG.0b013e3181f20177 Naoulou, 2012, Efficacy of tranexamic acid in the treatment of idiopathic and non-functional heavy menstrual bleeding: a systematic review, Acta Obstet Gynecol Scand, 91, 529, 10.1111/j.1600-0412.2012.01361.x Lindoff, 1993, Treatment with tranexamic acid during pregnancy, and the risk of thrombo-embolic complications, Thromb Haemost, 70, 238, 10.1055/s-0038-1649475 Sundstrom, 2009, The risk of venous thromboembolism associated with the use of tranexamic acid and other drugs used to treat menorrhagia: a case-control study using the General Practice Research Database, BJOG, 116, 91, 10.1111/j.1471-0528.2008.01926.x Donnez, 2012, Ulipristal acetate versus leuprolide acetate for uterine fibroids, N Engl J Med, 366, 421, 10.1056/NEJMoa1103180 Hamani, 2010, Intrauterine balloon tamponade as a treatment for immune thrombocytopenic purpura-induced severe uterine bleeding, Fertil Steril, 94, e13, 10.1016/j.fertnstert.2010.04.058 Goldrath, 1983, Uterine tamponade for the control of acute uterine bleeding, Am J Obstet Gynecol, 147, 869, 10.1016/0002-9378(83)90237-5 Thorp, 1991, Submucous myomas treated with gonadotropin releasing hormone agonist and resulting in vaginal hemorrhage. A case report, J Reprod Med, 36, 625 Richards, 1994, Endometrial ablation for life-threatening abnormal uterine bleeding. A report of two cases, J Reprod Med, 39, 741 Osuga, 2001, Successful emergency endometrial ablation for intractable uterine bleeding in a postmenopausal woman complicated with liver cirrhosis and morbid obesity, Surg Endosc, 15, 898, 10.1007/s004640040042 Woolf, 2003, Canadian Task Force on Preventive Health Care. New grades for recommendations from the Canadian Task Force on Preventive Health Care, CMAJ, 169, 207