Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca2+ channel

Costantini, D. L. et al. The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell 123, 347–358 (2005)

Yao, L., McCaig, C. D. & Zhao, M. Electrical signals polarize neuronal organelles, direct neuron migration, and orient cell division. Hippocampus 19, 855–868 (2009)

Adams, D. S. et al. Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates. Development 133, 1657–1671 (2006)

Zhao, M. et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature 442, 457–460 (2006)

Watanabe, T., Delbridge, L. M., Bustamante, J. O. & McDonald, T. F. Heterogeneity of the action potential in isolated rat ventricular myocytes and tissue. Circ. Res. 52, 280–290 (1983)

Milan, D. J., Giokas, A. C., Serluca, F. C., Peterson, R. T. & MacRae, C. A. Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development 133, 1125–1132 (2006)

Chi, N. C. et al. Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol. 6, e109 (2008)

Hoyt, R. H., Cohen, M. L. & Saffitz, J. E. Distribution and three-dimensional structure of intercellular junctions in canine myocardium. Circ. Res. 64, 563–574 (1989)

Chung, C. Y., Bien, H. & Entcheva, E. The role of cardiac tissue alignment in modulating electrical function. J. Cardiovasc. Electrophysiol. 18, 1323–1329 (2007)

Auman, H. J. et al. Functional modulation of cardiac form through regionally confined cell shape changes. PLoS Biol. 5, e53 (2007)

Sehnert, A. J. et al. Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Nature Genet. 31, 106–110 (2002)

Etard, C. et al. The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis. Dev. Biol. 308, 133–143 (2007)

Cohen, E. D., Tian, Y. & Morrisey, E. E. Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal. Development 135, 789–798 (2008)

Eisenberg, C. A. & Eisenberg, L. M. WNT11 promotes cardiac tissue formation of early mesoderm. Dev. Dyn. 216, 45–58 (1999)

Pandur, P., Lasche, M., Eisenberg, L. M. & Kuhl, M. Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Nature 418, 636–641 (2002)

Zhou, W. et al. Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nature Genet. 39, 1225–1234 (2007)

Flaherty, M. P. & Dawn, B. Noncanonical Wnt11 signaling and cardiomyogenic differentiation. Trends Cardiovasc. Med. 18, 260–268 (2008)

Thisse, C. & Thisse, B. High throughput expression analysis of ZF-models consortium clones. ZFIN Direct Data Submission ZDB-PUB-051025-1 〈 http://zfin.org/cgi-bin/webdriver?MIval=aa-pubview2apg&OID=ZDB-PUB-051025-1 〉 (2005)

Robu, M. E. et al. p53 activation by knockdown technologies. PLoS Genet. 3, e78 (2007)

Yao, S. et al. Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation. FEBS Lett. 582, 2325–2332 (2008)

Heisenberg, C. P. et al. Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature 405, 76–81 (2000)

Veeman, M. T., Axelrod, J. D. & Moon, R. T. A second canon. Dev. Cell 5, 367–377 (2003)

Jessen, J. R. et al. Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements. Nature Cell Biol. 4, 610–615 (2002)

Veeman, M. T., Slusarski, D. C., Kaykas, A., Louie, S. H. & Moon, R. T. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr. Biol. 13, 680–685 (2003)

Slusarski, D. C., Corces, V. G. & Moon, R. T. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 390, 410–413 (1997)

Bers, D. M. Calcium cycling and signaling in cardiac myocytes. Annu. Rev. Physiol. 70, 23–49 (2008)

Stainier, D. Y. et al. Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development 123, 285–292 (1996)

Witzel, S., Zimyanin, V., Carreira-Barbosa, F., Tada, M. & Heisenberg, C. P. Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. J. Cell Biol. 175, 791–802 (2006)

Rottbauer, W. et al. Reptin and pontin antagonistically regulate heart growth in zebrafish embryos. Cell 111, 661–672 (2002)

Angers, S. & Moon, R. T. Proximal events in Wnt signal transduction. Nature Rev. Mol. Cell Biol. 10, 468–477 (2009)

Loew, L. M. et al. A naphtyl analog of the aminostyryl pyridinium class of potentiometric membrane dyes shows consistent sensitivity in a variety of tissue, cell, and model membrane preparations. J. Membr. Biol. 130, 1–10 (1992)

Fast, V. G. & Kleber, A. G. Microscopic conduction in cultured strands of neonatal rat heart cells measured with voltage-sensitive dyes. Circ. Res. 73, 914–925 (1993)

Rohr, S. & Salzberg, B. M. Multiple site optical recording of transmembrane voltage (MSORTV) in patterned growth heart cell cultures: assessing electrical behaviour, with microsecond resolution, on a cellular and subcellular scale. Biophys. J. 67, 1301–1315 (1994)

Girouard, S. D., Laurita, K. R. & Rosenbaum, D. S. Unique properties of cardiac action potentials recorded with voltage-sensitive dyes. J. Cardiovasc. Electrophysiol. 7, 1024–1038 (1996)

Rohr, S. & Kucera, J. P. Optical recording system based on a fiber optic image conduit: assessment of microscopic activation patterns in cardiac tissue. Biophys. J. 75, 1062–1075 (1998)

Windisch, H. in Optical Mapping of Cardiac Excitation and Arrhythmias (eds Rosenbaum, D. S. & Jalife, J.) 97–112 (Futura, 2001)

Milan, D. J., Jones, I. L., Ellinor, P. T. & MacRae, C. A. In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation. Am. J. Physiol. Heart Circ. Physiol. 291, H269–H273 (2006)

Kikuchi, K. et al. Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes. Nature 464, 601–605 (2010)

Fast, V. G. & Kleber, A. G. Cardiac tissue geometry as a determinant of unidirectional conduction block: assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model. Cardiovasc. Res. 29, 697–707 (1995)

Bayly, P. V. et al. Estimation of conduction velocity vector fields from epicardial mapping data. IEEE Trans. Biomed. Eng. 45, 563–571 (1998)

Eloff, B. C. et al. High resolution optical mapping reveals conduction slowing in connexin43 deficient mice. Cardiovasc. Res. 51, 681–690 (2001)

Mills, R. W., Narayan, S. M. & McCulloch, A. D. Mechanisms of conduction slowing during myocardial stretch by ventricular volume loading in the rabbit. Am. J. Physiol. Heart Circ. Physiol. 295, H1270–H1278 (2008)