Functional connectivity in the resting brain: A network analysis of the default mode hypothesis

Proceedings of the National Academy of Sciences of the United States of America - Tập 100 Số 1 - Trang 253-258 - 2003
Michael D. Greicius1, Ben Krasnow1, Allan L. Reiss1, Vinod Menon1
1Departments of Psychiatry and Behavioral Sciences and Neurology and Neurological Sciences, Program in Neurosciences, and Stanford Brain Research Center, Stanford University School of Medicine, Stanford, CA 94305-5719

Tóm tắt

Functional imaging studies have shown that certain brain regions, including posterior cingulate cortex (PCC) and ventral anterior cingulate cortex (vACC), consistently show greater activity during resting states than during cognitive tasks. This finding led to the hypothesis that these regions constitute a network supporting a default mode of brain function. In this study, we investigate three questions pertaining to this hypothesis: Does such a resting-state network exist in the human brain? Is it modulated during simple sensory processing? How is it modulated during cognitive processing? To address these questions, we defined PCC and vACC regions that showed decreased activity during a cognitive (working memory) task, then examined their functional connectivity during rest. PCC was strongly coupled with vACC and several other brain regions implicated in the default mode network. Next, we examined the functional connectivity of PCC and vACC during a visual processing task and show that the resultant connectivity maps are virtually identical to those obtained during rest. Last, we defined three lateral prefrontal regions showing increased activity during the cognitive task and examined their resting-state connectivity. We report significant inverse correlations among all three lateral prefrontal regions and PCC, suggesting a mechanism for attenuation of default mode network activity during cognitive processing. This study constitutes, to our knowledge, the first resting-state connectivity analysis of the default mode and provides the most compelling evidence to date for the existence of a cohesive default mode network. Our findings also provide insight into how this network is modulated by task demands and what functions it might subserve.

Từ khóa


Tài liệu tham khảo

10.1162/jocn.1997.9.5.648

10.1016/S0361-9230(00)00437-8

10.1073/pnas.98.2.676

10.1038/35094500

10.1162/089892999563265

P K McGuire, E Paulesu, R S Frackowiak, C D Frith NeuroReport 7, 2095–2099 (1996).

10.1002/mrm.1910340409

10.1006/nimg.1997.0315

D Cordes, V M Haughton, K Arfanakis, J D Carew, P A Turski, C H Moritz, M A Quigley, M E Meyerand Am J Neuroradiol 22, 1326–1333 (2001).

10.1002/hbm.10022

10.1073/pnas.162486399

D Kim, E Adalsteinsson, G Glover, S Spielman Proceedings of the 8th Annual Meeting of ISMRM (ISMRM, Denver), pp. 1685 (2000).

10.1002/hbm.460030303

J Talairach, P Tournoux Co-Planar Stereotaxic Atlas of the Human Brain (Thieme, New York, 1988).

10.1002/hbm.460020402

10.1016/S1053-8119(18)31587-8

10.1093/brain/124.5.849

10.1073/pnas.221462998

10.1136/jnnp.57.11.1308

10.1016/S0001-6918(99)00004-9

10.1016/S0079-6123(01)34005-0

10.1523/JNEUROSCI.19-13-05506.1999

10.1006/nimg.1998.0414

10.1002/(SICI)1098-1063(1999)9:1<54::AID-HIPO6>3.0.CO;2-O

10.1016/S0306-4522(01)00108-7

10.1006/nimg.2001.0995

10.1006/nimg.2002.1063

10.1002/ana.410420114

10.1212/WNL.50.6.1563

10.1002/cne.903500402

10.1046/j.1460-9568.1999.00672.x

10.1007/s002210000399

10.1006/nimg.1998.0359

10.1523/JNEUROSCI.14-05-02775.1994

10.1523/JNEUROSCI.18-13-05026.1998

10.1093/brain/119.1.159

10.1093/brain/122.10.1963

B A Vogt, D M Finch, C R Olson Cereb Cortex 2, 435–443 (1992).

10.1038/79871

10.1016/S0896-6273(01)00491-3

10.1176/jnp.9.3.471

10.1073/pnas.98.2.683

10.1073/pnas.98.2.688

10.1093/cercor/10.3.206

10.1016/S0361-9230(99)00245-2

10.1038/375121a0

Thông tin
Thông tin xuất bản

Proceedings of the National Academy of Sciences of the United States of America

Tập 100 Số 1

253-258

Thông tin tác giả