Association of antioxidant status and inflammatory markers with metabolic syndrome in Thais
Tóm tắt
An oxidant/antioxidant disequilibrium has been suggested as having a role in the pathogenesis of some diseases. Metabolic syndrome (MS) is significantly associated with cardiovascular disease and type 2 diabetes. The pathogenesis of MS is complex and not well understood. The purposes of the present study were to compare enzymatic and non-enzyme antioxidants, anthropometric, hematological, and biochemical findings between subjects with MS and without MS and to evaluate the relationship between antioxidant status and hematological parameters with the components of MS. Metabolic syndrome was assessed by using the modified National Cholesterol Education Program, Adult Treatment Panel III criteria. Three hundred Thais, 124 with MS and 176 without MS, were included in the study. Each subject was tested for erythrocyte superoxide dismutase (SOD), glutathione peroxidase, (GPX), catalase (CAT), albumin and vitamin C levels, and hematological findings. Subjects with MS had lower SOD and CAT levels than those without MS (p < 0.01). Subjects with MS had lower vitamin C and albumin levels than those without MS (p < 0.05). The hematological findings were not significantly different between those with and without MS except the white blood cell (WBC) count which was significantly higher in those with MS. SOD and CAT levels were significantly positively associated with HDL-C levels and negatively associated with components of MS. After adjusting for potential covariates, we found lower SOD and vitamin C levels and higher WBC counts were significantly associated with MS (p < 0.05). These findings suggest an alteration in antioxidant status and an increase in inflammatory markers are associated with MS and its components among Thais; subjects with MS may be more likely to have oxidative stress problems.
Tài liệu tham khảo
Mozumdar A, Liguori G. Persistent increase of prevalence of metabolic syndrome among U.S. adults: NHANES III to NHANES 1999–2006. Diabetes Care. 2011;34:216–9.
Kaur J. A comprehensive review on metabolic syndrome. Cardiol Res Pract. 2014;2014:1–21.
Aekplakorn W, Kessomboon P, Sangthong R, et al. Urban and rural variation in clustering of metabolic syndrome components in the Thai population: results from the fourth National Health Examination Survey 2009. BMC Public Health. 2011;11:854.
Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013;123:2764–72.
Roberts CK, Sindhu KK. Oxidative stress and metabolic syndrome. Life Sci. 2009;84:705–12.
De Marchi E, Baldassari F, Bononi A, Wieckowski MR, Pinton P. Oxidative stress in cardiovascular diseases and obesity: role of p66Shc and protein kinase C. Oxidative Med Cell Longev. 2013;2013:564961.
Bryan S, Baregzay B, Spicer D, Singal PK, Khaper N. Redox-inflammatory synergy in the metabolic syndrome. Can J Physiol Pharmacol. 2013;91:22–30.
Farhangi MA, Keshavarz SA, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi AA. White blood cell count in women: relation to inflammatory biomarkers, hamatological profiles, visceral adiposity, and other cardiovascular risk factors. J Health Popul Nutr. 2013;31:58–64.
Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E. The antioxidant properties of serum albumin. FEBS Lett. 2008;582:1783–7.
Chen SJ, Yen CH, Huang YC, Lee BJ, Hsia S, Lin PT. Relationships between inflammation, adiponectin, and oxidative stress in metabolic syndrome. PLoS One. 2012;7:e45693.
Yokota T, Kinugawa S, Yamato M, et al. Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients with metabolic syndrome. Diabetes Care. 2013;36:1341–6.
Cardona F, Tu’nez I, Tasse I, Montilla P, Collantes E, Tinahones FJ. Fat overload aggravates oxidative stress in patients with the metabolic syndrome. Eur J Clin Investig. 2008;38:510–5.
Ziobro A, Duchnowicz P, Mulik A, Koter-Michalak M, Broncel M. Oxidative damages in erythrocytes of patients with metabolic syndrome. Mol Cell Biochem. 2013;378:267–73.
Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention National Heart, Lung, and Blood Institute American Heart Association World Heart Federation International Atherosclerosis Society and International Association for the Study of obesity. Circulation. 2009;120:1640–5.
Dacie JV, Lewis SM. Practical haematology. 7th ed. London: Churchill Livingstone; 2007.
Liu TZ, Chin N, Kiser MD, Bigler WN. Specific spectrophotometry of ascorbic acid in serum or plasma by use of ascorbate oxidase. Clin Chem. 1982;28:2225–8.
Aebi H. Catalase in vitro. Methods Enzymol. 1984;105:121–6.
Bogdanska JJ, Korneti P, Todorova B. Erythrocyte superoxide dismutase, glutathione peroxidase and catalase activities in healthy male subjects in Republic of Macedonia. Bratisl Lek Listy. 2003;104:108–14.
Harnroongroj T, Jintaridhi P, Vudhivai N, et al. B vitamins, vitamin C and hematological measurements in overweight and obese Thais in Bangkok. J Med Assoc Thail. 2002;85:17–25.
Al-Gaithy ZK. Clinical value of total white blood cells and neutrophil counts in patients with suspected appendicitis: retrospective study. World J Emerg Surg. 2012;7:32.
Viroonudomphol D, Pongpaew P, Tungtrongchitr R, et al. Erythrocyte antioxidant enzymes and blood pressure in relation to overweight and obese Thai in Bangkok. Southeast Asian J Trop Med Public Health. 2000;31:325–34.
Lebovitz HE. Insulin resistance: definition and consequences. Exp Clin Endocrinol Diabetes. 2001;109:S135–48.
Nillakupt K. Viravathana N. a survey of metabolic syndrome and its components in Thai medical cadets. J Med Assoc Thail. 2010;93:S179–85.
Mackness MI, Arrol S, Abbott C, Durrington PN. Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase. Atherosclerosis. 1993;104:129–35.
Karaouzene N, Merzouk H, Aribi M, Merzouk SA, Berrouiguet AY, Narce M. Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young men. Nutr Metab Cardiovasc Dis. 2011;21:792–9.
Choi SW, Benzie IF, Ma SW, Strain JJ, Hannigan BM. Acute hyperglycemia and oxidative stress: direct cause and effect? Free Radic Biol Med. 2008;44:1217–31.
Kirkman HN, Galiano S, Gaetani GF. The function of catalase-bound NADPH. J Biol Chem. 1987;262:660–6.
Mansengo ML, Redon J, Martinez-Hervas S, et al. Different impacts of cardiovascular risk factor on oxidative stress. Int J Mol Sci. 2011;12:6146–63.
Baradaran A, Nasri H, Rafieian-Kopaei M. Oxidative stress and hypertension: possibility of hypertension therapy with antioxidants. J Res Med Sci. 2014;19:358–67.
Amirkhizi F, Siassi F, Djalali M, Shahraki SH. Impaired enzymatic antioxidant defense in erythrocytes of women with general and abdominal obesity. Obes Res Clin Pract. 2014;8:e26–34.
Godala M, Materek-Kuśmierkiewicz I, Moczulski D, et al. Physical activity in patients with symptoms of metabolic syndrome reduces the concentration of plasma antioxidant vitamins-protective effect of vitamin C. Pol Merkur Lekarski. 2015;38:258–62.
Ford ES, Mokdad AH, Giles WH, Brown DW. The metabolic syndrome and antioxidant concentrations: findings from the Third National Health and Nutrition Examination Survey. Diabetes. 2003;52:2346–52.
Gutteridge JM. Antioxidant properties of the proteins caeruloplasmin, albumin and transferrin. A study of their activity in serum and synovial fluid from patients with rheumatoid arthritis. Biochim Biophys Acta. 1986;869:119–27.
García OP, Ronquillo D, del Carmen Caamaño M, Martínez G, Camacho M, Rosado JL. Zinc, iron and vitamins A, C and e are associated with obesity, inflammation, lipid profile and insulin resistance in Mexican school-aged children. Nutrients. 2013;5:5012–30.
Panek J, Kuśnierz-Cabala B, Dolecki M, Pietron J. Serum proinflammatory cytokine levels and white blood cell differential count in patients with different degrees of severity of acute alcoholic pancreatitis. Pol Przegl Chir. 2012;84:230–7.
Bowie AG, O’Neill LAJ. Vitamin C inhibits NF-kB activation by TNF via the activation of p38 mitogen-activated protein kinase. The J Immunol. 2000;165:7180–8.
Wang YY, Lin SY, Liu PH, Cheung BM, Lai WA. Association between hematological parameters and metabolic syndrome components in a Chinese population. J Diabetes Complicat. 2004;18:322–7.
Jonas MI, Kurylowicz A, Bartoszewicz Z, et al. Interleukins 6 and 15 levels are higher in subcutaneous adipose tissue, but obesity is associated with their increased content in visceral fat depots. Int J Mol Sci. 2015;16:25817–30.
Fernandez-Real JM, Vayreda M, Richart C, et al. Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. J Clin Endocrinol Metab. 2001;86:1154–9.