STAT3 signaling in immunity
Tài liệu tham khảo
Lutticken, 1994, Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130, Science, 263, 89, 10.1126/science.8272872
Standke, 1994, Mammary gland factor activated by prolactin on mammary epithelial cells and acute-phase response factor activated by interleukin-6 in liver cells share DNA binding and transactivation potential, Mol. Endocrinol., 8, 469
Zhong, 1994, Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6, Science, 264, 95, 10.1126/science.8140422
Wegenka, 1994, The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family, Mol. Cell. Biol., 14, 3186, 10.1128/MCB.14.5.3186
Akira, 1994, Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway, Cell, 77, 63, 10.1016/0092-8674(94)90235-6
Raz, 1994, Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors, J. Biol. Chem., 269, 24391, 10.1016/S0021-9258(19)51096-1
Ruff-Jamison, 1994, Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver, J. Biol. Chem., 269, 21933, 10.1016/S0021-9258(17)31735-0
Tian, 1994, Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor, Blood, 84, 1760, 10.1182/blood.V84.6.1760.1760
Yu, 1995, Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein, Science, 269, 81, 10.1126/science.7541555
Bromberg, 1998, Stat3 activation is required for cellular transformation by v-src, Mol. Cell. Biol., 18, 2553, 10.1128/MCB.18.5.2553
Ram, 2000, Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein, Science, 287, 142, 10.1126/science.287.5450.142
Zhang, 2000, Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity, J. Biol. Chem., 275, 24935, 10.1074/jbc.M002383200
Gough, 2009, Mitochondrial STAT3 supports Ras-dependent oncogenic transformation, Science, 324, 1713, 10.1126/science.1171721
Gough, 2013, The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation, PLoS One, 8, e83395, 10.1371/journal.pone.0083395
Boulton, 1995, STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase, Proc. Natl. Acad. Sci. U. S. A., 92, 6915, 10.1073/pnas.92.15.6915
Wen, 1995, Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation, Cell, 82, 241, 10.1016/0092-8674(95)90311-9
Shen, 2004, Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation, Mol. Cell. Biol., 24, 407, 10.1128/MCB.24.1.407-419.2004
Wen, 1997, Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3, Nucleic Acids Res., 25, 2062, 10.1093/nar/25.11.2062
Shuai, 1993, A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma, Science, 261, 1744, 10.1126/science.7690989
Shuai, 1992, Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein, Science, 258, 1808, 10.1126/science.1281555
Schindler, 1992, Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor, Science, 257, 809, 10.1126/science.1496401
Becker, 1998, Three-dimensional structure of the Stat3beta homodimer bound to DNA, Nature, 394, 145, 10.1038/28101
Heim, 1995, Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway, Science, 267, 1347, 10.1126/science.7871432
Horvath, 1995, A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain, Genes Dev., 9, 984, 10.1101/gad.9.8.984
Shuai, 1994, Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions, Cell, 76, 821, 10.1016/0092-8674(94)90357-3
Paulson, 1999, Stat protein transactivation domains recruit p300/CBP through widely divergent sequences, J. Biol. Chem., 274, 25343, 10.1074/jbc.274.36.25343
Vinkemeier, 1998, Structure of the amino-terminal protein interaction domain of STAT-4, Science, 279, 1048, 10.1126/science.279.5353.1048
Chen, 1998, Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA, Cell, 93, 827, 10.1016/S0092-8674(00)81443-9
Zhang, 2000, The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6, Mol. Cell. Biol., 20, 7132, 10.1128/MCB.20.19.7132-7139.2000
Ota, 2004, N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation, Nat. Immunol., 5, 208, 10.1038/ni1032
Hou, 2008, The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain, J. Biol. Chem., 283, 30725, 10.1074/jbc.M805941200
Yuan, 2005, Stat3 dimerization regulated by reversible acetylation of a single lysine residue, Science, 307, 269, 10.1126/science.1105166
Yang, 2010, Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes, Proc. Natl. Acad. Sci. U. S. A., 107, 21499, 10.1073/pnas.1016147107
Dasgupta, 2014, Critical role for lysine 685 in gene expression mediated by transcription factor unphosphorylated STAT3, J. Biol. Chem., 289, 30763, 10.1074/jbc.M114.603894
Dasgupta, 2015, STAT3-driven transcription depends upon the dimethylation of K49 by EZH2, Proc. Natl. Acad. Sci. U. S. A., 112, 3985, 10.1073/pnas.1503152112
Bromberg, 1999, Stat3 as an oncogene, Cell, 98, 295, 10.1016/S0092-8674(00)81959-5
Sadowski, 1993, A common nuclear signal transduction pathway activated by growth factor and cytokine receptors, Science, 261, 1739, 10.1126/science.8397445
Darnell, 1994, Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins, Science, 264, 1415, 10.1126/science.8197455
Schindler, 1995, Transcriptional responses to polypeptide ligands: the JAK-STAT pathway, Annu. Rev. Biochem., 64, 621, 10.1146/annurev.bi.64.070195.003201
Darnell, 1997, STATs and gene regulation, Science, 277, 1630, 10.1126/science.277.5332.1630
Levy, 2002, Stats: transcriptional control and biological impact, Nat. Rev. Mol. Cell. Biol., 3, 651, 10.1038/nrm909
Stark, 2007, How cells respond to interferons revisited: from early history to current complexity, Cytokine Growth Factor Rev., 18, 419, 10.1016/j.cytogfr.2007.06.013
Yang, 2005, Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation, Cancer Res., 65, 939, 10.1158/0008-5472.939.65.3
Yang, 2007, Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB, Genes Dev., 21, 1396, 10.1101/gad.1553707
Yang, 2008, Roles of unphosphorylated STATs in signaling, Cell Res., 18, 443, 10.1038/cr.2008.41
Timofeeva, 2012, Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA, J. Biol. Chem., 287, 14192, 10.1074/jbc.M111.323899
Narimatsu, 2001, Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells, Mol. Cell. Biol., 21, 6615, 10.1128/MCB.21.19.6615-6625.2001
Wegrzyn, 2009, Function of mitochondrial Stat3 in cellular respiration, Science, 323, 793, 10.1126/science.1164551
Garama, 2015, A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3, Mol. Cell. Biol., 35, 3646, 10.1128/MCB.00541-15
Carbognin, 2016, Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency, EMBO J., 35, 618, 10.15252/embj.201592629
Lipinski, 2010, A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions, Dev. Cell, 18, 1041, 10.1016/j.devcel.2010.05.005
Shen, 2012, Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity, Mol. Cell, 48, 667, 10.1016/j.molcel.2012.09.013
Niso-Santano, 2013, Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy, Autophagy, 9, 415, 10.4161/auto.22910
Der, 1982, Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses, Proc. Natl. Acad. Sci. U. S. A., 79, 3637, 10.1073/pnas.79.11.3637
Parada, 1982, Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene, Nature, 297, 474, 10.1038/297474a0
Santos, 1982, T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes, Nature, 298, 343, 10.1038/298343a0
Corcoran, 2011, STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis, Cancer Res., 71, 5020, 10.1158/0008-5472.CAN-11-0908
Gough, 2014, STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation, Blood, 124, 2252, 10.1182/blood-2013-02-484196
Grabner, 2015, Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis, Nat. Commun., 6, 6285, 10.1038/ncomms7285
Minegishi, 2006, Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity, Immunity, 25, 745, 10.1016/j.immuni.2006.09.009
Zhang, 2009, Combined immunodeficiency associated with DOCK8 mutations, N. Engl. J. Med., 361, 2046, 10.1056/NEJMoa0905506
Engelhardt, 2009, Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome, J. Allergy Clin. Immunol., 124, 1289, 10.1016/j.jaci.2009.10.038
Holland, 2007, STAT3 mutations in the hyper-IgE syndrome, N. Engl. J. Med., 357, 1608, 10.1056/NEJMoa073687
Minegishi, 2007, Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome, Nature, 448, 1058, 10.1038/nature06096
Freeman, 2008, The hyper-IgE syndromes, Immunol. Allergy Clin. North Am., 28, 277, 10.1016/j.iac.2008.01.005
Freeman, 2009, Hyper IgE (Job’s) syndrome: a primary immune deficiency with oral manifestations, Oral Dis., 15, 2, 10.1111/j.1601-0825.2008.01463.x
Minegishi, 2009, Hyper-IgE syndrome, Curr. Opin. Immunol., 21, 487, 10.1016/j.coi.2009.07.013
Minegishi, 2009, Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency, Int. Immunol., 21, 105, 10.1093/intimm/dxn134
Takeda, 1999, Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils, Immunity, 10, 39, 10.1016/S1074-7613(00)80005-9
Takeda, 1998, Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice, J. Immunol., 161, 4652
Minegishi, 2009, Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome, J. Exp. Med., 206, 1291, 10.1084/jem.20082767
Steward-Tharp, 2014, A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3, Blood, 123, 2978, 10.1182/blood-2013-09-523167
Barrett, 2008, Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease, Nat. Genet., 40, 955, 10.1038/ng.175
Cho, 2008, The genetics and immunopathogenesis of inflammatory bowel disease, Nat. Rev. Immunol., 8, 458, 10.1038/nri2340
Jakkula, 2010, Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene, Am. J. Hum. Genet., 86, 285, 10.1016/j.ajhg.2010.01.017
Tsoi, 2012, Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity, Nat. Genet., 44, 1341, 10.1038/ng.2467
Flanagan, 2014, Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease, Nat Genet., 46, 812, 10.1038/ng.3040
Haapaniemi, 2015, Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3, Blood, 125, 639, 10.1182/blood-2014-04-570101
Milner, 2015, Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations, Blood, 125, 591, 10.1182/blood-2014-09-602763
Vogel, 2015, The Ying and Yang of STAT3 in human disease, J. Clin. Immunol., 35, 615, 10.1007/s10875-015-0187-8
Yao, 2007, Nonredundant roles for Stat5a/b in directly regulating Foxp3, Blood, 109, 4368, 10.1182/blood-2006-11-055756
Xu, 2010, Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I, Immunity, 33, 313, 10.1016/j.immuni.2010.09.001
Laurence, 2012, STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease, Immunity, 37, 209, 10.1016/j.immuni.2012.05.027
Brunkow, 2001, Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse, Nat. Genet., 27, 68, 10.1038/83784
Fontenot, 2003, Foxp3 programs the development and function of CD4 + CD25+ regulatory T cells, Nat. Immunol., 4, 330, 10.1038/ni904
Kim, 2007, Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice, Nat. Immunol., 8, 191, 10.1038/ni1428
Lahl, 2007, Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease, J. Exp. Med., 204, 57, 10.1084/jem.20061852
Kim, 2009, Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice, J. Immunol., 183, 7631, 10.4049/jimmunol.0804308
Takeda, 1997, Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality, Proc. Natl. Acad. Sci. U. S. A., 94, 3801, 10.1073/pnas.94.8.3801
Raz, 1999, Essential role of STAT3 for embryonic stem cell pluripotency, Proc. Natl. Acad. Sci. U. S. A., 96, 2846, 10.1073/pnas.96.6.2846
Lee, 2002, STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation, Immunity, 17, 63, 10.1016/S1074-7613(02)00336-9
Welte, 2003, STAT3 deletion during hematopoiesis causes Crohn’s disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity, Proc. Natl. Acad. Sci. U. S. A., 100, 1879, 10.1073/pnas.0237137100
Alonzi, 2004, Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis, Cytokine, 26, 45, 10.1016/j.cyto.2003.12.002
Panopoulos, 2006, STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils, Blood, 108, 3682, 10.1182/blood-2006-02-003012
Akira, 2000, Roles of STAT3 defined by tissue-specific gene targeting, Oncogene, 19, 2607, 10.1038/sj.onc.1203478
Manz, 2014, Emergency granulopoiesis, Nat. Rev. Immunol., 14, 302, 10.1038/nri3660
Cheers, 1988, Production of colony-stimulating factors (CSFs) during infection: separate determinations of macrophage-, granulocyte-, granulocyte-macrophage-, and multi-CSFs, Infect. Immun., 56, 247, 10.1128/IAI.56.1.247-251.1988
Lieschke, 1994, Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization, Blood, 84, 1737, 10.1182/blood.V84.6.1737.1737
Boettcher, 2014, Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis, Blood, 124, 1393, 10.1182/blood-2014-04-570762
Panopoulos, 2008, Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and ‘emergency’ hematopoiesis, Cytokine, 42, 277, 10.1016/j.cyto.2008.03.002
McLemore, 2001, STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation, Immunity, 14, 193, 10.1016/S1074-7613(01)00101-7
Laouar, 2003, STAT3 is required for Flt3L-dependent dendritic cell differentiation, Immunity, 19, 903, 10.1016/S1074-7613(03)00332-7
Zhang, 2010, STAT3 controls myeloid progenitor growth during emergency granulopoiesis, Blood, 116, 2462, 10.1182/blood-2009-12-259630
Nguyen-Jackson, 2010, STAT3 controls the neutrophil migratory response to CXCR2 ligands by direct activation of G-CSF-induced CXCR2 expression and via modulation of CXCR2 signal transduction, Blood, 115, 3354, 10.1182/blood-2009-08-240317
Mantel, 2012, Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype, Blood, 120, 2589, 10.1182/blood-2012-01-404004
Li, 2012, The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development, Blood, 120, 4363, 10.1182/blood-2012-07-441311
Johansen, 2001, c-Myc is a critical target for c/EBPalpha in granulopoiesis, Mol. Cell. Biol., 21, 3789, 10.1128/MCB.21.11.3789-3806.2001
Hirai, 2006, C/EBPbeta is required for ‘emergency' granulopoiesis, Nat. Immunol., 7, 732, 10.1038/ni1354
Nguyen-Jackson, 2012, G-CSF-activated STAT3 enhances production of the chemokine MIP-2 in bone marrow neutrophils, J. Leukoc. Biol., 92, 1215, 10.1189/jlb.0312126
Fielding, 2008, IL-6 regulates neutrophil trafficking during acute inflammation via STAT3, J. Immunol., 181, 2189, 10.4049/jimmunol.181.3.2189
Croker, 2004, SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis, Immunity, 20, 153, 10.1016/S1074-7613(04)00022-6
Wormald, 2004, Inhibitors of cytokine signal transduction, J. Biol. Chem., 279, 821, 10.1074/jbc.R300030200
Murray, 2007, The JAK-STAT signaling pathway: input and output integration, J. Immunol., 178, 2623, 10.4049/jimmunol.178.5.2623
Auernhammer, 1999, Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter, Proc. Natl. Acad. Sci. U. S. A., 96, 6964, 10.1073/pnas.96.12.6964
Babon, 2012, Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity, Immunity, 36, 239, 10.1016/j.immuni.2011.12.015
Kershaw, 2013, SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition, Nat. Struct. Mol. Biol., 20, 469, 10.1038/nsmb.2519
Croker, 2008, Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation, Exp. Hematol., 36, 786, 10.1016/j.exphem.2008.02.008
Matsukawa, 2003, Aberrant inflammation and lethality to septic peritonitis in mice lacking STAT3 in macrophages and neutrophils, J. Immunol., 171, 6198, 10.4049/jimmunol.171.11.6198
Hill, 1974, Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections, Lancet, 1, 183, 10.1016/S0140-6736(74)92493-3
Hill, 1974, Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent cold staphylococcal abscesses, Lancet, 2, 617, 10.1016/S0140-6736(74)91942-4
Mintz, 2010, Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients, Immunol. Lett., 130, 97, 10.1016/j.imlet.2009.12.006
Mogensen, 2013, STAT3 and the Hyper-IgE syndrome: clinical presentation, genetic origin, pathogenesis, novel findings and remaining uncertainties, Jakstat, 2, e23435
Liu, 1997, Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation, Blood, 90, 2583, 10.1182/blood.V90.7.2583
Liu, 1996, Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice, Immunity, 5, 491, 10.1016/S1074-7613(00)80504-X
Richards, 2003, Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway, Blood, 102, 3562, 10.1182/blood-2003-02-0593
Semerad, 1999, A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation, Immunity, 11, 153, 10.1016/S1074-7613(00)80090-4
Panopoulos, 2002, Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1, J. Biol. Chem., 277, 19001, 10.1074/jbc.M112271200
MacNamara, 2011, Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-gamma signaling, J. Immunol., 186, 1032, 10.4049/jimmunol.1001893
de Bruin, 2012, IFNgamma induces monopoiesis and inhibits neutrophil development during inflammation, Blood, 119, 1543, 10.1182/blood-2011-07-367706
Jouanguy, 1999, IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men, Curr. Opin. Immunol., 11, 346, 10.1016/S0952-7915(99)80055-7
Gardner, 2014, G-CSF drives a posttraumatic immune program that protects the host from infection, J. Immunol., 192, 2405, 10.4049/jimmunol.1302752
Merad, 2009, Dendritic cell homeostasis, Blood, 113, 3418, 10.1182/blood-2008-12-180646
Merad, 2013, The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting, Annu. Rev. Immunol., 31, 563, 10.1146/annurev-immunol-020711-074950
McKenna, 2000, Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells, Blood, 95, 3489, 10.1182/blood.V95.11.3489
Esashi, 2008, The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8, Immunity, 28, 509, 10.1016/j.immuni.2008.02.013
Singh, 2012, Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells, Blood, 119, 1671, 10.1182/blood-2011-03-342428
D'Amico, 2003, The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3, J. Exp. Med., 198, 293, 10.1084/jem.20030107
Onai, 2006, Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development, J. Exp. Med., 203, 227, 10.1084/jem.20051645
Hegde, 2009, Stat3 promotes the development of erythroleukemia by inducing Pu: 1 expression and inhibiting erythroid differentiation, Oncogene, 28, 3349, 10.1038/onc.2009.202
Carotta, 2010, The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner, Immunity., 32, 628, 10.1016/j.immuni.2010.05.005
Watowich, 2010, Mechanisms regulating dendritic cell specification and development, Immunol. Rev., 238, 76, 10.1111/j.1600-065X.2010.00949.x
Melillo, 2010, Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function, J. Immunol., 184, 2638, 10.4049/jimmunol.0902960
Cisse, 2008, Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development, Cell, 135, 37, 10.1016/j.cell.2008.09.016
Hacker, 2003, Transcriptional profiling identifies Id2 function in dendritic cell development, Nat. Immunol., 4, 380, 10.1038/ni903
Kee, 2009, E and ID proteins branch out, Nat. Rev. Immunol., 9, 175, 10.1038/nri2507
Li, 2013, Diversification of dendritic cell subsets: emerging roles for STAT proteins, JAKSTAT, 2, e25112
Cheng, 2003, A critical role for Stat3 signaling in immune tolerance, Immunity, 19, 425, 10.1016/S1074-7613(03)00232-2
Wang, 2004, Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells, Nat. Med., 10, 48, 10.1038/nm976
Nefedova, 2004, Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer, J. Immunol., 172, 464, 10.4049/jimmunol.172.1.464
Lunz, 2007, Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription 3 activity, Hepatology, 46, 1946, 10.1002/hep.21906
Lin, 2010, Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth, Immunol. Lett., 127, 77, 10.1016/j.imlet.2009.09.003
Park, 2004, IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation, J. Immunol., 173, 3844, 10.4049/jimmunol.173.6.3844
Kitamura, 2005, IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells, Immunity, 23, 491, 10.1016/j.immuni.2005.09.010
Cheng, 2008, Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein, J. Exp. Med., 205, 2235, 10.1084/jem.20080132
Wolfle, 2011, PD-L1 expression on tolerogenic APCs is controlled by STAT-3, Eur. J. Immunol., 41, 413, 10.1002/eji.201040979
Corinti, 2001, Regulatory activity of autocrine IL-10 on dendritic cell functions, J. Immunol., 166, 4312, 10.4049/jimmunol.166.7.4312
Liang, 2008, Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6–STAT3 signaling pathway, Proc. Natl. Acad. Sci. U. S. A., 105, 8357, 10.1073/pnas.0803341105
Nefedova, 2005, Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway, Cancer Res., 65, 9525, 10.1158/0008-5472.CAN-05-0529
Bharadwaj, 2007, Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation, Cancer Res., 67, 5479, 10.1158/0008-5472.CAN-06-3963
Sanseverino, 2014, STAT3-silenced human dendritic cells have an enhanced ability to prime IFNgamma production by both alphabeta and gammadelta T lymphocytes, Immunobiology, 219, 503, 10.1016/j.imbio.2014.02.012
Kobayashi, 2003, Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice, J. Clin. Invest., 111, 1297, 10.1172/JCI17085
Reindl, 2007, Essential crosstalk between myeloid and lymphoid cells for development of chronic colitis in myeloid-specific signal transducer and activator of transcription 3-deficient mice, Immunology, 120, 19, 10.1111/j.1365-2567.2006.02473.x
Kuhn, 1993, Interleukin-10-deficient mice develop chronic enterocolitis, Cell, 75, 263, 10.1016/0092-8674(93)80068-P
Hoshi, 2012, MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice, Nat. Commun., 3, 1120, 10.1038/ncomms2113
Lang, 2002, Shaping gene expression in activated and resting primary macrophages by IL-10, J. Immunol., 169, 2253, 10.4049/jimmunol.169.5.2253
Williams, 2004, Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages, J. Immunol., 172, 567, 10.4049/jimmunol.172.1.567
El Kasmi, 2006, General nature of the STAT3-activated anti-inflammatory response, J. Immunol., 177, 7880, 10.4049/jimmunol.177.11.7880
Williams, 2007, Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages, J. Biol. Chem., 282, 6965, 10.1074/jbc.M609101200
Murray, 2005, The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription, Proc. Natl. Acad. Sci. U. S. A., 102, 8686, 10.1073/pnas.0500419102
El Kasmi, 2007, Cutting edge: a transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway, J. Immunol., 179, 7215, 10.4049/jimmunol.179.11.7215
Schaljo, 2009, Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10, J. Immunol., 183, 1197, 10.4049/jimmunol.0803883
Chan, 2012, Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor-alpha translation through a SHIP1-dependent pathway, J. Biol. Chem., 287, 38020, 10.1074/jbc.M112.348599
Gaba, 2012, Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production, J. Immunol., 189, 2089, 10.4049/jimmunol.1201126
Smith, 2011, A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3, J. Biol. Chem., 286, 23582, 10.1074/jbc.M111.249235
Hutchins, 2012, Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages, Blood, 119, e110, 10.1182/blood-2011-09-381483
Curtale, 2013, Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b, Proc. Natl. Acad. Sci. U. S. A., 110, 11499, 10.1073/pnas.1219852110
Hutchins, 2013, The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges, Brief Funct. Genomics, 12, 489, 10.1093/bfgp/elt028
Zhang, 2014, STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13, Nat. Commun., 5, 5798, 10.1038/ncomms6798
Yasukawa, 2003, IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages, Nat. Immunol., 4, 551, 10.1038/ni938
Johnston, 2003, Matching SOCS with function, Nat. Immunol., 4, 507, 10.1038/ni0603-507
Heimall, 2010, Pathogenesis of hyper IgE syndrome, Clin. Rev. Allergy Immunol., 38, 32, 10.1007/s12016-009-8134-1
Saito, 2011, Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells, J. Exp. Med., 208, 235, 10.1084/jem.20100799
Sowerwine, 2014, Bone density and fractures in autosomal dominant hyper IgE syndrome, J. Clin. Immunol., 34, 260, 10.1007/s10875-013-9982-2
Kano, 2003, Endothelial cells require STAT3 for protection against endotoxin-induced inflammation, J. Exp. Med., 198, 1517, 10.1084/jem.20030077
Burdelya, 2005, Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects, J. Immunol., 174, 3925, 10.4049/jimmunol.174.7.3925
Sugimoto, 2008, IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis, J. Clin. Invest., 118, 534
Pickert, 2009, STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing, J. Exp. Med., 206, 1465, 10.1084/jem.20082683
Takatori, 2009, Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22, J. Exp. Med., 206, 35, 10.1084/jem.20072713
Chou, 2006, STAT3 positively regulates an early step in B-cell development, Blood, 108, 3005, 10.1182/blood-2006-05-024430
Fornek, 2006, Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells, Blood, 107, 1085, 10.1182/blood-2005-07-2871
Leonard, 2008, Interleukin 21: a cytokine/cytokine receptor system that has come of age, J. Leukoc. Biol., 84, 348, 10.1189/jlb.0308149
Diehl, 2012, IL-6 triggers IL-21 production by human CD4+ T cells to drive STAT3-dependent plasma cell differentiation in B cells, Immunol. Cell Biol., 90, 802, 10.1038/icb.2012.17
Ding, 2013, IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells, J. Immunol., 190, 1827, 10.4049/jimmunol.1201678
Hunter, 2015, IL-6 as a keystone cytokine in health and disease, Nat. Immunol., 16, 448, 10.1038/ni.3153
Wang, 2014, Interleukin-35 induces regulatory B cells that suppress autoimmune disease, Nat. Med., 20, 633, 10.1038/nm.3554
Speckmann, 2008, Reduced memory B cells in patients with hyper IgE syndrome, Clin. Immunol., 129, 448, 10.1016/j.clim.2008.08.002
Avery, 2010, B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans, J. Exp. Med., 207, 155, 10.1084/jem.20091706
Ma, 2012, Functional STAT3 deficiency compromises the generation of human T follicular helper cells, Blood, 119, 3997, 10.1182/blood-2011-11-392985
Ma, 2015, Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies, J. Allergy Clin. Immunol., 136, 993, 10.1016/j.jaci.2015.05.036
Kanno, 2012, Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity, Annu. Rev. Immunol., 30, 707, 10.1146/annurev-immunol-020711-075058
Liu, 2008, Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases, J. Immunol., 180, 6070, 10.4049/jimmunol.180.9.6070
Laurence, 2007, Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation, Immunity, 26, 371, 10.1016/j.immuni.2007.02.009
Yang, 2007, STAT3 regulates cytokine-mediated generation of inflammatory helper T cells, J. Biol. Chem., 282, 9358, 10.1074/jbc.C600321200
Zhou, 2007, IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways, Nat. Immunol., 8, 967, 10.1038/ni1488
Nurieva, 2007, Essential autocrine regulation by IL-21 in the generation of inflammatory T cells, Nature, 448, 480, 10.1038/nature05969
Ivanov, 2006, The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells, Cell, 126, 1121, 10.1016/j.cell.2006.07.035
Yang, 2008, T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma, Immunity, 28, 29, 10.1016/j.immuni.2007.11.016
Gaffen, 2009, Structure and signalling in the IL-17 receptor family, Nat. Rev. Immunol., 9, 556, 10.1038/nri2586
Gaffen, 2011, Recent advances in the IL-17 cytokine family, Curr. Opin. Immunol., 23, 613, 10.1016/j.coi.2011.07.006
Nurieva, 2008, Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages, Immunity, 29, 138, 10.1016/j.immuni.2008.05.009
Liu, 2012, Bcl6 expression specifies the T follicular helper cell program in vivo, J. Exp. Med., 209, 1841, 10.1084/jem.20120219
Batten, 2010, IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells, J. Exp. Med., 207, 2895, 10.1084/jem.20100064
Yang, 2008, Molecular antagonism and plasticity of regulatory and inflammatory T cell programs, Immunity, 29, 44, 10.1016/j.immuni.2008.05.007
Chaudhry, 2011, Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation, Immunity, 34, 566, 10.1016/j.immuni.2011.03.018
Chaudhry, 2009, CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner, Science, 326, 986, 10.1126/science.1172702
Chaudhry, 2013, Control of inflammation by integration of environmental cues by regulatory T cells, J. Clin. Invest., 123, 939, 10.1172/JCI57175
Yang, 2011, Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5, Nat. Immunol., 12, 247, 10.1038/ni.1995
Minegishi, 2011, Molecular mechanisms of the immunological abnormalities in hyper-IgE syndrome, Ann. N. Y. Acad. Sci., 1246, 34, 10.1111/j.1749-6632.2011.06280.x
Cui, 2011, An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells, Immunity, 35, 792, 10.1016/j.immuni.2011.09.017
Kaech, 2012, Transcriptional control of effector and memory CD8+ T cell differentiation, Nat. Rev. Immunol., 12, 749, 10.1038/nri3307
Laidlaw, 2015, Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells, Nat. Immunol., 16, 871, 10.1038/ni.3224
Siegel, 2011, A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory, Immunity, 35, 806, 10.1016/j.immuni.2011.09.016
Ives, 2013, Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function, J. Allergy Clin. Immunol., 132, 400, 10.1016/j.jaci.2013.05.029
Siegel, 2013, Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation, J. Allergy Clin. Immunol., 132, 1388, 10.1016/j.jaci.2013.08.045
Yan, 2013, IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation, J. Immunol., 190, 5882, 10.4049/jimmunol.1201881