Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

Cell - Tập 121 - Trang 335-348 - 2005
Akira Orimo1, Piyush B. Gupta1,2, Dennis C. Sgroi3, Fernando Arenzana-Seisdedos4, Thierry Delaunay5, Rizwan Naeem6, Vincent J. Carey7, Andrea L. Richardson8, Robert A. Weinberg1,2
1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
2Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
3Department of Pathology, Harvard Medical School, Molecular Pathology Research Unit, Massachusetts General Hospital, Boston, Massachusetts 02129
4Unité d’Immunologie Virale, Institute Pasteur, Paris 75724, France
5INRA, Villenave d’Ornon 33883, France
6Texas Children’s Cancer Center, Department of Pediatrics and Pathology, Baylor College of Medicine, Houston, Texas 77030
7Channing Laboratory, Harvard Medical School, Boston, Massachusetts 02115
8Department of Pathology, The Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115

Tài liệu tham khảo

Allinen, 2004, Molecular characterization of the tumor microenvironment in breast cancer, Cancer Cell, 6, 17, 10.1016/j.ccr.2004.06.010 Anderson, 2003, Potent suppression of HIV type 1 infection by a short hairpin anti-CXCR4 siRNA, AIDS Res. Hum. Retroviruses, 19, 699, 10.1089/088922203322280928 Asahara, 1997, Isolation of putative progenitor endothelial cells for angiogenesis, Science, 275, 964, 10.1126/science.275.5302.964 Askari, 2003, Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy, Lancet, 362, 697, 10.1016/S0140-6736(03)14232-8 Balkwill, 2004, Cancer and the chemokine network, Nat. Rev. Cancer, 4, 540, 10.1038/nrc1388 Barcellos-Hoff, 2000, Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells, Cancer Res., 60, 1254 Bertolini, 2003, Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells, Cancer Res., 63, 4342 Bhowmick, 2004, TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia, Science, 303, 848, 10.1126/science.1090922 Bhowmick, 2004, Stromal fibroblasts in cancer initiation and progression, Nature, 432, 332, 10.1038/nature03096 Bissell, 2001, Putting tumours in context, Nat. Rev. Cancer, 1, 46, 10.1038/35094059 Bogatkevich, 2001, Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway, J. Biol. Chem., 276, 45184, 10.1074/jbc.M106441200 Brisken, 2002, IGF-2 is a mediator of prolactin-induced morphogenesis in the breast, Dev. Cell, 3, 877, 10.1016/S1534-5807(02)00365-9 Cardone, 1997, Prognostic value of desmoplastic reaction and lymphocytic infiltration in the management of breast cancer, Panminerva Med., 39, 174 Ceradini, 2004, Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1, Nat. Med., 10, 858, 10.1038/nm1075 Coulomb-L’Hermin, 1999, Stromal cell-derived factor 1 (SDF-1) and antenatal human B cell lymphopoiesis: expression of SDF-1 by mesothelial cells and biliary ductal plate epithelial cells, Proc. Natl. Acad. Sci. USA, 96, 8585, 10.1073/pnas.96.15.8585 Coussens, 2002, Inflammation and cancer, Nature, 420, 860, 10.1038/nature01322 Cunha, 2003, Role of the stromal microenvironment in carcinogenesis of the prostate, Int. J. Cancer, 107, 1, 10.1002/ijc.11335 Darash-Yahana, 2004, Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis, FASEB J., 18, 1240, 10.1096/fj.03-0935fje De Falco, 2004, SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells, Blood, 104, 3472, 10.1182/blood-2003-12-4423 Doench, 2003, siRNAs can function as miRNAs, Genes Dev., 17, 438, 10.1101/gad.1064703 Douglas, 2002, Why does inflammation persist: a dominant role for the stromal microenvironment?, Expert Rev. Mol. Med., 2002, 1, 10.1017/S1462399402005264 Dvorak, 1986, Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing, N. Engl. J. Med., 315, 1650, 10.1056/NEJM198612253152606 Elenbaas, 2001, Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells, Genes Dev., 15, 50, 10.1101/gad.828901 Fox, 1995, Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density, Chalkley count, and computer image analysis, J. Pathol., 177, 275, 10.1002/path.1711770310 Fukino, 2004, Combined total genome loss of heterozygosity scan of breast cancer stroma and epithelium reveals multiplicity of stromal targets, Cancer Res., 64, 7231, 10.1158/0008-5472.CAN-04-2866 Hall, 2003, Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells, Mol. Endocrinol., 17, 792, 10.1210/me.2002-0438 Hatzopoulos, 1998, Isolation and characterization of endothelial progenitor cells from mouse embryos, Development, 125, 1457, 10.1242/dev.125.8.1457 Heissig, 2002, Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand, Cell, 109, 625, 10.1016/S0092-8674(02)00754-7 Hinz, 2001, Alpha-smooth muscle actin expression upregulates fibroblast contractile activity, Mol. Biol. Cell, 12, 2730, 10.1091/mbc.12.9.2730 Ikawa, 1995, A rapid and non-invasive selection of transgenic embryos before implantation using green fluorescent protein (GFP), FEBS Lett., 375, 125, 10.1016/0014-5793(95)01162-8 Ishii, 2003, Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction, Biochem. Biophys. Res. Commun., 309, 232, 10.1016/S0006-291X(03)01544-4 Jacobs, 1999, Radial scars in benign breast-biopsy specimens and the risk of breast cancer, N. Engl. J. Med., 340, 430, 10.1056/NEJM199902113400604 Kalka, 2000, Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization, Proc. Natl. Acad. Sci. USA, 97, 3422, 10.1073/pnas.97.7.3422 Kasid, 1985, Transfection of v-rasH DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity, Science, 228, 725, 10.1126/science.4039465 Kurose, 2002, Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas, Nat. Genet., 32, 355, 10.1038/ng1013 Lapteva, 2005, CXCR4 knockdown by small interfering RNA abrogates breast tumor growth in vivo, Cancer Gene Ther., 12, 84, 10.1038/sj.cgt.7700770 Lyden, 2001, Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth, Nat. Med., 7, 1194, 10.1038/nm1101-1194 Maeshima, 2002, Modified scar grade: a prognostic indicator in small peripheral lung adenocarcinoma, Cancer, 95, 2546, 10.1002/cncr.11006 Moinfar, 2000, Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis, Cancer Res., 60, 2562 Mueller, 2004, Friends or foes—bipolar effects of the tumour stroma in cancer, Nat. Rev. Cancer, 4, 839, 10.1038/nrc1477 Olumi, 1999, Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium, Cancer Res., 59, 5002 Orimo, 2001, Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression, Clin. Cancer Res., 7, 3097 Pablos, 1999, Stromal-cell derived factor is expressed by dendritic cells and endothelium in human skin, Am. J. Pathol., 155, 1577, 10.1016/S0002-9440(10)65474-0 Petit, 2002, G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4, Nat. Immunol., 3, 687, 10.1038/ni813 Pinheiro, 2000 Rafii, 2003, Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration, Nat. Med., 9, 702, 10.1038/nm0603-702 Ronnov-Jessen, 1996, Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction, Physiol. Rev., 76, 69, 10.1152/physrev.1996.76.1.69 Rubin, 2003, A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors, Proc. Natl. Acad. Sci. USA, 100, 13513, 10.1073/pnas.2235846100 Sappino, 1988, Smooth-muscle differentiation in stromal cells of malignant and non-malignant breast tissues, Int. J. Cancer, 41, 707, 10.1002/ijc.2910410512 Schober, 2003, Crucial role of stromal cell-derived factor-1alpha in neointima formation after vascular injury in apolipoprotein E-deficient mice, Circulation, 108, 2491, 10.1161/01.CIR.0000099508.76665.9A Serini, 1999, Mechanisms of myofibroblast activity and phenotypic modulation, Exp. Cell Res., 250, 273, 10.1006/excr.1999.4543 Shirozu, 1995, Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene, Genomics, 28, 495, 10.1006/geno.1995.1180 Sieweke, 1990, Mediation of wound-related Rous sarcoma virus tumorigenesis by TGF-beta, Science, 248, 1656, 10.1126/science.2163544 Smith, 2004, CXCR4 regulates growth of both primary and metastatic breast cancer, Cancer Res., 64, 8604, 10.1158/0008-5472.CAN-04-1844 Staller, 2003, Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL, Nature, 425, 307, 10.1038/nature01874 Stewart, 2003, Lentivirus-delivered stable gene silencing by RNAi in primary cells, RNA, 9, 493, 10.1261/rna.2192803 Suratt, 2004, Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis, Blood, 104, 565, 10.1182/blood-2003-10-3638 Tlsty, 2001, Stromal cells can contribute oncogenic signals, Semin. Cancer Biol., 11, 97, 10.1006/scbi.2000.0361 Weidner, 1991, Tumor angiogenesis and metastasis—correlation in invasive breast carcinoma, N. Engl. J. Med., 324, 1, 10.1056/NEJM199101033240101 Yang, 2004, Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis, Cancer Cell, 6, 409, 10.1016/j.ccr.2004.08.031