Heterologous transporter expression for improved fatty alcohol secretion in yeast

Metabolic Engineering - Tập 45 - Trang 51-58 - 2018
Yating Hu1, Zhiwei Zhu1,2, Jens Nielsen1,2,3,4, Verena Siewers1,2
1Department of Biology and Biological Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden
2Novo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, SE-41296 Gothenburg, Sweden
3Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2800, Kgs. Lyngby, Denmark
4Science for Life Laboratory, Royal Institute of Technology, SE-17121 Stockholm, Sweden

Tài liệu tham khảo

Alper, 2006, Engineering yeast transcription machinery for improved ethanol tolerance and production, Science, 314, 1565, 10.1126/science.1131969 Bird, 2007, Characterization of Arabidopsis ABCG11/WBC11, an ATP binding cassette (ABC) transporter that is required for cuticular lipid secretion, Plant J., 52, 485, 10.1111/j.1365-313X.2007.03252.x Black, 2000, 275, 38547 Black, 2009, Targeting the fatty acid transport proteins (FATP) to understand the mechanisms linking fatty acid transport to metabolism, Immunol. Endocr. Metab. Agents Med. Chem., 9, 11, 10.2174/187152209788009850 Black, 1997, Mutational analysis of a fatty acyl-coenzyme a synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity, J. Biol. Chem., 272, 4896, 10.1074/jbc.272.8.4896 Bonen, 2004, Regulation of fatty acid transport by fatty acid translocase/CD36, Proc. Nutr. Soc., 63, 245, 10.1079/PNS2004331 Chen, 2013, Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism, Metab. Eng., 15, 48, 10.1016/j.ymben.2012.11.002 Chiu, 2005, Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy, Circ. Res., 96, 225, 10.1161/01.RES.0000154079.20681.B9 Coe, 1999, The fatty acid transport protein (FATP1) is a very long chain acyl-CoA synthetase, J. Biol. Chem., 274, 36300, 10.1074/jbc.274.51.36300 DiRusso, 2008, Functional domains of the fatty acid transport proteins: studies using protein chimeras, Biochim. Biophys. Acta, 1781, 135, 10.1016/j.bbalip.2008.01.002 DiRusso, 2005, Comparative biochemical studies of the murine fatty acid transport proteins (FATP) expressed in yeast, J. Biol. Chem., 280, 16829, 10.1074/jbc.M409598200 Doege, 2006, Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis, Gastroenterology, 130, 1245, 10.1053/j.gastro.2006.02.006 Doshi, 2013, Transporter-mediated biofuel secretion, Proc. Natl. Acad. Sci. USA, 110, 7642, 10.1073/pnas.1301358110 Dunlop, 2011, Engineering microbes for tolerance to next- generation biofuels, Biotechnol. Biofuels, 4, 32, 10.1186/1754-6834-4-32 Dunlop, 2011, Engineering microbial biofuel tolerance and export using efflux pumps, Mol. Syst. Biol., 7, 487, 10.1038/msb.2011.21 Falcon, 2010, FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase, AJP Endocrinol. Metab., 299, E384, 10.1152/ajpendo.00226.2010 Fisher, 2014, Enhancing tolerance to short-chain alcohols by engineering the Escherichia coli AcrB efflux pump to secrete the non-native substrate n-butanol, ASC Synth. Biol., 3, 30, 10.1021/sb400065q Fortman, 2008, Biofuel alternatives to ethanol: pumping the microbial well, Trends Biotechnol., 26, 375, 10.1016/j.tibtech.2008.03.008 Gibson, 2009, Enzymatic assembly of DNA molecules up to several hundred kilobases, Nat. Methods, 6, 343, 10.1038/nmeth.1318 Gimeno, 2003, Characterization of a heart-specific fatty acid transport protein, J. Biol. Chem., 278, 16039, 10.1074/jbc.M211412200 Glatz, 2010, Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease, Physiol. Rev., 90, 367, 10.1152/physrev.00003.2009 Halter, 2006, ABC lipid transporters: extruders, flippases, or flopless activators?, FEBS Lett., 580, 1171, 10.1016/j.febslet.2005.12.019 Hamacher, 2002, Characterization of the xylose-transporting properties of yeast hexose transporters and their influence on xylose utilization, Microbiology, 148, 2783, 10.1099/00221287-148-9-2783 Herrmann, 2001, Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase, Gene, 270, 31, 10.1016/S0378-1119(01)00489-9 Herrmann, 2001, Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase, Gene, 270, 31, 10.1016/S0378-1119(01)00489-9 Hirsch, 1998, A family of fatty acid transporters conserved from mycobacterium to man, Proc. Natl. Acad. Sci. USA, 95, 8625, 10.1073/pnas.95.15.8625 Hisanaga, 2004, Structural basis of the substrate-specific two-step catalysis of long chain fatty acyl-CoA synthetase dimer, J. Biol. Chem., 279, 31717, 10.1074/jbc.M400100200 Kerr, 2007, Global warming is changing the world, Science, 316, 188, 10.1126/science.316.5822.188 Khoomrung, 2013, Rapid quantification of yeast lipid using microwave-assisted total lipid extraction and HPLC-CAD, Anal. Chem., 85, 4912, 10.1021/ac3032405 Kieboom, 1998, Identification and molecular characterization of an efflux pump involved in Pseudomonas putida S12 solvent tolerance, J. Biol. Chem., 273, 85, 10.1074/jbc.273.1.85 Kochan, 2009, Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A, J. Mol. Biol., 388, 997, 10.1016/j.jmb.2009.03.064 Le Hir, 2013, ABCG9, ABCG11 and ABCG14 ABC transporters are required for vascular development in Arabidopsis, Plant J., 76, 811, 10.1111/tpj.12334 Li, 2016, Enabling glucose/xylose co-transport in yeast through the directed evolution of a sugar transporter, Appl. Microbiol. Biotechnol., 100, 10215, 10.1007/s00253-016-7879-8 Li, 2016, Fatty acid and lipid transport in plant cells, Trends Plant Sci., 21, 145, 10.1016/j.tplants.2015.10.011 Martin, 2000, The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression, genomics, 66, 296, 10.1006/geno.2000.6191 McFarlane, 2010, Arabidopsis ABCG transporters, which are required for export of diverse cuticular lipids, dimerize in different combinations, Plant Cell, 22, 3066, 10.1105/tpc.110.077974 Mihalik, 2002, Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling, J. Biol. Chem., 277, 24771, 10.1074/jbc.M203295200 Minty, 2011, Evolution combined with genomic study elucidates genetic bases of isobutanol tolerance in Escherichia coli, Microb. Cell Fact., 10, 18, 10.1186/1475-2859-10-18 Nijland, 2016, Improving pentose fermentation by preventing ubiquitination of hexose transporters in Saccharomyces cerevisiae, Biotechnol. Biofuels, 9, 158, 10.1186/s13068-016-0573-3 Pei, 2004, Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells, J. Biol. Chem., 279, 54454, 10.1074/jbc.M410091200 Rutter, 2015, Engineering Yarrowia lipolytica for production of medium-chain fatty acids, Appl. Microbiol. Biotechnol., 99, 7359, 10.1007/s00253-015-6764-1 Schaffer, 1994, Expression cloning and characterization of a novel adipocyte long-chain fatty-acid transport protein, Cell, 79, 427, 10.1016/0092-8674(94)90252-6 Schmuth, 2005, Differential expression of fatty acid transport proteins in epidermis and skin appendages, J. Investig. Dermatol., 125, 1174, 10.1111/j.0022-202X.2005.23934.x Shin, 2017, The amino-terminal tail of Hxt11 confers membrane stability to the Hxt2 sugar transporter and improves xylose fermentation in the presence of acetic acid, Biotechnol. Bioeng., 114, 1937, 10.1002/bit.26322 Stahl, 2001, Fatty acid transport proteins: a current view of a growing family, Trends Endocrinol. Metab., 12, 266, 10.1016/S1043-2760(01)00427-1 Stephanopoulos, 2007, Challenges in engineering microbes for biofuels production, Science, 315, 801, 10.1126/science.1139612 Tang, 2015, Enhanced production of fatty alcohols by engineering the TAGs synthesis pathway in Saccharomyces cerevisiae, Biotechnol. Bioeng., 112, 386, 10.1002/bit.25356 Turner, 2015, Trade-offs in improving biofuel tolerance using combinations of efflux pumps, ACS Synth. Biol., 4, 1056, 10.1021/sb500307w Van Helvoort, 1996, MDR1 p-glycoprotein is a lipid translocase of broad specificity, while MDR3 p-glycoprotein specifically translocates phosphatidylcholine, Cell, 87, 507, 10.1016/S0092-8674(00)81370-7 Verduyn, 1992, Effect of benzoic acid on metabolic fluxes in yeasts: a continuous-culture study on the regulation of respiration and alcoholic fermentation, Yeast, 8, 501, 10.1002/yea.320080703 Watkins, 1999, Human very long.chain acyl.CoA synthetase and two human homologs- initial characterization and relationship to fatty acid transport protein, Prostaglandins, Leukot. Essent. Fat. Acids, 60, 323, 10.1016/S0952-3278(99)80007-6 Xu, 2013, CD36 Enhances fatty acid uptake by increasing the rate of intracellular esterification but not transport across the plasma membrane, Biochemistry, 52, 7254, 10.1021/bi400914c Youngquist, 2013, Production of medium chain length fatty alcohols from glucose in Escherichia coli, Metab. Eng., 20, 177, 10.1016/j.ymben.2013.10.006 Zhou, 2014, Fatty acid-derived biofuels and chemicals production in Saccharomyces cerevisiae, Front. Bioeng. Biotechnol., 2, 32, 10.3389/fbioe.2014.00032 Zhou, 2016, Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories, Nat. Commun., 7, 11709, 10.1038/ncomms11709 Zou, 2002, Fatty acid transport in Saccharomyces cerevisiae: directed mutagenesis of FAT1 distinguishes the biochemical activities associated with Fat1p, J. Biol. Chem., 277, 31062, 10.1074/jbc.M205034200