Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
Leena P. Bharath1, Madhur Agrawal2,3, Grace McCambridge1, Dequina A. Nicholas4, Hatice Hasturk5, Jing Liu6, Kai Jiang7, Rui Liu8, Zhenheng Guo2, Jude Deeney9, Caroline M. Apovian9, Jennifer Snyder-Cappione10,11, Gregory S. Hawk12, Rebecca M. Fleeman13, Riley M.F. Pihl11, Katherine Thompson12, Anna C. Belkina11,14, Licong Cui6,15, Elizabeth A. Proctor13,16, Philip A. Kern3,17
1Department of Nutrition and Public Health, Merrimack College, North Andover, MA, USA
2Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA
3Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, USA
4Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of California, San Diego, San Diego, CA, USA
5Forsyth Institute, Cambridge, MA, USA
6Department of Computer Science, University of Kentucky, Lexington, KY, USA
7Department of Physiology, University of Kentucky, Lexington, KY, USA
8Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA
9Department of Medicine, Endocrinology, Diabetes & Nutrition, Boston University School of Medicine, Boston, MA, USA
10Department of Microbiology, Boston University School of Medicine, Boston, MA, USA
11Flow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, USA
12Department of Statistics, University of Kentucky, Lexington, KY, USA
13Departments of Neurosurgery and Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA
14Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA
15School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA
16Departments of Biomedical Engineering, and Engineering Science & Mechanics and Center for Neural Engineering, Pennsylvania State University, University Park, PA, USA
17Department of Medicine, University of Kentucky, Lexington, KY USA
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Thông tin xuất bản
Cell Metabolism
Tập 32
44-55.e6
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