The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization

Journal of Molecular Biology - Tập 426 - Trang 1848-1860 - 2014
Andrea E. Prota1, Franck Danel2, Felix Bachmann2, Katja Bargsten1, Rubén M. Buey1, Jens Pohlmann2, Stefan Reinelt2, Heidi Lane2, Michel O. Steinmetz1
1Laboratory of Biomolecular Research, Department of Biology and Chemistry Paul Scherrer Institut, 5232 Villigen, Switzerland
2Basilea Pharmaceutica International Ltd., 4058 Basel, Switzerland

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