Changes in islet blood flow in rats with NIDDM
Tóm tắt
Islet blood flow was quantified in NIDDM rats either of the GK strain on after neonatal injection of STZ (n0-STZ), using the non-radioactive microsphere technique. In the basal state, there was a good correlation between plasma insulin level and islet blood flow, i.e. both were increased or decreased in comparison to those of control rats in GK and n0-STZ rats, respectively. The increased islet blood flow and plasma insulin levels observed in the GK rats were abolished by bilateral subdiaphragmatic vagotomy. During a glucose challenge, whereas plasma insulin and islet blood flow were doubled in control rats, these parameters were not modified in the diabetic rats. These data demonstrate an alteration in the islet blood flow of diabetic rats during a glucose challenge which could participate in the abnormal glucose-induced insulin secretion previously described in these two models.
Tài liệu tham khảo
Giroix MH, Portha B, Kergoat M, Picon L (1983) Glucose insensitivity and amino acid hypersensitivity of insulin release in rats with non insulin dependent diabetes. A study with the perfused pancreas. Diabetes 32: 445–451
Portha B, Blondel O, Serradas P, et al. (1989) The rats models of non insulin-dependent diabetes induced by neonatal streptozotocin. Diab Metab 15: 61–75
McMillan DE (1984) The microcirculation in diabetes. Microcirc Endothelium Lymphatics 1: 3–24
Jansson L (1984) The blood flow to the pancreas and the islets of Langerhans during an intraperitoneal glucose load in the rat. Diabetes Res 1: 111–114
Jansson L, Hellerström C (1983) Stimulation by glucose of the blood flow to the pancreatic islets of the rats. Diabetologia 25: 45–50
Jansson L, Hellerström C (1986) Glucose induced changes in pancreatic islet blood flow mediated by central nervous system. Am J Physiol 251: E644-E647
Atef N, Ktorza A, Picon L, Pénicaud L (1992) Increased islet blood flow in obese rats: role of the autonomic nervous system. Am J Physiol 262: E736-E740
Blondel O, Bailbe D, Portha B (1989) Relation of insulin deficiency to impaired insulin action in NIDDM adult rats given streptozotocin as neonates. Diabetes 36: 610–617
Goto Y, Suzuki K, Sasaki M, Ono T, Abe S (1988) GK rats as model of non-insulin-dependent diabetes. Selective breeding over 35 generations. In: Shafrir E, Renold AE (eds) Frontiers in diabetes research. Lessons from animal diabetes II. Libbey London, pp 301–303
Portha B, Serradas P, Bailbé D, Suzuki K, Goto Y, Giroix MH (1991) B cell insensitivity to glucose in the GK rats, a spontaneous nonobese model for type II diabetes. Diabetes 40: 486–491
Giroix MH, Vesco L, Portha B (1992) Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of non insulin dependent diabetes. Endocrinol 132: 815–822
Jansson L, Hellerström C (1981) A rapid method of visualizing the pancreatic islets of studies of islet capillary blood flow using non radioactive microspheres. Acta Physiol Scand 113: 371–374
Jansson L (1985) Dissociation between pancreatic islet blood flow and insulin release in the rat. Acta Physiol Scand 124: 223–228
Jansson L, Sandler S (1991) Partial pancreatectomy in rats causes an impairment of the glucose induced stimulation of pancreatic islet blood flow. Experientia 47: 627–629
Sandler S, Jansson L (1987) Blood flow measurements in autotransplanted pancreatic islets of the rat. J Clin Invest 80: 17–21
Svensson AM, Abdel-Halim SM, Efendic S, Jansson L, Bodin B, Östenson C-G (1993) F1-hybrids of the GK-Wistar rat have a nervously mediated increased islet blood perfusion. Diabetologia 36 [Suppl 1]: A86 (Abstract)
Jansson L, Sandler S (1992) Alloxan but not streptozotocin, increases blood perfusion of pancreatic islets in rats. Am J Physiol 263: E57-E63
Portha B, Kergoat M (1985) Dynamics of glucose-induced insulin release during the spontaneous remission of streptozotocin diabetes induced in newborn rat. Diabetes 34: 574–579
Haddy FJ, Scott JB (1968) Metabolically linked vasoactive chemicals in local regulation of blood flow. Physiol Rev 48: 688–707
Styrud J, Eriksson UJ, Jansson L (1992) A continuous 48-hour glucose infusion in rats causes both an acute and a persistent redistribution of the blood flow within the pancreas. Endocrinol 130: 2692–2696