Rare earth elements (REE) in biology and medicine

P. Ascenzi1, M. Bettinelli2, A. Boffi3, M. Botta4, G. De Simone1, C. Luchinat5, E. Marengo4, H. Mei6, S. Aime7
1Dipartimento di Scienze, Università Roma Tre, Rome, Italy
2Dipartimento di Biotecnologie, Università di Verona, Verona, Italy
3Dipartimento di Biochimica, Università “Sapienza” Roma, Rome, Italy
4Dipartimento di Scienze e Tecnologie, Università del Piemonte Orientale, Alessandria, Italy
5Dipartimento di Chimica, Università di Firenze, Florence, Italy
6Deutsches Reuma-Forschungszentrum, a Leibniz Institute, Berlin, Germany
7Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università di Torino, Turin, Italy

Tóm tắt

This survey reports on topics that were presented at the workshop on “Challenges with Rare Earth Elements. The Periodic Table at work for new Science & Technology” hold at the Academia dei Lincei in November 2019. The herein reported materials refer to presentations dealing with studies and applications of rare earth elements (REE) in several areas of Biology and Medicine. All together they show the tremendous impact REE have in relevant fields of living systems and highlight, on one hand, the still existing knowledge gap for an in-depth understanding of their function in natural systems as well as the very important role they already have in providing innovative scientific and technological solutions in a number of bio-medical areas and in fields related to the assessment of the origin of food and on their manufacturing processes. On the basis of the to-date achievements one expects that new initiatives will bring, in a not too far future, to a dramatic increase of our understanding of the REE involvement in living organisms as well as a ramp-up in the exploitation of the peculiar properties of REE for the design of novel applications in diagnostic procedures and in the set-up of powerful medical devices. This scenario calls the governmental authorities for new responsibilities to guarantee a continuous availability of REE to industry and research labs together with providing support to activities devoted to their recovery/recycling.

Từ khóa


Tài liệu tham khảo

Aceto M (2016) The Use of ICP-MS in Food Traceability. In: Espineira M, Santaclara FJ (eds) Advances in food traceability techniques and technologies: improving quality throughout the food chain. Elsevier, UK, pp 137–164

Aceto M, Baldizzone M, Oddone M (2009) Keeping the track of quality: Authentication and traceability studies on wine. In: O’Byrne P (ed) Red Wine and Health. Nova Science, New York, pp 429–466

Aceto M, Robotti E, Oddone M, Baldizzone M, Bonifacino G, Bezzo G, Di Stefano R, Gosetti F, Mazzucco E, Manfredi M, Marengo E (2013) A traceability study on the Moscato wine chain. Food Chem 138:1914–1922

Aceto M, Musso D, Calà E, Arieri F, Oddone M (2017) Role of lanthanides in the traceability of the milk production chain. J Agric Food Chem 65:4200–4208

Aceto M, Calà E, Musso D, Regalli N, Oddone M (2019) A preliminary study on the authentication and traceability of extra virgin olive oil made from Taggiasca olives by means of trace and ultra-trace elements distribution. Food Chem 298:125047

Agarwal N, Kalra VK (1983) Interaction of lanthanide cations and uranyl ion with the calcium/proton antiport system in Mycobacterium phlei. Biochim Biophys Acta 727:285–292

Aime S, Botta M, Fasano M, Terreno E (1998) Lanthanide(III) chelates for NMR biomedical applications. Chem Soc Rev 27:19–29

Aime S, Botta M, Terreno E (2005) Gd(III)-based contrast agents for MRI. Adv Inorg Chem 57:173–232

Anthony C (2004) The quinoprotein dehydrogenases for methanol and glucose. Arch Biochem Biophys 428:2–9

Ballabio D, Robotti E, Grisoni F, Quasso F, Bobba M, Vercelli S, Gosetti F, Calabrese G, Sangiorgi E, Orlandi M, Marengo E (2018) Chemical profiling and multivariate data fusion methods for the identification of the botanical origin of honey. Food Chem 266:79–89

Banci L, Bertini I, Bren KL, Cremonini MA, Gray HB, Luchinat C, Turano P (1996) The use of pseudocontact shifts to refine solution structures of paramagnetic metalloproteins: Met80Ala cyano-cytochrome c as an example. J Biol Inorg Chem 1:117–126

Banci L, Bertini I, Huber JG et al (1998) Partial orientation of oxidized and reduced cytochrome b5at high magnetic fields: magnetic susceptibility anisotropy contributions and consequences for protein solution structure determination. J Am Chem Soc 120:12903–12909

Bandura DR, Baranov VI, Ornatsky OI, Antonov A, Kinach R, Lou X, Pavlov S, Vorobiev S, Dick JE, Tanner SD (2009) Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry. Anal Chem 81:6813–6822

Baumgart S, Peddinghaus A, Schulte-Wrede U, Mei HE, Grützkau A (2017) OMIP-034: comprehensive immune phenotyping of human peripheral leukocytes by mass cytometry for monitoring immunomodulatory therapies. Cytometry A. 91:34–38

Bendall SC, Simonds EF, Qiu P et al (2011) Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science 332:687–696

Bertini I, Capozzi F, Luchinat C, Nicastro G, Xia Z (1993) Water proton relaxation for some lanthanide aqua ions in solution. J Phys Chem 97:6351–6354

Bertini I, Janik MBL, Lee YM, Luchinat C, Rosato C (2001a) Magnetic susceptibility tensor anisotropies for a lanthanide ion series in a fixed protein matrix. J Am Chem Soc 123:4181–4188

Bertini I, Luchinat C, Parigi G (2001) Solution NMR of paramagnetic molecules: applications to metallobiomolecules and models. In: Current methods in inorganic chemistry. Elsevier, Amsterdam

Bodenmiller B (2016) Multiplexed epitope-based tissue imaging for discovery and healthcare applications. Cell Syst. 2:225–238

Bogart JA, Lewis AJ, Schelter EJ (2015) DFT study of the active site of the XoxF-type natural, cerium-dependent methanol dehydrogenase enzyme. Chemistry 21:1743–1748

Böttcher C, Schlickeiser S, Sneeboer MAM et al (2019) Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry. Nat Neurosci 22:78–90

Budzinski L, Schulz AR, Baumgart S et al (2019) Osmium-labeled microspheres for bead-based assays in mass cytometry. J Immunol 202:3103–3112

Bunzli JC (2004) Luminescent lanthanide probes as diagnostic and therapeutic tools. Met Ions Biol Syst 42:39–75

Calisti L, Trabuco MC, Boffi A, Testi C, Montemiglio LC, des Georges A et al (2018) Engineered ferritin for lanthanide binding. PLoS ONE 13(8):e0201859. https://doi.org/10.1371/journal.pone.0201859

Catena R, Özcan A, Zivanovic N, Bodenmiller B (2016) Enhanced multiplexing in mass cytometry using osmium and ruthenium tetroxide species. Cytometry A. 89:491–497

Chang Q, Ornatsky OI, Siddiqui I, Straus R, Baranov VI, Hedley DW (2016) Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues. Sci Rep. 6:36641

Chen Y, Luo Y, Qiu N, Fei H, Sheng L, Wang R, Cao F (2015) Ce3+ induces flavonoids accumulation by regulation of pigments, ions, chlorophyll fluorescence and antioxidant enzymes in suspension cells of Ginkgo biloba L. Plant Cell Tiss Organ Cult 123:283–296

Chistoserdova L (2016) Lanthanides: new life metals? World J Microbiol Biotechnol 32:138

Cossarizza A et al (2019) Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol. 49:1457–1973

Cotruvo JA Jr (2019) The chemistry of lanthanides in biology: recent discoveries, emerging principles, and technological applications. ACS Cent Sci 5:1496–1506

Daumann LJ (2019) Essential and ubiquitous: the emergence of lanthanide metallobiochemistry. Angew Chem Int 58:12795–12802

De Simone G, Polticelli F, Aime S, Ascenzi P (2019) No lanthanides-based catalysis in eukaryotes. IUBMB Life 71:398–399

Ene CD, Ruta LL, Nicolau I, Popa CV, Iordache V, Neagoe AD, Farcasanu IC (2015) Interaction between lanthanide ions and Saccharomyces cerevisiae cells. J Biol Inorg Chem 20:1097–1107

Fashui H (2002) Study on the mechanism of cerium nitrate effects on germination of aged rice seed. Biol Trace Elem Res 87:191–200

Fitriyanto NA, Fushimi M, Matsunaga M, Pertiwiningrum A, Iwama T, Kawai K (2011) Molecular structure and gene analysis of Ce3+-induced methanol dehydrogenase of Bradyrhizobium sp. MAFF211645. J Biosci Bioeng 111:613–617

Ghosh M, Anthony C, Harlos K, Goodwin MG, Blake C (1995) The refined structure of the quinoprotein methanol dehydrogenase from Methylobacterium extorquens at 1.94 Å. Structure 3:177–187

Guo Y, Baumgart S, Stärk HJ, Harms H, Müller S (2017) Mass cytometry for detection of silver at the bacterial single cell level. Front Microbiol 8:1326

Han G, Chen SY, Gonzalez VD, Zunder ER, Fantl WJ, Nolan GP (2017) Atomic mass tag of bismuth-209 for increasing the immunoassay multiplexing capacity of mass cytometry. Cytometry A. 91:1150–1163

Hibi Y, Asai K, Arafuka H, Hamajima M, Iwama T, Kawai K (2011) Molecular structure of La3+-induced methanol dehydrogenase-like protein in Methylobacteriumn radiotolerans. J Biosci Bioeng 111:547–549

Keltjens JT, Pol A, Reimann J, Op den Camp HJ (2014) PQQ-dependent methanol dehydrogenases: rare-earth elements make a difference. Appl Microbiol Biotechnol 98:6163–6183

López-Serrano Oliver A, Haase A, Peddinghaus A, Wittke D, Jakubowski N, Luch A, Grützkau A, Baumgart S (2019) Mass cytometry enabling absolute and fast quantification of silver nanoparticle uptake at the single cell level. Anal Chem 91:11514–11519

Lou X, Zhang G, Herrera I, Kinach R, Ornatsky O, Baranov V, Nitz M, Winnik MA (2007) Polymer-based elemental tags for sensitive bioassays. Angew Chem Int Ed Engl 46:6111–6114

Manfredi M, Robotti E, Quasso F, Mazzucco E, Calabrese G, Marengo E (2018) Fast classification of hazelnut cultivars through portable infrared spectroscopy and chemometrics. Spectrochimica Acta 189:427–435

Marengo E, Aceto M, Robotti E, Liparota MC, Bobba M, Pantò G (2005) Archaeometric characterisation of ancient pottery belonging to the archaeological site of Novalesa Abbey (Piedmont, Italy) by ICP-MS and spectroscopic techniques coupled to multivariate statistical tools. Anal Chim Acta 537:359–375

Mei HE, Leipold MD, Schulz AR, Chester C, Maecker HT (2015) Barcoding of live human peripheral blood mononuclear cells for multiplexed mass cytometry. J Immunol. 194:2022–2031

Mei HE, Leipold MD, Maecker HT (2016) Platinum-conjugated antibodies for application in mass cytometry. Cytometry A. 89:292–300

Nair N, Mei HE, Chen SY et al (2015) Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy. Arthritis Research & Therapy 17:127

Nakagawa T, Mitsui R, Tani A, Sasa K, Tashiro S, Iwama T, Hayakawa T, Kawai K (2012) A catalytic role of XoxF1 as La3+-dependent methanol dehydrogenase in Methylobacterium extorquens strain AM1. PLoS ONE 7:e50480

Nitsche C and Otting G (2018) Intrinsic and Extrinsic Paramagnetic Probes in Paramagnetism. In Luchinat C, Parigi G, Ravera E (Eds.) Experimental Biomolecular NMR,, RSC, chapter 2

Nojiri M, Hira D, Yamaguchi K, Okajima T, Tanizawa K, Suzuki S (2006) Crystal structures of cytochrome cL and methanol dehydrogenase from Hyphomicrobium denitrificans: structural and mechanistic insights into interactions between the two proteins. Biochemistry 45:3481–3492

Oddone M, Aceto M, Baldizzone M, Musso D, Osella D (2009) Authentication and traceability study of hazelnuts from piedmont, Italy. J Agric Food Chem 57:3404–3408

Parigi G, Ravera E, Luchinat C (2019) Magnetic susceptibility and paramagnetism-based NMR. Prog Nucl Magn Reson Spectrosc 114–115:211–236

Pichaandi J, Zhao G, Bouzekri A et al (2019) Lanthanide nanoparticles for high sensitivity multiparameter single cell analysis. Chem Sci. 10:2965–2974

Picone N, Op den Camp HJ (2019) Role of rare earth elements in methanol oxidation. Curr Opin Chem Biol 49:39–44

Pol A, Barends TR, Dietl A, Khadem AF, Eygensteyn J, Jetten MS, Op den Camp HJ (2014) Rare earth metals are essential for methanotrophic life in volcanic mudpots. Environ Microbiol 16:255–264

Qin X, Xiaowang Liu, Huang W, Bettinelli M, Xiaogang Liu (2017) Lanthanide-activated phosphors based on 4f-5d optical transitions: theoretical and experimental aspects. Chem Rev 117:4488–4527

Rajapakse HE, Reddy DR, Mohandessi S, Butlin NG, Miller LW (2009) Luminescent terbium protein labels for time-resolved microscopy and screening. Angew Chem Int 48:4990–4992

Ramírez-Olvera SM, Trejo-Téllez LI, García-Morales S, Pérez-Sato JA, Gómez-Merino FC (2018) Cerium enhances germination and shoot growth, and alters mineral nutrient concentration in rice. PLoS ONE 13:e0194691

Ronda C, Wieczorek H, Khanin V, Rodnyi P (2016) Review-Scintillators for medical imaging: a tutorial overview. ECS J Solid State Sci Technol 5:R3121–R3125

Sala D, Giachetti A, Luchinat C, Rosato A (2016) A protocol for the refinement of NMR structures using simultaneously pseudocontact shift restraints from multiple lanthanide ions. J Biomol NMR 66:175–185

Schulz AR, Mei HE (2019) Surface barcoding of live PBMC for multiplexed mass cytometry. Methods Mol Biol 1989:93–108

Schulz AR, Stanislawiak S, Baumgart S, Grützkau A, Mei HE (2017) Silver nanoparticles for the detection of cell surface antigens in mass cytometry. Cytometry A. 91:25–33

Terreno E, Delli Castelli D, Viale A, Aime S (2010) Challenges for molecular magnetic resonance imaging. Chem Rev 110:3019–3042

Wahsner J, Gale EM, Rodríguez-Rodríguez A, Caravan P (2019) Chemistry of MRI contrast agents: current challenges and new frontiers. Chem Rev 119:957–1057

Wang X, Lin Y, Liu D, Xu H, Liu H, Zhao F (2012) Cerium toxicity, uptake and translocation in Arabidopsis thaliana seedlings. J Rare Earth 30:579–585

Williams PA, Coates L, Mohammed F, Gill R, Erskine PT, Coker A, Wood SP, Anthony C, Cooper JB (2005) The atomic resolution structure of methanol dehydrogenase from Methylobacterium extorquens. Acta Crystallogr D Biol Crystallogr 61:75–79

Willis LM, Park H, Watson MWL, Majonis D, Watson JL, Nitz M (2018) Tellurium-based mass cytometry barcode for live and fixed cells. Cytometry A. 93:685–694

Zhao J, Jin JC, Zhou ZQ, Xia CF, Yang XG, Jiang FL, Dai J, Liu Y (2013) High concentration of gadolinium ion modifying isolated rice mitochondrial biogenesis. Biol Trace Elem Res 156:308–315