Small animals models for drug discovery
Tài liệu tham khảo
Schuessler, 1995, A computer-controlled research ventilator for small animals: design and evaluation, IEEE Trans Biomed Eng, 42, 860, 10.1109/10.412653
1986, Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, Am Rev Respir Dis, 1987, 225
Shampain, 1982, An animal model of late pulmonary responses to alternaria challenge, Am Rev Respir Dis, 126, 493
Eidelman, 1988, Late airway responses to antigen challenge in sensitized inbred rats, Am Rev Respir Dis, 137, 1033, 10.1164/ajrccm/137.5.1033
Hamel, 1986, Late pulmonary responses induced by ascaris allergen in conscious squirrel monkeys, J Appl Physiol, 61, 2081, 10.1152/jappl.1986.61.6.2081
Soler, 1991, Separation of late bronchial responses from airway hyperresponsiveness in allergic sheep, J Appl Physiol, 70, 617, 10.1152/jappl.1991.70.2.617
Fornhem, 1995, Allergen-induced late-phase airways obstruction in the pig - the role of endogenous cortisol, Eur Respir J, 8, 928, 10.1183/09031936.95.08071100
Gauvreau, 2008, Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses, Am J Respir Crit Care Med, 177, 952, 10.1164/rccm.200708-1251OC
Wenzel, 2007, Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies, Lancet, 370, 1422, 10.1016/S0140-6736(07)61600-6
Herszberg, 2006, Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling, J Allergy Clin Immunol, 118, 382, 10.1016/j.jaci.2006.03.044
Hirt, 2009, Airway hyperresponsiveness to adenosine 5’-monophosphate in feline chronic inflammatory lower airway disease, Vet J
Bartlett, 2008, Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation, Nat Med, 14, 199, 10.1038/nm1713
Hoymann, 2007, Invasive and noninvasive lung function measurements in rodents, J Pharmacol Toxicol Methods, 55, 16, 10.1016/j.vascn.2006.04.006
Bates, 2009, Pulmonary mechanics: a system identification perspective, Conf Proc IEEE Eng Med Biol Soc, 1, 170
Lundblad, 2007, Penh is not a measure of airway resistance!, Eur Respir J, 30, 805, 10.1183/09031936.00091307
Glaab, 2001, Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice, Am J Physiol Lung Cell Mol Physiol, 280, L565, 10.1152/ajplung.2001.280.3.L565
Glaab, 2004, Repetitive measurements of pulmonary mechanics to inhaled cholinergic challenge in spontaneously breathing mice, J Appl Physiol, 97, 1104, 10.1152/japplphysiol.01182.2003
Thamrin, 2004, Sensitivity analysis of respiratory parameter estimates in the constant-phase model, Ann Biomed Eng, 32, 815, 10.1023/B:ABME.0000030257.88945.81
Kumar, 2002, Modeling allergic asthma in mice: pitfalls and opportunities, Am J Respir Cell Mol Biol, 27, 267, 10.1165/rcmb.F248
Mosmann, 1986, Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins, J Immunol, 136, 2348, 10.4049/jimmunol.136.7.2348
Harrington, 2005, Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages, Nat Immunol, 6, 1123, 10.1038/ni1254
Wolk, 2010, Biology of interleukin-22, Semin Immunopathol, 32, 17, 10.1007/s00281-009-0188-x
Annunziato, 2009, Heterogeneity of human effector CD4+ T cells, Arthritis Res Ther, 11, 257, 10.1186/ar2843
Berlin, 2006, Inhibition of SCF attenuates peribronchial remodeling in chronic cockroach allergen-induced asthma, Lab Invest, 86, 557, 10.1038/labinvest.3700419
Nemeth, 2010, Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma, Proc Natl Acad Sci U S A, 107, 5652, 10.1073/pnas.0910720107
Hammad, 2009, House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells, Nat Med, 15, 410, 10.1038/nm.1946
Lambrecht, 2009, Biology of lung dendritic cells at the origin of asthma, Immun, 31, 412, 10.1016/j.immuni.2009.08.008
Henrickson, 2008, T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation, Nat Immunol, 9, 282, 10.1038/ni1559
Blink, 2010, IgE regulates T helper cell differentiation through FcgammaRIII mediated dendritic cell cytokine modulation, Cell Immunol, 264, 54, 10.1016/j.cellimm.2010.04.011
Ito, 2005, TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand, J Exp Med, 202, 1213, 10.1084/jem.20051135
Sokol, 2008, A mechanism for the initiation of allergen-induced T helper type 2 responses, Nat Immunol, 9, 310, 10.1038/ni1558
Yang, 2008, Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses, J Exp Med, 205, 79, 10.1084/jem.20062027
Dillon, 2004, A toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells, J Immunol, 172, 4733, 10.4049/jimmunol.172.8.4733
Machida, 2004, Cysteinyl leukotrienes regulate dendritic cell functions in a murine model of asthma, J Immunol, 172, 1833, 10.4049/jimmunol.172.3.1833
Barrett, 2009, Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells, J Immunol, 182, 1119, 10.4049/jimmunol.182.2.1119
Huh, 2003, Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa but not in the lung parenchyma, J Exp Med, 198, 19, 10.1084/jem.20021328
Watanabe, 1995, Transfer of allergic airway responses with antigen-primed CD4+ but not CD8+ T cells in brown Norway rats, J Clin Invest, 96, 1303, 10.1172/JCI118165
Sapienza, 1990, Role of leukotriene D4 in the early and late pulmonary responses of rats to allergen challenge, Am Rev Respir Dis, 142, 353, 10.1164/ajrccm/142.2.353
Martin, 1993, Leukotrienes in bile during the early and the late airway responses after allergen challenge of sensitized rats, Am Rev Respir Dis, 147, 104, 10.1164/ajrccm/147.1.104
Yu, 1995, Cellular infiltration and eicosanoid synthesis in brown Norway rat lungs after allergen challenge, Am J Respir Cell Mol Biol, 13, 477, 10.1165/ajrcmb.13.4.7546778
Cartier, 1982, Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway caliber, J Allergy Clin Immunol, 70, 170, 10.1016/0091-6749(82)90038-0
Yager, 1989, Amplification of airway constriction due to liquid filling of airway interstices, J Appl Physiol, 66, 2873, 10.1152/jappl.1989.66.6.2873
Wagers, 2004, The allergic mouse model of asthma: normal smooth muscle in an abnormal lung?, J Appl Physiol, 96, 2019, 10.1152/japplphysiol.00924.2003
Wagers, 2007, Intrinsic and antigen-induced airway hyperresponsiveness are the result of diverse physiological mechanisms, J Appl Physiol, 102, 221, 10.1152/japplphysiol.01385.2005
Dunnill, 1969, A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis and in emphysema, Thorax, 24, 176, 10.1136/thx.24.2.176
Heard, 1973, Hyperplasia of bronchial muscle in asthma, J Pathol, 110, 319, 10.1002/path.1711100406
Sapienza, 1991, Structural changes in the airways of sensitized Brown Norway rats after antigen challenge, Am Rev Respir Dis, 144, 423, 10.1164/ajrccm/144.2.423
Panettieri, 1995, Repeated allergen inhalations induce DNA synthesis in airway smooth muscle and epithelial cells in vivo, Chest, 107, S 94, 10.1378/chest.107.3_Supplement.94S
Salmon, 1999, Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodelling, Eur Respir J, 14, 633, 10.1034/j.1399-3003.1999.14c25.x
Leigh, 2002, Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation, Am J Respir Cell Mol Biol, 27, 526, 10.1165/rcmb.2002-0048OC
Henderson, 2002, A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model, Am J Respir Crit Care Med, 165, 108, 10.1164/ajrccm.165.1.2105051
Tamaoka, 2008, The epidermal growth factor receptor mediates allergic airway remodeling in the rat, Eur Respir J, 10.1183/09031936.00166907
Palmans, 2000, Prolonged allergen exposure induces structural airway changes in sensitized rats, Am J Respir Crit Care Med, 161, 627, 10.1164/ajrccm.161.2.9902094
Pini, 2006, Airway remodeling in allergen-challenged Brown Norway rats: distribution of proteoglycans, Am J Physiol Lung Cell Mol Physiol, 290, L1052, 10.1152/ajplung.00122.2005
Labonte, 2009, The effects of repeated allergen challenge on airway smooth muscle structural and molecular remodeling in a rat model of allergic asthma, Am J Physiol Lung Cell Mol Physiol, 297, L698, 10.1152/ajplung.00142.2009
Vanacker, 2001, Fluticasone inhibits but does not reverse allergen-induced structural airway changes, Am J Respir Crit Care Med, 163, 674, 10.1164/ajrccm.163.3.2004160
Kumar, 2002, Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma, Clin Exp Allergy, 32, 1104, 10.1046/j.1365-2222.2002.01420.x
Leigh, 2004, Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice, Am J Respir Crit Care Med, 169, 860, 10.1164/rccm.200305-706OC
Hogaboam, 2000, Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus, Am J Pathol, 156, 723, 10.1016/S0002-9440(10)64775-X
Dharajiya, 2007, Pollen NAD(P)H oxidases and their contribution to allergic inflammation, Immunol Allergy Clin North Am, 27, 45, 10.1016/j.iac.2006.11.007
Tang, 2010, The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling, Nat Immunol, 11, 608, 10.1038/ni.1883
Brooks, 1985, Reactive airways dysfunction syndrome (RADS). Persistent asthma syndrome after high level irritant exposures, Chest, 88, 376, 10.1378/chest.88.3.376
Andersson, 2006, Incidence of asthma among workers exposed to sulphur dioxide and other irritant gases, Eur Respir J, 27, 720, 10.1183/09031936.06.00034305
Takeda, 2009, Long-term pathologic consequences of acute irritant-induced asthma, J Allergy Clin Immunol, 124, 975, 10.1016/j.jaci.2009.08.008
McGovern, 2010, Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma, Respir Res, 11, 138, 10.1186/1465-9921-11-138
Pichavant, 2008, Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17, J Exp Med, 205, 385, 10.1084/jem.20071507
Akbari, 2008, ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and Homeostatic survival, J Immunol, 180, 5448, 10.4049/jimmunol.180.8.5448
Jin, 2007, Airway hyperresponsiveness through synergy of gammadelta} T cells and NKT cells, J Immunol, 179, 2961, 10.4049/jimmunol.179.5.2961
Gavett, 1994, Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia, Am J Respir Cell Mol Biol, 10, 587, 10.1165/ajrcmb.10.6.8003337
Haczku, 1997, Adoptive transfer of allergen-specific CD4+ T cells induces airway inflammation and hyperresponsiveness in brown-Norway rats, Immunology, 91, 176, 10.1046/j.1365-2567.1997.d01-2221.x
Isogai, 2004, CD8(+) alpha beta T cells can mediate late airway responses and airway eosinophilia in rats, J Allergy Clin Immunol, 114, 1345, 10.1016/j.jaci.2004.09.021
Isogai, 2007, Interferon-gamma-dependent inhibition of late allergic airway responses and eosinophilia by CD8+ gammadelta T cells, Immunology, 122, 230, 10.1111/j.1365-2567.2007.02632.x
Joetham, 2007, Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta, J Immunol, 178, 1433, 10.4049/jimmunol.178.3.1433
Curotto de Lafaille, 2008, Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation, Immunity, 29, 114, 10.1016/j.immuni.2008.05.010
Wallace, 1997, Nonspecific airway hyperresponsiveness in HIV disease. Pulmonary complications of HIV infection study Group, Chest, 111, 121, 10.1378/chest.111.1.121
Alexander, 1992, Trial of cyclosporin in corticosteroid-dependent chronic severe asthma, Lancet, 339, 324, 10.1016/0140-6736(92)91646-P
Xu, 2001, Inhaled budesonide inhibits OVA-induced airway narrowing, inflammation, and cys-LT synthesis in BN rats, J Appl Physiol, 89, 1852, 10.1152/jappl.2000.89.5.1852
Eum, 2003, Inhibition of allergic airways inflammation and airway hyperresponsiveness in mice by dexamethasone: role of eosinophils, IL-5, eotaxin, and IL-13, J Allergy Clin Immunol, 111, 1049, 10.1067/mai.2003.1416
Cox, 2007, Asthma control during the year after bronchial thermoplasty, N Engl J Med, 356, 1327, 10.1056/NEJMoa064707
Inman, 2001, Dose-dependent effects of inhaled mometasone furoate on airway function and inflammation after allergen inhalation challenge, Am J Respir Crit Care Med, 164, 569, 10.1164/ajrccm.164.4.2007063
Leung, 2005, Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features, J Allergy Clin Immunol, 115, 989, 10.1016/j.jaci.2005.01.036
McKinley, 2008, TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice, J Immunol, 181, 4089, 10.4049/jimmunol.181.6.4089
Wilson, 2009, Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness, Am J Respir Crit Care Med, 180, 720, 10.1164/rccm.200904-0573OC
Rabb, 1994, The role of the leukocyte adhesion molecules VLA-4, LFA-1 and Mac-1 in allergic airway responses in the rat, Am J Respir Crit Care Med, 149, 1186, 10.1164/ajrccm.149.5.8173758
Ramos-Barbon, 2001, Effect of alpha4-integrin blockade on CD4+ cell-driven late airway responses in the rat, Am J Respir Crit Care Med, 163, 101, 10.1164/ajrccm.163.1.2001093
Issekutz, 1991, T lymphocyte migration to arthritic joints and dermal inflammation in the rat: differing migration patterns and the involvement of VLA-4, Clin Immunol Immunopathol, 61, 436, 10.1016/S0090-1229(05)80014-5
Gosset, 1995, Expression of E-selectin, ICAM-1 and VCAM-1 on bronchial biopsies from allergic and non-allergic asthmatic patients, Int Arch Allergy Immunol, 106, 69, 10.1159/000236892
Pelaquini, 2010, Role of the Mac-1 and VLA-4 integrins, and concomitant Th2-cytokine production, in nitric oxide modulated eosinophil migration from bone marrow to lungs in allergic mice, Int Immunopharmacol
Ravensberg, 2006, The effect of a single inhaled dose of a VLA-4 antagonist on allergen-induced airway responses and airway inflammation in patients with asthma, Allergy, 61, 1097, 10.1111/j.1398-9995.2006.01146.x
Ihaku, 1999, Montelukast, a leukotriene receptor antagonist, inhibits the late airway response to antigen, airway eosinophilia, and IL-5- expressing cells in Brown Norway rats, J Allergy Clin Immunol, 104, 1147, 10.1016/S0091-6749(99)70006-0
Eum, 2003, Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouse, Am J Respir Cell Mol Biol, 28, 25, 10.1165/rcmb.4532
Henderson, 1996, The importance of leukotrienes in airway inflammation in a mouse model of asthma, J Exp Med, 184, 1483, 10.1084/jem.184.4.1483
Wang, 1993, Role of leukotriene D4 in allergen-induced increases in airway smooth muscle in the rat, Am Rev Respir Dis, 148, 413, 10.1164/ajrccm/148.2.413
Salmon, 1999, Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats, Br J Pharmacol, 127, 1151, 10.1038/sj.bjp.0702669
Henderson, 2006, Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade, Am J Respir Crit Care Med, 173, 718, 10.1164/rccm.200501-088OC
Vargaftig, 2003, Leukotrienes mediate part of ova-induced lung effects in mice via EGFR, Am J Physiology-Lung Cell Mol Physiol, 285, L808, 10.1152/ajplung.00377.2002
Kelly, 2006, Montelukast treatment attenuates the increase in myofibroblasts following low-dose allergen challenge, Chest, 130, 741, 10.1378/chest.130.3.741
Maekawa, 2009, GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4, Proc Natl Acad Sci U S A, 106, 11685, 10.1073/pnas.0905364106
Maekawa, 2010, GPR17 regulates immune pulmonary inflammation induced by house dust mites, J Immunol, 185, 1846, 10.4049/jimmunol.1001131
Corry, 1996, Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity, J Exp Med, 183, 109, 10.1084/jem.183.1.109
Henderson, 2000, Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma, J Immunol, 164, 1086, 10.4049/jimmunol.164.2.1086
Borish, 2001, Efficacy of soluble IL-4 receptor for the treatment of adults with asthma, J Allergy Clin Immunol, 107, 963, 10.1067/mai.2001.115624
Lee, 2004, Defining a link with asthma in mice congenitally deficient in eosinophils, Science, 305, 1773, 10.1126/science.1099472
Kung, 1995, Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody, Am J Respir Cell Mol Biol, 13, 360, 10.1165/ajrcmb.13.3.7654390
Eum, 2005, IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway smooth muscle, Am J Physiol Lung Cell Mol Physiol, 288, L576, 10.1152/ajplung.00380.2003
Mould, 2000, The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity, J Immunol, 164, 2142, 10.4049/jimmunol.164.4.2142
Leckie, 2000, Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response, Lancet, 356, 2144, 10.1016/S0140-6736(00)03496-6
Nair, 2009, Mepolizumab for prednisone-dependent asthma with sputum eosinophilia, N Engl J Med, 360, 985, 10.1056/NEJMoa0805435
Haldar, 2009, Mepolizumab and exacerbations of refractory eosinophilic asthma, N Engl J Med, 360, 973, 10.1056/NEJMoa0808991
Allakhverdi, 2006, Multitargeted approach using antisense oligonucleotides for the treatment of asthma, Ann N Y Acad Sci, 1082, 62, 10.1196/annals.1348.047
Maes, 2011, Gene therapy for allergic airway diseases, Curr Allergy Asthma Rep, 11, 163, 10.1007/s11882-011-0177-8
Wills-Karp, 2001, IL-12/IL-13 axis in allergic asthma, J Allergy Clin Immunol, 107, 9, 10.1067/mai.2001.112265
Walter, 2001, Critical role for IL-13 in the development of allergen-induced airway hyperreactivity, J Immunol, 167, 4668, 10.4049/jimmunol.167.8.4668
Yang, 2004, Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling, Cytokine, 28, 224, 10.1016/j.cyto.2004.08.007
Kuperman, 2002, Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma, Nat Med, 8, 885, 10.1038/nm734
Moore, 2002, IL-13 and IL-4 cause eotaxin release in human airway smooth muscle cells: a role for ERK, Am J Physiol Lung Cell Mol Physiol, 282, L847, 10.1152/ajplung.00245.2001
Doucet, 1998, IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblasts, Int Immunol, 10, 1421, 10.1093/intimm/10.10.1421
Whittaker, 2002, Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9, Am J Respir Cell Mol Biol, 27, 593, 10.1165/rcmb.4838
Richter, 2001, The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma, Am J Respir Cell Mol Biol, 25, 385, 10.1165/ajrcmb.25.3.4437
Zheng, 2008, IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung, J Immunol, 180, 522, 10.4049/jimmunol.180.1.522
Deshpande, 2004, Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway, Am J Respir Cell Mol Biol, 31, 36, 10.1165/rcmb.2003-0313OC
Chiba, 2010, MicroRNAs and their therapeutic potential for human diseases: MiR-133a and bronchial smooth muscle hyperresponsiveness in asthma, J Pharmacol Sci, 114, 264, 10.1254/jphs.10R10FM
Gauvreau, 2010, The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma, Am J Respir Crit Care Med
Tomkinson, 2010, Inhaled vs subcutaneous effects of a dual IL-4/IL-13 antagonist in a monkey model of asthma, Allergy, 65, 69, 10.1111/j.1398-9995.2009.02156.x
Choi, 2005, TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation, J Allergy Clin Immunol, 116, 537, 10.1016/j.jaci.2005.05.034
Busse, 2009, Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor alpha in a murine model of allergic asthma, Ann Allergy Asthma Immunol, 103, 295, 10.1016/S1081-1206(10)60528-5
Berry, 2006, Evidence of a role of tumor necrosis factor alpha in refractory asthma, N Engl J Med, 354, 697, 10.1056/NEJMoa050580
Wenzel, 2009, A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma, Am J Respir Crit Care Med, 179, 549, 10.1164/rccm.200809-1512OC
Temann, 1998, Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness, J Exp Med, 188, 1307, 10.1084/jem.188.7.1307
Temann, 2007, IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells, Int Immunol, 19, 1, 10.1093/intimm/dxl117
Cheng, 2002, Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model, Am J Respir Crit Care Med, 166, 409, 10.1164/rccm.2105079
McMillan, 2002, The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity, J Exp Med, 195, 51, 10.1084/jem.20011732
Kearley, 2010, IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways, Am J Respir Crit Care Med
Shimbara, 2000, IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma, J Allergy Clin Immunol, 105, 108, 10.1016/S0091-6749(00)90185-4
White, 2009, Two first-in-human, open-label, phase I dose-escalation safety trials of MEDI-528, a monoclonal antibody against interleukin-9, in healthy adult volunteers, Clin Ther, 31, 728, 10.1016/j.clinthera.2009.04.019
Blease, 2000, Airway remodeling is absent in CCR1-/- mice during chronic fungal allergic airway disease, J Immunol, 165, 1564, 10.4049/jimmunol.165.3.1564
Schuh, 2002, The role of CC chemokine receptor 5 (CCR5) and RANTES/CCL5 during chronic fungal asthma in mice, FASEB J, 16, 228, 10.1096/fj.01-0528fje
Schuh, 2002, Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus, Am J Physiol Lung Cell Mol Physiol, 283, L198, 10.1152/ajplung.00341.2001
Vijayanand, 2010, Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients, J Immunol, 184, 4568, 10.4049/jimmunol.0901342
Perros, 2009, Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation, Allergy, 64, 995, 10.1111/j.1398-9995.2009.02095.x
Finotto, 2002, Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet, Science, 295, 336, 10.1126/science.1065544
Gavett, 1995, Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice, J Exp Med, 182, 1527, 10.1084/jem.182.5.1527
Schwarze, 1998, Local treatment with IL-12 is an effective inhibitor of airway hyperresponsiveness and lung eosinophilia after airway challenge in sensitized mice, J Allergy Clin Immunol, 102, 86, 10.1016/S0091-6749(98)70058-2
Okano, 1998, Interleukin-12 inhibits production of interleukin-5 but not of granulocyte/macrophage colony-stimulating factor by antigen-stimulated blood mononuclear cells in allergic bronchial asthmatics, Int Arch Allergy Immunol, 115, 83, 10.1159/000023834
Boguniewicz, 1993, Treatment of steroid-dependent asthma with recombinant interferon-gamma, Clin Exp Allergy, 23, 785, 10.1111/j.1365-2222.1993.tb00367.x
Bryan, 2000, Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response, Lancet, 356, 2149, 10.1016/S0140-6736(00)03497-8
Kline, 1998, Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma, J Immunol, 160, 2555, 10.4049/jimmunol.160.6.2555
Hessel, 2005, Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction, J Exp Med, 202, 1563, 10.1084/jem.20050631
Tulic, 2004, Amb a 1-immunostimulatory oligodeoxynucleotide conjugate immunotherapy decreases the nasal inflammatory response, J Allergy Clin Immunol, 113, 235, 10.1016/j.jaci.2003.11.001
Gauvreau, 2006, Immunostimulatory sequences regulate interferon-inducible genes but not allergic airway responses, Am J Respir Crit Care Med, 174, 15, 10.1164/rccm.200601-057OC
Moisan, 2006, TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway, Am J Physiology-Lung Cell Mol Physiol, 290, L987, 10.1152/ajplung.00440.2005
Camateros, 2007, Chronic asthma-induced airway remodeling is prevented by toll-like receptor-7/8 ligand S28463, Am J Respir Crit Care Med, 175, 1241, 10.1164/rccm.200701-054OC
Blease, 2001, IL-13 fusion cytotoxin ameliorates chronic fungal-induced allergic airway disease in mice, J Immunol, 167, 6583, 10.4049/jimmunol.167.11.6583
Thorburn, 2010, Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease, Thorax, 65, 1053, 10.1136/thx.2009.131508
Preston, 2011, Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells, Eur Respir J, 37, 53, 10.1183/09031936.00049510
Blease, 2005, Targeting kinases in asthma, Expert Opin Investig Drugs, 14, 1213, 10.1517/13543784.14.10.1213
Duan, 2004, Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model, J Immunol, 172, 7053, 10.4049/jimmunol.172.11.7053
Underwood, 2000, SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence, J Pharmacol Exp Ther, 293, 281
Nath, 2005, Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125, Eur J Pharmacol, 506, 273, 10.1016/j.ejphar.2004.11.040
Eynott, 2003, Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N-terminal kinase, Br J Pharmacol, 140, 1373, 10.1038/sj.bjp.0705569
Stenton, 2002, Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase, J Immunol, 169, 1028, 10.4049/jimmunol.169.2.1028
Matsubara, 2006, Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness, Am J Respir Crit Care Med, 173, 56, 10.1164/rccm.200503-361OC
Polosa, 2002, Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects, J Allergy Clin Immunol, 109, 75, 10.1067/mai.2002.120274
Takeyama, 2008, Role of epidermal growth factor receptor in maintaining airway goblet cell hyperplasia in rats sensitized to allergen, Clin Exp Allergy, 38, 857, 10.1111/j.1365-2222.2008.02951.x
Hirota, 2011, In vivo role of platelet derived growth Factor-BB in airway smooth muscle proliferation in mouse lung, Am J Respir Cell Mol Biol, 10.1165/rcmb.2010-0277OC
Lee, 2004, Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung, Nat Med, 10, 1095, 10.1038/nm1105
Ammit, 2001, Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma, Faseb J, 15, 1212, 10.1096/fj.00-0742fje
Nishiuma, 2008, Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model, Am J Physiol Lung Cell Mol Physiol, 294, L1085, 10.1152/ajplung.00445.2007
Matloubian, 2004, Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1, Nature, 427, 355, 10.1038/nature02284
White, 2010, Chlorine gas inhalation: human clinical evidence of toxicity and experience in animal models, Proc Am Thorac Soc, 7, 257, 10.1513/pats.201001-008SM
Leustik, 2008, Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidants, Am J Physiol Lung Cell Mol Physiol, 295, L733, 10.1152/ajplung.90240.2008
Nadeem, 2003, Increased oxidative stress and altered levels of antioxidants in asthma, J Allergy Clin Immunol, 111, 72, 10.1067/mai.2003.17
Trifilieff, 2009, Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips, Naunyn Schmiedebergs Arch Pharmacol, 380, 303, 10.1007/s00210-009-0438-4
Imaoka, 2007, Effects of thioredoxin on established airway remodeling in a chronic antigen exposure asthma model, Biochem Biophys Res Commun, 360, 525, 10.1016/j.bbrc.2007.06.019
Caceres, 2009, A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma, Proc Natl Acad Sci U S A, 106, 9099, 10.1073/pnas.0900591106
Maghni, 2000, Dichotomy between neurokinin receptor actions in modulating allergic airway responses in an animal model of helper T cell type 2 cytokine- associated inflammation, Am J Respir Crit Care Med, 162, 1068, 10.1164/ajrccm.162.3.9910089
Anderson, 2008, Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease, Lancet, 372, 1107, 10.1016/S0140-6736(08)61452-X
Bautista, 2006, TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents, Cell, 124, 1269, 10.1016/j.cell.2006.02.023
Bianchi, 2007, DAMPs, PAMPs and alarmins: all we need to know about danger, J Leukoc Biol, 81, 1, 10.1189/jlb.0306164