Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease

Thiele, 1989, Intestinal graft-versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes, J Clin Invest, 83, 1947, 10.1172/JCI114383 Eigenbrodt, 1990, Histologic similarity of murine colonic graft-versus-host disease (GVHD) to human colonic GVHD and inflammatory bowel disease, Am J Pathol, 137, 1065 Ferrara, 1995, Cytokine inhibitors and graft-versus-host disease, Ann NY Acad Sci, 770, 227, 10.1111/j.1749-6632.1995.tb31058.x Korngold, 1985, Surface markers of T cells causing lethal graft-versus-host disease to class I vs class II H-2 differences, J Immunol, 135, 3004, 10.4049/jimmunol.135.5.3004 Koide, 1997, Increased expression of tissue cytokines in graft-versus-host disease after small bowel transplantation in the rat, Transplantation, 64, 518, 10.1097/00007890-199708150-00023 Vallera, 1995, Interleukin 1 or tumor necrosis factor-alpha antagonists do not inhibit graft-versus-host disease induced across the major histocompatibility barrier in mice, Transplantation, 60, 1371 Piguet, 1987, Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs-host disease, J Exp Med, 166, 1280, 10.1084/jem.166.5.1280 Speiser, 1997, TNF receptor p55 controls early acute graft-versus-host disease, J Immunol, 158, 5185, 10.4049/jimmunol.158.11.5185 Kolls, 1994, Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer, Proc Natl Acad Sci USA, 91, 215, 10.1073/pnas.91.1.215 Peppel, 1991, A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity, J Exp Med, 174, 1483, 10.1084/jem.174.6.1483 Brown, 1995, CD27-CD27 ligand/CD70 interactions enhance alloantigen-induced proliferation and cytolytic activity in CD8+ T lymphocytes, J Immunol, 154, 3686, 10.4049/jimmunol.154.8.3686 Brown, 1997, Adenoviral vectors given intravenously to immunocompromised mice yield stable transduction of the colonic epithelium, Gastroenterology, 112, 1586, 10.1016/S0016-5085(97)70040-4 Zsengeller, 1995, Persistence of replication deficient adenovirus mediated gene transfer in lungs of immune-deficient (nu/nu) mice, Hum Gene Ther, 6, 457, 10.1089/hum.1995.6.4-457 Meddings, 1998, Discrimination of site-specific alterations in gastrointestinal permeability in the rat, Gastroenterology, 114, 83, 10.1016/S0016-5085(98)70636-5 Stack, 1997, Randomised controlled trial for CDP571 antibody to tumor necrosis factor α in Crohn's disease, Lancet, 349, 521, 10.1016/S0140-6736(97)80083-9 van Dullemen, 1995, Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2), Gastroenterology, 109, 129, 10.1016/0016-5085(95)90277-5 Piguet, 1985, GVHD elucidated by products of class I or class II lock of the MHC: analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GVHD induced mortality, medullary aplasia, and enteropathy, J Immunol, 135, 1637, 10.4049/jimmunol.135.3.1637 Guy Grand, 1986, Gut injury in mouse graft-versus-host reaction: study of its occurrence and mechanism, J Clin Invest, 77, 1584, 10.1172/JCI112474 Mowat, 1986, Hypersensitivity reactions in the small intestine VII. Induction of the intestinal phase of murine graft-versus-host reaction by Lyt 2-T cells activated by I-A alloantigens, Transplantation, 41, 192, 10.1097/00007890-198602000-00012 Herve, 1992, Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease, Blood, 79, 3362, 10.1182/blood.V79.12.3362.bloodjournal79123362 Holler, 1995, Modulation of acute graft-versus-host-disease after allogeneic bone marrow transplantation by tumor necrosis factor alpha (TNF alpha) release in the course of pretransplant conditioning: role of conditioning regimens and prophylactic application of a monoclonal antibody neutralizing human TNF alpha (MAK 195F), Blood, 86, 890, 10.1182/blood.V86.3.890.890 Targan, 1997, A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group, N Engl J Med, 337, 1029, 10.1056/NEJM199710093371502 Dinarello, 1986, Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1, J Exp Med, 163, 1433, 10.1084/jem.163.6.1433 Pober, 1986, Overlapping pattern of activation of human endothelial cells by interleukin 1, tumor necrosis factor and immune interferon, J Immunol, 137, 1893, 10.4049/jimmunol.137.6.1893 Ker, 1984, Apoptosis in recent advances in histopathology, 1 Duval, 1986, Death and the cell, Immunol Today, 7, 115, 10.1016/0167-5699(86)90152-0 Jon Hilden, 1996, Intestinal permeability changes in response to acetylsalicylic acid in relatives of patients with Crohn's disease, Gastroenterology, 110, 1395, 10.1053/gast.1996.v110.pm8613043