A Review: The Bioactivities and Pharmacological Applications of Polygonatum sibiricum polysaccharides

Springer Science and Business Media LLC - Tập 23 Số 5 - Trang 1170
Xiaowei Cui1, Shiyuan Wang2, Hui Cao1, Hong Guo1, Yujuan Li1, Fangxue Xu1, Mengmeng Zheng1, Xiaozhi Xi1, Chunchao Han1
1School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
2School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China

Tóm tắt

Traditional Chinese Medicine (TCM) has been widely used in China and is regarded as the most important therapeutic. Polygonatum sibiricum (PS), a natural plant used in traditional Chinese medicine, has various functions associated with a number of its components. There are many compositions in PS including polysaccharides, steroids, anthraquinone, alkaloids, cardiac glycosides, lignin, vitamins, various acids, and so on. Of these, polysaccharides play a significant role in PS-based therapeutics. This article summarizes Polygonatum sibiricum polysaccharides (PSP) have many pharmacological applications and biological activities, such as their antioxidant activity, anti-aging activity, an anti-fatigue effect, immunity enhancement effect, antibacterial effect, anti-inflammatory effect, hypolipidemic and antiatherosclerotic effects, anti-osteoporosis effect, liver protection, treatment of diabetes mellitus (DM), anti-cancer effect, and may help prevent Alzheimer’s disease, and so on. This review summarized the extraction method, purification method, compositions, pharmacological applications, biological activities, biosynthesis, and prospects of PSP, providing a basis for further study of PS and PSP.

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