Role of RNA structures present at the 3′UTR of dengue virus on translation, RNA synthesis, and viral replication

Virology - Tập 339 - Trang 200-212 - 2005
Diego E. Alvarez1, Ana Laura De Lella Ezcurra1, Silvana Fucito1, Andrea V. Gamarnik1
1Fundación Instituto Leloir, Avenida Patricias Argentinas 435, Buenos Aires 1405, Argentina

Tài liệu tham khảo

Alvarez, 2005, Long-range RNA–RNA interactions circularize the dengue virus genome, J. Virol., 79, 6631, 10.1128/JVI.79.11.6631-6643.2005 Blaney, 2004, Vaccine candidates derived from a novel infectious cDNA clone of an American genotype dengue virus type 2, BMC Infect. Dis., 4, 39, 10.1186/1471-2334-4-39 Brinton, 1986, The 3′-nucleotides of flavivirus genomic RNA form a conserved secondary structure, Virology, 153, 113, 10.1016/0042-6822(86)90012-7 Cologna, 2003, American genotype structures decrease dengue virus output from human monocytes and dendritic cells, J. Virol., 77, 3929, 10.1128/JVI.77.7.3929-3938.2003 Durbin, 2001, Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3′-untranslated region, Am. J. Trop. Med. Hyg., 65, 405, 10.4269/ajtmh.2001.65.405 Elghonemy, 2005, The majority of the nucleotides in the top loop of the genomic 3′ terminal stem loop structure are cis-acting in a West Nile virus infectious clone, Virology, 331, 238, 10.1016/j.virol.2004.11.008 Gubler, 1998, Dengue and dengue hemorrhagic fever, Clin. Microbiol. Rev., 11, 480, 10.1128/CMR.11.3.480 Gubler, 1978, Epidemiologic, clinical, and virologic observations on dengue in the Kingdom of Tonga, Am. J. Trop. Med. Hyg., 27, 581, 10.4269/ajtmh.1978.27.581 Hahn, 1987, Conserved elements in the 3′ untranslated region of flavivirus RNAs and potential cyclization sequences, J. Mol. Biol., 198, 33, 10.1016/0022-2836(87)90455-4 Hanley, 2004, Introduction of mutations into the non-structural genes or 3′ untranslated region of an attenuated dengue virus type 4 vaccine candidate further decreases replication in rhesus monkeys while retaining protective immunity, Vaccine, 22, 3440, 10.1016/j.vaccine.2004.02.031 Holden, 2004, Enhancement of dengue virus translation: role of the 3′ untranslated region and the terminal 3′ stem–loop domain, Virology, 329, 119, 10.1016/j.virol.2004.08.004 Khromykh, 1998, trans-Complementation of flavivirus RNA polymerase gene NS5 by using Kunjin virus replicon-expressing BHK cells, J. Virol., 72, 7270, 10.1128/JVI.72.9.7270-7279.1998 Khromykh, 2001, Essential role of cyclization sequences in flavivirus RNA replication, J. Virol., 75, 6719, 10.1128/JVI.75.14.6719-6728.2001 Khromykh, 2003, Significance in replication of the terminal nucleotides of the flavivirus genome, J. Virol., 77, 10623, 10.1128/JVI.77.19.10623-10629.2003 Kinney, 1997, Construction of infectious cDNA clones for dengue 2 virus: strain 16681 and its attenuated vaccine derivative, strain PDK-53, Virology, 230, 300, 10.1006/viro.1997.8500 Kong, 2002, Cytoplasmic expression of mRNAs containing the internal ribosome entry site and 3′ noncoding region of hepatitis C virus: effects of the 3′ leader on mRNA translation and mRNA stability, J. Virol., 76, 12457, 10.1128/JVI.76.24.12457-12462.2002 Leitmeyer, 1999, Dengue virus structural differences that correlate with pathogenesis, J. Virol., 73, 4738, 10.1128/JVI.73.6.4738-4747.1999 Lo, 2003, Functional analysis of mosquito-borne flavivirus conserved sequence elements within 3′ untranslated region of West Nile virus by use of a reporting replicon that differentiates between viral translation and RNA replication, J. Virol., 77, 10004, 10.1128/JVI.77.18.10004-10014.2003 Mackenzie, 1998, Subcellular localization and some biochemical properties of the flavivirus Kunjin nonstructural proteins NS2A and NS4A, Virology, 245, 203, 10.1006/viro.1998.9156 Markoff, 2003, 5′ and 3′ NCRs in Flavivirus RNA, vol. 60 Men, 1996, Dengue type 4 virus mutants containing deletions in the 3′ noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus monkeys, J. Virol., 70, 3930, 10.1128/JVI.70.6.3930-3937.1996 Nomaguchi, 2004, Requirements for West Nile virus (−)-and (+)-strand subgenomic RNA synthesis in vitro by the viral RNA-dependent RNA polymerase expressed in Escherichia coli, J. Biol. Chem., 279, 12141, 10.1074/jbc.M310839200 Pang, 2001, Development of Dengue virus type 2 replicons capable of prolonged expression in host cells, BMC Microbiol., 1, 18, 10.1186/1471-2180-1-18 Proutski, 1997, Secondary structure of the 3′ untranslated region of flaviviruses: similarities and differences, Nucleic Acids Res., 25, 1194, 10.1093/nar/25.6.1194 Proutski, 1999, Biological consequences of deletions within the 3′-untranslated region of flaviviruses may be due to rearrangements of RNA secondary structure, Virus Res., 64, 107, 10.1016/S0168-1702(99)00079-9 Rauscher, 1997, Secondary structure of the 3′-noncoding region of flavivirus genomes: comparative analysis of base pairing probabilities, RNA, 3, 779 Rice, 2001, Flaviviridae: The Viruses and Their Replication, vol. 1 Rico-Hesse, 1997, Origins of dengue type 2 viruses associated with increased pathogenicity in the Americas, Virology, 230, 244, 10.1006/viro.1997.8504 Ryan, 1994, Foot-and-mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein, EMBO J., 13, 928, 10.1002/j.1460-2075.1994.tb06337.x Shurtleff, 2001, Genetic variation in the 3′ non-coding region of dengue viruses, Virology, 281, 75, 10.1006/viro.2000.0748 Tilgner, 2004, Structure and function of the 3′ terminal six nucleotides of the West Nile virus genome in viral replication, J. Virol., 78, 8159, 10.1128/JVI.78.15.8159-8171.2004 Tilgner, 2005, The flavivirus-conserved penta-nucleotide in the 3′ stem–loop of the West Nile virus genome requires a specific sequence and structure for RNA synthesis, but not for viral translation, Virology, 331, 375, 10.1016/j.virol.2004.07.022 Troyer, 2001, A live attenuated recombinant dengue-4 virus vaccine candidate with restricted capacity for dissemination in mosquitoes and lack of transmission from vaccinees to mosquitoes, Am. J. Trop. Med. Hyg., 65, 414, 10.4269/ajtmh.2001.65.414 Westaway, 1997, Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures, J. Virol., 71, 6650, 10.1128/JVI.71.9.6650-6661.1997 Westaway, 1999, Nascent flavivirus RNA colocalized in situ with double-stranded RNA in stable replication complexes, Virology, 258, 108, 10.1006/viro.1999.9683 Whitehead, 2003, A live, attenuated dengue virus type 1 vaccine candidate with a 30-nucleotide deletion in the 3′ untranslated region is highly attenuated and immunogenic in monkeys, J. Virol., 77, 1653, 10.1128/JVI.77.2.1653-1657.2003 2004 You, 1999, A novel in vitro replication system for Dengue virus. Initiation of RNA synthesis at the 3′-end of exogenous viral RNA templates requires 5′-and 3′-terminal complementary sequence motifs of the viral RNA, J. Biol. Chem., 274, 33714, 10.1074/jbc.274.47.33714 You, 2001, In vitro RNA synthesis from exogenous dengue viral RNA templates requires long range interactions between 5′-and 3′-terminal regions that influence RNA structure, J. Biol. Chem., 276, 15581, 10.1074/jbc.M010923200 Yu, 2005, The topology of bulges in the long stem of the flavivirus 3′ stem–loop is a major determinant of RNA replication competence, J. Virol., 79, 2309, 10.1128/JVI.79.4.2309-2324.2005 Zeng, 1998, Identification of specific nucleotide sequences within the conserved 3′-SL in the dengue type 2 virus genome required for replication, J. Virol., 72, 7510, 10.1128/JVI.72.9.7510-7522.1998