Vitamin E and ginseng combined supplement for treatment of male erectile dysfunction: A double-blind, placebo-controlled, randomized, clinical trial

McMahon, 2014, Erectile dysfunction, Intern. Med. J., 44, 18, 10.1111/imj.12325 McCabe, 2016, Incidence and prevalence of sexual dysfunction in women and men: a consensus statement from the fourth international consultation on sexual medicine 2015, J. Sex. Med., 13, 144, 10.1016/j.jsxm.2015.12.034 Shamloul, 2013, Erectile dysfunction, Lancet, 381, 153, 10.1016/S0140-6736(12)60520-0 Osondu, 2018, The relationship of erectile dysfunction and subclinical cardiovascular disease: a systematic review and meta-analysis, Vasc. Med., 23, 9, 10.1177/1358863X17725809 Dean, 2005, Physiology of penile erection and pathophysiology of erectile dysfunction, Urol. Clin. North Am., 32, 379, 10.1016/j.ucl.2005.08.007 Setter, 2005, Phosphodiesterase 5 inhibitors for erectile dysfunction, Ann. Pharmacother., 39, 1286, 10.1345/aph.1E487 Ventimiglia, 2016, The safety of phosphodiesterase type 5 inhibitors for erectile dysfunction, Expert Opin. Drug Saf., 15, 141, 10.1517/14740338.2016.1131818 Brock, 2002, Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses, J. Urol., 168, 1332, 10.1097/00005392-200210010-00006 Carson, 2002, The efficacy of sildenafil citrate (Viagra) in clinical populations: an update, Urology, 60, 12, 10.1016/S0090-4295(02)01687-4 Porst, 2001, The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial, Int. J. Impot. Res., 13, 192, 10.1038/sj.ijir.3900713 Brant, 2007, Treatment options for erectile dysfunction, Endocrinol. Metab. Clin. North Am., 36, 465, 10.1016/j.ecl.2007.02.001 Nair, 2012, The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE), Indian J. Urol., 28, 15, 10.4103/0970-1591.94946 Vecchio, 2010, Interventions for treating sexual dysfunction in patients with chronic kidney disease, Cochrane Database Syst. Rev. de Young, 2004, Oxidative stress and antioxidant therapy: their impact in diabetes-associated erectile dysfunction, J. Androl., 25, 830, 10.1002/j.1939-4640.2004.tb02862.x Hong, 2002, A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report, J. Urol., 168, 2070, 10.1016/S0022-5347(05)64298-X Jang, 2008, Red ginseng for treating erectile dysfunction: a systematic review, Br. J. Clin. Pharmacol., 66, 444, 10.1111/j.1365-2125.2008.03236.x Rosen, 1997, The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction, Urology, 49, 822, 10.1016/S0090-4295(97)00238-0 Rosen, 2002, The International Index of Erectile Function (IIEF): a state-of-the-science review, Int. J. Impot. Res., 14, 226, 10.1038/sj.ijir.3900857 Pakpour, 2014, Validation of a translated and culturally adapted Iranian version of the International Index of Erectile Function, J. Sex Marital Ther., 40, 541, 10.1080/0092623X.2013.788110 Cappelleri, 2016, Simplified interpretation of the erectile function domain of the international index of erectile function, J. Sex. Med., 13, 690, 10.1016/j.jsxm.2016.02.159 Modabbernia, 2012, Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial, Psychopharmacology (Berl.), 223, 381, 10.1007/s00213-012-2729-6 Kondoh, 2008, Salvage therapy trial for erectile dysfunction using phosphodiesterase type 5 inhibitors and vitamin E: preliminary report, Aging Male, 11, 167, 10.1080/13685530802273624 De Young, 2003, Effect of PDE5 inhibition combined with free oxygen radical scavenger therapy on erectile function in a diabetic animal model, Int. J. Impot. Res., 15, 347, 10.1038/sj.ijir.3901026 Helmy, 2012, Evaluation of vitamin E in the treatment of erectile dysfunction in aged rats, Life Sci., 90, 489, 10.1016/j.lfs.2011.12.019 Zalba, 2000, Vascular oxidant stress: molecular mechanisms and pathophysiological implications, J. Physiol. Biochem., 56, 57, 10.1007/BF03179777 Agarwal, 2006, Role of oxidative stress in the pathophysiological mechanism of erectile dysfunction, J. Androl., 27, 335, 10.2164/jandrol.05136 Niki, 2014, Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence, Free Radic. Biol. Med., 66, 3, 10.1016/j.freeradbiomed.2013.03.022 Kim, 2017, Panax ginseng Meyer prevents radiation-induced liver injury via modulation of oxidative stress and apoptosis, J. Ginseng Res., 41, 159, 10.1016/j.jgr.2016.02.006 Wang, 2015, Neuroprotective effect of ginseng against spinal cord injury induced oxidative stress and inflammatory responses, Int. J. Clin. Exp. Med., 8, 3514 Lim, 2017, Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells, Lab. Invest., 97, 1271, 10.1038/labinvest.2017.75 Sood, 2018, Indian Ginseng (Withania somnifera) supplementation ameliorates oxidative stress and mitochondrial dysfunctions in experimental model of stroke, Metab. Brain Dis., 33, 1261, 10.1007/s11011-018-0234-2 Liu, 2018, Ginseng (Panax ginseng Meyer) oligopeptides protect against binge drinking-induced liver damage through inhibiting oxidative stress and inflammation in rats, Nutrients, 10, 10.3390/nu10111665 Han, 2015, Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation, J. Ginseng Res., 39, 105, 10.1016/j.jgr.2014.09.001 Ying, 2018, Structural-activity relationship of ginsenosides from steamed ginseng in the treatment of erectile dysfunction, Am. J. Chin. Med., 46, 137, 10.1142/S0192415X18500088 Cho, 2013, Effects of Korean ginseng berry extract (GB0710) on penile erection: evidence from in vitro and in vivo studies, Asian J. Androl., 15, 503, 10.1038/aja.2013.49 Lee, 2017, Implications of red Panax ginseng in oxidative stress associated chronic diseases, J. Ginseng Res., 41, 113, 10.1016/j.jgr.2016.03.003