Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents

Bax, 2000, Int. J. Antimicrob. Agents, 16, 51, 10.1016/S0924-8579(00)00189-8 Ritter, 2001, Angew. Chem. Int. Ed., 40, 3508, 10.1002/1521-3773(20011001)40:19<3508::AID-ANIE3508>3.0.CO;2-I Coates, 2002, Nat. Rev. Drug Discov., 895, 10.1038/nrd940 Wijkmans, 2002, DDT, 7, 126, 10.1016/S1359-6446(01)02092-X (a) Tong, Y.C. US 3850929, Nov. 26, 1974. (b) Clark, M. T.; Gilmore, I. J. GB 2122492, Jan 18, 1984. Camilleri, 1987, J. Chem. Soc., Perkin Trans. 2, 1671, 10.1039/p29870001671 Gasco, 1969, J. Heterocyclic Chem., 6, 769, 10.1002/jhet.5570060532 Sato, 1978, J. Org. Chem., 43, 341, 10.1021/jo00396a038 Gunasekaran, 1995, J. Heterocyclic Chem., 32, 1405, 10.1002/jhet.5570320452 Zelenin, 1997, J. Heterocyclic Chem., 34, 1057, 10.1002/jhet.5570340355 Pirrung, 1995, J. Org. Chem., 60, 2461, 10.1021/jo00113a029 Taylor, 1998, J. Am. Chem. Soc., 120, 12783, 10.1021/ja982711r Sheldrake, 1998, J. Chem. Soc., Perkin Trans. 1, 3003, 10.1039/a803853h