N-Acetyl cysteine: could it be an effective adjuvant therapy in ICSI cycles? A preliminary study

Ahola, 1999, Pharmacokinetics of intravenous N-acetylcysteine in pre-term new-born infants, Eur. J. Clin. Pharmacol., 55, 645, 10.1007/s002280050687 Al-Inany, 2002, GnRH antagonist in assisted reproduction: a Cochrane review, Hum. Reprod., 17, 874, 10.1093/humrep/17.4.874 Al-Inany, 2006, Gonadotrophin-releasing hormone antagonists for assisted conception, Cochrane Database Syst. Rev., CD001750 Ben-Ari, 2000, N-Acetylcysteine in acute hepatic failure (non-paracetamol-induced), Hepatogastroenterology, 47, 786 Billig, 1994, Gonadotrophin releasing hormone directly induces apoptotic cell death in the rat ovary biochemical and in situ detection of deoxyribonucleic acid fragmentation in granulosa cells, Endocrinology, 134, 245, 10.1210/en.134.1.245 Bosco, 2005, Apoptosis in human unfertilized oocytes after intracytoplasmic sperm injection, Fertil. Steril., 84, 1417, 10.1016/j.fertnstert.2005.05.038 Clavero, 2003, Apoptosis in human granulosa cells after induction of ovulation in women participating in an Intracytoplasmic sperm injection program, Eur. J. Obstet. Gynaecol. Reprod. Biol., 110, 181, 10.1016/S0301-2115(03)00243-4 Elnasher, 2007, N-Acetyl cysteine vs metformin in treatment of clomiphene citrate resistant polycystic ovary syndrome: a prospective randomized controlled study, Fertil. Steril., 88, 406, 10.1016/j.fertnstert.2006.11.173 Erkkilä, 1998, N-Acetyl-l-cysteine inhibits apoptosis in human male germ cells in vitro, J. Clin. Endocrinol. Metab., 83, 2523, 10.1210/jc.83.7.2523 Fadok, 1992, Exposure of phosphatidylserine on the surface of apoptotic lymphocyte triggers recognition and removal by macrophages, J. Immunol., 148, 2207, 10.4049/jimmunol.148.7.2207 Fulghesu, 2002, N-Acetyl cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome, Fertil. Steril., 77, 1128, 10.1016/S0015-0282(02)03133-3 Gafaar, 2007, The use of N-acetyl cysteine as an adjuvant to soft induction in cases prepared for ICSI improves cycle parameters: a randomized controlled study, Egypt. J. Fertil. Steril., 11, 75, 10.21608/egyfs.2007.4957 Giampietro, 2006, Levels of apoptosis in human granulosa cells seem to be comparable after therapy with a gonadotropin-releasing hormone agonist or antagonist, Fertil. Steril., 85, 412, 10.1016/j.fertnstert.2005.08.020 Grundker, 2003, Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer, Reprod. Biol. Endocrinol., 1, 65, 10.1186/1477-7827-1-65 Hung, 2009, N-Acetylcysteine-mediated anti-oxidation prevents hyperglycemia-induced apoptosis and collagen synthesis in rat mesangial cells, Am. J. Nephrol., 29, 192, 10.1159/000155657 Kaneko, 2000, Effects of controlled ovarian hyperstimulation on oocyte quality in terms of the incidence of apoptotic granulosa cells, J. Assist. Reprod. Genet., 17, 580, 10.1023/A:1026439409584 Lee, 2000, Effects of protease inhibitors and antioxidants on in vitro survival of porcine primordial germ cells, Biol. Reprod., 63, 887, 10.1095/biolreprod63.3.887 Matsubara, 2000, Gonadotrophins and cytokines affect luteal function through control of apoptosis in human luteinized granulosa cells, J. Clin. Endocrinol. Metab., 85, 1620, 10.1210/jc.85.4.1620 Nakahara, 1997, Incidence of apoptotic bodies in membrana granulosa of the patients participating in an in vitro fertilization program, Fertil. Steril., 67, 302, 10.1016/S0015-0282(97)81915-2 Nakahara, 1997, The incidence of apoptotic bodies in membrana granulosa can predict prognosis of ova from patients participating in IVF programs, Fertil. Steril., 68, 312, 10.1016/S0015-0282(97)81521-X Oosterhuis, 1998, Apoptotic cell death in human granulosa-lutein cells: a possible indicator of in vitro fertilization outcome, Fertil. Steril., 70, 747, 10.1016/S0015-0282(98)00266-0 Otala, 2002, Ovary and oogenesis cell death and its suppression in human ovarian tissue culture, Mol. Hum. Reprod., 8, 228, 10.1093/molehr/8.3.228 Pias, 2002, Apoptosis in mitotic competent undifferentiated cells is induced by cellular redox imbalance independent of reactive oxygen species production, FASEB J., 16, 781, 10.1096/fj.01-0784com Quirk, 2004, Ovarian follicular growth and atresia: the relationship between cell proliferation and survival, J. Anim. Sci., 82, 40, 10.2527/2004.8213_supplE40x Rizk, 2005, Clomiphene–acetyl cysteine combination as a new protocol to a friendly IVF cycle, Middle East Fertil. Steril. J., 10, 130 Saito, 2000, Relatively poor oocyte quality is an indication for intracytoplasmic sperm injection, Fertil. Steril., 73, 465, 10.1016/S0015-0282(99)00547-6 Suh, 2002, Prognostic implication of apoptosis in human luteinized granulosa cells during IVF-ET, J. Assist. Reprod. Genet., 19, 209, 10.1023/A:1015319617598 Wentzel, 1997, Teratogenic effect of diabetic serum is prevented by supplementation of superoxide dismutase and N-acetyl cysteine in rat embryo culture, Diabetologia, 40, 7, 10.1007/s001250050636 Zhao, 2000, Effects of gonadotrophin-releasing hormone agonist on the incidence of apoptosis in porcine and human granulosa cells, Gynecol. Obstet. Invest., 49, 52, 10.1159/000010213