Nivolumab plus ipilimumab versus sunitinib in first-line treatment for advanced renal cell carcinoma: extended follow-up of efficacy and safety results from a randomised, controlled, phase 3 trial
Robert J Motzer1, Brian I Rini2, David F McDermott3, Osvaldo Arén Frontera4, Hans J Hammers5, Michael A Carducci5, Pamela Salman6, Bernard Escudier7, Benoit Beuselinck8, Asim Amin9, Camillo Porta10, Saby George11, Victoria Neiman12,13, Sergio Bracarda14, Scott S Tykodi15, Philippe Barthélémy16, Raya Leibowitz-Amit17, Elizabeth R Plimack18, Sjoukje F Oosting19, Bruce Redman20
1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
2Department of Hematology and Medical Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA
3Department of Hematology and Medical Oncology, Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center, Boston, MA, USA
4Department of Medical Oncology, Centro de Invetigación Clínica Bradford Hill, Santiago, Chile
5Department of Oncology and Urology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
6Department of Medical Oncology, Fundación Arturo López Pérez, Santiago, Chile
7Department of Medical Oncology, Gustave Roussy, Villejuif, France
8Department of Oncology, University Hospitals Leuven, Leuven, Belgium
9Levine Cancer Institute, Atrium Healthcare, Charlotte, NC, USA
10Department of Medical Oncology, IRCCS San Matteo University Hospital Foundation, Pavia, Italy
11Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
12Department of Oncology, Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel
13Tel Aviv University Tel Aviv, Israel
14Department of Oncology, Ospedale San Donato, Azienda USL Toscana Sud-Est, IstitutoToscanoTumori, Arezzo, Italy
15Department of Medicine, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA, USA
16Department of Medical Oncology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
17Oncology Department, Sheba Medical Center, Ramat Gan, Israel
18Department of Hematology and Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA
19Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
20Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
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The Lancet Oncology
Tập 20
1370-1385
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