Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal
Tài liệu tham khảo
Beerman, 2010, Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion, Proc. Natl. Acad. Sci. USA, 107, 5465, 10.1073/pnas.1000834107
Beerman, 2013, Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging, Cell Stem Cell, 12, 413, 10.1016/j.stem.2013.01.017
Bernstein, 2006, A bivalent chromatin structure marks key developmental genes in embryonic stem cells, Cell, 125, 315, 10.1016/j.cell.2006.02.041
Blaney Davidson, 2005, Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity, Arthritis Res. Ther., 7, R1338, 10.1186/ar1833
Challen, 2010, Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1, Cell Stem Cell, 6, 265, 10.1016/j.stem.2010.02.002
Challen, 2012, Dnmt3a is essential for hematopoietic stem cell differentiation, Nat. Genet., 44, 23, 10.1038/ng.1009
Chambers, 2007, Hematopoietic fingerprints: an expression database of stem cells and their progeny, Cell Stem Cell, 1, 578, 10.1016/j.stem.2007.10.003
Chambers, 2007, Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation, PLoS Biol., 5, e201, 10.1371/journal.pbio.0050201
Cho, 2008, A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells, Blood, 111, 5553, 10.1182/blood-2007-11-123547
Cook, 2004, PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain, Blood, 104, 3437, 10.1182/blood-2004-06-2234
Curran, 2007, Lifespan regulation by evolutionarily conserved genes essential for viability, PLoS Genet., 3, e56, 10.1371/journal.pgen.0030056
de Haan, 1999, Dynamic changes in mouse hematopoietic stem cell numbers during aging, Blood, 93, 3294, 10.1182/blood.V93.10.3294.410k07_3294_3301
Delhommeau, 2009, Mutation in TET2 in myeloid cancers, N. Engl. J. Med., 360, 2289, 10.1056/NEJMoa0810069
Dhayalan, 2010, The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation, J. Biol. Chem., 285, 26114, 10.1074/jbc.M109.089433
Dykstra, 2011, Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells, J. Exp. Med., 208, 2691, 10.1084/jem.20111490
Ergen, 2012, Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing, Blood, 119, 2500, 10.1182/blood-2011-11-391730
Fan, 2002, Transient disruption of autocrine TGF-beta signaling leads to enhanced survival and proliferation potential in single primitive human hemopoietic progenitor cells, J. Immunol., 168, 755, 10.4049/jimmunol.168.2.755
Greer, 2010, Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans, Nature, 466, 383, 10.1038/nature09195
Greer, 2011, Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans, Nature, 479, 365, 10.1038/nature10572
Grewal, 2009, Insulin/TOR signaling in growth and homeostasis: a view from the fly world, Int. J. Biochem. Cell Biol., 41, 1006, 10.1016/j.biocel.2008.10.010
Gründemann, 1998, Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter, Nat. Neurosci., 1, 349, 10.1038/1557
Gu, 2011, Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling, Nat. Protoc., 6, 468, 10.1038/nprot.2010.190
Hamilton, 2005, A systematic RNAi screen for longevity genes in C. elegans, Genes Dev., 19, 1544, 10.1101/gad.1308205
Hidalgo, 2012, Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest, Cell Stem Cell, 11, 649, 10.1016/j.stem.2012.08.001
Hodges, 2011, Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment, Mol. Cell, 44, 17, 10.1016/j.molcel.2011.08.026
Imamura, 1997, Smad6 inhibits signalling by the TGF-beta superfamily, Nature, 389, 622, 10.1038/39355
Jacobsen, 1995, Transforming growth factor-beta potently inhibits the viability-promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells, Blood, 86, 2957, 10.1182/blood.V86.8.2957.2957
Jeong, 2014, Large conserved domains of low DNA methylation maintained by Dnmt3a, Nat. Genet., 46, 17, 10.1038/ng.2836
Kaeberlein, 2005, Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients, Science, 310, 1193, 10.1126/science.1115535
Kamminga, 2006, The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion, Blood, 107, 2170, 10.1182/blood-2005-09-3585
Ko, 2011, Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice, Proc. Natl. Acad. Sci. USA, 108, 14566, 10.1073/pnas.1112317108
Langemeijer, 2009, Acquired mutations in TET2 are common in myelodysplastic syndromes, Nat. Genet., 41, 838, 10.1038/ng.391
Ley, 2010, DNMT3A mutations in acute myeloid leukemia, N. Engl. J. Med., 363, 2424, 10.1056/NEJMoa1005143
Li, 2011, Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies, Blood, 118, 4509, 10.1182/blood-2010-12-325241
Linton, 2004, Age-related changes in lymphocyte development and function, Nat. Immunol., 5, 133, 10.1038/ni1033
Liu, 2013, Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging, Cell Rep, 4, 189, 10.1016/j.celrep.2013.05.043
Loffredo, 2013, Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy, Cell, 153, 828, 10.1016/j.cell.2013.04.015
López-Otín, 2013, The hallmarks of aging, Cell, 153, 1194, 10.1016/j.cell.2013.05.039
Maegawa, 2010, Widespread and tissue specific age-related DNA methylation changes in mice, Genome Res., 20, 332, 10.1101/gr.096826.109
Mayle, 2013, Flow cytometry analysis of murine hematopoietic stem cells, Cytometry A, 83, 27, 10.1002/cyto.a.22093
Meissner, 2008, Genome-scale DNA methylation maps of pluripotent and differentiated cells, Nature, 454, 766, 10.1038/nature07107
Min, 2008, The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells, Cell Stem Cell, 2, 380, 10.1016/j.stem.2008.01.015
Molofsky, 2006, Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing, Nature, 443, 448, 10.1038/nature05091
Moran-Crusio, 2011, Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation, Cancer Cell, 20, 11, 10.1016/j.ccr.2011.06.001
Morrison, 1996, The aging of hematopoietic stem cells, Nat. Med., 2, 1011, 10.1038/nm0996-1011
Narla, 2010, Ribosomopathies: human disorders of ribosome dysfunction, Blood, 115, 3196, 10.1182/blood-2009-10-178129
Pan, 2007, Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans, Aging Cell, 6, 111, 10.1111/j.1474-9726.2006.00266.x
Papaemmanuil, 2011, Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts, N. Engl. J. Med., 365, 1384, 10.1056/NEJMoa1103283
Quivoron, 2011, TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis, Cancer Cell, 20, 25, 10.1016/j.ccr.2011.06.003
Ramos-Casals, 2003, Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly, Lupus, 12, 341, 10.1191/0961203303lu383ed
Rossi, 2005, Cell intrinsic alterations underlie hematopoietic stem cell aging, Proc. Natl. Acad. Sci. USA, 102, 9194, 10.1073/pnas.0503280102
Sirin, 2010, The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells, Nat. Cell Biol., 12, 1213, 10.1038/ncb2125
Stadler, 2011, DNA-binding factors shape the mouse methylome at distal regulatory regions, Nature, 480, 490, 10.1038/nature10716
Sun, 2014, MOABS: model based analysis of bisulfite sequencing data, Genome Biol., 15, R38, 10.1186/gb-2014-15-2-r38
Syntichaki, 2007, eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans, Nature, 445, 922, 10.1038/nature05603
Venezia, 2004, Molecular signatures of proliferation and quiescence in hematopoietic stem cells, PLoS Biol., 2, e301, 10.1371/journal.pbio.0020301
Villeda, 2011, The ageing systemic milieu negatively regulates neurogenesis and cognitive function, Nature, 477, 90, 10.1038/nature10357
Wang, 2012, A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage, Cell, 148, 1001, 10.1016/j.cell.2012.01.040
Weishaupt, 2010, Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells, Blood, 115, 247, 10.1182/blood-2009-07-235176
Wilson, 2010, Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators, Cell Stem Cell, 7, 532, 10.1016/j.stem.2010.07.016
Xie, 2013, Epigenomic analysis of multilineage differentiation of human embryonic stem cells, Cell, 153, 1134, 10.1016/j.cell.2013.04.022
Yan, 2011, Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia, Nat. Genet., 43, 309, 10.1038/ng.788
Yu, 2000, Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis, Genes Dev., 14, 163, 10.1101/gad.14.2.163
Ziller, 2013, Charting a dynamic DNA methylation landscape of the human genome, Nature, 500, 477, 10.1038/nature12433