Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal
Deqiang Sun1, Min Luo2, Mira Jeong2, Benjamin Rodriguez1, Zheng Xia1, Rebecca Hannah3, Hui Wang4, Thuc Le5, Kym F. Faull5, Rui Chen4, Hongcang Gu6, Christoph Bock6,7, Alexander Meissner6, Berthold Göttgens3, Gretchen J. Darlington8, Wei Li1, Margaret A. Goodell2,1
1Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
2Stem Cells and Regenerative Medicine Center, Department of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
3Department of Hematology, Cambridge Institute for Medical Research and Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge University, Hills Road, CB2 0XY Cambridge, UK
4Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
5Pasarow Mass Spectrometry Laboratory, Department of Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
6Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
7Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02142, USA
8Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA