Gut microbiota-derived metabolites in CRC progression and causation

Journal of Cancer Research and Clinical Oncology - Tập 147 - Trang 3141-3155 - 2021
Nishu Dalal1,2, Rekha Jalandra1,3, Nitin Bayal1, Amit K. Yadav4, Harshulika5, Minakshi Sharma3, Govind K. Makharia6, Pramod Kumar7, Rajeev Singh2, Pratima R. Solanki4, Anil Kumar1
1Gene Regulation Laboratory, National Institute of Immunology, New Delhi, India
2Department of Environmental Science, Satyawati College, Delhi University, Delhi, India
3Department of Zoology, Maharshi Dayanand University, Rohtak, India
4Special Centre for Nanoscience, Jawaharlal Nehru University, New Delhi, India
5Ministry of Environment, Forest and Climate Change, New Delhi, India
6Department of Gastroenterology and Human Nutrition, AIIMS, New Delhi, India
7Sri Aurobindo College, Delhi University, New Delhi, India

Tóm tắt

Based on recent research reports, dysbiosis and improper concentrations of microbial metabolites in the gut may result into the carcinogenesis of colorectal cancer. Recent advancement also highlights the involvement of bacteria and their secreted metabolites in the cancer causation. Gut microbial metabolites are functional output of the host–microbiota interactions and produced by anaerobic fermentation of food components in the diet. They contribute to influence variety of biological mechanisms including inflammation, cell signaling, cell-cycle disruption which are majorly disrupted in carcinogenic activities. In this review, we intend to discuss recent updates and possible molecular mechanisms to provide the role of bacterial metabolites, gut bacteria and diet in the colorectal carcinogenesis. Recent evidences have proposed the role of bacteria, such as Fusobacterium nucleaturm, Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis and Clostridium septicum, in the carcinogenesis of CRC. Metagenomic study confirmed that these bacteria are in increased abundance in CRC patient as compared to healthy individuals and can cause inflammation and DNA damage which can lead to development of cancer. These bacteria produce metabolites, such as secondary bile salts from primary bile salts, hydrogen sulfide, trimethylamine-N-oxide (TMAO), which are likely to promote inflammation and subsequently cancer development. Recent studies suggest that gut microbiota-derived metabolites have a role in CRC progression and causation and hence, could be implicated in CRC diagnosis, prognosis and therapy.

Tài liệu tham khảo

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