Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Nature - Tập 391 Số 6665 - Trang 387-390 - 1998
Bart De Strooper1, Paul Säftig2, Katleen Craessaerts1, Hugo Vanderstichele, Gundula Guhde3, Wim Annaert1, Kurt Von Figura3, Freddy Van Leuven1
1Experimental Genetics Group, Flemish Institute for Biotechnology (VIB4), Center for Human Genetics, K.U.Leuven, Belgium
2Innogenetics NV, Industriepark Zw.7, 9057, Gent, Belgium
3Abteilung Biochemie II, Zentrum Biochemie und Molekular Zellbiologie, Universität Göttingen, 37073, Göttingen, Germany

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