Caveolin, cholesterol, and lipid bodies

Liu, 2004, Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic, J Biol Chem, 279, 3787, 10.1074/jbc.M311945200 Roy, 1999, Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains, Nat Cell Biol, 1, 98, 10.1038/15687 Pol, 2001, A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance, J Cell Biol, 152, 1057, 10.1083/jcb.152.5.1057 Pol, 2004, Dynamic and regulated association of caveolin with lipid bodies: modulation of lipid body motility and function by a dominant negative mutant, Mol Biol Cell, 15, 99, 10.1091/mbc.E03-06-0368 Brasaemle, 2004, Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes, J Biol Chem, 279, 46835, 10.1074/jbc.M409340200 Trigatti, 1999, Identification of caveolin-1 as a fatty acid binding protein, Biochem Biophys Res Commun, 255, 34, 10.1006/bbrc.1998.0123 Murata, 1995, VIP21/caveolin is a cholesterol-binding protein, Proc Natl Acad Sci USA, 92, 10339, 10.1073/pnas.92.22.10339 Fielding, 2001, Caveolae and intracellular trafficking of cholesterol, Adv Drug Deliv Rev, 49, 251, 10.1016/S0169-409X(01)00140-5 Ikonen, 2000, Caveolins and cellular cholesterol balance, Traffic, 1, 212, 10.1034/j.1600-0854.2000.010303.x Ikonen, 2004, Caveolins and membrane cholesterol, Biochem Soc Trans, 32, 121, 10.1042/bst0320121 Murphy, 2001, The biogenesis and functions of lipid bodies in animals, plants and microorganisms, Prog Lipid Res, 40, 325, 10.1016/S0163-7827(01)00013-3 Murphy, 1999, Mechanisms of lipid-body formation, Trends Biochem Sci, 24, 109, 10.1016/S0968-0004(98)01349-8 Hussain, 2000, A proposed model for the assembly of chylomicrons, Atherosclerosis, 148, 1, 10.1016/S0021-9150(99)00397-4 Olofsson, 1999, The assembly and secretion of apolipoprotein B-containing lipoproteins, Curr Opin Lipidol, 10, 341, 10.1097/00041433-199908000-00008 Keenan, 2001, Assembly and secretion of the lipid globules of milk, Adv Exp Med Biol, 501, 125, 10.1007/978-1-4615-1371-1_16 Prattes, 2000, Intracellular distribution and mobilization of unesterified cholesterol in adipocytes: triglyceride droplets are surrounded by cholesterol-rich ER-like surface layer structures, J Cell Sci, 113, 2977, 10.1242/jcs.113.17.2977 Londos, 1995, Perilipin: unique proteins associated with intracellular neutral lipid droplets in adipocytes and steroidogenic cells, Biochem Soc Trans, 23, 611, 10.1042/bst0230611 Schultz, 2002, Role of adipocyte differentiation-related protein in surfactant phospholipid synthesis by type II cells, Am J Physiol Lung Cell Mol Physiol, 283, L288, 10.1152/ajplung.00204.2001 Azais-Braesco, 1995, Vitamin A contained in the lipid droplets of rat liver stellate cells is substrate for acid retinyl ester hydrolase, Biochim Biophys Acta, 1259, 271, 10.1016/0005-2760(95)00173-5 Imanishi, 2004, Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye, J Cell Biol, 164, 373, 10.1083/jcb.200311079 Weller, 1994, Eosinophils: structure and functions, Curr Opin Immunol, 6, 85, 10.1016/0952-7915(94)90038-8 Brown, 2001, Lipid droplets: proteins floating on a pool of fat, Curr Biol, 11, R446, 10.1016/S0960-9822(01)00257-3 van Meer, 2001, Caveolin, cholesterol, and lipid droplets?, J Cell Biol, 152, F29, 10.1083/jcb.152.5.F29 Blanchette-Mackie, 1995, Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes, J Lipid Res, 36, 1211, 10.1016/S0022-2275(20)41129-0 Tauchi-Sato, 2002, The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid composition, J Biol Chem, 277, 44507, 10.1074/jbc.M207712200 Umlauf, 2004, Association of stomatin with lipid bodies, J Biol Chem, 279, 23699, 10.1074/jbc.M310546200 Ramsammy, 1982, Lysophosphatidylcholine-cholesterol complex, J Biol Chem, 257, 3570, 10.1016/S0021-9258(18)34817-8 Novikoff, 1980, Organelle relationships in cultured 3T3-L1 preadipocytes, J Cell Biol, 87, 180, 10.1083/jcb.87.1.180 Yamaguchi, 2004, CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome, J Biol Chem, 279, 30490, 10.1074/jbc.M403920200 Lefevre, 2001, Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome, Am J Hum Genet, 69, 1002, 10.1086/324121 Igal, 1997, Neutral lipid storage disease with fatty liver and cholestasis, J Pediatr Gastroenterol Nutr, 25, 541, 10.1097/00005176-199711000-00011 Srebrnik, 1998, Dorfman-Chanarin syndrome: morphologic studies and presentation of new cases, Am J Dermatopathol, 20, 79, 10.1097/00000372-199802000-00016 von Bohlen und Halbach, 2004, Genes, proteins, and neurotoxins involved in Parkinson's disease, Prog Neurobiol, 73, 151, 10.1016/j.pneurobio.2004.05.002 Cole, 2002, Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein, J Biol Chem, 277, 6344, 10.1074/jbc.M108414200 Czaja, 1998, Host- and disease-specific factors affecting steatosis in chronic hepatitis C, J Hepatol, 29, 198, 10.1016/S0168-8278(98)80004-4 McLauchlan, 2002, Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets, EMBO J, 21, 3980, 10.1093/emboj/cdf414 Weihofen, 2002, Identification of signal peptide peptidase, a presenilin-type aspartic protease, Science, 296, 2215, 10.1126/science.1070925 Hope, 2000, Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein, J Gen Virol, 81, 1913, 10.1099/0022-1317-81-8-1913 Alonzi, 2004, Steatosis and intrahepatic lymphocyte recruitment in hepatitis C virus transgenic mice, J Gen Virol, 85, 1509, 10.1099/vir.0.19724-0 Londos, 1999, Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells, Semin Cell Dev Biol, 10, 51, 10.1006/scdb.1998.0275 Gronke, 2003, Control of fat storage by a Drosophila PAT domain protein, Curr Biol, 13, 603, 10.1016/S0960-9822(03)00175-1 Teixeira, 2003, Drosophila Perilipin/ADRP homologue Lsd2 regulates lipid metabolism, Mech Dev, 120, 1071, 10.1016/S0925-4773(03)00158-8 Tansey, 2001, Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity, Proc Natl Acad Sci USA, 98, 6494, 10.1073/pnas.101042998 Brasaemle, 1997, Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein, J Lipid Res, 38, 2249, 10.1016/S0022-2275(20)34939-7 Serrero, 2000, Adipose differentiation related protein: expression, purification of recombinant protein in Escherichia coli and characterization of its fatty acid binding properties, Biochim Biophys Acta, 1488, 245, 10.1016/S1388-1981(00)00128-1 Diaz, 1998, TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking, Cell, 93, 433, 10.1016/S0092-8674(00)81171-X Miura, 2002, Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium, J Biol Chem, 277, 32253, 10.1074/jbc.M204410200 Fujimoto, 2004, Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7, Biochim Biophys Acta, 1644, 47, 10.1016/j.bbamcr.2003.10.018 Ganley, 2004, Rab9 GTPase regulates late endosome size and requires effector interaction for its stability, Mol Biol Cell, 10.1091/mbc.E04-08-0747 Athenstaedt, 1999, Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae, J Bacteriol, 181, 6441, 10.1128/JB.181.20.6441-6448.1999 Kurzchalia, 1999, Membrane microdomains and caveolae, Curr Opin Cell Biol, 11, 424, 10.1016/S0955-0674(99)80061-1 Liu, 2002, Multiple functions of caveolin-1, J Biol Chem, 277, 41295, 10.1074/jbc.R200020200 Parton, 2003, Caveolae—from ultrastructure to molecular mechanisms, Nat Rev Mol Cell Biol, 4, 162, 10.1038/nrm1017 Kogo, 2002, Identification of a splice variant of mouse caveolin-2 mRNA encoding an isoform lacking the C-terminal domain, Arch Biochem Biophys, 401, 108, 10.1016/S0003-9861(02)00009-7 Kogo, 2000, Caveolin-1 isoforms are encoded by distinct mRNAs. Identification of mouse caveolin-1 mRNA variants caused by alternative transcription initiation and splicing, FEBS Lett, 465, 119, 10.1016/S0014-5793(99)01730-5 Parolini, 1999, Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex, J Biol Chem, 274, 25718, 10.1074/jbc.274.36.25718 Fra, 1995, De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin, Proc Natl Acad Sci USA, 92, 8655, 10.1073/pnas.92.19.8655 Way, 1995, M-caveolin, a muscle-specific caveolin-related protein, FEBS Lett, 376, 108, 10.1016/0014-5793(95)01256-7 Song, 1996, Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins, J Biol Chem, 271, 15160, 10.1074/jbc.271.25.15160 Razani, 2001, Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities, J Biol Chem, 276, 38121, 10.1074/jbc.M105408200 Drab, 2001, Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice, Science, 9, 9 Galbiati, 2001, Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities, J Biol Chem, 276, 21425, 10.1074/jbc.M100828200 Parton, 2001, Life without caveolae, Science, 293, 2405, 10.1126/science.1065677 Scherer, 1997, Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo, J Biol Chem, 272, 29337, 10.1074/jbc.272.46.29337 Scheiffele, 1998, Caveolin-1 and -2 in the exocytic pathway of MDCK cells, J Cell Biol, 140, 795, 10.1083/jcb.140.4.795 Galbiati, 1999, Phenotypic behavior of caveolin-3 mutations that cause autosomal dominant limb girdle muscular dystrophy (LGMD-1C). Retention of LGMD-1C caveolin-3 mutants within the golgi complex, J Biol Chem, 274, 25632, 10.1074/jbc.274.36.25632 Dietzen, 1995, Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae, J Biol Chem, 270, 6838, 10.1074/jbc.270.12.6838 Dupree, 1993, Caveolae and sorting in the trans-Golgi network of epithelial cells, EMBO J, 12, 1597, 10.1002/j.1460-2075.1993.tb05804.x Monier, 1995, VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro, Mol Biol Cell, 6, 911, 10.1091/mbc.6.7.911 Montesano, 1980, Distribution of filipin-cholesterol complexes at sites of exocytosis—a freeze-fracture study of degranulating mast cells, Cell Biol Int Rep, 4, 975, 10.1016/0309-1651(80)90170-8 Simionescu, 1983, Rings of membrane sterols surround the openings of vesicles and fenestrae, in capillary endothelium, J Cell Biol, 97, 1592, 10.1083/jcb.97.5.1592 Severs, 1983, Failure of filipin to detect cholesterol-rich domains in smooth muscle plasma membrane, Nature, 303, 637, 10.1038/303637a0 Severs, 1988, Caveolae: static inpocketings of the plasma membrane, dynamic vesicles or plain artifact?, J Cell Sci, 90, 341, 10.1242/jcs.90.3.341 Rothberg, 1992, A protein component of caveolae membrane coats, Cell, 68, 673, 10.1016/0092-8674(92)90143-Z Thiele, 2000, Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles, Nat Cell Biol, 2, 42, 10.1038/71366 Monier, 1996, Oligomerization of VIP21-caveolin in vitro is stabilized by long chain fatty acylation or cholesterol, FEBS Lett, 388, 143, 10.1016/0014-5793(96)00519-4 Uittenbogaard, 2000, Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complex formation, and rapid transport of cholesterol to caveolae, J Biol Chem, 275, 25595, 10.1074/jbc.M003401200 Fielding, 1995, Plasma membrane caveolae mediate the efflux of cellular free cholesterol, Biochemistry, 34, 14288, 10.1021/bi00044a004 Smart, 1994, Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation, J Cell Biol, 127, 1185, 10.1083/jcb.127.5.1185 Smart, 1996, A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane, J Biol Chem, 271, 29427, 10.1074/jbc.271.46.29427 Foster, 2003, Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors, Proc Natl Acad Sci USA, 100, 5813, 10.1073/pnas.0631608100 Fu, 2004, Expression of caveolin-1 enhances cholesterol efflux in hepatic cells, J Biol Chem, 279, 14140, 10.1074/jbc.M311061200 Pike, 2002, Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking, Biochemistry, 41, 10315, 10.1021/bi025943i Bist, 1997, Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol, Proc Natl Acad Sci USA, 94, 10693, 10.1073/pnas.94.20.10693 Hailstones, 1998, Regulation of caveolin and caveolae by cholesterol in MDCK cells, J Lipid Res, 39, 369, 10.1016/S0022-2275(20)33898-0 Fra, 2000, Genomic organization and transcriptional analysis of the human genes coding for caveolin-1 and caveolin-2, Gene, 243, 75, 10.1016/S0378-1119(99)00559-4 Fielding, 1999, Intracellular cholesterol transport in synchronized human skin fibroblasts, Biochemistry, 38, 2506, 10.1021/bi981012o Lau, 2004, RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR, J Biol Chem, 279, 36828, 10.1074/jbc.M404927200 Carozzi, 2002, Inhibition of lipid raft-dependent signaling by a dystrophy-associated mutant of caveolin-3, J Biol Chem, 277, 17944, 10.1074/jbc.M110879200 Fielding, 2003, Relationship between cholesterol trafficking and signaling in rafts and caveolae, Biochim Biophys Acta, 1610, 219, 10.1016/S0005-2736(03)00020-8 Fielding, 2004, Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80, Biochemistry, 43, 2578, 10.1021/bi035442c Shigematsu, 2003, The adipocyte plasma membrane caveolin functional/structural organization is necessary for the efficient endocytosis of GLUT4, J Biol Chem, 278, 10683, 10.1074/jbc.M208563200 Schlegel, 2001, Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum, J Biol Chem, 276, 4398, 10.1074/jbc.M005448200 Razani, 2002, Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities, J Biol Chem, 277, 8635, 10.1074/jbc.M110970200 Thomsen, 2002, Caveolae are highly immobile plasma membrane microdomains, which are not involved in constitutive endocytic trafficking, Mol Biol Cell, 13, 238, 10.1091/mbc.01-06-0317 Pelkmans, 2004, Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic, Cell, 118, 767, 10.1016/j.cell.2004.09.003 Kirkham, 2005, Ultrastructural identification of uncoated caveolin-independent early endcytic vesicles, J Cell Biol, 168, 465, 10.1083/jcb.200407078 Heino, 2000, Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface, Proc Natl Acad Sci USA, 97, 8375, 10.1073/pnas.140218797 Hao, 2002, Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle, J Biol Chem, 277, 609, 10.1074/jbc.M108861200 Parat, 2001, Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible, J Biol Chem, 276, 15776, 10.1074/jbc.M006722200 Uittenbogaard, 1998, Characterization of a cytosolic heat-shock protein-caveolin chaperone complex. Involvement in cholesterol trafficking, J Biol Chem, 273, 6525, 10.1074/jbc.273.11.6525 Mukherjee, 1998, Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog, Biophys J, 75, 1915, 10.1016/S0006-3495(98)77632-5 Fujimoto, 2001, Caveolin-2 is targeted to lipid droplets, a new “membrane domain” in the cell, J Cell Biol, 152, 1079, 10.1083/jcb.152.5.1079 Ostermeyer, 2001, Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets, J Cell Biol, 152, 1071, 10.1083/jcb.152.5.1071 Marchesan, 2003, A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free system, J Biol Chem, 278, 27293, 10.1074/jbc.M301430200 Huang, 1996, Oleosins and oil bodies in seeds and other organs, Plant Physiol, 110, 1055, 10.1104/pp.110.4.1055 Targett-Adams, 2003, Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein, J Biol Chem, 278, 15998, 10.1074/jbc.M211289200 Hope, 2002, The domains required to direct core proteins of hepatitis C virus and GB virus-B to lipid droplets share common features with plant oleosin proteins, J Biol Chem, 277, 4261, 10.1074/jbc.M108798200 Ostermeyer, 2004, Role of the hydrophobic domain in targeting caveolin-1 to lipid droplets, J Cell Biol, 164, 69, 10.1083/jcb.200303037 Nakamura, 2003, Adipose differentiation-related protein has two independent domains for targeting to lipid droplets, Biochem Biophys Res Commun, 306, 333, 10.1016/S0006-291X(03)00979-3 Garcia, 2003, The central domain is required to target and anchor perilipin A to lipid droplets, J Biol Chem, 278, 625, 10.1074/jbc.M206602200 Welte, 1998, Developmental regulation of vesicle transport in Drosophila embryos: forces and kinetics, Cell, 92, 547, 10.1016/S0092-8674(00)80947-2 Jackle, 1998, Vesicle transport: klarsicht clears up the matter, Curr Biol, 8, R542, 10.1016/S0960-9822(07)00343-0 Valetti, 1999, Role of dynactin in endocytic traffic: effects of dynamitin overexpression and colocalization with CLIP-170, Mol Biol Cell, 10, 4107, 10.1091/mbc.10.12.4107 Scherer, 1994, Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles, J Cell Biol, 127, 1233, 10.1083/jcb.127.5.1233 Cohen, 2004, Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation, Diabetes, 53, 1261, 10.2337/diabetes.53.5.1261 Brasaemle, 2000, The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets, Biochim Biophys Acta, 1483, 251, 10.1016/S1388-1981(99)00179-1 Clifford, 2000, Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes, J Biol Chem, 275, 5011, 10.1074/jbc.275.7.5011 Sztalryd, 2003, Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation, J Cell Biol, 161, 1093, 10.1083/jcb.200210169 Razani, 1999, Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A, J Biol Chem, 274, 26353, 10.1074/jbc.274.37.26353 Tabas, 2002, Consequences of cellular cholesterol accumulation: basic concepts and physiological implications, J Clin Invest, 110, 905, 10.1172/JCI0216452 Gargalovic, 2003, Cellular apoptosis is associated with increased caveolin-1 expression in macrophages, J Lipid Res, 44, 1622, 10.1194/jlr.M300140-JLR200 Feng, 2003, The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages, Nat Cell Biol, 5, 781, 10.1038/ncb1035 Pelat, 2003, Rosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E−/− mice in vivo, Circulation, 107, 2480, 10.1161/01.CIR.0000065601.83526.3E Gargalovic, 2003, Caveolins and macrophage lipid metabolism, J Lipid Res, 44, 11, 10.1194/jlr.R200005-JLR200 Frank, 2004, Genetic ablation of caveolin-1 confers protection against atherosclerosis, Arterioscler Thromb Vasc Biol, 24, 98, 10.1161/01.ATV.0000101182.89118.E5