The Relationship Between Adverse Childhood Experiences, Symptom Severity, Negative Thinking, Comorbidity, and Treatment Response in Youth with Obsessive-Compulsive Disorder

Mariana Vazquez1, Amanda Palo1, McKenzie Schuyler2, Brent J. Small3, Joseph F. McGuire4, Sabine Wilhelm2,5, Wayne K. Goodman1, Daniel Geller2,5, Eric A. Storch1
1Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, USA
2Massachusetts General Hospital, Boston, USA
3University of South Florida, Tampa, USA
4Department of Psychiatry and Behavioral Science; Johns Hopkins University School of Medicine; Baltimore USA
5Harvard Medical School, Boston, USA;

Tóm tắt

Although youth and adults with obsessive-compulsive disorder (OCD) endorse elevated incidence of exposure to traumatic life events during childhood, the existing literature on adverse childhood experiences (ACEs) and OCD is mixed and studies focusing on pediatric OCD are limited. The present study examines the relationship between ACEs and OCD onset, symptom severity, negative cognitive patterns, comorbidity, and cognitive-behavioral therapy (CBT) response in 142 children and adolescents with OCD. ACEs were ascertained from parent reports. Most parents reported child exposure to ACEs. Out of the parents who reported ACEs, 50% reported ACE exposure prior to OCD diagnosis and 50% reported ACE exposure after OCD diagnosis. No significant associations between ACEs and comorbidity or CBT response were found, suggesting that CBT for pediatric OCD is effective regardless of ACE exposure. Family financial problems were associated with increased obsessive-compulsive symptom severity and negative thinking. Implications for research and practice are discussed.

Tài liệu tham khảo

Portwood SG, Lawler MJ, Roberts MC (2021) Science, practice, and policy related to adverse childhood experiences: framing the conversation. Am Psychol 2:181–187 Chang X, Jiang X, Mkandarwire T, Shen M (2019) Associations between adverse childhood experiences and health outcoes in adults aged 18–59 years. PLoS ONE 2:e0211850–e0211850 Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V et al (1998) Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the adverse childhood experiences (ACE) study. Am J Prev Med 4:245–258 Kalmakis KA, Chandler GE (2015) Health consequences of adverse childhood experiences: a systematic review. J Am Assoc Nurse Pract 8:457–465 Scully C, Mclaughlin J, Fitzgerald A(2020) The relationship between adverse childhood experiences, family functioning, and mental health problems among children and adolescents: a systematic review.J Fam Ther291–316 Green JG, Mclaughlin KA, Berglund PA, Gruber MJ, Sampson NA, Zaslavsky AM et al (2010) Childhood adversities and adult psychiatric disorders in the National Comorbidity Survey replication I: associations with first onset of DSM-IV disorders. Arch Gen Psychiatry 2:113–123 Kessler RC, Mclaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky AM et al (2010) Childhood adversities and adult psychopathology in the WHO World Mental Health surveys. Br J Psychiatry 5:378–385 Mclaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky AM, Kessler RC (2012) Childhood adversities and first onset of psychiatric disorders in a national sample of US adolescents. Arch Gen Psychiatry 11:1151–1160 Mclaughlin KA(2017) The long shadow of adverse childhood experiences.Psychological Science Agenda4 Nurius PS, Green S, Logan-Greene P, Borja S(2015) Life course pathways of adverse childhood experiences toward adult psychological well-being: a stress process analysis.Child Abuse Negl143–153 Ruscio AM, Stein DJ, Chiu WT, Kessler RC (2010) The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry 1:53–63 Caspi A, Vishne T, Sasson Y, Gross R, Livne A, Zohar J (2008) Relationship between childhood sexual abuse and obsessive-compulsive disorder: case control study. Isr J Psychiatry Relat Sci 3:177–182 Grisham JR, Fullana MA, Mataix-Cols D, Moffitt TE, Caspi A, Poulton R (2011) Risk factors prospectively associated with adult obsessive–compulsive symptom dimensions and obsessive–compulsive disorder. Psychol Med 12:2495–2506 Lafleur DL, Petty C, Mancuso E, Mccarthy K, Biederman J, Faro A et al (2011) Traumatic events and obsessive compulsive disorder in children and adolescents: is there a link? J Anxiety Disord 4:513–519 Lochner C, Du Toit PL, Zungu-Dirwayi N, Marais A, Van Kradenburg J, Seedat S et al (2002) Childhood trauma in obsessive-compulsive disorder, trichotillomania, and controls. Depress Anxiety 2:66–68 Goodman WK, Storch EA, Sheth SA (2021) Harmonizing the neurobiology and treatment of obsessive-compulsive disorder. Am J Psychiatry 1:17–29 De Silva P, Marks M (1999) The role of traumatic experiences in the genesis of obsessive-compulsive disorder. Behav Res Ther 10:941–951 Sasson Y, Dekel S, Nacasch N, Chopra M, Zinger Y, Amital D et al (2005) Posttraumatic obsessive-compulsive disorder: a case series. Psychiatry Res 2:145–152 Pitman RK (1993) Posttraumatic obsessive-compulsive disorder: a case study. Compr Psychiatry 2:102–107 Benedetti F, Poletti S, Radaelli D, Pozzi E, Giacosa C, Ruffini C et al (2012) Caudate gray matter volume in obsessive-compulsive disorder is influenced by adverse childhood experiences and ongoing drug treatment. J Clin Psychopharmacol 4:544–547 Someshwar A, Holla B, Agarwal P, Thomas A, Jose A, Joseph B et al (2020) Adverse childhood experiences in families with multiple members diagnosed to have psychiatric illnesses. Aust N Z J Psychiatry 11:1086–1094 Cromer KR, Schmidt NB, Murphy DL (2007) An investigation of traumatic life events and obsessive-compulsive disorder. Behav Res Ther 7:1683–1691 Destrée L, Brierley ME, Albertella L, Jobson L, Fontenelle LF(2021) The effect of childhood trauma on the severity of obsessive-compulsive symptoms: a systematic review.J Psychiatr Res345–360 Visser HA, Van Minnen A, Van Megen H, Eikelenboom M, Hoogendoorn A, Kaarsemaker M et al (2014) The relationship between adverse childhood experiences and symptom severity, chronicity, and comorbidity in patients with obsessive-compulsive disorder. J Clin Psychiatry 10:1034–1039 Arbel R, Schacter HL, Kazmierski KFM, Daspe ME, Margolin G (2018) Adverse childhood experiences, daily worries, and positive thoughts: a daily diary multi-wave study. Br J Clin Psychol 4:514–519 Mansueto G, Cavallo C, Palmieri S, Ruggiero GM, Sassaroli S, Caselli G (2021) Adverse childhood experiences and repetitive negative thinking in adulthood: a systematic review. Clin Psychol Psychother 3:557–568 Gershuny BS, Baer L, Jenike MA, Minichiello WE, Wilhelm S (2002) Comorbid posttraumatic stress disorder: impact on treatment outcome for obsessive-compulsive disorder. Am J Psychiatry 5:852–854 Shavitt RG, Valerio C, Fossaluza V, Da Silva EM, Cordeiro Q, Diniz JB et al (2010) The impact of trauma and post-traumatic stress disorder on the treatment response of patients with obsessive-compulsive disorder. Eur Arch Psychiatry Clin Neurosci 2:91–99 Fricke S, Köhler S, Moritz S, Schäfer I (2007) Early interpersonal trauma in obsessive-compulsive disorder: a pilot study. Behav Ther 4:243–250 Benarous X, Raffin M, Bodeau N, Dhossche D, Cohen D, Consoli A (2017) Adverse childhood experiences among inpatient youths with severe and early-onset psychiatric disorders: prevalence and clinical correlates. Child Psychiatry Hum Dev 2:248–259 Storch EA, Wilhelm S, Sprich S, Henin A, Micco J, Small BJ et al (2016) Efficacy of augmentation of cognitive behavior therapy with weight-adjusted d-cycloserine vs placebo in pediatric obsessive-compulsive disorder: a randomized clinical trial. JAMA Psychiatry 8:779–788 World Health Organization (2018) Adverse Childhood Experiences International Questionnaire (ACE-IQ). Retrieved 12 December 2022, from https://www.who.int/publications/m/item/adverse-childhood-experiences-international-questionnaire-(ace-iq) Finkelhor D, Shattuck A, Turner H, Hamby S (2013) Improving the adverse childhood experiences study scale. JAMA Pediatr 167:70–75 Gipson JD, Koenig MA, Hindin MJ (2008) The effects of unintended pregnancy on infant, child, and parental health: a review of the literature. Stud Fam Plann 39:18–38 Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P et al (1997) Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 7:980–988 Scahill L, Riddle M, Mcswiggin-Hardin M, Ort SI, King RA, Goodman WK et al (1997) Children’s Yale-Brown Obsessive compulsive scale: reliability and validity. J Am Acad Child Adolesc Psychiatry 6:844–852 Storch EA, Lewin AB, De Nadai AS, Murphy TK (2010) Defining treatment response and remission in obsessive-compulsive disorder: a signal detection analysis of the Childrenʼs Yale-Brown Obsessive compulsive scale. J Am Acad Child Adolesc Psychiatry 7:708–717 Storch EA, Murphy TK, Geffken GR, Soto O, Sajid M, Allen P et al (2004) Psychometric evaluation of the Children’s Yale-Brown obsessive-compulsive scale. Psychiatry Res 1:91–98 Piacentini J, Peris TS, Bergman L, Chang S, Jaffer M (2007) Functional impairment in childhood OCD: development and psychometrics properties of the child obsessive-compulsive impact scale-revised (COIS-R). J Clin Child Adolesc Psychol 4:645–653 Piacentini J, Bergman L, Keller M, Mccracken J(2003) Functional impairment in children and adolescents with obsessive-compulsive disorder.J Child Adolesc PsychopharmacolS61-S69 Guy W (ed) (1976) Early clinical drug evaluation Unit Assessment Manual for Psychopharmacology. US Department of Heath, Education, and Welfare Public Health Service Alcohol. Rockville, MD, Drug Abuse, and Mental Health Administration Coles ME, Wolters LH, Sochting I, De Haan E, Pietrefesa AS, Whiteside SP (2010) Development and initial validation of the obsessive belief questionnaire-child version (OBQ-CV). Depress Anxiety 10:982–991 Crouch E, Probst JC, Radcliff E, Bennett KJ, Mckinney SH(2019) Prevalence of adverse childhood experiences (ACEs) among US children.Child Abuse Negl209–218 Boger S, Ehring T, Berberich G, Werner GG (2020) Impact of childhood maltreatment on obsessive-compulsive disorder symptom severity and treatment outcome. Eur J Psychotraumatol 1:1753942 Du Plessis LJ, Lochner C, Louw D, Hendricks G, Bowles S, Fischer M et al(2021) A comprehensive view of functional impairment in children and adolescents with obsessive-compulsive disorder adds value.Early Interv Psychiatry1–8 Geller DA, Abramovitch A, Mittelman A, Stark A, Ramsey K, Cooperman A et al (2018) Neurocognitive function in pediatric obsessive-compulsive disorder. World J Biol Psychiatry 2:142–151 Weidle B, Jozefiak T, Ivarsson T, Thomsen PH (2014) Quality of life in children with OCD with and without comorbidity. Health Qual Life Outcomes 1:152 Walker J, Crawford K, Taylor F (2008) Listening to children: gaining a perspective of the experiences of poverty and social exclusion from children and young people of single-parent families. Health Soc Care Community 4:429–436 Conger RD, Wallace LE, Sun Y, Simons RL, Mcloyd VC, Brody GH (2002) Economic pressure in african american families: a replication and extension of the family stress model. Dev Psychol 2:179–193 Landers-Potts M, Wickrama K, Simons LG, Gibbons F, Conger R (2015) An extension and moderational analysis of the family stress model. Fam Relat 2:233–248