Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

Nature - Tập 408 Số 6808 - Trang 86-89 - 2000
Amy E. Pasquinelli1, Brenda J. Reinhart2, Frank J. Slack3, Mark Q. Martindale4, Mitzi I. Kuroda5, Betsy Maller3, David C. Hayward6, Eldon E. Ball6, Bernard M. Degnan7, Peter Müller8, Jürg Spring8, Ashok Srinivasan9, Mark C. Fishman9, John R. Finnerty10, Joseph C. Corbo11, Michael Levine11, Patrick Leahy12, Eric A. Davidson12, Gary Ruvkun2
1Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
2Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, USA
3Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, USA
4Kewalo Marine Lab, Pacific Biomedical Research Center, University of Hawaii, Honolulu, USA
5Howard Hughes Medical Institute, Baylor College of Medicine, Houston, USA
6Research School of Biological Sciences, PO Box 475, Australian National University, Canberra, Australia
7Department of Zoology and Entomology, University of Queensland, Brisbane, Australia,
8Institute of Zoology, University of Basel, Basel, (Switzerland)
9Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, USA
10Department of Biology, Boston University, Boston, USA
11Department of Molecular and Cell biology, University of California, Berkeley, USA
12Division of Biology 156−29, California Institute of Technology, Pasadena, USA

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Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843–854 ( 1993).

Reinhart, B. et al. The 21-nucleotide let-7 RNA regulates developmental timing in C. elegans. Nature 403, 901–906 (2000).

Chalfie, M., Horvitz, H. R. & Sulston, J. E. Mutations that lead to reiterations in the cell lineages of C. elegans. Cell 24, 59– 69 (1981).

Ambros, V. & Horvitz, H. R. The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events. Genes Dev. 1, 398– 414 (1987).

Wightman, B., Ha, I. & Ruvkun, G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75, 855–862 ( 1993).

Slack, F. et al. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol. Cell 5, 659– 669 (2000).

Aguinaldo, A. M. et al. Evidence for a clade of nematodes, arthropods and other moulting animals. Nature 387, 489– 493 (1997).

Zamore, P. D., Tuschl, T., Sharp, P. A. & Bartel, D. P. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101, 25–33 (2000).

Hammond, S. M., Bernstein, E., Beach, D. & Hannon, G. J. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404, 293– 296 (2000).

Tuschl, T., Zamore, P. D., Lehmann, R., Bartel, D. P. & Sharp, P. A. Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev. 13, 3191 –3197 (1999).

Montgomery, M. K., Xu, S. & Fire, A. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabiditis elegans. Proc. Natl Acad. Sci. USA 95, 15502–15507 (1998).

Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhbditis elegans. Nature 391, 806–810 (1998).

Olsen, P. H. & Ambros, V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev. Biol. 216, 671–680 (1999).

Tabara, H. et al. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell 99, 123– 132 (1999).