Morphogen-related therapeutic targets for liver fibrosis

Eileen Fung1, Hidekazu Tsukamoto1
1Department of Pathology, Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Greater Los Angeles VA Healthcare System, Los Angeles, CA, USA

Tài liệu tham khảo

Michalopoulos, 2010, Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas, Am J Pathol, 176, 2, 10.2353/ajpath.2010.090675 Stanger, 2015, Cellular homeostasis and repair in the mammalian liver, Annu Rev Physiol, 77, 179, 10.1146/annurev-physiol-021113-170255 Friedman, 2003, Liver fibrosis – from bench to bedside, J Hepatol, 38, S38, 10.1016/S0168-8278(02)00429-4 Friedman, 2008, Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver, Physiol Rev, 88, 125, 10.1152/physrev.00013.2007 Tsukamoto, 2008, Fat paradox of steatohepatitis, J Gastroenterol Hepatol, 23, S104, 10.1111/j.1440-1746.2007.05294.x Ito, 1968, Electron microscopic study on the hepatic sinusoidal wall and the fat-storing cells in the normal human liver, Arch Histol Jpn, 29, 137, 10.1679/aohc1950.29.137 Miyahara, 2000, Peroxisome proliferator-activated receptors and hepatic stellate cell activation, J Biol Chem, 275, 35715, 10.1074/jbc.M006577200 Hazra, 2004, Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells, J Biol Chem, 279, 11392, 10.1074/jbc.M310284200 Lecuit, 2007, Orchestrating size and shape during morphogenesis, Nature, 450, 189, 10.1038/nature06304 Turing, 1952, The chemical basis of morphogenesis, Philosophical Transactions, 10.1098/rstb.1952.0012 Wolpert, 1969, Positional information and the spatial pattern of cellular differentiation, J Theor Biol, 25, 1, 10.1016/S0022-5193(69)80016-0 Wessells, 1967, Early pancreas organogenesis: morphogenesis, tissue interactions, and mass effects, Dev Biol, 15, 237, 10.1016/0012-1606(67)90042-5 Zaret, 2008, Generation and regeneration of cells of the liver and pancreas, Science, 322, 1490, 10.1126/science.1161431 Lee, 2005, The initiation of liver development is dependent on Foxa transcription factors, Nature, 435, 944, 10.1038/nature03649 Rossi, 2001, Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm, Genes Dev, 15, 1998, 10.1101/gad.904601 Asahina, 2011, Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver, Hepatology, 53, 983, 10.1002/hep.24119 Macdonald, 1961, “Lifespan” of liver cells. Autoradio-graphic study using tritiated thymidine in normal, cirrhotic, and partially hepatectomized rats, Arch Intern Med, 107, 335, 10.1001/archinte.1961.03620030023003 Maeda, 2012, Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis, Nat Med, 18, 405, 10.1038/nm.2653 Naskar, 2014, Wnt5a–Rac1–NF-κB homeostatic circuitry sustains innate immune functions in macrophages, J Immunol, 192, 4386, 10.4049/jimmunol.1302817 Schlessinger, 2009, Wnt signaling pathways meet Rho GTPases, Genes Dev, 23, 265, 10.1101/gad.1760809 Myung, 2007, Wnt signaling enhances the activation and survival of human hepatic stellate cells, FEBS Lett, 581, 2954, 10.1016/j.febslet.2007.05.050 Jiang, 2006, Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation, J Hepatol, 45, 401, 10.1016/j.jhep.2006.03.016 Cheng, 2008, Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis, Am J Physiol Gastrointest Liver Physiol, 294, G39, 10.1152/ajpgi.00263.2007 Bennett, 2002, Regulation of Wnt signaling during adipogenesis, J Biol Chem, 277, 30998, 10.1074/jbc.M204527200 Ross, 2000, Inhibition of adipogenesis by Wnt signaling, Science, 289, 950, 10.1126/science.289.5481.950 Kordes, 2008, Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells, Biochem Biophys Res Commun, 367, 116, 10.1016/j.bbrc.2007.12.085 Barker, 2002, The MAGE proteins: emerging roles in cell cycle progression, apoptosis, and neurogenetic disease, J Neurosci Res, 67, 705, 10.1002/jnr.10160 Kuwajima, 2004, Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells, J Biol Chem, 279, 40484, 10.1074/jbc.M404143200 Tseng, 2005, Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin, Nat Cell Biol, 7, 601, 10.1038/ncb1259 Zhu, 2010, The Necdin-Wnt pathway causes epigenetic peroxisome proliferator-activated receptor gamma repression in hepatic stellate cells, J Biol Chem, 285, 30463, 10.1074/jbc.M110.156703 Zong, 2009, Notch signaling controls liver development by regulating biliary differentiation, Development, 136, 1727, 10.1242/dev.029140 Tanimizu, 2004, Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors, J Cell Sci, 117, 3165, 10.1242/jcs.01169 Sparks, 2011, Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice, Dis Model Mech, 4, 359, 10.1242/dmm.005793 D'Souza, 2010, Canonical and non-canonical Notch ligands, Curr Top Dev Biol, 92, 73, 10.1016/S0070-2153(10)92003-6 Kohler, 2004, Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration, Hepatology, 39, 1056, 10.1002/hep.20156 Reister, 2011, The epigenetic regulation of stem cell factors in hepatic stellate cells, Stem Cells Dev, 20, 1687, 10.1089/scd.2010.0418 Furubo, 2013, Roles of myofibroblasts and notch and hedgehog signaling pathways in the formation of intrahepatic bile duct lesions in polycystic kidney rats, Pediatr Dev Pathol, 16, 177, 10.2350/12-11-1267-OA.1 Zhu, 2012, Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration, J Biol Chem, 287, 10355, 10.1074/jbc.M111.312751 Smas, 1993, Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation, Cell, 73, 725, 10.1016/0092-8674(93)90252-L Tanimizu, 2003, Isolation of hepatoblasts based on the expression of Dlk/Pref-1, J Cell Sci, 116, 1775, 10.1242/jcs.00388 Yanai, 2010, Dlk-1, a cell surface antigen on foetal hepatic stem/progenitor cells, is expressed in hepatocellular, colon, pancreas and breast carcinomas at a high frequency, J Biochem, 148, 85, 10.1093/jb/mvq034 Kim, 2009, Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity, Cancer Res, 69, 9271, 10.1158/0008-5472.CAN-09-1605 Nusslein-Volhard, 1980, Mutations affecting segment number and polarity in Drosophila, Nature, 287, 795, 10.1038/287795a0 Yang, 2008, Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells, J Hepatol, 48, 98, 10.1016/j.jhep.2007.07.032 Lin, 2008, Hedgehog-mediated paracrine interaction between hepatic stellate cells and marrow-derived mesenchymal stem cells, Biochem Biophys Res Commun, 372, 260, 10.1016/j.bbrc.2008.05.029 Omenetti, 2007, Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation, Lab Invest, 87, 499, 10.1038/labinvest.3700537 Qiu, 2014, Curcumin regulates delta-like homolog 1 expression in activated hepatic stellate cell, Eur J Pharmacol, 728, 9, 10.1016/j.ejphar.2014.01.074 Michelotti, 2013, Smoothened is a master regulator of adult liver repair, J Clin Invest, 123, 2380 Kisseleva, 2012, Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis, Proc Natl Acad Sci U S A, 109, 9448, 10.1073/pnas.1201840109