The effect of denosumab and alendronate on trabecular plate and rod microstructure at the distal tibia and radius: A post-hoc HR-pQCT study

Parfitt, 2000, Structural and cellular changes during bone growth in healthy children, Bone., 27, 487, 10.1016/S8756-3282(00)00353-7 Seeman, 2006, Bone quality—the material and structural basis of bone strength and fragility, N. Engl. J. Med., 354, 2250, 10.1056/NEJMra053077 Hattner, 1965, Suggested sequential mode of control of changes in cell behaviour in adult bone remodelling, Nature., 206, 489, 10.1038/206489a0 Vedi, 1983, Histomorphometric analysis of dynamic parameters of trabecular bone formation in the iliac crest of normal British subjects, Metab. Bone Dis. Relat. Res., 5, 69, 10.1016/0221-8747(83)90004-8 Lips, 1978, Mean wall thickness of trabecular bone packets in the human iliac crest: changes with age, Calcif. Tissue Res., 26, 13, 10.1007/BF02013227 Bjørnerem, 2018, Menopause-related appendicular bone loss is mainly cortical and results in increased cortical porosity, J. Bone Miner. Res., 33, 598, 10.1002/jbmr.3333 Wang, 2015, Trabecular plates and rods determine elastic modulus and yield strength of human trabecular bone, Bone., 72, 71, 10.1016/j.bone.2014.11.006 Liu, 2009, Contributions of trabecular rods of various orientations in determining the elastic properties of human vertebral trabecular bone, Bone., 45, 158, 10.1016/j.bone.2009.04.201 Fields, 2011, Influence of vertical trabeculae on the compressive strength of the human vertebra, J. Bone Miner. Res., 26, 263, 10.1002/jbmr.207 Liu, 2008, Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone, J. Bone Miner. Res., 23, 223, 10.1359/jbmr.071009 Schaffler, 1988, Stiffness of compact bone: effects of porosity and density, J. Biomech., 21, 13, 10.1016/0021-9290(88)90186-8 Liu, 2008, Dynamic simulation of three dimensional architectural and mechanical alterations in human trabecular bone during menopause, Bone., 43, 292, 10.1016/j.bone.2008.04.008 McClung, 2006, Denosumab in postmenopausal women with low bone mineral density, N. Engl. J. Med., 354, 821, 10.1056/NEJMoa044459 Manolagas, 2000, Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis, Endocr. Rev., 21, 115 Cummings, 2009, Denosumab for prevention of fractures in postmenopausal women with osteoporosis, N. Engl. J. Med., 361, 756, 10.1056/NEJMoa0809493 Seeman, 2019, Antiresorptive and anabolic agents in the prevention and reversal of bone fragility, Nat. Rev. Rheumatol., 15, 225, 10.1038/s41584-019-0172-3 Brown, 2009, Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial, J. Bone Miner. Res., 24, 153, 10.1359/jbmr.0809010 Kendler, 2010, Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy, J. Bone Miner. Res., 25, 72, 10.1359/jbmr.090716 Seeman, 2010, Microarchitectural deterioration of cortical and trabecular bone: differing effects of denosumab and alendronate, J. Bone Miner. Res., 25, 1886, 10.1002/jbmr.81 Zebaze, 2014, Differing effects of denosumab and alendronate on cortical and trabecular bone, Bone, 59, 173, 10.1016/j.bone.2013.11.016 Liu, 2011, Individual trabecula segmentation (ITS)-based morphological analysis of microscale images of human tibial trabecular bone at limited spatial resolution, J. Bone Miner. Res., 26, 2184, 10.1002/jbmr.420 Zhou, 2016, In vivo precision of digital topological skeletonization based individual trabecula segmentation (ITS) analysis of trabecular microstructure at the distal radius and tibia by HR-pQCT, Pattern Recogn. Lett., 76, 83, 10.1016/j.patrec.2015.03.012 Stein, 2014, Skeletal structure in postmenopausal women with osteopenia and fractures is characterized by abnormal trabecular plates and cortical thinning, J. Bone Miner. Res., 29, 1101, 10.1002/jbmr.2144 Nishiyama, 2014, Teriparatide increases strength of the peripheral skeleton in premenopausal women with idiopathic osteoporosis: a pilot HR-pQCT study, J. Clin. Endocrinol. Metab., 99, 2418, 10.1210/jc.2014-1041 Nishiyama, 2013, Clinical imaging of bone microarchitecture with HR-pQCT, Curr. Osteoporos. Rep., 11, 147, 10.1007/s11914-013-0142-7 Boutroy, 2005, In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography, J. Clin. Endocrinol. Metab., 90, 6508, 10.1210/jc.2005-1258 Buie, 2007, Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis, Bone., 41, 505, 10.1016/j.bone.2007.07.007 MacNeil, 2007, Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality, Med. Eng. Phys., 29, 1096, 10.1016/j.medengphy.2006.11.002 Liu, 2010, Individual trabeculae segmentation (ITS)-based morphological analysis of high-resolution peripheral quantitative computed tomography images detects abnormal trabecular plate and rod microarchitecture in premenopausal women with idiopathic osteoporosis, J. Bone Miner. Res., 25, 1496, 10.1002/jbmr.50 Goldstein, 1987, The mechanical properties of trabecular bone: dependence on anatomic location and function, J. Biomech., 20, 1055, 10.1016/0021-9290(87)90023-6 Mueller, 2011, Computational finite element bone mechanics accurately predicts mechanical competence in the human radius of an elderly population, Bone, 48, 1232, 10.1016/j.bone.2011.02.022 Ghasem-Zadeh, 2017, Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions, Bone., 101, 206, 10.1016/j.bone.2017.05.010 Wang, 2016, Deterioration of trabecular plate-rod and cortical microarchitecture and reduced bone stiffness at distal radius and tibia in postmenopausal women with vertebral fractures, Bone., 88, 39, 10.1016/j.bone.2016.04.003 Sornay-Rendu, 2007, Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study, J. Bone Miner. Res., 22, 425, 10.1359/jbmr.061206 Stein, 2010, Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures, J. Bone Miner. Res., 25, 2572, 10.1002/jbmr.152 Agarwal, 2016, In vivo assessment of bone structure and estimated bone strength by first- and second-generation HR-pQCT, Osteoporos. Int., 27, 2955, 10.1007/s00198-016-3621-8 Manske, 2015, Human trabecular bone microarchitecture can be assessed independently of density with second generation HR-pQCT, Bone, 79, 213, 10.1016/j.bone.2015.06.006 Seeman, 2010, Bone morphology in response to alendronate as seen by high-resolution computed tomography: through a glass darkly, J. Bone Miner. Res., 25, 2553, 10.1002/jbmr.261