Machine perfusion enhances hepatocyte isolation yields from ischemic livers

Gomez-Lechon, 2007, Hepatocytes–the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo, Chem. Biol. Interact., 168, 30, 10.1016/j.cbi.2006.10.013 Bonora-Centelles, 2010, Functional characterization of hepatocytes for cell transplantation: customized cell preparation for each receptor, Cell Transplant., 19, 21, 10.3727/096368909X474267 A. Dhawan, Strom, S.C., Sokal, E., Fox, I.J., Human hepatocyte transplantation, in: P. Maurel (Ed.), Hepatocytes, vol. 640, Springer Science + Business Media, 2010, pp. 525–534. Nyberg, 2012, Bridging the gap: advances in artificial liver support, Liver Transpl., 18, S10, 10.1002/lt.23506 Demetriou, 2004, Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure, Ann. Surg., 239, 660, 10.1097/01.sla.0000124298.74199.e5 Bhogal, 2011, Isolation of primary human hepatocytes from normal and diseased liver tissue: a one hundred liver experience, PLoS ONE, 6, e18222, 10.1371/journal.pone.0018222 Hughes, 2006, Isolation of hepatocytes from livers from non-heart-beating donors for cell transplantation, Liver Transpl., 12, 713, 10.1002/lt.20732 Tolboom, 2009, Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion, Transplantation, 87, 170, 10.1097/TP.0b013e318192df6b Schön, 2001, Liver transplantation after organ preservation with normothermic extracorporeal perfusion, Ann. Surg., 233, 114, 10.1097/00000658-200101000-00017 Abu-Amara, 2010, Liver ischemia/reperfusion injury: processes in inflammatory networks – a review, Liver Transpl., 16, 1016, 10.1002/lt.22117 Jaeschke, 1998, Mechanisms of reperfusion injury after warm ischemia of the liver, J. Hepatobiliary Pancreat. Surg., 5, 402, 10.1007/s005340050064 Izamis, 2012, Simple machine perfusion significantly enhances hepatocyte yields of ischemic and fresh rat livers, Cell Med., 4, 109, 10.3727/215517912X658927 J. Fischer, J. Baker, R. G.L. Shorr, Composition for maintaining organ and cell viability, United States Patent US 7,220,538 B2, 2007. Stowe, 2008, Low-flow perfusion of guinea pig isolated hearts with 26C air-saturated Lifor solution for 20 hours preserves function and metabolism, J. Heart Lung Transpl., 27, 1008, 10.1016/j.healun.2008.05.028 Olschewski, 2010, The influence of storage temperature during machine perfusion on preservation quality of marginal donor livers, Cryobiology, 60, 337, 10.1016/j.cryobiol.2010.03.005 Stowe, 2007, Ten-hour preservation of guinea pig isolated hearts perfused at low flow with air-saturated Lifor solution at 26C: comparison to ViaSpan solution, Am. J. Physiol. Heart Circ. Physiol., 293, H895, 10.1152/ajpheart.00149.2007 Gage, 2009, Room temperature pulsatile perfusion of renal allografts with Lifor compared with hypothermic machine pump solution, Transpl. Proc., 41, 3571, 10.1016/j.transproceed.2009.06.228 Deng, 2013, Machine perfusion versus cold storage of kidneys derived from donation after cardiac death: a meta-analysis, PLoS ONE, 8, e56368, 10.1371/journal.pone.0056368 Guarrera, 2009, Hypothermic machine preservation in human liver transplantation: the first clinical series, Am. J. Transplant., 10, 372, 10.1111/j.1600-6143.2009.02932.x Seglen, 1976, Preparation of isolated rat liver cells, Method. Cell Biol., 13, 29, 10.1016/S0091-679X(08)61797-5 Dunn, 1991, Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration, Biotechnol. Progr., 7, 237, 10.1021/bp00009a007 Berendsen, 2012, A simplified subnormothermic machine perfusion model restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation, Tranplant. Res., 1, 6, 10.1186/2047-1440-1-6 Tolboom, 2011, Subnormothermic machine perfusion for recovery and preservation of ischemic rat liver grafts, J. Surg. Res., 175 Delriviere, 1996, Detailed modification technique for safer harvesting and preparation of liver graft in the rat, Microsurgery, 17, 690, 10.1002/(SICI)1098-2752(1996)17:12<690::AID-MICR6>3.0.CO;2-R Jackson, 1980, Principal components and factor analysis: part I – Principal Components, J. Qual. Technol., 12, 201, 10.1080/00224065.1980.11980967 Tracy, 1992, Multivariate control charts for individual observations, J. Qual. Contr., 24, 88 Nomikos, 1994, Monitoring batch processes using multi-way principal component analysis, AIChE J., 40, 1361, 10.1002/aic.690400809 Nomikos, 1995, Multi-way partial least squares in monitoring batch processes, Chemometr. Intell. Lab., 30, 97, 10.1016/0169-7439(95)00043-7 Nomikos, 1995, Multivariate SPC charts for monitoring batch processes, Technometrics, 37, 41, 10.1080/00401706.1995.10485888 A. Cinar, S.J. Parulekar, C. Undey, G. Birol, Batch Fermentation: modeling, monitoring, and control: Marcel Dekker, 2003. Undey, 2002, Statistical monitoring of multi-stage, multi-phase batch processes, IEEE Contr. Syst. Mag., 22, 40, 10.1109/MCS.2002.1035216 Wold, 1987, Multi-way principal components and PLS analysis, J. Chemometr., 41, 10.1002/cem.1180010107 L. Eriksson, E. Johansson, N. Kettaneh-Wold, J. Trygg, C. Wikstrom, S. Wold, Multi- and Megavariate Data Analysis Part I: Basic Principles and Applications: Umetrics, 2006. Blaxter, 1989 Hamamoto, 1993, Isolated perfusion of rat livers: effect of temperature on O2 consumption, enzyme release, energy store, and morphology, Nippon Geka Hokan, 62, 58 Izamis, 2013, Resuscitation of ischemic donor livers with normothermic machine perfusion: a dynamic metabolic analysis of treatment in rats, PLoS ONE, 8, e69758, 10.1371/journal.pone.0069758 Izamis, 2010, In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury, Biotechnol. Bioeng., 108, 839, 10.1002/bit.22998 H. Wold, Parial Least Squares, 1985. Izamis, 2012, Addressing the donor liver shortage with machine perfusion, J. Healthcare Eng., 3, 279, 10.1260/2040-2295.3.2.279 Fuller, 2007, Hypothermic perfusion preservation: the future of organ preservation revisited?, Cryobiology, 54, 129, 10.1016/j.cryobiol.2007.01.003 Pirenne, 2001, Type of donor aortic preservation solution and not cold ischemia time is a major determinant of biliary strictures after liver transplantation, Liver Transpl., 7, 540, 10.1053/jlts.2001.24641 Bessems, 2005, Wash-out of the non-heart-beating donor liver: a comparison between ringer lactate, HTK, and polysol, Transpl. Proc., 37, 395, 10.1016/j.transproceed.2004.12.260 Luer, 2010, Role of oxygen during hypothermic machine perfusion preservation of the liver, Transpl. Int., 23, 944 de Rougemont, 2009, One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts donated after cardiac death, Ann. Surg., 250, 674, 10.1097/SLA.0b013e3181bcb1ee Vairetti, 2008, Correlation between liver temperature employed during machine perfusion and reperfusion damage: role of Ca2+, Liver Transpl., 14, 494, 10.1002/lt.21421 Fondevila, 2012, Hypothermic oxygenated machine perfusion in porcine donation after circulatory determination of death liver transplant, Transplantation, 94, 22, 10.1097/TP.0b013e31825774d7 Perk, 2011, A metabolic index of ischemic injury for perfusion-recovery of cadaveric rat livers, PLoS ONE, 6, e28518, 10.1371/journal.pone.0028518 Perk, 2012, A fitness index for transplantation of machine-perfused cadaveric rat livers, BMC Res. Notes, 5, 10.1186/1756-0500-5-325 Bond, 2009, The effectiveness and cost-effectiveness of methods of storing donated kidneys from deceased donors: a systematic review and economic model, Health Technol. Assess., 13, 1, 10.3310/hta13380 Dutkowski, 2013, HOPE for human liver grafts obtained from donors after cardiac death, J. Hepatol., 60, 765, 10.1016/j.jhep.2013.11.023 Wallinder, 2012, Transplantation of initially rejected donor lungs after ex vivo lung perfusion, J. Thorac. Cardiovasc. Surg., 144, 1222, 10.1016/j.jtcvs.2012.08.011 Cypel, 2012, Experience with the first 50 ex vivo lung perfusions in clinical transplantation, J. Thorac. Cardiovasc. Surg., 144, 1200, 10.1016/j.jtcvs.2012.08.009 Collins, 2008, Preserving and evaluating hearts with ex vivo machine perfusion: an avenue to improve early graft performance and expand the donor pool, Eur. J. Cardiothorac. Surg., 34, 318, 10.1016/j.ejcts.2008.03.043 Bruinsma, 2014, Subnormothermic machine perfusion for ex vivo preservation and recovery of the human liver for transplantation, Am. J. Transpl., 10.1111/ajt.12727 Izamis, 2014, The effects of air embolism size and location on porcine hepatic microcirculation in machine perfusion, Liver Transpl., 10.1002/lt.23838