Ways and Methods for Controlling Biomolecular Structures Using Magnetic Nanoparticles Activated by an Alternating Magnetic Field

Pleiades Publishing Ltd - Tập 13 - Trang 295-304 - 2018
Yu. I. Golovin1,2, A. O. Zhigachev2, M. V. Efremova1,3, A. G. Majouga1,3,4, A. V. Kabanov1,5, N. L. Klyachko1,5
1Department of Chemistry, Moscow State University, Moscow, Russia
2Research Institute of Nanotechnologies and Nanomaterials, Derzhavin State University, Tambov, Russia
3National University of Science and Technology “MISiS”, Moscow, Russia
4Mendeleev University of Chemical Technology of Russia, Moscow, Russia
5University of North Carolina at Chapel Hill, Chapel Hill, USA

Tóm tắt

Functionalized magnetic nanoparticles (MNPs) controlled by an external magnetic field provide a new generation of promising nanobiomedical platform. Due to their ability to locally change the state of a biochemical system through two physical processes—thermal and nanomagnetomechanical—they are already used in experiments on targeted drug delivery and therapy of oncological diseases. This work considers the peculiarities, advantages, and drawbacks of each of these processes and the main parameters of the magnetic field controlling the MNP effect on different biomolecular targets. A brief review and comparative analysis of main experimental studies carried out in the scope of magnetic hyperthermia and nanomagnetomechanical actuation are carried out.

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