Relationship between caffeine intake and infertility: a systematic review of controlled clinical studies
Tóm tắt
For a long time, the relationship between caffeine consumption and infertility in the general population is unclear, this study is aimed to systematically review the evidence from any type of controlled clinical studies to explore whether caffeine intake is a risk factor for human infertility. Seven databases were searched from inception to May 2019. We included women/men without a history of infertility but were willing to have children in prospective studies and women/men who were diagnosed with infertility in retrospective studies. The observed exposure factor should be caffeine or caffeine containing beverage. Diagnosis of infertility or not for participants was the key outcome. The Newcastle-Ottawa scale (NOS) or Cochrane risk of bias tool were used to assess the methodological quality of included studies. Meta-analysis was conducted if there were acceptable clinical and statistical heterogeneity among studies. The GRADE method was used to assess the certainty of the evidence. Four studies (one cohort study and three case-control studies) involving 12,912 participants were included. According NOS, the average score of case-control studies was 6, and the cohort study achieved 9. Meta-analysis and subgroup analysis were conducted. The results showed that low (OR 0.95, 95%CI 0.78–1.16), medium (OR 1.14, 95%CI 0.69–1.86) and high doses (OR 1.86, 95%CI 0.28–12.22) of caffeine intake may not increase the risk of infertility. The quality of the current evidence bodies were all low. Our study provides low quality evidence that regardless of low, medium and high doses of caffeine intake do not appear increase the risk of infertility. But the conclusion should be treated with caution.
Tài liệu tham khảo
WHO | Infertility definitions and terminology. Available at: https://www.who.int/reproductivehealth/topics/infertility/definitions/en/. Accessed June 26, 2019.
Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med. 2012;9(12):e1001356.
Makar RS, Toth TL. The evaluation of infertility. Am J Clin Pathol. 2002;117(Suppl):S95–S103.
Sunderam S, Kissin DM, Flowers L, Anderson JE, Folger SG, Jamieson DJ, et al. Assisted reproductive technology surveillance--United States, 2009. MMWR Surveill Summ. 2012;61(7):1–23.
NHS Choices - Should I limit caffeine during pregnancy?. Available at: https://www.nhs.uk/common-health-questions/pregnancy/should-i-limit-caffeine-during-pregnancy/. Accessed June 26, 2019.
Cano-Marquina A, Tarin JJ, Cano A. The impact of coffee on health. Maturitas. 2013;75(1):7–21.
Qi H, Li S. Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson’s disease. Geriatr Gerontol Int. 2014;14(2):430–9.
Greenwood DC, Thatcher NJ, Ye J, Garrard L, Keogh G, King LG, et al. Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose-response meta-analysis. Eur J Epidemiol. 2014;29(10):725–34.
Ricci E, Vigano P, Cipriani S, Somigliana E, Chiaffarino F, Bulfoni A, et al. Coffee and caffeine intake and male infertility: a systematic review. Nutr J. 2017;16(1):37.
Hakim RB, Gray RH, Zacur H. Alcohol and caffeine consumption and decreased fertility. Fertil Steril. 1998;70(4):632–7.
Jensen TK, Henriksen TB, Hjollund NH, Scheike T, Kolstad H, Giwercman A, et al. Caffeine intake and fecundability: a follow-up study among 430 Danish couples planning their first pregnancy. Reprod Toxicol. 1998;12(3):289–95.
Bolumar F, Olsen J, Rebagliato M, Bisanti L. Caffeine intake and delayed conception: a European multicenter study on infertility and subfecundity. European study group on infertility subfecundity. Am J Epidemiol. 1997;145(4):324–34.
Curtis KM, Savitz DA, Arbuckle TE. Effects of cigarette smoking, caffeine consumption, and alcohol intake on fecundability. Am J Epidemiol. 1997;146(1):32–41.
Stanton CK, Gray RH. Effects of caffeine consumption on delayed conception. Am J Epidemiol. 1995;142(12):1322–9.
Joesoef MR, Beral V, Rolfs RT, Aral SO, Cramer DW. Are caffeinated beverages risk factors for delayed conception? Lancet. 1990;335(8682):136–7.
Wilcox A, Weinberg C, Baird D. Caffeinated beverages and decreased fertility. Lancet. 1988;2(8626–8627):1453–6.
Cao H, Ren J, Feng X, Yang G, Liu J. Is caffeine intake a risk factor leading to infertility? A protocol of an epidemiological systematic review of controlled clinical studies. Syst Rev. 2016;5:45.
Wells G, Shea B, O'Connell J. The Newcastle-Ottawa Scale (NOS) for Assessing The Quality of Nonrandomised Studies in Meta-analyses; 2014. p. 7.
Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. Cochrane Collaboration:2011 Available at http://handbook.cochrane.org. Accessed June 26, 2019.
Ioannidis JP, Patsopoulos NA, Evangelou E. Uncertainty in heterogeneity estimates in meta-analyses. BMJ. 2007;335(7626):914–6.
Mittlbock M, Heinzl H. A simulation study comparing properties of heterogeneity measures in meta-analyses. Stat Med. 2006;25(24):4321–33.
Brockwell SE, Gordon IR. A comparison of statistical methods for meta-analysis. Stat Med. 2001;20(6):825–40.
Sterne JA, Gavaghan D, Egger M. Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol. 2000;53(11):1119–29.
Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924–6.
Buiatti E, Barchielli A, Geddes M, Nastasi L, Kriebel D, Franchini M, et al. Risk factors in male infertility: a case-control study. Arch Environ Health. 1984;39(4):266–70.
Grodstein F, Goldman MB, Ryan L, Cramer DW. Relation of female infertility to consumption of caffeinated beverages. Am J Epidemiol. 1993;137(12):1353–60.
Parazzini F, Marchini M, Tozzi L, Mezzopane R, Fedele L. Risk factors for unexplained dyspermia in infertile men: a case-control study. Arch Androl. 1993;31(2):105–13.
SL I, Jensen A, Juul KE, Kesmodel US, Frederiksen K, Kjaer SK, et al. Coffee, tea and caffeine consumption and risk of primary infertility in women: a Danish cohort study. Acta Obstet Gynecol Scand. 2018;97(5):570–6.
Cao H, Liu J. A systematic review of analytical studies on relationship between caffeine intake during pregnancy and spontaneous abortion. Chin J Prac Gynecol Obstetr. 2014;30(12):945–50.
Gaskins AJ, Chavarro JE. Diet and fertility: a review. Am J Obstet Gynecol. 2018;218(4):379–89.